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All Journal Medula Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Sains dan Teknologi Pangan JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Prosiding Seminar Nasional Riset Kuantitatif Terapan 2017 Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Borneo Journal Of Pharmascientech Indonesian Journal of Pharmaceutical Education Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Farmasi Sains dan Praktis MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Panacea Jurnal Pengabdian Masyarakat Jurnal Informatika dan Kesehatan
Nuralifah Nuralifah, Nuralifah
Departemen Farmakologi, Fakultas Farmasi, Universitas Halu Oleo, Kendari, Indonesia Kampus Hijau Bumi Tridharma Anduonohu. Jl. H.E.A. Mokodompit, Kendari 93232,
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Profil Histologi Pankreas pada Kemanjuran Ekstrak Purifikasi Batang Galing terhadap Diabetes yang Diinduksi Streptozotocin pada Tikus Model Diabetes Muhammad Ilyas Y.; Nuralifah; Dian Munasari Solo; Nirwati Rusli; Esti Badia
Jurnal Informatika dan Kesehatan Vol. 1 No. 2 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i2.3363

Abstract

The galing plant (Cayratia trifolia L.Domin), one of the endemic plants in Southeast Sulawesi, is proven to contain bioactive flavonoid, alkaloid, and tannin compounds that have various pharmacological effects such as anti-diabetes and strong antioxidants, especially the stem, so it has the potential to be developed as an alternative to diabetes treatment. However, scientific information about the effects of pancreatic organ repair in diabetes still needs to be scientifically proven. The purpose of this study was to reveal the role of purified extract of galing stem on the repair of pancreatic organs of streptozotocin-induced diabetic model white rats. This study is an experimental study, with a post-test design with a control group design using 18 male white rats divided into normal control groups (non-DM), negative control (DM + Na.CMC), positive control (DM + glibenclamide 0.018 mg/kg BW) and treatment samples (DM + purified extract of galing stem 400 mg/kg BW). The results of this study indicate that the administration of purified extract of galing stem is proven to be able to repair damage to the pancreas organs in diabetic model rats shown by the improvement of the morphology of the pancreatic beta cell structure and an increase in the number of endocrine cells in the islets of Langerhans compared to the negative control that was not treated with the extract so that these findings as new scientific data for the development of potential anti-diabetic drugs from galing plants.   ABSTRAK Tumbuhan galing (Cayratia trifolia L.Domin) salah satu  tumbuhan endemik di Sulawesi Tenggara terbukti mengandung senyawa bioaktif flavanoid, alkaloid dan tanin yang memiliki berbagai efek farmakologi seperti anti diabetes dan antioksidan kuat khususnya bagian batang, sehingga berpotensi dikembangkan sebagai alternatif penanganan penyakit diabetes, namun informasi ilmiah tumbuhan ini tentang efikasi pada perbaikan organ pankreas pada diabetes masih perlu dibuktikan secara ilmiah. Tujuan penelitian ini untuk mengungkap peran ekstrak purifikasi batang galing terhadap perbaikan organ pankreas tikus putih model  diabetes yang diinduksi streptozotocin. Penelitian ini adalah penelitian eksperimental, dengan desain rancangan post test with control group design menggunakan 18 ekor tikus putih jantan dibagi dalam kelompok kontrol normal (non DM), kontrol negatif (DM+Na.CMC), kontrol positif (DM+glibenklamid 0,018  mg/kg BB) dan perlakuan sampel (DM+ekstrak purifikasi batang galing 400 mg/kg BB). Hasil penelitian ini menunjukan bahwa pemberian ekstrak terpurifikasi batang galing terbukti dapat memperbaiki kerusakan organ pankreas pada tikus model diabetes yang ditunjukan adanya perbaikan morfologi struktur sel beta pangkreas dan terjadi peningkatan jumlah sel endokrin di pulau langerhans dibandingkan dengan kontrol negatif yang tidak diberi perlakuan ekstrak, sehingga temuan ini sebagai data ilmiah baru untuk pengembangan obat anti diabetes yang potensil dari tumbuhan galing.  
Sosialisasi Edukatif Program DAGUSIBU dan Resiko Penyalahgunaan Obat pada Remaja di Kelurahan Ranomeeto Kasmawati, Henny; Fristiohady, Adryan; Nuralifah, Nuralifah; Zubaydah, Wa Ode Sitti; Arfan, Arfan
Jurnal Pengabdian Masyarakat Panacea Vol 2, No 3 (2024): Jurnal Pengabdian Masyarakat Panacea
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpmp.v2i3.13502

Abstract

Berbagai permasalahan kesehatan, khususnya yang berkaitan dengan penggunaan obat, masih sering dijumpai dalam masyarakat dan dapat diakibatkan oleh kurangnya pemahaman mengenai pengelolaan dan penggunaan obat yang benar. Salah satu strategi pengelolaan obat yang efektif adalah penerapan program Dapatkan, Gunakan, Simpan, Buang (DAGUSIBU), terutama di kalangan remaja, mengingat penyalahgunaan obat-obatan di usia dini merupakan isu yang memerlukan perhatian serius. Tujuan dari sosialisasi ini adalah untuk memberikan edukasi kepada siswa usia remaja, serta meningkatkan pemahaman mengenai penggunaan obat yang tepat melalui program DAGUSIBU. Kegiatan ini dilaksanakan melalui ceramah interaktif dan diskusi mengenai cara yang tepat untuk mendapatkan, menggunakan, menyimpan, dan membuang obat pada tanggal 26 Agustus 2024, dengan peserta sebanyak 40 orang siswa SMPN 1 Konawe Selatan. Peningkatan pemahaman siswa diukur dan diamati dari tingkat antusiasme dan kemampuan dalam menjawab pertanyaan dengan benar. Hasil kegiatan menunjukkan bahwa siswa mengalami peningkatan pemahaman mengenai penggunaan obat yang benar serta mengenal peran profesi apoteker. Secara keseluruhan, kegiatan sosialisasi ini berlangsung dengan baik, tercermin dari tingginya antusiasme, respons positif, dan partisipasi aktif siswa dalam diskusi, yang secara signifikan meningkatkan pemahaman mereka. Kegiatan ini diharapkan dapat berkontribusi dalam meningkatkan kesadaran dan pemahaman di kalangan remaja dan masyarakat tentang pengelolaan obat yang tepat, yang pada gilirannya dapat mengurangi risiko penyalahgunaan obat di masa depan.Kata Kunci: Edukasi Obat, Manajemen Obat, Peningkatan Kesehatan, RemajaVarious health issues, particularly those related to medication use, remain prevalent in society and are often attributed to a lack of understanding regarding proper medication management and usage. One of the effective strategies to address this issue is the implementation of the DAGUSIBU (Obtain, Use, Store, Dispose) program, particularly targeted at adolescents, as early-age drug misuse is a critical concern requiring serious attention. The primary objective of this outreach initiative is to educate adolescent students and enhance their understanding of proper medication use through the DAGUSIBU program. The program was delivered through interactive lectures and discussions with students at SMPN 1 Konawe Selatan, focusing on appropriate methods for obtaining, using, storing, and disposing of medications. The increase in students' understanding was assessed through their enthusiasm and ability to correctly respond to questions. The results indicated a notable improvement in students' comprehension of proper medication use, along with greater awareness of the pharmacist's role. Overall, the outreach program was conducted successfully, as evidenced by high levels of enthusiasm, positive feedback, and active student participation in discussions, which significantly enhanced their understanding. This initiative is expected to contribute to improving awareness and understanding among adolescents and the wider community regarding proper medication management, thereby potentially reducing the risk of drug misuse in the future.
PENYULUHAN DAN PENCEGAHAN NARKOTIKA, PSIKOTROPIKA DAN ZAT ADIKTIF (NAPZA) BAGI PELAJAR SMP NEGERI 10 KENDARI Pascayantri, Asniar; Nuralifah, Nuralifah; Jabbar, Asriullah; Dinata, Ade Sundari; Sari, Anita Puspita; Halim, Hikma Lestari; Hajar, Siti; Dewi, Pahtma Purnama Sari
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i6.1367

Abstract

The abuse of Narcotics, Psychotropics, and Addictive Substances (NAPZA) has become a serious issue among adolescents, including junior high school students. A lack of understanding and low awareness of the dangers of NAPZA can increase the risk of misuse at an early age. This community service activity aimed to enhance the knowledge and awareness of students at SMP Negeri 10 Kendari regarding the dangers of NAPZA and strategies for its prevention. The method used was an educational intervention through interactive counseling sessions, including discussions and the distribution of educational materials. Evaluation results showed an improvement in students' understanding of the types of NAPZA, the consequences of misuse, and prevention efforts. This activity demonstrates that appropriate and communicative education can serve as an effective preventive measure to reduce the potential for NAPZA abuse among students.
Uji Toksisitas Akut Ekstrak Air Dan Ekstrak Etanol Daun Kacapiring (Gardenia jasminoides Ellis) Terhadap Larva Artemia Salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT) Nuralifah, Nuralifah; Parawansah, Parawansah; Nur, Hasniana
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.11462

Abstract

A toxicity test is a test to detect the toxic effect of a substance on a biological system and to obtain typical dose-response data from the test preparation. This study aims to determine the content of secondary metabolites from the aqueous extract and ethanolic extract of gardenia leaves, characterization of gardenia leaf extract, and acute toxicity using the BSLT method against Artemia salina Leach shrimp larvae.Phytochemical screening tests were carried out by the color change method which included the alkaloid test, flavonoid test, tannin test, saponin test, and terpenoid test. Extract characterization tests include determination of water-soluble extract, determination of ethanol-soluble extract, determination of water content, and determination of ash content. Acute toxicity test using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae.The results of the phytochemical screening test for the aqueous extract of gardenia leaves showed positive results on saponins, while the phytochemical screening tests on ethanol extracts showed positive results on alkaloids, flavonoids, saponins, tannins, and terpenoids. The results of the characterization test on the aqueous extract of gardenia leaves were that the ethanol-soluble extract content was 20.19%, the water-soluble extract content was 23.17%, the water content was 99.13% and the ash content was 0.29%. Meanwhile, in the ethanolic extract of gardenia leaves, the ethanol-soluble extract content was 60.80%, the water-soluble extract content was 57.14%, the water content was 7.87% and the ash content was 3.22%. The results show that gardenia leaves are not toxic with the LC50 value of the water extract of the gardenia leaves is 1399.64 g/mL and the LC50 value of the ethanolic extract of the gardenia leaves is 1080.96 so that it can be used as traditional medicine. 
Co-Authors Akib, Nurlliyin Alya Zuhriyah Amirudin Eso Antrie, Geong Arba, Muhammad Arfan Arfan Arfan Arfan Ariani, Eno Retno Arismawati, A Armadany, Fery Indradewi Asriulah Jabar Damu, Rusliati Dewi, Pahtma Purnama Sari Dian Munasari Solo Dinata, Ade Sundari Eso, Amiruddin Esti Badia Fadhliyah Malik Feri Indradewi Ferry Sandra Fery Indradewi Armadani Fery Indradewi Armadany Fitrawan, L.O.M. Fitrawan, La Ode Muhammad Fitriani Sonaru Fristiohady, Adryan Gemini Alam Halim, Hikma Lestari Hasniar, Wa Ode Helma Yanda Serah I Putu Sudayasa I Putu Sudayasa Iko, Ria Agus Indah Amalia Lestari Indah Purnamasari Irma Irvan Anwar Jabbar, Asriullah Jabbar, Asriullah Jamsir, Asmaidah Karmilah Kasmawati, Henny La Ode Muhammad Fitrawan Loly Subhiaty Idrus Malina, Rachma Mardiani, Siti Mesi Leorita, Mesi Mesrawati Trisetya Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Yusuf Mulyawati, Sufiah Asri Munasari, Dian Murniaty Mursyidah Apriatin Muslihin, Sari Melyana Ni Nyoman Fitri Astari Ningsih, Warda Ayu Nining Yulianti Nirwati Rusli Nita Trinovitasari Nur illiyyin Akib Nur, Hasniana Nurramadhani A. Sida Nurramadhani Asida Nurrokhmadhani, Wa Ode Sitti Nurul Febrina Rahmawati Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah, Parawansah Parawansah, P Parawansah, P Pascayantri, Asniar Pratiwi, Aulif Puteri Febriyanthi Rachman Rahmat Ramadhan Rahmawati Rahmawati Rifa’atul Mahmudah Rini, Risky Sesa Rosdiana Natzir Sabarudin Sabarudin Sabarudin, S Sari, Anita Puspita Satriana Nasrun Septiyana, Wanda Siti Hajar Sitti Fazrianti Saputri Sofianti Tarta Sri oktaviani Sudiman, Aswan Sunandar Ihsan Sunandar Ihsan, Sunandar Syarifin, Andi Noor Kholidha Syasna, Annisa Tomy Nurtamin Ulan Dwi Shintia Wa Ode Arlina Misnaeni Wa Ode Nurmayanti Wa Ode Siti Rahayu Fathanah Wa Ode Sitti Asfiah Udu, Wa Ode Sitti Asfiah Wa Ode Tika Ertia Wahid Wahyuni Wahyuni Yulfa Yulfa Zubaydah, Wa Ode Sitti