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Profil Farmakokinetik Senyawa Flavonoid Ekstrak Metanol Bunga Telang (Clitoria ternatea.L) Pada Kelinci (Oryctolagus cuniculus) Menggunakan High-Performance Liquid Chromatography Abdulkadir, Widy Susanti; Hiola, Faramita; Papeo, Dizky Ramadani Putri; Djuarno, Endah Nurrohwinta; Domili, Rahmat Hidayat
Jambura Journal of Chemistry Vol 8, No 1 (2026): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v8i1.35084

Abstract

Butterfly pea (Clitoria ternatea L.) is a climbing plant known for its medicinal properties and contains bioactive compounds such as tannins, carbohydrates, saponins, triterpenoids, polyphenols, flavanol glycosides, proteins, alkaloids, anthraquinones, anthocyanins, stigmasterol-4-ene-3,6-dione, volatile oils, and steroids. This study aimed to determine the pharmacokinetic profile—Area Under the Curve (AUC), maximum concentration (Cmax), time to reach maximum concentration (Tmax), half-life (t½), elimination rate constant (Ke), absorption rate constant (Ka), clearance (Cl), and volume of distribution (Vd)—of flavonoid compounds from the methanolic extract of butterfly pea (Clitoria ternatea L.) in rabbit plasma using a time-series experimental design.Two rabbits were fasted for 12 hours, then administered a positive control dose of 16.05 mg/kg and an extract dose of 5.952 mg orally. Blood samples were collected at 0, 1, 2, 4, 6, 12, and 24 hours after administration, and plasma concentrations were analyzed using HPLC with quercetin as the standard. The results showed that flavonoid compounds were detected in plasma with an AUC of 633.316 µg·h/mL, Cmax of 20.59 µg/mL, Tmax of 4 hours, t½ of 22.5 hours, Ka of 0.7202/h, Ke of 0.03375/h, and Vd of 48.451 mL. 
Co-Authors A. Djakaria, Abdul Rahman A. Mu’thi Andy Suryadi Abd. Ghiaz Putra Ramadan Ahmad Abd. Latif, Novia Nur Agiska Abdulkadir, Widy Susanty Adati, Agnesia Ade Ari Puspitadewi Ahmad Rifly Suleman Akuba, Juliyanti Andi Makkulawu Andini Putri Sabihi Anggai, Rifka Anggraini Arini Arini Az-zahra, Vivilia Aziz, Rezky Nur Begali, Musdhalifah M. Bumulo, Mohamad Ramdan Rahmat Chinta Suryaningrum Daud, Nurfitrah Ramdawati Delia, Faizha Putri Dewi Rahmawaty Moo djuarno, endah nurrohwinta Domili, Rahmat Hidayat Dr. Apt. Hamsidar Hasan S.Si.,M.Si Elvie F Dungga Endah Nurrohwinta Djuwarno Erika Dami Fazril Pakaya, Mohamad Fhigra Marfiah Fika Nuzul Ramadhani Gilalom, Amanda Septiyani Gubali, Jihan AR. Gunawan, Selvi Ayu Setiaarini Gusti Pandi Liputo Hiola, Faramita Hiola, Paramita Ibrahim, Deshika Nur Azizah Idrus Mohamad, Marsela Immaculata, Maria Intan Nusi Irmayanti Irmayanti, Irmayanti Ishak Isa Julianty Akuba Kadaria Toana Kahar, Oktaviani Kasim, Sesha Ramadhani Kongkolu, Sitty Rahma Hutami Kuengo, Gerrald Hariyawan Latif, Multiani S. Laurina, Nur Fadhilah Lia Amalia Madania, Madania Mahdalena Sy Pakaya Maimun Datau Makkulawu, Andi Mamu, Safira Mahadewi Marhaba, Zulkarnain Mohamad Adam Mustapa Mohamad Aprianto Paneo Mubaraq, Fajar Saril Muhammad Taupik Muhammad Taupik Nabila Novreini Djunaidi Ngani, Altaufik Nur Ain Thomas Nur Rasdianah Nur'ain Dj. Silaka Nurhayati Salam Putra, Andi El Jalaludin Putri, Eka Fadhila Qarlan Pratama, Mohammad Rahmatia Samatowa Ramadani, Fika Nuzul Robert Tungadi Rukmawati, Iis Sabunge, Annisa Sri Wahyuni Suleman, Windy Riani Suyadi, A. Mu’thi Andy Teti Sutriati Tuloli Teti Sutriyati Tuloli Tri Septian Maksum Upara, Nana Nurindah Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yuni Sarah Manoppo Yusuf, Siti Rahmatia Zahra Zakia, Wavika Zulkarnain Marhaba Zuriati Uno, Wiwit