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Journal : Jurnal Medik Veteriner

Mammary Tumors in Dogs, Recent Perspectives and Antiangiogenesis as a Therapeutic Strategy: Literature Study Sewoyo, Palagan Senopati; Adi, Anak Agung Ayu Mirah; Winaya, Ida Bagus Oka; Wirata, I Wayan
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.271-287

Abstract

A particular type of tumor that is frequently detected in female dogs who are sexually active is a mammary tumor. Neoplasia results from DNA-based alterations in cell cycle regulating genes. The mammary gland is prone to the formation of tumors due to its dynamic structure. The development of this tumor is supported by numerous variables. It has been recently discovered that there is substantial evidence linking the BRCA2 gene to the process of cancer. Standard examination techniques, such as fine needle aspiration, histopathology, and immunohistochemistry, are used along with ancillary tests to determine the tumor type and degree of malignancy. The primary treatment option for malignant tumors is surgical resection followed by adjuvant chemotherapy; benign tumors necessitate surgical resection as well. Adjuvant therapy options include hormone therapy and non-steroidal anti-inflammatory medications. Tumor tissue undergoes angiogenesis as it grows and develops to accommodate the abundant supply of nutrients. Therefore, angiogenesis-inhibiting therapies can be utilized to halt the growth of tumor cells. A number of antiangiogenic medications are now being studied in clinical settings on humans, and several more are undergoing trials on animals. In addition to pharmaceuticals, viruses may be used as a therapeutic to block tumor angiogenesis.
Sebaceous Adenoma in a Geriatric Poodle Dog: A Case Report Winaya, Ida Bagus Oka; Adi, Anak Agung Ayu Mirah; Sudimartini, Luh Made; Merdana, I Made; Sudipa, Putu Henrywaesa; Pemayun, I Gusti Agung Gde Putra; Sewoyo, Palagan Senopati
Jurnal Medik Veteriner Vol. 7 No. 2 (2024): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol7.iss2.2024.413-419

Abstract

A 14-year-old black male Poodle was brought to the Animal Teaching Hospital, Udayana University by its owner with clinical signs of frequent licking of its left front paw. Upon examination, red bumps were observed on the left front leg, accompanied by small, round black spots scattered on the dorsal side of the body. Additionally, black nodules were present on the lower eyelids and hind limbs. Surgical intervention was undertaken to excise the tumor mass, with the animal under anesthesia induced by ketamine at 5 mg/kg BW intravenously. The reddish nodule was excised by performing an elliptical incision at the base of tumor. Postoperatively, the animal received an antibacterial injection comprising ceftriaxone and tazobactam at 25 mg/kg BW intramuscularly and antiseptic wound dressing for supportive care. Microscopic examination revealed neoplastic cells arranged into lobules of varying sizes and shapes within the tumor mass. These lobules consisted of differentiated sebocytes and basaloid cells. At the periphery of the neoplastic lobules, the basaloid cells displayed several layers and exhibited invasion with moderate anisocytosis. The mitotic index was no more than ten cells in one field of view. Based on these histopathological features, the tumor was confirmed to be a sebaceous adenoma. After a 10-month follow-up period, there were no signs of tumor recurrence observed.
Co-Authors Agung Arta Putra, I Gusti AGUSTINA SETIA Aida Lousie Tenden Rompis Alberto Agustinho Pereira Da Costa Joao Anak Agung Bagus Bramardipa Anak Agung Bagus Bramardipa Anak Agung Keswari Krisnandika Anak Agung Oka Wijaya Aras, Fatmawati Aristawati, I Dewa Agung Ayu Irma Astuti Nur Astuti Nur ASWEROS UMBU ZOGARA Bayu Setiabudi Benu, Lolang Loriana Bire, Ienoliski Rohi BORO, REGINA MARIA Chiharu Hongo Costa, Santa Luciana LDV da da Costa, Santa Luciana Diaz Vera Dewa Ayu Agus Sri Laksmi Dzikri Nurma'rifah Takariyanti Eisaku Tamura Elyda . Fedri Rell Ferbian Milas Siswanto Gusti Ayu Yuniati Kencana Hernomoadi Huminto Hidayatullah, Lalu Syarif I Dewa Made Adhiwitana I Gede Hendra Prasetya Wicaksana I Gusti Agung Arta Putra I GUSTI AGUNG AYU AMBARAWATI I Gusti Agung Dewi Sarihati I Gusti Agung Gede Putra Pemayun I Gusti Made Krisna Erawan I Gusti Ngurah Kade Mahardika I Kadek Swastika I Ketur Berata I Ketut Berata I Ketut Berata, I I KETUT ELI SUPARTIKA I Ketut Eli Supartika I Ketut Suastika I Made Anom Sutrisna Wijaya I Made Galih Diparayoga I Made Kardena I Made Kardena, I I Made Merdana I Made Sudarmaja I Made Sukada i Nengah Wandia I NYOMAN MANTIK ASTAWA I Nyoman Suartha I Wayan Wirata I Wayan Wita Ida Bagus Kade Suardana Ida Bagus Komang Ardana Ida Bagus Oka Winaya Ida Bagus Oka Winaya, Ida Ida Bagus Windia Adnyana Jane Austen Peni Jayawardhita, Anak Agung Gde Juni Gressilda L. Sine Kadek Karang Agustina Komang Andika Purnama Komang, Nadia Eprillia Sary Darma Ni L.Sin, Juni Gressilda Lies Parede Hernomoadi Loaloka, Meirina S Loaloka, Meirina S Loaloka Luh Made Sudimartini M. Farhan Al Ma'arif Mada, Maria Magdalena Ki Maria F Vinsensia D P Kewa Niron Maria Goreti Pantaleon Marissa Divia Dayanti Marissa Divia Dayanti Marson, Fransiska Gratia Sonita Meirina S Loaloka Meirina Sulastri Loaloka Mia Monica Nadira, Laras Ayu Ni Luh Putu Eka Diarthini Nita, Maria Helena Dua Nofantri, Lidia Nopita Wati, Ni Made Nur Baiti Palagan Senopati Sewoyo Palagan Senopati Sewoyo Pinem, Nuh Lasjuardi Purnasari, Maria Elisabeth Putra, I Putu Werdikta Jayantika Putu Agus Trisna Kusuma Antara Putu Ayu Asri Damayanti Putu Henrywaesa Sudipa Rahmat Grahadi Regina Maria Boro Ruwa idah, Ruwa Sampelimbong, Marissa Santa Luciana da Costa Sartika, Nola Alfien Sartika, Nola Alfieni Sembiring, Anita Ch Sewoyo, Palagan Senopati Sine, Juni Gressilda L Sine, Juni Gressilda L. Tampubolon, Yandri Putra Lumatas Wijaya, Anak Agung Gede Oka Wira, Amar Yasunobu Matsumoto Yeni Ratna Sari