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All Journal Jurnal Teknik Jurnal Fitofarmaka Indonesia Majalah Farmaseutik Martabe : Jurnal Pengabdian Kepada Masyarakat Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Abdidas Jurnal Ilmiah Wahana Pendidikan Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Jurnal Kesehatan Farmasi Journal of Pharmaceutical and Sciences. Jambura Medical and Health Science Journal Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Lontara Journal Of Health Science And Technology Jurnal Farmasi Teknologi Sediaan dan Kosmetika (JFTSK) Journal of Community and Clinical Pharmacy Journal of Pharmacology and Natural Products Jurnal Widya Medika Jurnal Riset dan Pengabdian Interdisipliner
Papeo, Dizky Ramadani Putri
Universitas Negeri Gorontalo
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Uji Penyembuhan Luka Bakar Gel Enzim Bromelin Menggunakan Carbopol 940 Secara In Vivo Nur Ain Thomas; Muhammad Taupik; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Nabila Novreini Djunaidi
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20364

Abstract

Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in  burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.
Potensi Ekstrak Biji Pala (Myristica fragrans L) Terhadap Penyembuhan Luka Bakar pada Mencit (Mus musculus) Widy Susanti Abdulkadir; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Zulkarnain Marhaba
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18996

Abstract

The Nutmeg Plant (Myristica Fragrans L) is one of the spices plants empirically used as a therapeutic option for injury healing. Burn injury is damage to the skin's integrity caused by contact with a source with a high-temperature difference. This research aimed to determine the effectiveness of Nutmeg (Myristica Fragrans L) Seed extract on burn injury healing in Male Mice (Mus Musculus). Extraction was carried out through Maceration with Methanol solvent. Eighteen mice were divided into 6 groups: negative control (Na-CMC), positive control (Bioplacenton), and treatment groups with concentrations of 3%, 5%, 7%, and 10%. Burn injury was created using a 2 cm x 2 cm iron plate on the mice's back, and the healing of the burn injury diameter was observed from day 1 to day 20, with observation intervals at day 5, 10, 15, and 20. The data were analyzed using one-way ANOVA followed by an LSD test to determine the differences between test groups. The resalts indicate that the ethanol extract of Nutmeg (Myristica Fragrans L) see haseng effect on burn injury, with the most effective concentration being the extraet onoration of 10%, with a burn injury healing rate of up to 89,15%.
Pola terapi pengobatan glaukoma di RSUD Hasri Ainun Habibie Kabupaten Gorontalo Dizky Ramadani Putri Papeo; Ahmad Rifly Suleman; Kadaria Toana; Chinta Suryaningrum; Intan Nusi; Erika Dami; Fhigra Marfiah
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 4 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i4.191

Abstract

Background: Glaucoma is an eye condition that damages the optic nerve, causing loss of vision and even blindness. Damage to the optic nerve is often associated with high intraocular pressure (IOP), but in some cases, glaucoma can occur with normal IOP levels. There are several types of glaucoma, one of which is primary angle closure glaucoma. Angle-closure glaucoma can cause sudden and severe symptoms such as eye pain, headache, nausea, and blurred vision. Objective: This study aims to determine the pattern of glaucoma treatment therapy in one of the hospitals in Gorontalo District. Methods: Using patient medical record data, the SOAP method, and several literature studies. Results: Obtained some medical record data. From medical records, it found that the most widely used drugs to reduce intraocular pressure were tim ophthal eye drops 0.25% and glauceta 250 mg oral drug. Timolol maleate is the most commonly used beta adreno-receptor blocker, especially in the treatment of glaucoma. Glauceta 250 is a drug that contains Acetazolamide indicated to reduce the fluid that accumulates in the eyeball and reduce eyeball tension. Conclusion: From the results of the study, it can conclude that the treatment pattern of most glaucoma patients used the 0.25% tim ophthal drug with the results of 5 times the ophthal 0.25% team administration and the administration of 3 eye drops, namely HPMC + dextran 70 + glycerin, Potassium iodide + sodium iodide dan HPMC + dextran.
Gambaran Penggunaan Obat Antipendarahan dan Antinyeri pada Pasien Rawat Inap Kanker Serviks Di Rumah Sakit X Wilayah Kota Gorontalo Periode 2021-2022 Dizky Ramadani putri Papeo; Rahmatia Samatowa; Nur'ain Dj. Silaka; Andini Putri Sabihi; Arini Arini; Nurhayati Salam; Abd. Ghiaz Putra Ramadan Ahmad
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.341

Abstract

Kanker serviks atau kanker rahim merupakan keganasan dari leher rahim (serviks) yang dapat disebabkan karena adanya virus HPV (Human papiloma virus). Data dari World Health Organization (WHO) diketahui terdapat 493.243 jiwa pertahunpenderita kanker serviks baru dengan angka kematian sebanyak 273.505 jiwa pertahun. Tujuan dari penelitian ini yaitu untuk mengetahui gambaran penggunaan obat antipendarahan dan antinyeri pada pasien kanker serviks di rumah sakit “X”. Penelitian ini menggunakan metode deskriptif retrospektif dengan populasi 8 pasien yang terdiagnosa kanker serviks di rumah sakit “X” di wilayah Kota Gorontalo periode 2021-2022. Berdasarkan hasil penelitian terdapat pasien kanker serviks yang menjalani  rawat inap di rumah sakit  “X” wilayah kota Gorontalo diketahui bahwa antinyeri yang paling banyak digunakan yaitu asam mefenamat dengan persentase 6,67% dengan dosis 500 mg, Fibrinolitik yang paling banyak digunakan di rumah sakit “X” yaitu asam tranexamat dengan dosis 500 mg.
Uji Kandungan Formalin dan Boraks pada sampel Ikan Asin Taupik, Muhammad; Isa, Ishak; Ramadani Putri Papeo, Dizky; Kasim, Sesha Ramadhani
Jambura Journal of Chemistry Vol 6, No 1 (2024): February
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/jambchem.v6i1.27260

Abstract

Salted fish is a well-known dish in Indonesia. Nationally, salted fish is one of the important fishery products, with almost 65% of fishery products being processed and preserved through salting. Formalin is a solution of 30- 50% formaldehyde gas (CH2O), commonly used for embalming, disinfecting, and as an antiseptic, as well as in plastics, antifreeze, paper, carpet, textile, construction materials, paint, and furniture industries. Borax is a chemical compound known as sodium tetraborate (Na2B4O7 10 Hâ‚‚O). Borax or boric acid is usually used in making detergents and antiseptics. The purpose of this research is to identify the presence of formalin and borax in salted fish and to determine the levels of formalin and borax in salted fish. This research employed qualitative analysis, using the permanganate, citric acid, and chromotropic acid methods for formalin detection. Turmeric paper, flame test, and AgNO3 precipitation methods were used for borax detection. Meanwhile, the quantitative analysis was conducted using the UV-Vis Spectrophotometry method. Based on the qualitative research results, all four samples tested negative for formalin, while one sample tested positive for borax. Consequently, the sample that tested positive for borax underwent quantitative analysis, revealing a borax level of 0,0975 g/kg in sample B.
Edukasi Pemanfaatan Limbah Bonggol Jagung Sebagai Makanan Bergizi Bagi Anak Di Desa Lemito Utara Amalia, Lia; Papeo, Dizky Ramadani Putri
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 3, No 3 (2024)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v3i3.27552

Abstract

Proses tumbuh kembang anak dipengaruhi oleh nutrisi pada makanan. Makanan yang sehat merupakan kunci kecukupan gizi balita terpenuhi. Salah satu jenis sumber makanan yang banyak dikonsumsi oleh masyarakat Indonesia selain padi adalah jagung. Pemanfaatan jagung sebagai bahan makanan seringkali menghasilkan limbah dari bonggol jagung yang selama ini hanya dimanfaatkan untuk pakan ternak. Perlu ada upaya untuk memanfaatkan limbah bonggol jagung dengan meningkatkan nilai tambahnya, salah satunya dengan mengubahnya menjadi tepung jagung. Upaya ini juga perlu diperkenalkan kepada masyarakat agar mereka dapat memanfaatkan limbah bonggol jagung menjadi tepung jagung yang kemudian dapat diolah sebagai bahan makanan bergizi. Tujuan dari kegiatan ini adalah untuk menjadikan program edukasi dan pelatihan pemanfaatan limbah bonggol jagung sebagai makanan bergizi bagi anak di desa Lemito Utara sebagai program unggulan guna membantu untuk memperbaiki asupan gizi pada anak di Desa Lemito Utara. Metode yang digunakan dalam pelaksanaan program ini adalah pemberian edukasi serta pelatihan melalui video. Dalam pelaksanaannya, metode ini dibagi menjadi beberapa tahap, yakni tahap pencarian bonggol jagung segar, pencucian, pengeringan, penghalusan hingga menjadi tepung dan membuatnya menjadi produk yang banyak dikonsumsi, yakni pancake. Hasil pelaksanaan kegiatan edukasi dan pelatihan pemanfaatan limbah bonggol jagung sebagai makanan bergizi bagi anak di desa lemito utara untuk mencegah stunting berhasil menambah pengetahuan dan pemahaman bagi ibu yang menyusui dan memiliki anak dan balita di TK Kemuning tentang manfaat dari limbah bonggol jagung.
Perngaruh Ekstrak Bunga Rosella (Hibiscus Sabdariffa) Sebagai Hepatoprotektorterhadap Kadar SGPT dan SGOT Abdulkadir, Widy Susanti; Akuba, Juliyanti; Hiola, Faramita; Papeo, Dizky Ramadani Putri; Gunawan, Selvi Ayu Setiaarini
Journal of Pharmacology and Natural Products Vol. 1 No. 1 (2024): Volume 1, Edisi 1, Tahun 2024
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jpnp.v1i1.5

Abstract

Hati merupakan organ tubuh yang memiliki fungsi besar bagi pusat metabolisme tubuh manusia. Fungsi dari organ hati tersebut sebagai tempat menyimpan nutrisi dan juga vitamin serta melakukan detoksifikasi terhadap racun atau zat berbahaya. Tujuan penelitian ini yaitu utnuk mengetahui efektivitas dan dosis efektivitas ekstrak herbal Bunga Rosella (Hibiscus sabdariffa) sebagai hepatoprotektor pada tikus (Rattus norvegicus) yang diinduksikan Parasetamol dengan dosis toksik. Penelitin ini merupakan jenis penelitian Eksperimental untuk mengetahui efektivitas dari ekstrak Bunga Rosella (Hibiscus sabdariffa) sebagai efek hepatoprotektor. Bunga Rosella di ekstraksi hingga menjadi ekstrak kental Bunga Rosella. Pelnguljian ini melnggulnakan selbanyak 15 elkor Tikus (Rattus norvegicus) yang dibagi melnjadi 5 kellompok perlakuan yaitul kellompok I diberikan Aquadest (kontrol negatif), kolompok II diberikan tablet Curkumin ( kontrol positif), kelompok III diberikan ekstrak Rosella (dosis 250 mg/kgBB), kelompok IV diberikan ekstrak Rosella (dosis 500 mg/kgBB), kelompok V diberikan ekstrak Rosella (dosis 750 mg/kgBB) dengam menggunakan metode pemberian secara oral. Sebelum diberikan perlakuan terlebih dahulu diukur kadar SGPT dan SGOT darah tikus. Hasil yang diperoleh yaitu dosis II (500 mg/kg BB) dosis III (750 mg/kg BB) dapat memperlihatkan efek hepatoprotektor pada tikus jantan (Rattus norvegicus).
Gambaran Kepatuhan Minum Obat Pada Psien Hipertensi Di Puskesmas Botupingge Di Kabupaten Bone Bolango Madania; Endah N. Djuwarno; Dizky Ramadani Putri Papeo; Mohamad Aprianto Paneo; baruadi., siti_yustika.; Manno, Mohamad Reski
Journal of Community and Clinical Pharmacy Vol. 2 No. 2 (2025): Volume 2, Number 2, 2025
Publisher : Jurnal Literasi Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70075/jccp.v2i2.183

Abstract

Hipertensi merupakan salah satu penyakit dengan pravalensi tertinggi. Salah satu masalah yang sering terjadi adalah ketidak patuhan pasien dalam pengobatan. Faktor penyebab ketidakpatuhan minum obat yaitu usia, jenis kelamin, pendidikan, dan pekerjaan. Kepatuhan dalam pengobatan dapat diartikan sebagai perilaku pasien yang mentaati semua nasehat dan petunjuk yang dianjurkan oleh kalangan tenaga medis untuk mencapai tujuan pengobatan. Tujuan penelitian ini untuk mengetahui kepatuhan minum obat pada pasien hipertensi di Puskesmas Botupingge Kabupaten Bone Bolango. Menggunakan kuesioner MMAS-8 terhadap 140 responden. Penelitian ini menggunakan metode observasional dan pengambilan data dilakukan dengan teknik purposive sampling. Hasil penelitian menunjukkan mayoritas pasien berusia 51-70 tahun sebesar 71,4%, berjenis kelamin perempuan sebesar 51,4%, pendidikan SD 56,4%, pekerjaan IRT dan Wiraswasta 35,7%. Berdasarkan gambaran kepatuhan minum obat pada pasien hipertensi di Puskesmas Botupingge dengan metode MMAS-8 termasuk dalam kategori patuh 63%.
Hubungan Antara Kepatuhan Minum Obat (MMAS-8) Dan Kualitas Hidup (WHOQOL-BREF) Penderita Tuberkulosis Di Puskesmas Di Kota Bandung Papeo, Dizky Ramadani Putri; Immaculata, Maria; Rukmawati, Iis
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.11143

Abstract

Backgroumd: Tuberculosis (TB) is an infectious disease which is until now has not been able to be threated, i.e., because of patient non-adherence in taking anti-tuberculosis drug (ATD) Objective: The objective of this research is  to study the relationship between patients adherence in taking ATD determined by MMAS-8 questionnaire with QoL of patient determined by WHOQOL questionnaire. Method: Tuberculosis patients who undergo treatment for at least 4 weeks are the subjects in this study. This study was conducted by a cross-sectional method using the MMAS-8 and WHOQOL-BREF questionnaire of tuberculosis patients at Ibrahim Adjiand Gumuruh primary health care during March - August 2018. Result: Based on MMAS-8 questionnaire filled out by 75 patients, there was 69% of high adherence, 15% moderate,  and 16% has low adherence in taking ATD. Of the 6 characteristic factors (i.e., age, sex, occupation, income, education and length of treatment), only gender (p0.01) and occupation (p0.03) factors that influence the patient adherence significantly. Based on MMAS-8 and WHOQOL-BREF questionnaire analyses, there is only psychological health aspect (domain two) that have a significant (p = 0.01) correlated with patient adherence. Conclusion: Based on the results,the psychological health of tuberculosis patients play an important role in patient adherence. 
Overview of Pneumonia Treatment in Hospitalized Geriatric Patients at One of the Gorontalo Provincial Hospitals: Case Report Papeo, ⁠Dizky Ramadani Putri; Kai, Mohamad Nur Fadjri; Isa, Moh. Arya Avrilio; Sumaga, Nabila Natasya; Mursidi, Sitti Rahmawaty Sisilia; Canon, Afifah Aliya
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1445

Abstract

Pneumonia is a common respiratory infection affecting all age groups, particularly the elderly, who are more susceptible due to comorbidities and age-related decline in immune function. This case report aims to evaluate the role of clinical pharmacy in the management of community-acquired pneumonia (CAP) in a geriatric patient. A descriptive qualitative method was conducted through retrospective analysis of medical records, including clinical presentation, diagnostic findings, pharmacological and non-pharmacological interventions, and patient outcomes. The pharmacological therapy included ceftriaxone and azithromycin as antibiotics, mucolytics, bronchodilators, antipyretics, gastrointestinal protection, and vitamin supplementation, with clinical pharmacy involvement in therapy optimization and monitoring. Non-pharmacological strategies involved oxygen therapy, semi-Fowler positioning, effective coughing techniques, and hydration support. The patient showed marked clinical improvement with increased SpO₂ from 95% to 98%, a reduction in respiratory rate from 30 to 22 breaths/minute, and symptom resolution by day four. This report highlights that the integration of clinical pharmacy interventions significantly contributes to effective and safer management of CAP in elderly patients
Co-Authors A. Mu’thi Andy Suryadi Abd. Ghiaz Putra Ramadan Ahmad Abd. Latif, Novia Nur Agiska Abdul Rahman A. Djakaria Adati, Agnesia Ade Ari Puspitadewi Ahmad Rifly Suleman Akuba, Juliyanti Andi Makkulawu Andini Putri Sabihi Annisa Sabunge Arini Arini Az-zahra, Vivilia Aziz, Rezky Nur baruadi., siti_yustika. Bastari, Aditya Putra Begali, Musdhalifah M. Bumulo, Mohamad Ramdan Rahmat Canon, Afifah Aliya Chinta Suryaningrum Daud, Nurfitrah Ramdawati Delia, Faizha Putri Deshika Nur Azizah Ibrahim Detasya Detasya Dewi Rahmawaty Moo Dr. Apt. Hamsidar Hasan S.Si.,M.Si Elvie F Dungga Endah N. Djuwarno Endah Nurrohwinta Djuarno Endah Nurrohwinta Djuwarno Erika Dami Fadhiela Vidya Moerad Fazril Pakaya, Mohamad Fhigra Marfiah Fika Nuzul Ramadani Fika Nuzul Ramadhani Gilalom, Amanda Septiyani Gubali, Jihan AR. Gunawan, Selvi Ayu Setiaarini Gusti Pandi Liputo Hamsidar Hasan Hiola, Faramita Hiola, Paramita Hulopi, Rizki Mohamad Idrus Mohamad, Marsela Immaculata, Maria Indhitya R Padiku Intan Nusi Irmayanti Irmayanti, Irmayanti Isa, Moh. Arya Avrilio Ishak Isa Ishak Isa Julianty Akuba Kadaria Toana Kahar, Oktaviani Kai, Mohamad Nur Fadjri Kasim, Sesha Ramadhani Kongkolu, Sitty Rahma Hutami Kuengo, Gerrald Hariyawan Lalu, Indah Nurwahida Latif, Multiani S. Laurina, Nur Fadhilah Lia Amalia Lillyan Hadjaratie Madania Madania, Madania Mahdalena Sy Pakaya Maimun Datau Makkulawu, Andi Mamu, Safira Mahadewi Manno, Mohamad Reski Marhaba, Zulkarnain Moh. Arya Avrilio Isa Mohamad Adam Mustapa Mohamad Aprianto Paneo Mubaraq, Fajar Saril Muh. Fikri F. Walahe Muhammad Taupik Multiani S Latif Mursidi, Sitti Rahmawaty Sisilia Mutia Anggraini Gobel Nabila Novreini Djunaidi Ngani, Altaufik Niawahyuni Nusi Nur Ain Thomas Nur Rasdianah Nur'ain Dj. Silaka Nurhayati Salam Puspita Tolinggi Putra, Andi El Jalaludin Putri, Eka Fadhila Qarlan Pratama, Mohammad Rahmat Hidayat Domili Rahmatia Samatowa Rahmola, Siti Fauziyah Rifka Anggraini Anggai Robert Tungadi Rukmawati, Iis Sri Mulia Ningsih S. Uno Sri Wahyuni Suleman, Windy Riani Sumaga, Nabila Natasya Supriyadi A Arief Suyadi, A. Mu’thi Andy Teti Supriyati Tuloli Teti Sutriati Tuloli Teti Sutriyati Tuloli Tri Septian Maksum Unga, Rani Orelia Ambo Upara, Nana Nurindah Weny Almoravid Dungga Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanti Abdulkadir Widy Susanty Abdulkadir Widysusanti Abdulkadir Wiwit Zuriati Uno Yuni Sarah Manoppo Yusuf, Annisa Humaira Yusuf, Siti Rahmatia Zahra Zakia, Wavika Zulkarnain Marhaba Zuriati Uno, Wiwit