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The role of serum ferritin as a biomarker of iron and inflammation in anemia: a systematic literature review Kedaton, Rafi Andyah Arum; Devi, Nabila Sinta; Kusworini, Kusworini; Wardani, Diadjeng Setya
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.4137

Abstract

Background: Anemia remains a major global health concern, particularly in low- and middle-income countries where distinguishing Iron Deficiency Anemia (IDA) from Anemia of Inflamation (AI) remains diagnostically challenging. Hemoglobin alone cannot differentiate these conditions, necessitating more specific biomarkers. Serum ferritin, the primary iron-storage protein, reflects body iron reserves but is also elevated during inflammation through interleukin-6-mediated hepcidin induction. Objective: This review examines the dual role of ferritin as an iron biomarker and an inflammatory marker. Methods: A literature search was conducted in PubMed, ScienceDirect, SpringerLink, and the Cochrane Library with a ten-year publication limit. Of the 89 articles identified, only eight studies met the inclusion criteria and directly evaluated the relationship between ferritin, iron status, and inflammatory processes. Results: Ferritin remains a key indicator of iron reserves, but its interpretation needs to take into account the inflammatory status. Conclusion: The combination of ferritin with inflammatory biomarkers such as C-Reactive Protein (CRP)and Alpha-1-acid glycoprotein (AGP) improves the diagnostic accuracy for anemia related to both iron deficiency and inflammation.
Peer Group Discussion–Based Reproductive Health Education and Adolescents’ Attitudes Toward Early Marriage: A Quasi-Experimental Study Diadjeng Setya Wardani; Rafi’ Andyah Arum Kedaton; Nabila Sinta Devi
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 9 No. 4 (2026): April 2026
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i4.9135

Abstract

Introduction: Early marriage is defined as marriage occurring before the age of 19 years. The incidence of early marriage remains high in East Java, Indonesia. Early marriage is associated with limited educational attainment, increased health risks, and emotional instability among adolescents. Adolescence is a critical developmental period during which attitudes and decision-making are strongly influenced by peers. Peer group discussion-based reproductive health education provides an interactive learning approach that may enhance adolescents’ understanding of puberty, reproductive rights, and marriage readiness. This study aimed to analyze changes in adolescents’ attitudes toward early marriage after receiving peer group discussion-based reproductive health education at SMPN 2 Singosari, Malang, East Java. Methods: This study employed a pre-experimental one-group pretest-posttest design without a control group. The research was conducted from November to December 2024. The population consisted of all seventh-grade students (n-256). Using purposive sampling based on inclusion criteria, 72 adolescents were selected as participants. Respondents completed a questionnaire assessing attitudes toward early marriage before and after the intervention. The intervention consisted of structured peer group discussions on reproductive health, facilitated over several scheduled sessions. Data were analyzed using descriptive statistics and the Wilcoxon to assess differences in pretest and posttest attitude scores. Results: The majority of respondents were 13 years old, female and Javanese ethnicity. Some respondents had parents or relatives who married at an early age. Prior to intervention, most adolescents demonstrated a moderate attitude toward early marriage. However, after the intervention, the majority demonstrated a good attitude. The Wilcoxon test yielded a p-value < 0,05 indicating a statistically significant improvement adolescents’ attitudes. Conclusion: Peer group discussion-based reproductive health education significantly improves adolescents’ attitudes toward early marriage. Future research is recommended to include a control group, a longer follow-up and a larger sample size.
The Role of Parenting Style in Shaping Adolescent’s Knowledge and Attitudes Toward Early Marriage: A Cross-Sectional Study Diadjeng Setya Wardani; Devi, Nabila Sinta; Rafi Andyah Arum Kedaton
Jurnal Kebidanan Midwiferia Vol. 12 No. 1 (2026): April
Publisher : Universitas Muhammadiyah Sidoarjo

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Abstract

Early marriage refers to marriage occurring before the age of 18 years and remains a significant social and public health concern. Several factors contribute to the practice of early marriage, including environmental influences, family conditions, and adolescents’ personal perspectives. In the family context, parenting style is regarded as a significant factor influencing adolescents' comprehension and attitudes regarding social issues, such as early marriage. This study aimed to analyze the relationship between parenting styles and adolescents’ knowledge and attitudes toward early marriage among students at SMPN 2 Singosari, Malang. This study employed a cross-sectional design. Using simple random sampling, 72 ninth-graders were chosen from a population of 244 students to make up the sample. Structured questionnaires that evaluated parenting style, knowledge, and attitudes toward early marriage were used to gather data. The Chi-square test was used to analyze the data at a significance level of (p < 0.05). Adolescents' knowledge of early marriage was significantly correlated with parenting style (p < 0.001). Adolescents' opinions regarding early marriage were also significantly correlated with parenting style (p < 0.001). Parenting style is significantly related to both adolescents’ knowledge and their attitudes in responding to early marriage among students at SMPN 2 Singosari, Malang.
Mother-Daughter Relationship and Self-Esteem Levels in Undergraduate Midwifery Students at Brawijaya University Prasanti, Gayatri Anindya; Ariani, Dewi; Maharani, Afniari; Wardani, Diadjeng Setya
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 8 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i8.628

Abstract

Introduction: Self-esteem plays an important role in mental health and personal development. However, limited evidence is available regarding the relationship between mother–daughter relationships and self-esteem among midwifery students, particularly in the Indonesian context. Objective: This study aims to examine the association between mother-daughter relationship and self-esteem among undergraduate midwifery students at Brawijaya University. Method: with a cross-sectional. A total of 174 female students were selected from cohorts 2022–2024. The Mother-Adult Daughter Questionnaire (MADQ) was used to assess mother-daughter relationship and the Rosenberg Self-Esteem Scale (RSES) was used to measure self-esteem. Data were analyzed using Spearman rank correlation and ordinal logistic regression. This study employed an observational analytical design. Results and Discussion: Most respondents had high self-esteem and strong mother-daughter relationships. All three dimensions connectedness (r 0.386; p < 0.05;), interdependency dimension has a significant relationship with self-esteem (p < r 0.189; p<0.05), and the trust in hierarchy (; r 0.278 ; p < 0.05) were significantly associated with self-esteem. In multivariate analysis, only connectedness remained a significant predictor. Conclusion: Mother-daughter relationship are significantly associated with self-esteem among midwifery students, with emotional connectedness emerging as the most influential factor. These findings highlight the importance of supportive family relationships in promoting students’ psychological well-being
The Influence of Nutritional Status on the Incidence of Postpartum Hemorrhage in Three Community Health Centers (CHCs) in Dili, Timor Leste Alcinda Pinto Fernandes; Novida Ariani; Diadjeng Setya Wardani; Hermes Peguinho; Hadidja Binti Ali Hosman Maia; Filomena Soares; Mirioldis Matos Rodríguez
Contagion: Scientific Periodical Journal of Public Health and Coastal Health Vol 7, No 2 (2025): CONTAGION
Publisher : Universitas Islam Negeri Sumatera Utara, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/contagion.v7i2.24975

Abstract

Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality in low- and middle-income countries, including Timor-Leste. This analytical cross-sectional study, conducted from January to December 2024 in three community health centers (CHCs) in Dili, examined the association between maternal nutritional status and the incidence of PPH. Nutritional indicators included pre-pregnancy body mass index (BMI), gestational weight gain, anemia status, and mid-upper arm circumference (MUAC). Data were collected from medical records of 130 postpartum mothers (65 with PPH, 65 without). The prevalence of PPH was 50%. Among participants, 22.1% had anemia (hemoglobin <11 g/dL), 50.8% had MUAC <23.5 cm, and 41.5% had a pre-pregnancy BMI outside the WHO normal range (18.5-24.9 kg/m²). Only 26.4% achieved gestational weight gain within Institute of Medicine guidelines. Logistic regression analysis revealed that anemia significantly increased the risk of PPH (OR = 3.4; 95% CI: 1.38-8.40; p = 0.011), while other nutritional indicators showed no significant association. These findings highlight the critical role of antenatal anemia screening and targeted nutritional interventions in reducing PPH risk. This study provides locally relevant evidence to inform maternal health strategies in Timor-Leste. Keywords: Postpartum hemorrhage, Pre-pregnancy BMI, weight gain, Mid-Upper Arm Circumference, Antenatal Care, Community health center
Co-Authors Agus Adi Putrawan Aisyah Ardiana, Hanida Alcinda Pinto Fernandes Alidha Nur Rakhmani Anika Pratiwi, Sindy Anis Puji Rahayu Arcelia Putri Nurcahyani Arifiandi, Maya Devi Arifin Syamsul Bambang Rahardjo Chusna, Safira Mauliyatul da Silva, João Francisco Lela da Silva, Zelita Fernandes Devi, Nabila Sinta Dewi Ariani Dewi Kartika Sari Diana Fransisca, Ratna Dini Syarafina, Hafizahah Duhitatrissari, Fifin Pradina Emiliana, Farica Eri Kurniasari Fajar Ari Nugroho Fatmawati Fatmawati Fernandes, Alcinda Pinto Filomena Soares Gumanti, Kentri Anggarina Hadidja Binti Ali Hosman Maia Hafshah, Hafshah Hastuti, Novianti Tri Hastuti, Nur Aini Retno Hermes Peguinho Hernistanti, Alya Dwi Rahma Hinisa, Fariha Nuzulul I Wayan Agung Indrawan I Wayan Agung Indrawan Intan, Dara Jesica Mulyadi Kedaton, Rafi Andyah Arum Krisjentha Iffah Agustasari Kristianingsih, Rey Kusworini Handono Lionardy, Chandra Maharani, Afniari Mergy Gayatri Miftahul Jannah MIFTAHUL JANNAH Mirioldis Matos Rodríguez Nabila Sinta Devi Nabila Sinta Devi Novida Ariani Novida Ariani Nur Aini Retno Hastuti Nurazizah, Devita Alifia Nurul Fathiyyah Peguinho, Hermes Permata Sari, Hannie Prasanti, Gayatri Anindya Puspita, Alfi Laili Putu Sudewi Arsini Rafi Andyah Arum Kedaton Rafi’ Andyah Arum Kedaton Rahayuningsih, Elba Putri rahmah, shofi nur Ratna Diana Fransisca Ratna Diana Fransiska Ratna Diana Fransiska Retnaningtyas, Nining Retno Hastuti, Nur Aini Rismaina Putri Rismaina Putri Sabilla Khaerunissa, Dymphna Sebrina, Keyko Dyandra Setiawati, Lisa Sholikhah, Laila Aminatus Simanjuntak, Roganda Sinta Devi, Nabila Sinta, Dewi Sri Andarini Sri Andarini Sri Andarini Telaumbanua, May Kristina Indah K Viera Wardhani Wahyuningtyas, Mariana Wardani, Arti Wati, Linda Ratna Widya Risanti, Arini Zamanti, Arfiyani