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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Althea Medical Journal Molecular and Cellular Biomedical Sciences (MCBS) Pendas : Jurnah Ilmiah Pendidikan Dasar IRJE (Indonesian Research Journal in Education) Journal of Health Science MEDIC MEdical Dedication Jurnal Karya Abdi Masyarakat Journal of Medical Studies Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Indonesian Journal of Biomedicine and Clinical Sciences International Journal Of Health And Social Behavior Medika Tadulako: Jurnal Ilmiah Kedokteran Fakultas Kedokteran
Anggelia Puspasari
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Dose-Dependent Mild Kidney Injury Induced by Ethanol Extract of Rhodomyrtus tomentosa in Female Rats Ekaputri, Tia Wida; Andani, Firstasya; Enis, Rina Nofri; Tarawifa, Susan; Puspasari, Anggelia; Maharani, Citra; Utami, Erisca Ayu
Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Vol. 14 No. 1 (2026): JAMBI MEDICAL JOURNAL: Jurnal Kedokteran dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jmj.v14i1.54229

Abstract

Background: Rhodomyrtus tomentosa is widely used in traditional medicine, but its subchronic renal safety profile remains insufficiently explored. This study aimed to assess mild kidney injury induced by R. tomentosa leaf ethanol extract through qualitative and quantitative histopathological evaluation in female Rattus norvegicus. Methods: Twenty-four female rats were divided into six groups: a control and five treatment groups receiving the extract at doses of 200, 400, 800, 1600, and 3200 mg/kgBW for 14 days. Kidney tissues were evaluated via hematoxylin-eosin staining and image-based digital quantification across five fields of view per specimen to determine glomerular and tubular damage. Results: Qualitative evaluation revealed dose-dependent alterations, transitioning from mild glomerular hypercellularity at lower doses to focal necrosis and hemorrhage at higher doses. Quantitative analysis clarified a distinct compartmental vulnerability. Glomerular damage showed a descriptive upward trend across doses (9.75% to 13.53%) but lacked statistical significance (Kruskal-Wallis, p = 0.05). Conversely, tubular damage increased sharply from 1.99% to 17.49%, demonstrating a highly significant dose-dependent escalation (p = 0.001). Post-hoc pairwise comparisons confirmed that significant tubular degeneration manifested critically at elevated exposures of 1600 mg/kgBW (p = 0.014) and 3200 mg/kgBW (p = 0.002) compared to the control group. Conclusion: The ethanol extract of R. tomentosa leaves induces dose-dependent renal alterations, with tubular structures exhibiting significantly higher susceptibility than glomeruli due to active metabolic clearance. However, the absolute tissue damage remains strictly within the mild, non-destructive category, establishing a reassuring safety margin for its pharmaceutical development.
The Relationship Between the Use of Intrauterine Device and the Incidence of Ectopic Pregnancy in Jambi Inesha Deariana; Suhair Quzwain; Anggelia Puspasari; Zakiyah Salim; Attiya Istarini
International Journal of Health and Social Behavior Vol. 3 No. 3 (2026): August: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v3i3.658

Abstract

Ectopic pregnancy occurs when a fertilized ovum implants outside the uterine cavity and may cause life-threatening internal bleeding. Although the intrauterine device is an effective contraceptive method, pregnancies resulting from contraceptive failure have a greater likelihood of becoming ectopic. This study aimed to determine the relationship between intrauterine device use and the incidence of ectopic pregnancy at RSUD Raden Mattaher and RSI Arafah Jambi. An analytical observational design with a retrospective approach was applied. The samples were selected using total sampling from the medical records of first-trimester pregnant women treated between 2020 and 2024 who met the inclusion and exclusion criteria, resulting in 99 respondents. Statistical analysis showed a p-value of 0.013 (p < 0.05) and an odds ratio of 0.172. These findings indicate a statistically significant association between intrauterine device use and the incidence of ectopic pregnancy, with intrauterine device use associated with a lower risk of ectopic pregnancy in the study population. Therefore, intrauterine device use was significantly related to the incidence of ectopic pregnancy among patients at RSUD Raden Mattaher and RSI Arafah Jambi.  
FATHER ENGAGEMENT PROGRAM FOR STUNTING PREVENTION: A COMMUNITY SERVICE ACTIVITY IN TALANG BANJAR PRIMARY HEALTH CENTER, JAMBI CITY Sonia, Gina; Kusdiyah, Erny; Tri Hardiningsih, Denok; Puspasari, Anggelia; Nuriyah, Nuriyah; Fitri, Amelia Dwi; Herlambang, Herlambang
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 9 No. 1 (2026): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Background: Stunting remains a significant health problem in Jambi City, with Talang Banjar Primary Health Center recording the highest number of cases (113 children) in 2024. Fathers’ involvement in stunting prevention is often overlooked despite their strategic role in family decision-making. Objective: This community service activity aimed to implement a father engagement program to increase fathers’ awareness and participation in stunting prevention in the working area of Talang Banjar Primary Health Center. Methods: The activity was conducted through a one-day workshop attended by 40 fathers of children aged 0-59 months. The program included an interactive lecture on stunting prevention, a nutritional label reading practice session, and a group discussion on fathers’ roles in family nutrition. Results: The workshop was attended by 40 fathers from for villages in the working area of Talang Banjar Primary Health Center. Participants showed high enthusiasm during the interactive lecture and practical sessions. Based on observations and discussions, fathers expressed increased awareness of the importance of their involvement in stunting prevention. Several challenges were identified, including time constraints and economic factors, which need to be addressed in future programs. Conclusions: The father engagement program through a one-day workshop successfully engaged fathers and increased their awareness of stunting prevention. This community service activity demonstrates he potential of rather-focused interventions to support stunting reduction efforts in Jambi City. Recommendations for future programs include integrating father engagement into routine primary health center activities and conducting follow-up evaluations. Keywords: father engagement; stunting prevention; community service; workshop
COMMUNITY-BASED OBESITY EDUCATION USING AUDIOVISUAL MEDIA TO ENHANCE KNOWLEDGE Enis, Rina Nofri; Shafira, Nyimas Natasha Ayu; Herlambang, Herlambang; Syauqy, Ahmad; Fitri, Amelia Dwi; Puspasari, Anggelia; Maharani, Citra; Kusdiyah, Erny; Aurora, Wahyu Indah Dewi; Delfira, Annissa; Sulistiawan, Andika; Arisya, Qothrunnada
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 9 No. 1 (2026): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Abstract

Background: Obesity is a growing public health concern associated with an increased risk of non-communicable diseases. Improving public knowledge through health education is an important strategy for promoting healthy lifestyles and preventing obesity. Audiovisual media have been widely adopted to enhance educational effectiveness and participant engagement. Objective: This study evaluated the effectiveness of a community-based obesity education program using PowerPoint presentations and an educational video to improve participants' knowledge. Methods: A pre-experimental one-group pretest–posttest design was conducted among community participants in Jambi, Indonesia, in 2026. Participants completed a 10-item multiple-choice questionnaire before and after the educational session. The intervention covered the definition of obesity, body mass index classification, waist circumference, risk factors, complications, and lifestyle-based prevention strategies. Data were analyzed using the Shapiro–Wilk test and the Wilcoxon signed-rank test, with statistical significance set at p < 0.05. Results: Forty-five participants completed both assessments. The mean knowledge score increased from 86.67 ± 12.25 at baseline to 94.89 ± 6.95 after the intervention. The distribution of score differences was non-normal (Shapiro–Wilk: W = 0.749, p < 0.001). The Wilcoxon signed-rank test demonstrated a significant improvement in knowledge following the educational intervention (W = 0, p < 0.001). Participant evaluation also indicated high acceptance of the educational program across all assessed domains, including material quality, video presentation quality, perceived educational benefits, and overall participant satisfaction. Conclusion: The community-based obesity education program effectively improved participants' knowledge and was well accepted by the participants. Integrating presentations with audiovisual media represents a practical approach to strengthening health literacy and supporting community-based obesity prevention. Keywords: audiovisual education; obesity; community intervention; health promotion; knowledge.
Rationality of ACE-Inhibitor Use in Hypertension Patients at Community Health Center Simpang IV Sipin in Jambi City, During 2023-2024 Fayza Nurrahmi; Mara Imam Taufiq Siregar; Anggelia Puspasari; Indrianti Indrianti; Budi Justitia
International Journal of Health and Social Behavior Vol. 3 No. 3 (2026): August: International Journal of Health and Social Behavior
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62951/ijhsb.v3i3.657

Abstract

Hypertension is a chronic disease with a high global prevalence and a major risk factor for cardiovascular complications. Angiotensin-Converting Enzyme Inhibitors (ACE-Is) are widely recommended as first-line antihypertensive therapy, making evaluation of their rational use essential to ensure treatment safety and effectiveness. This descriptive observational study employed a retrospective design using medical records of hypertensive outpatients at Puskesmas Simpang IV Sipin, Jambi, from January 2023 to December 2024. A total of 100 eligible patients were included. The evaluation assessed the appropriateness of indication, dosage, frequency, duration of therapy, and potential drug interactions based on World Health Organization (WHO) criteria and the JNC 8 guidelines. Most patients were aged 60 years or older and were diagnosed with essential hypertension or hypertensive heart disease. All ACE-I prescriptions were appropriate for their clinical indications (100%), while dosage, frequency, and treatment duration fully complied with guideline recommendations. Most identified drug interactions were synergistic, whereas antagonistic (11%) and potentiation (25%) interactions were generally mild to moderate and clinically manageable. Overall, ACE-I prescribing was considered rational. Continuous monitoring remains important, particularly for patients at risk of clinically significant drug interactions to optimize therapeutic outcomes and patient safety.
HUBUNGAN TINGKAT AKTIVITAS FISIK DAN ASUPAN KALORI TERHADAP MASSA LEMAK MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS JAMBI TAHUN 2024: Studi Analitik pada Mahasiswa Fakultas Kedokteran Universitas Jambi Tahun 2024 M. FATUR REYHAN MEIDRIN; RITA HALIM; ANGGELIA PUSPASARI
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 11 No. 03 (2026): Volume 11 Nomor 03, September 2026 Published
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

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Abstract

Peningkatan massa lemak tubuh merupakan salah satu faktor risiko utama berbagai penyakit metabolik yang dipengaruhi oleh keseimbangan antara asupan energi dan aktivitas fisik. Mahasiswa dengan beban akademik yang tinggi cenderung memiliki pola makan yang tidak teratur serta tingkat aktivitas fisik yang rendah, sehingga berpotensi mengalami perubahan komposisi tubuh. Penelitian ini bertujuanmenganalisis hubungan antara asupan kalori dan tingkat aktivitas fisik dengan massa lemak tubuh pada mahasiswa kedokteran. Penelitian menggunakan desain analitik observasional dengan pendekatan cross-sectional yang melibatkan 77 responden yang dipilih melalui teknik simple random sampling. Asupan kalori diukur menggunakan Food Record 3×24 jam, aktivitas fisik diukur menggunakan International Physical Activity Questionnaire–Short Form (IPAQ-SF), sedangkan massa lemak tubuh diukur menggunakan alat Bioelectrical Impedance Analysis. Data dianalisis menggunakan uji Chi-square dengan tingkat signifikansi 5%. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat aktivitas fisik rendah (46,8%), asupan kalori berlebih (40,3%), dan massa lemak tubuh dalam kategori normal (42,9%). Analisis statistik menunjukkan terdapat hubungan yang signifikan antara asupan kalori dengan massa lemak tubuh (p=0,030) serta antara tingkat aktivitas fisik dengan massa lemak tubuh (p=0,022). Temuan ini menunjukkan bahwa keseimbangan antara asupan energi dan aktivitas fisik berperan penting dalam mempertahankan massa lemak tubuh pada mahasiswa. Oleh karena itu, diperlukan upaya untuk mendorong penerapan pola makan yang sesuai dengan kebutuhan energi serta peningkatan aktivitas fisik secara teratur sebagai bagian dari strategi menjaga komposisi tubuh yang sehat.
Variasi Genetik APOA5 rs662799 dalam Metabolisme Trigliserida dan Obesitas Sentral: Sebuah Tinjauan Naratif Nazilh Rizky Nandhita Lubis; Anggelia Puspasari; Hasna Dewi; Citra Maharani; Mara Imam Taufiq Siregar
Vitalitas Medis : Jurnal Kesehatan dan Kedokteran Vol. 3 No. 3 (2026): Juli: Vitalitas Medis : Jurnal Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/vimed.v3i3.3365

Abstract

Apolipoprotein A-5 (APOA5) is a hepatic regulator of triglyceride-rich lipoprotein metabolism, and the promoter polymorphism rs662799 is its most extensively investigated variant. This narrative review synthesises current evidence on the molecular consequences of rs662799 and its relationship with lipid profile, central obesity, and metabolic syndrome, with particular attention to its relevance for Asian and Indonesian populations. Literature published between 2011 and 2026 was retrieved from PubMed, ScienceDirect, SpringerLink, Google Scholar, and Garuda, and thirty-nine sources met the selection criteria. The minor allele reduces promoter transcriptional activity, lowers APOA5 concentration, and impairs lipoprotein lipase-mediated triglyceride clearance, resulting in higher plasma triglyceride and lower high-density lipoprotein cholesterol. Meta-analyses report a 1.3- to 1.5-fold increase in metabolic syndrome risk among minor allele carriers, whereas associations with central obesity are inconsistent and frequently conditional on energy intake, sex, or degree of adiposity. Minor allele frequency is substantially higher in East Asian than in European populations, indicating population-specific clinical implications. Evidence relating this variant to lipid-lowering pharmacotherapy response remains scarce and warrants investigation, particularly in Indonesia where population data are still limited.
Co-Authors Ahmad Hamim Sadewa Ahmad Syauqy Ahmad Syauqy Alya Dwiva Juhari Amalia, Fenny Amatullah, Afifah Ameli Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri Amelia Dwi Fitri, Amelia Dwi Amelia Minarfah Anati Purwakanthi, Anati Andani, Firstasya Andika Sulistiawan Annissa Delfira Arif, Cut Wulan Arisya, Qothrunnada Armaidi Darmawan Aryanti, Nindya Asro Hayani Harahap ATTIYA ISTARINI Ave Olivia Rahman Betty Marlina Budi Justitia Charles Apul Simanjuntak Citra Maharani Denok Tri Hardiningsih Devy Afriyanti dewi, hasna Dhea Assyifa Effendi, Ian Ekaputri, Tia Wida Elfiani Elfiani Elfiani Erny Kusdiyah Esa Indah Ayu, Esa Indah Fairuz, Fairuz Farrah Balqis Fayza Nurrahmi Fitriyanti Gading, Patrick Wiliam Hana Nurul Qur’ani Harahap, Asro Hayani Harahap, Huntari Hasmita, Debby Hasna Dewi Herlambang Herlambang HERLAMBANG HERLAMBANG Herlambang Herlambang Ika Setyawati Indrianti Indrianti Inesha Deariana Irawan Anasta Irlianissa, Mutiara Iskandar, Mirna Marhami Ismi Nurwaqiah Ibnu Khairunnisa, Dhia Fairuz M. FATUR REYHAN MEIDRIN Maharani, Amrina Mara Imam Taufiq Siregar Muhammad Faiz Mus, Rosdiana Nadilla Sitepu Nazilh Rizky Nandhita Lubis Neldi, Vina Nindya Aryanty Nuriyah, Nuriyah Nurul Fitriani Nyimas Natasha Ayu Shafira Nys. Natasha Ayu S Pramudji Hastuti Priskila, Loury Rina Nofri Enis Rini Kartika Rita Halim Rita Halim S, Nys. Natasha Ayu Simanjuntak, Charles Apul Sonia, Gina Suhaimi, Novadian Suhair Quzwain Suprapti Suprapti Suzan, Raihanah Syatria Esa Putra Syukur, Astian Nathaniel Tarawifa, Susan Tarigan, Nadir Putra Indra Tengku Arief Buana Perkasa Tia Wida Ekaputri Utami, Erisca Ayu Virginsia, Sonya Vivekanantharasa, Raveenthiran Wahyu Indah Dewi Aurora Widyawati, Dwi Zakiyah Salim Zulkhair Ali