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All Journal Medula Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Sains dan Teknologi Pangan JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Prosiding Seminar Nasional Riset Kuantitatif Terapan 2017 Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Borneo Journal Of Pharmascientech Indonesian Journal of Pharmaceutical Education Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Farmasi Sains dan Praktis MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Panacea Jurnal Pengabdian Masyarakat JIPITI: Jurnal Pengabdian kepada Masyarakat Jurnal Kefarmasian Indonesia Jurnal Sains dan Teknologi Pangan MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Nuralifah Nuralifah, Nuralifah
Departemen Farmakologi, Fakultas Farmasi, Universitas Halu Oleo, Kendari, Indonesia Kampus Hijau Bumi Tridharma Anduonohu. Jl. H.E.A. Mokodompit, Kendari 93232,
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Sosialisasi Edukatif Program DAGUSIBU dan Resiko Penyalahgunaan Obat pada Remaja di Kelurahan Ranomeeto Kasmawati, Henny; Fristiohady, Adryan; Nuralifah, Nuralifah; Zubaydah, Wa Ode Sitti; Arfan, Arfan
Jurnal Pengabdian Masyarakat Panacea Vol 2, No 3 (2024): Jurnal Pengabdian Masyarakat Panacea
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jpmp.v2i3.13502

Abstract

Berbagai permasalahan kesehatan, khususnya yang berkaitan dengan penggunaan obat, masih sering dijumpai dalam masyarakat dan dapat diakibatkan oleh kurangnya pemahaman mengenai pengelolaan dan penggunaan obat yang benar. Salah satu strategi pengelolaan obat yang efektif adalah penerapan program Dapatkan, Gunakan, Simpan, Buang (DAGUSIBU), terutama di kalangan remaja, mengingat penyalahgunaan obat-obatan di usia dini merupakan isu yang memerlukan perhatian serius. Tujuan dari sosialisasi ini adalah untuk memberikan edukasi kepada siswa usia remaja, serta meningkatkan pemahaman mengenai penggunaan obat yang tepat melalui program DAGUSIBU. Kegiatan ini dilaksanakan melalui ceramah interaktif dan diskusi mengenai cara yang tepat untuk mendapatkan, menggunakan, menyimpan, dan membuang obat pada tanggal 26 Agustus 2024, dengan peserta sebanyak 40 orang siswa SMPN 1 Konawe Selatan. Peningkatan pemahaman siswa diukur dan diamati dari tingkat antusiasme dan kemampuan dalam menjawab pertanyaan dengan benar. Hasil kegiatan menunjukkan bahwa siswa mengalami peningkatan pemahaman mengenai penggunaan obat yang benar serta mengenal peran profesi apoteker. Secara keseluruhan, kegiatan sosialisasi ini berlangsung dengan baik, tercermin dari tingginya antusiasme, respons positif, dan partisipasi aktif siswa dalam diskusi, yang secara signifikan meningkatkan pemahaman mereka. Kegiatan ini diharapkan dapat berkontribusi dalam meningkatkan kesadaran dan pemahaman di kalangan remaja dan masyarakat tentang pengelolaan obat yang tepat, yang pada gilirannya dapat mengurangi risiko penyalahgunaan obat di masa depan.Kata Kunci: Edukasi Obat, Manajemen Obat, Peningkatan Kesehatan, RemajaVarious health issues, particularly those related to medication use, remain prevalent in society and are often attributed to a lack of understanding regarding proper medication management and usage. One of the effective strategies to address this issue is the implementation of the DAGUSIBU (Obtain, Use, Store, Dispose) program, particularly targeted at adolescents, as early-age drug misuse is a critical concern requiring serious attention. The primary objective of this outreach initiative is to educate adolescent students and enhance their understanding of proper medication use through the DAGUSIBU program. The program was delivered through interactive lectures and discussions with students at SMPN 1 Konawe Selatan, focusing on appropriate methods for obtaining, using, storing, and disposing of medications. The increase in students' understanding was assessed through their enthusiasm and ability to correctly respond to questions. The results indicated a notable improvement in students' comprehension of proper medication use, along with greater awareness of the pharmacist's role. Overall, the outreach program was conducted successfully, as evidenced by high levels of enthusiasm, positive feedback, and active student participation in discussions, which significantly enhanced their understanding. This initiative is expected to contribute to improving awareness and understanding among adolescents and the wider community regarding proper medication management, thereby potentially reducing the risk of drug misuse in the future.
PENYULUHAN DAN PENCEGAHAN NARKOTIKA, PSIKOTROPIKA DAN ZAT ADIKTIF (NAPZA) BAGI PELAJAR SMP NEGERI 10 KENDARI Pascayantri, Asniar; Nuralifah, Nuralifah; Jabbar, Asriullah; Dinata, Ade Sundari; Sari, Anita Puspita; Halim, Hikma Lestari; Hajar, Siti; Dewi, Pahtma Purnama Sari
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i6.1367

Abstract

The abuse of Narcotics, Psychotropics, and Addictive Substances (NAPZA) has become a serious issue among adolescents, including junior high school students. A lack of understanding and low awareness of the dangers of NAPZA can increase the risk of misuse at an early age. This community service activity aimed to enhance the knowledge and awareness of students at SMP Negeri 10 Kendari regarding the dangers of NAPZA and strategies for its prevention. The method used was an educational intervention through interactive counseling sessions, including discussions and the distribution of educational materials. Evaluation results showed an improvement in students' understanding of the types of NAPZA, the consequences of misuse, and prevention efforts. This activity demonstrates that appropriate and communicative education can serve as an effective preventive measure to reduce the potential for NAPZA abuse among students.
Uji Toksisitas Akut Ekstrak Air Dan Ekstrak Etanol Daun Kacapiring (Gardenia jasminoides Ellis) Terhadap Larva Artemia Salina Leach Dengan Metode Brine Shrimp Lethality Test (BSLT) Nuralifah, Nuralifah; Parawansah, Parawansah; Nur, Hasniana
Indonesian Journal of Pharmaceutical Education Vol 1, No 2 (2021): Mei-Agustus 2021
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v1i2.11462

Abstract

A toxicity test is a test to detect the toxic effect of a substance on a biological system and to obtain typical dose-response data from the test preparation. This study aims to determine the content of secondary metabolites from the aqueous extract and ethanolic extract of gardenia leaves, characterization of gardenia leaf extract, and acute toxicity using the BSLT method against Artemia salina Leach shrimp larvae.Phytochemical screening tests were carried out by the color change method which included the alkaloid test, flavonoid test, tannin test, saponin test, and terpenoid test. Extract characterization tests include determination of water-soluble extract, determination of ethanol-soluble extract, determination of water content, and determination of ash content. Acute toxicity test using the Brine Shrimp Lethality Test (BSLT) method using Artemia salina Leach shrimp larvae.The results of the phytochemical screening test for the aqueous extract of gardenia leaves showed positive results on saponins, while the phytochemical screening tests on ethanol extracts showed positive results on alkaloids, flavonoids, saponins, tannins, and terpenoids. The results of the characterization test on the aqueous extract of gardenia leaves were that the ethanol-soluble extract content was 20.19%, the water-soluble extract content was 23.17%, the water content was 99.13% and the ash content was 0.29%. Meanwhile, in the ethanolic extract of gardenia leaves, the ethanol-soluble extract content was 60.80%, the water-soluble extract content was 57.14%, the water content was 7.87% and the ash content was 3.22%. The results show that gardenia leaves are not toxic with the LC50 value of the water extract of the gardenia leaves is 1399.64 g/mL and the LC50 value of the ethanolic extract of the gardenia leaves is 1080.96 so that it can be used as traditional medicine. 
Edukasi Kesehatan tentang Tuberkulosis: Membangun Komitmen Masyarakat untuk Pengendalian TBC Kasmawati, Henny; Hikmah, Nurull; Trinovitasari, Nita; Jannah, Sitti Raodah Nurul; Malina, Rachma; Suryani, Suryani; Nuralifah, Nuralifah; Aswani, Aswani
JIPITI: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 4 (2025): November 2025 - JIPITI: Jurnal Pengabdian kepada Masyarakat
Publisher : PT. Technology Laboratories Indonesia (TechnoLabs)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tuberculosis (TB) is an infectious disease that is still a global health problem, caused by the bacterium Mycobacterium tuberculosis, which is acid-resistant and mainly attacks the lungs, but can also attack other organs. This disease can affect people of all ages, including babies, children, adults, and the elderly. TB transmission occurs through the air from people who cough or sneeze, with the main factors affecting public health being environmental factors and behaviours, such as uncovered coughing and poor sanitation. TB cases in Southeast Sulawesi Province have shown a significant upward trend in recent years, with the incidence rate continuing to rise every year. The success of TB treatment is influenced by a variety of factors, including medication adherence, which is a major challenge to avoid the emergence of drug resistance, such as TB-MDR. The Government of Indonesia has issued policies and focuses on reducing TB incidence through education and socialisation to encourage active community involvement in TB control to achieve the national target by 2030.
The Activity of Notika Leaves (Archboldiodendron calosericeum Kobuski) Against Tumors Necrosis Factor Alpha (TNF-α) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 10 No. 1 (2022): Oktober
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum Kobuski). Purpose: This research was conducted to evaluate the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-α) in Wistar rats. Methods: The study used a post test only control group design. Rats were divided into five groups consisting of a positive control (diclofenac sodium), three extracts (100, 200 and 300 mg/kg BW) and Teeee carragenantrol gopre roups that are inlaporkan dari tanaman ketapang dalam spewa yang dilaporkan pada besar, dll --lar.negative control (NaCMC 0.5%). In vivo tests were carried out by induction of inflammatory using carragenan, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. Results: The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). Conclusion: The study concludes that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-α) in Wistar rats based on the reduction in levels with negative control and optimum dose was 100 mg/kgBW.
POTENSI ANTIDEPRESAN EKSTRAK ETANOL BUAH KUNDUR (Benincasa hispida) SEBAGAI PANGAN FUNGSIONAL: EVALUASI IN VIVO PERILAKU DEPRESI DAN KOORDINASI MOTORIK Jatnika, Yayat; Nuralifah, Nuralifah; Malik, Fadhliyah; Parawansah, Parawansah; Hariana, Hariana; Hikmah, Nurull; Wahyuni, Wahyuni; FRISTIOHADY, ADRYAN
Jurnal Sains dan Teknologi Pangan Vol. 11 No. 2 (2026): Jurnal Sains dan Teknologi Pangan
Publisher : Jurusan Ilmu dan Teknologi Pangan Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63071/f9ahq066

Abstract

Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak etanol buah kundur (Benincasa hispida) terhadap perilaku depresi pada mencit jantan menggunakan metode Elevated Plus Maze (EPM) Test serta mengetahui pengaruhnya terhadap koordinasi motorik melalui uji Rotarod. Mencit jantan dibagi menjadi enam kelompok: kontrol normal, kontrol negatif (Na CMC 0,5%), kontrol positif (amitriptilin 25 mg/kgBB), serta ekstrak buah kundur dosis 100, 200, dan 400 mg/kgBB. Parameter yang diamati meliputi persentase entri ke lengan terbuka (OAE) dan persentase waktu di lengan terbuka (TSOA), serta latency to fall, durasi terlama, dan frekuensi jatuh pada uji Rotarod. Hasil uji EPM menunjukkan bahwa ekstrak etanol buah kundur meningkatkan entri dan waktu berada di lengan terbuka secara signifikan pada dosis 400 mg/kgBB yang mendekati kontrol positif (p>0,05) menunjukkan penurunan perilaku depresi. Pada uji Rotarod, dosis 400 mg/kg BB menyebabkan peningkatan latency to fall, durasi dan frekuensi jatuh tetapi tidak signifikan, mengindikasikan efek samping gangguan motorik lebih rendah dibanding kontrol positif (p<0.05).
Anti-inflammatory Activity of Tectona grandis Linn. F. Extract Against TNF-α using In Vivo and Silico Methods Parawansah, Parawansah; Nuralifah, Nuralifah; Arfan, Arfan; Sulastrianah, Sulastrianah; Iswara, Radja Al Fath Widya; Murni, Kiki; Humairah, Sitti
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Tumor necrosis factor-alpha (TNF-α), a cytokine involved in inflammation, plays a critical role in inflammatory processes, particularly in synovial cells. Therefore, TNF-α represents a promising target for anti-inflammatory interventions. This study investigates the anti-inflammatory potential of Tectona grandis leaf extract by evaluating its ability to inhibit TNF-α activity. To identify bioactive compounds from the extract that may interact with the TNF-α receptor, molecular docking simulations were employed. In vivo experiments were conducted using different doses of the extract (100, 200, and 300 mg/kg body weight), and TNF-α levels were quantified to assess the anti-inflammatory effect. At a dose of 300 mg/kg, TNF-α levels were significantly reduced to 0.358 μg/L, indicating superior anti-inflammatory activity compared to the lower doses (0.539 μg/L at 100 mg/kg and 0.433 μg/L at 200 mg/kg). Molecular docking simulations revealed two bioactive compounds, Phaeophorbid A and (132S, 17S, 18S)-132-Hydroxy-20-Chloro-Ethylpheophorbide A, which demonstrated strong binding affinities (-5.4 kcal/mol and -5.2 kcal/mol, respectively) and interacted with the TNF-α receptor through hydrogen bonds and hydrophobic interactions. These results underscore the potential of Tectona grandis as a source of novel anti-inflammatory agents, suggesting its value in the development of therapeutic strategies targeting TNF-α in inflammation-related disorders.
Co-Authors Akib, Nurlliyin Alya Zuhriyah Amirudin Eso Antrie, Geong Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Arfan Ariani, Eno Retno Arismawati, A Armadany, Fery Indradewi Asriulah Jabar Aswani, Aswani Damu, Rusliati Dewi, Pahtma Purnama Sari Dian Munasari Solo Dinata, Ade Sundari Eso, Amiruddin Fadhliyah Malik Feri Indradewi Ferry Sandra Fery Indradewi Armadani Fery Indradewi Armadany Fitrawan, L.O.M. Fitrawan, La Ode Muhammad Fitriani Sonaru Fristiohady, Adryan Gemini Alam Halim, Hikma Lestari Hariana, Hariana Hasniar, Wa Ode Helma Yanda Serah Hikmah, Nurull Humairah, Sitti I Putu Sudayasa I Putu Sudayasa Iko, Ria Agus Indah Amalia Lestari Indah Purnamasari Irma Iswara, Radja Al Fath Widya Jabbar, Asriullah Jabbar, Asriullah Jamsir, Asmaidah Jannah, Sitti Raodah Nurul Jatnika, Yayat Karmilah Kasmawati, Henny La Ode Muhammad Fitrawan Loly Subhiaty Idrus Malina, Rachma Mardiani, Siti Mega Fatimah Rosana Mesi Leorita, Mesi Mesrawati Trisetya Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Ilyas Yusuf Mulyawati, Sufiah Asri Munasari, Dian Murni, Kiki Murniaty Mursyidah Apriatin Muslihin, Sari Melyana Ni Nyoman Fitri Astari Ningsih, Warda Ayu Nining Yulianti Nining Yulianti Nita Trinovitasari Nur illiyyin Akib Nur, Hasniana Nurramadhani A. Sida Nurramadhani Asida Nurrokhmadhani, Wa Ode Sitti Nurul Febrina Rahmawati Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah, Parawansah Parawansah, P Parawansah, P Pascayantri, Asniar Pratiwi, Aulif Puteri Febriyanthi Rachman Rahmat Ramadhan Rahmawati Rahmawati Rifa’atul Mahmudah Rini, Risky Sesa Rosdiana Natzir Sabarudin Sabarudin Sabarudin, S Sari, Anita Puspita Satriana Nasrun Septiyana, Wanda Siti Hajar Sitti Fazrianti Saputri Sofianti Tarta Sri oktaviani Sudiman, Aswan Sulastrianah Sulastrianah, Sulastrianah Sunandar Ihsan Sunandar Ihsan, Sunandar Suryani Suryani Syarifin, Andi Noor Kholidha Syasna, Annisa Tomy Nurtamin Trinovitasari, Nita Ulan Dwi Shintia Wa Ode Arlina Misnaeni Wa Ode Nurmayanti Wa Ode Siti Rahayu Fathanah Wa Ode Sitti Asfiah Udu, Wa Ode Sitti Asfiah Wa Ode Tika Ertia Wahid Wahyuni Wahyuni wahyuni wahyuni Yulfa Yulfa Zubaydah, Wa Ode Sitti