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All Journal Farmaka Jurnal Teknik Sipil dan Perencanaan Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology IDJP (Indonesian Journal of Pharmaceutics) Jurnal Medik Veteriner Proceedings of the International Conference on Applied Science and Health Jurnal Kartika Kimia Majalah Farmasetika Health Information : Jurnal Penelitian Letters in Information Technology Education (LITE) MAHESA : Malahayati Health Student Journal Journal of Innovation Research and Knowledge Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Medic Nutricia : Jurnal Ilmu Kesehatan Media Kesehatan Politeknik Kesehatan Makassar Journal of The Indonesian Society of Integrated Chemistry
Sriwidodo Sriwidodo, Sriwidodo
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Analisis Aktivitas Antioksidan Nanoemulsi Berbaris Tanaman dalam Aplikasi Farmasi dan Kosmetik : Kajian Literatur Aisyah, Nur; Sriwidodo, Sriwidodo; Husni, Patihul; Sinala, Santi
Media Kesehatan Politeknik Kesehatan Makassar Vol 20 No 1 (2025): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v20i1.1458

Abstract

Plant-based nanoemulsions are increasingly attracting attention in pharmaceutical and cosmetic applications due to their ability to enhance the stability, solubility, and bioavailability of natural active compounds, such as flavonoids, terpenoids, and polyphenols, which possess antioxidant activity. However, the challenge lies in optimizing the nanoemulsion formulation to enhance the efficacy of these compounds. This study aims to explore the potential of plant-based nanoemulsions in enhancing the effectiveness of antioxidant compounds and to provide recommendations for developing more stable and efficient nanoemulsion formulations for pharmaceutical and cosmetic applications. A literature review was conducted by analyzing relevant scientific articles on the use of plant-based nanoemulsions in enhancing antioxidant activity. This study includes various studies that describe the methods of preparation, physicochemical characteristics, and applications of nanoemulsions in the biomedical and cosmetic fields. Plant-based nanoemulsions, such as those using Cordyceps mushroom extract and Mucuna seeds, exhibit stronger antioxidant activity and good stability. Formulations with small particle sizes and uniform particle distribution exhibit higher bioavailability and efficacy, making them promising for application in medical therapy and skin care. Plant-based nanoemulsions offer significant potential for enhancing the efficacy of antioxidant compounds in the pharmaceutical and cosmetic fields. Further development is needed through laboratory and clinical testing to ensure the efficacy and stability of nanoemulsion formulations in real-world applications. Keywords: nanoemulsion, medicinal plants, bioavailability, drug delivery system
Review: Penggunaan Maltodekstrin pada Enkapsulasi Ekstrak Bahan Alam dan Stabilitasnya Terhadap Ph dan Suhu Rismawan, Haris; Eri, Amalia; Sriwidodo, Sriwidodo
MAHESA : Malahayati Health Student Journal Vol 5, No 6 (2025): Volume 5 Nomor 6 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i6.18572

Abstract

ABSTRACT Encapsulation is an effective technology used to protect active ingredients from adverse environmental conditions such as instability to heat, light, oxygen and acidity. In the pharmaceutical field, this technology is very appropriate to be applied especially to natural extracts where the bioactive compounds contained therein are unstable and easily degraded during the storage process.  Polymers that are widely used for the encapsulation of natural extracts are maltodextrin which serves to protect sensitive components such as antioxidant components, flavours, vitamins and colours, this is because maltodextrin has a strong binding power to the coated compounds and is able to provide a thin layer that is cohesive with the core material. Keywords: Encapsulation, Natural Extracts, Maltodextrin  ABSTRAK Enkapsulasi merupakan teknologi yang efektif digunakan untuk melindungi bahan aktif dari kondisi lingkungan yang merugikan seperti ketidakstabilannya terhadap suhu panas, cahaya, oksigen dan keasaman. Dalam bidang farmasi, teknologi ini sangat tepat diaplikasikan terutama terhadap ekstrak bahan alam dimana senyawa bioaktif yang terkandung didalamnya bersifat tidak stabil dan mudah terdegradasi selama proses penyimpan.  Polimer yang banyak digunakan untuk enkapsulasi ekstrak bahan alam adalah maltodekstrin yang berfungsi untuk melindungi komponen yang sensitif seperti komponen antioksidan, rasa, vitamin dan warna, hal ini dikarenakan maltodekstrin memiliki daya ikat yang kuat terhadap senyawa yang tersalut dan mampu memberikan lapisan tipis yang kohesif dengan bahan inti. Kata Kunci: Enkapsulasi, Ekstrak Bahan Alam, Maltodekstrin
 Risk Management in the Pharmaceutical Industry Supply Chain at the Pharmaceutical Wholesaler Level Evi, Sylvia; Sriwidodo, Sriwidodo; Masrahman, Roestan
Indonesian Journal of Pharmaceutics Vol 7, Issue 1, Jan - April 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i1.62708

Abstract

The pharmaceutical industry in Indonesia faces several challenges in risk management, particularly in stakeholder management, which includes the government, healthcare providers, distributors, and the public. The complexity of regulations, market fluctuations, and changes in healthcare policies necessitate the implementation of effective risk management strategies in interactions with stakeholders. This study aims to analyze the implementation of risk management in stakeholder management within Indonesia’s pharmaceutical industry, identify key risks that may impact business sustainability, and evaluate the mitigation approaches employed. A qualitative case study, incorporating in-depth interviews with key industry stakeholders, revealed that the primary risks include regulatory uncertainty, supply chain disruptions, and challenges in stakeholder communication and compliance. Effective mitigation strategies involve the adoption of adaptive compliance systems, strengthened communication and collaboration with regulators, and digitization of supply chains to enhance transparency and efficiency. This study underscores the importance of a risk-based approach in stakeholder management to ensure the sustainability and competitiveness of Indonesia’s pharmaceutical industry.
Plasma Fractionation: Conditions and Challenges Rambia, Ikhsan; Insyirah, Ariani; Claudiana, Nur Shelly Ester; Fath, Zulfa Tavira Al; Permadi, Najla Eksakta; Sriwidodo, Sriwidodo; Rustan, Mas Rahman
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.63343

Abstract

Plasma is a blood component that has a role in treating various diseases, such as haemophilia and blood-clotting disorders. Plasma used for treatment is referred to as plasma-derived drug products (PDMPs), which are obtained through the plasma fractionation process. This study aims to explore the conditions of plasma fractionation in various countries and highlight some of the challenges faced by the plasma fractionation industry. The methods used include searching for articles published over the past decade from trusted sources, such as Google Scholar, PubMed, and ScienceDirect, using specific keywords. The results of literature studies related to plasma fractionation were obtained from 20 countries spanning several continents. The conditions and challenges faced in plasma fractionation in those countries differ. Some of the challenges faced are related to technology, regulation, plasma sources, human resources, and the economy. Currently, Indonesia is working with South Korea to build the first plasma fractionation facility. Therefore, the conditions and challenges faced by various countries can serve as a reference for Indonesia in preparing the factors that influence plasma fractionation development, in accordance with the World Health Organization (WHO) recommendations.
Tableting Turmeric Rhizome (Curcuma domestica Val.) and Mangosteen Peel (Garcinia mangostana L.) Extract as Antioxidant Supplement Reyhani, Amalia; Sriwidodo, Sriwidodo; Chaerunisa, Anis Yohana; Umar, Abd. Kakhar; Sylvia Nurrasjid, Evi; Rahman Roestan, Mas
Indonesian Journal of Pharmaceutics Vol 4, Issue 3, Sep - November, 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i3.39667

Abstract

Free radicals are unstable molecules that lose electrons in their outer orbitals. These compounds can be toxins for the human body and cause various degenerative diseases. To avoid this, we need antioxidants. Examples of common sources of antioxidants are turmeric (Curcuma domestica Val.) and mangosteen rind (Garcinia mangostana L.). Both of these plants have very strong antioxidant activity but have a less favorable taste for consumption. This study aimed to obtain tablets containing turmeric rhizome and mangosteen rind extract that can cover the taste with a variety of binders. Subsequently, we observed the antioxidant  activity of two extracts before and after preparation. The tableting method was wet granulation and the characterization included the physical properties of the tablets. The levels of curcumin, alpha mangosteen, and total polyphenols were also checked. The antioxidant activity was measured using the DPPH method. Based on the characterization results, NaCMC 5% was the best binder for preparing tablets containing turmeric rhizome and mangosteen rind extract with a flow rate of 11.434 g/s, repose’s angle of 29.39ᵒ, loss on drying of 2.65%, carr’s index of 15.22, hardness of 43N, friability of 0.926%, and disintegration time of 16.44 minutes. The antioxidant test result showed that the combination of turmeric extract and mangosteen rind extract with a ratio of 1:2 had the best antioxidant activity with an IC50 value of 31.01 µg/ml, alpha mangosteen level of 29.77%, and curcumin level of 27.22%. The antioxidant activity of the preparation was not changed significantly after tableting. Based on the findings, it can be concluded that the tablet formulation of turmeric rhizome and mangosteen rind extract using 5% NaCMC can be potentially used as an antioxidant supplement.
Journal Review: Formulation and Evaluation of Anti-Oxidant Facial Serum and From Extracts of Various Plants Novika, Kandida Hilda; Chaerunissa, Anis Yohana; Sriwidodo, Sriwidodo; Annissya, Widia Primi
Eduvest - Journal of Universal Studies Vol. 4 No. 12 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i12.50059

Abstract

In the 19th century, the use of cosmetics began to gain attention, not only for beauty but also for health. Facial serum is a skin care product in the form of a gel or light lotion with a moisturizer that contains active ingredients that can penetrate deeper into the skin. UV rays can damage collagen/elastin in the skin, cause hyperpigmentation, damage skin components and trigger premature aging. So, antioxidants are needed to ward off free radicals. The main function of antioxidants is to capture and neutralize free radicals thereby reducing or preventing damage. The aim of this literature review is to provide information and evaluate the effectiveness of facial serums formulated from various extracts that have the potential to act as antioxidants. The method used in this literature review is using a data base in the form of Google Scholar, Pubmed, Pharmaceuticals, and Science Direct (2015-2023). Based on the results of the literature review, 55 journals were found with various types of plants as antioxidants all types of plants which has antioxidant activity in serum preparations which is classified as very strong is Mangosteen Fruit Extract (Garcinia Mangostana) with an IC50 value of 5-15 μg/mL.
IMPLEMENTASI PENDEKATAN LEAN MANUFACTURING DENGAN BERBAGAI METODE DI INDUSTRI FARMASI UNTUK MENINGKATKAN EFEKTIVITAS PROSES PRODUKSI Nurul Asih Ramadhani; Sriwidodo, Sriwidodo
Journal of Innovation Research and Knowledge Vol. 4 No. 6: Nopember 2024
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v4i6.8968

Abstract

The development of the pharmaceutical industry in particular and the industrial world in general has forced the industry to apply production efficiency principles. The Lean Manufacturing approach is an operational strategy that is oriented towards achieving the shortest possible cycle time by eliminating waste, a production system capable of increasing value added. This review article aims to provide an overview of the application of Lean Manufacturing which can reduce waste so as to increase the effectiveness of the production process in the pharmaceutical industry. The preparation of this article review was carried out by searching the literature online. In the results of the review, there are several methods discussed regarding methods in the Lean Manufacturing approach, namely Six Sigma, Value Stream Mapping (VSM), Single Minute of Exchange Die (SMED), and Takt Time
Co-Authors Aep W Irwan, Aep W Aliya Nur Hasanah Amalia, Eri Anis Yohana Chaerunisaa, Anis Yohana Annissya, Widia Primi Barmi Hartesi Ch., Anis Yohana CHAERUNISA, ANIS YOHANA Chaerunissa, Anis Yohana Charlie, Vandie Claudiana, Nur Shelly Ester Desy Nawangsari Diina, Tresnafuty Rasyiida Eli Halimah, Eli Eri, Amalia Evi, Sylvia Fath, Zulfa Tavira Al Firman Muharam Ida Musfiroh, Ida IMAN PERMANA MAKSUM Insyirah, Ariani Iyan Sopyan Jajan Solahudin, Jajan K Sari, Nia Khairinisa, Miski Aghnia Khodijah Khodijah Kustiyawan, Iwa LINDA APRIYANTI, LINDA Maisyarah, Intan Timur Marline Abdassah, Marline Marselina Endah Hiswati Masrahman, Roestan MAYANG KUSUMA DEWI, MAYANG KUSUMA Megawati, Ega Mohammad Diqi Muhaimin Muhaimin Nasrul Wathoni Norisca Aliza Putriana, Norisca Aliza Noverianus, Noverianus Novika, Kandida Hilda Nur Aisyah Nurrasjid, Evi Sylvia Nurul Asih Ramadhani O Suprijana, O Ordiyasa, I Wayan P Legowo, Wahyu Patihul Husni Permadi, Najla Eksakta Puspitadewi, Nurhanifah Rahman Roestan Rahman Roestan, Mas Rambia, Ikhsan Rembulan Kusmawati, Rembulan Reyhani, Amalia Rismawan, Haris Roestan, Mas Rahman Rostinawati, Titin Rustan, Mas Rahman Santosa Santosa Setyabudi, Iwan Sinala, Santi Sri A Sumiwi, Sri A Suseno Amin, Suseno Syihab, Namira Anjani Rahmadina Sylvia Nurrasjid, Evi Taofik Rusdiana Toto Subroto Tristiyanti, Deby Umar, Abd. Kakhar Wiratma, Harits Dwi Wiwiek Indriyati, Wiwiek Wulaningsih, Titiek Indah Yasmiwar Susilawati Yoga Windu Wardhana, Yoga Windu Yohana Chaerunisaa, Anis Yola Desnera Putri