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All Journal Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Science Midwifery Jurnal Kompilasi Hukum JOURNAL LA MEDIHEALTICO Narra J Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Risalah Kenotariatan Jurnal Farmasi Sains dan Praktis Molekul: Jurnal Ilmiah Kimia Media Farmasi Jurnal Pengabdian Masyarakat
Arba, Muhammad
Faculty of Pharmacy, Halu Oleo University, Kendari, 93231
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : media farmasi

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Review artikel: Potensi Tanaman Nilam (Pogostemon cablin Benth.) Sebagai Agen Antikanker: Article review : Potential of the Patchouli (Pogostemon cablin Benth.) as an Anticancer Agent Wulandari, Ayu; Fristiohady, Adryan; Wahyuni, Wahyuni; Sahidin, Sahidin; Arba, Muhammad; Irnawati, Irnawati
Media Farmasi Vol 21 No 1 (2025): Media Farmasi Edisi April 2025
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v21i1.1270

Abstract

Globally, cancer remains one of the leading causes of death, and the number of cases continues to increase along with world population growth, population aging and modern lifestyles. The prevalence of cancer in 2024 will still be influenced by many factors, including lifestyle, diet, environmental exposure, and advances in cancer detection and treatment. Currently, a lot of research related to alternative cancer therapy focuses on the use of natural product as anticancer agents that are more selective, effective, and with lower side effects. This article review aims to provide information regarding the patchouli plant (Pogostemon cablin) and its potential as an anticancer agent. This review was carried out by collecting literature from various databases published in the last 10 years (2014 – 2024). Based on literature searches, P. cablin is known to have anticancer activity against endometrial, ovarian, liver, skin, nasopharyngeal, prostate, blood, colorectal and lung cancer.
Lantana Camara Linnaeus : Profil Fitokimia dan Potensi Aktivitas Farmakologi Putri, Intan Permata; Irnawati, Irnawati; Fristiohady, Adryan; Sahidin; Arba, Muhammad
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2022

Abstract

Lantana camara L. is a tropical plant from the Verbenaceae family that is widely known for its invasive nature, but also has high ethnomedicinal value. This study aims to examine the phytochemical profile and potential pharmacological activities of L. camara plants based on the latest scientific data. The study method uses a literature study approach to scientific literature from the Scopus database in the period 2015–2025 with keywords related to the phytochemistry and pharmacology of L. camara. The collected data were analyzed descriptively to identify the main bioactive compounds and their biological activities. The results of the study indicate that L. camara contains triterpenoids, flavonoids, phenolics, and iridoid glycosides that play an important role in various pharmacological activities, including antidiabetic, anticancer, antimicrobial, antioxidant, anti-inflammatory, and neuroprotective. Compounds such as ursolic acid, lantadene A and B, and quercetin-3-O-glucoside are reported to have significant biological effects through different molecular mechanisms. Furthermore, the potential use of L. camara in nanoparticle synthesis shows broad application prospects in the pharmaceutical and industrial fields. In conclusion, L. camara is a promising natural bioactive source for modern drug development and sustainable therapeutic applications.
Tanaman Obat Sebagai Inhibitor Xanthine Oxidase Dengan Mekanisme Multitarget Pada Hiperurisemia Dan Gout Srimuliana; Nasrudin; Sahidin; Arba, Muhammad; Fristiohady, Adryan; Irnawati; Ilyas Y, Muhammad; Jabbar, Asriullah
Media Farmasi Vol 22 No 1 (2026): Media Farmasi Edisi April 2026
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v22i1.2024

Abstract

Hiperurisemia merupakan faktor utama penyebab gout yang berkaitan dengan peningkatan kadar asam urat akibat produksi berlebih maupun gangguan ekskresi. Enzim xanthine oxidase (XO) berperan penting dalam pembentukan asam urat sehingga menjadi target utama dalam terapi gout. Review ini bertujuan untuk mengidentifikasi dan menganalisis tanaman obat yang memiliki aktivitas penghambatan enzim xanthine oxidase (XO) serta potensi terapinya dalam penanganan hiperurisemia dan gout. Pencarian literatur dilakukan menggunakan metode literature review dengan menelusuri artikel yang dipublikasikan pada periode 2020- 2025. Database yang digunakan meliputi Scopus, PubMed, ScienceDirect, dan Google Scholar. Artikel yang diseleksi membahas aktivitas penghambatan XO oleh tanaman obat berdasarkan uji in vitro dan in vivo. Sebanyak 23 tanaman obat teridentifikasi memiliki aktivitas penghambatan XO yang signifikan. Senyawa aktif seperti chrysin (Piper sarmentosum), limonene (Pistacia chinensis), andrographolide (Andrographis paniculata), dan morin (Maclura cochinchinensis) menunjukkan potensi tinggi, bahkan pada beberapa studi melebihi allopurinol. Mekanisme kerja tanaman obat tidak hanya melalui inhibisi XO langsung, tetapi juga melibatkan modulasi transporter asam urat ginjal seperti URAT1, GLUT9, OAT1, dan ABCG2. Selain itu, aktivitas antioksidan dan anti-inflamasi melalui penekanan jalur NF-κB dan NLRP3 turut berkontribusi, yang sering disertai dengan efek perlindungan ginjal dan hati. Dengan mekanisme kerja yang bersifat multi-target dan profil keamanan yang lebih baik, tanaman obat berpotensi menjadi alternatif terapi gout, meskipun uji klinis lanjutan masih diperlukan.
Co-Authors Agustiana, Agustiana Ahmad Najib Aksan, Aisah Fitriani Arfan Ari Sartinah, Ari Asbah, Asbah Ayu Wulandari Bahar, Muhammad A. Candrayanti, Gusti Ayu Made Darmin, Wa Ode Yentri Putia Ningtiyas Djumardin, Djumardin Filmaharani, Filmaharani Firzan Nainu Fitrawan, La Ode Muhammad Fitrawan, La Ode Muhammad Fristiohady, Adryan Habibie Habibie Hamzah, Any Suryani Hasnawati Hasnawati Idrus, Loly Subhiaty Ilyas Y, Muhammad Indalifiany, Astrid Intan Permata Putri Irnawati Irnawati Irnawati Irvan Irvan Jabbar, Asriullah Kuncoro, Shienny L, Adryan Fristiohady. La Aba Latada, Nadila P. Malik, Fadhliah Mallarangeng, Andi Nafisah Tendri Adjeng Mega Fatimah Rosana Mudjahid, Mukarram Muhammad Jefriyanto B NASRUDIN Nur Illiyyin Akib nuralifa, nuralifa Nuralifah Nuralifah, Nuralifah Nurcahyani, Fitria Nurhasana, N Nurrokhmadhani, Wa Ode Sitti Olyvia, Ocha Omir, Sri Wahyuli Astian Pascayantri, Asniar Priarti, Linda Putri, Annisa A. Putri, Natalia Christiani Putri, Suci Rahmawati Ridwan, Harnina Rudiah Rudiah Ruslin, R Ruslin, Ruslin Ruslin, Ruslin Sabarudin Sabarudin Sahidin Sahidin . Saputra, L. Yusril Wira Saputri, Ulan Mulyani Setyanto Tri Wahyudi Sida, Nurramadhani A. Siswahyudianto Solo, Dian Munasari Srimuliana Sudiarto Sunandar Ihsan, Sunandar Suryani Suryani Sutrisna, Rahmad Trisnawati, Ayu wahyuni wahyuni Widodo Dwi Putro Wu, Chun Yamin, Y Yamin, Yamin Yodha, Agung Wibawa Mahatva Yuniansari, Rizki Zubair, Muhammad S.