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All Journal Medula Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Sains dan Teknologi Pangan JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA The Indonesian Biomedical Journal Prosiding Seminar Nasional Riset Kuantitatif Terapan 2017 Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Borneo Journal Of Pharmascientech Indonesian Journal of Pharmaceutical Education Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Jurnal Farmasi Sains dan Praktis MOSIRAHA : Jurnal Pengabdian Farmasi Lansau: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat Panacea Jurnal Pengabdian Masyarakat JIPITI: Jurnal Pengabdian kepada Masyarakat
Nuralifah Nuralifah, Nuralifah
Departemen Farmakologi, Fakultas Farmasi, Universitas Halu Oleo, Kendari, Indonesia Kampus Hijau Bumi Tridharma Anduonohu. Jl. H.E.A. Mokodompit, Kendari 93232,
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Medula

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Formulasi Sediaan Krim Anti Jerawat Ekstrak Etanol Biji Pepaya Muda (Carica papaya L.) Serta Uji Aktivitasnya Terhadap Bakteri Pseudomonas aeruginosaATCC 27825 dan Staphylococcus aureusATCC 25923 (Anti Acne Cream Formulation for Young Papaya Seed (Carica papaya L.) Ethanol Extract and Activity Test Against Pseudomonas aeruginosa ATCC 27825 and Staphylococcus aureus ATCC 25923) Nuralifah Nuralifah; Feri Indradewi; Parawansah Parawansah; Satriana Nasrun
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 7, No 1 (2019)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.139 KB) | DOI: 10.46496/medula.v7i1.11493

Abstract

Background: Young papaya seeds (Carica papaya L.) contained terpenoids, alkaloids karpain and flavonoids that have been examined has antibacterial activity. Purpose: This study aims to obtain anti-acne cream from extract of young papaya seeds (Carica papaya L.) that possess antibacterial activity against Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 27825. Methods: Extract of young papaya seeds (Carica papaya L.) was obtained by maceration process using ethanol 96% and the antibacterial activity of extract conducted by well diffusion method. then the extract formulated into anti acne cream dosage and then tested to characteristic properties including pH test, dispersive power test, organoleptic test, homogeneity test, viscosity test and irritation test. Result: The results showed anti acne creams of extract young papaya seeds (Carica papaya L.) produced qualified standard and did not cause irritation. Conclusion: Anti acne cream containing extract concentration of 10% can inhibited bacteria of S. aureus ATCC 25923 with inhibition zone of 17,5 mm and P. aeruginosa ATCC 27825 with inhibition zone of 19,3 mm.Keyword: seeds of papaya (Carica papaya L.), anti acne creamLatar Belakang: Biji pepaya muda (Carica papaya L) mengandung terpenoid, alkaloid karpain dan flavonoid, yang telah diteliti memiliki aktivitas antibakteri. Tujuan: Penelitian ini bertujuan untuk memperoleh sediaan krim anti jerawat dari ekstrak biji pepaya muda (Carica papaya L) yang memiliki aktivitas anti bakteri terhadap bakteri Staphylococcus aureus ATCC 25923 dan Pseudomonas aureginosa ATCC 27825. Metode: Ekstrak biji pepaya muda (Carica papaya L) diperoleh melalui proses maserasi menggunakan pelarut etanol 96%, serta uji aktivitas antibakteri ekstrak dilakukan dengan metode sumuran. Ekstrak selanjutnya diformulasikan menjadi sediaan krim anti jerawat dan dilakukan uji karakterisasi meliputi uji pH, uji daya sebar, uji organoleptik, uji homogenitas, uji viskositas dan uji iritasi. Hasil: Hasil pengamatan menunjukkan sediaan krim anti jerawat ekstrak biji pepaya muda (Carica papaya L) yang dihasilkan memenuhi syarat standar nilai pH, daya sebar dan viskositas. Hasil uji iritasi memperlihatkan formula krim tidak menimbulkan iritasi. Simpulan: Sediaan krim anti jerawat dengan konsentrasi ekstrak 10% dapat menghambat bakteri S.aureus ATCC 25923 dengan hambatan sebesar 17,5 mm dan P. aeruginosa ATCC 27825 dengan hambatan sebesar 19,3 mm.Kata Kunci: biji pepaya muda (Carica papaya L), krim anti jerawat
Pengaruh Ekstrak Labu Siam (Sechium edule (Jacq.) Swartz) Terhadap Waktu Koagulasi Pada Mus musculus Nuralifah Nuralifah; Wa Ode Tika Ertia Wahid; Muhammad Ilyas Yusuf
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 2, No 2 (2015)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (344.014 KB) | DOI: 10.46496/medula.v2i2.2546

Abstract

Chayote (Sechium edule (Jacq.) Swartz) is a type of vegetable that contains most of the calcium, the calcium in the blood which stimulates the release of thromboplastin phospholipid that will catalyze changes that have not been activated prothrombin into thrombin active. The purpose of this study was to prove the existance fromthe effect of squash extracts against coagulation time in mice. This study is experimental, which is divided into 5 treatment consisted of 3 repetitions. Extracts of squash as the test material is made a concentration of 100 mg / kg, 200 mg / kg, and 300 mg / kg. Observations made by looking fibrin threads formed on the fracture capillary tube ± for 2-6 minutes after exiting the first blood. The study was conducted in the laboratory of Pharmacology Bina Husada Kendari. Statistical analysis of the results obtained from the ANOVA showed that extracts of squash has an effective effect with 15.33 seconds at a concentration of 300 mg / kg. Results of ANOVA and LSD test showed extracts of squash has an effect on coagulation time significantly.Keywords: coagulation time, extract of squash, Sechium edule (Jacq.) Swartz
Antibacterial Activities of Kacapiring Leaf Ethanol Extract (Gardenia jasminoides Ellis) on the Bacteria of Staphylococcus aureus and Propionibacterium acnes Nuralifah Nuralifah; Fery Indradewi Armadani; Ni Nyoman Fitri Astari
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.208 KB) | DOI: 10.46496/medula.v6i3.9652

Abstract

ABSTRACTBackground and Objective(s): Infection is the process of entering pathogenic bacteria or microorganisms into the body capable of causing disease. Bacterial infections can cause skin infections such as acne. Acne is inflammation that is accompanied by blockage of the oil glands of the skin and hair (pilosebasea duct). Gardenia jasminoides Ellis is a plant that empirically can be used to treat infectious diseases caused by bacteria. This study was conducted to determine the antibacterial activity of the extracts of kacapiring leaves (Gardenia jasminoides Ellis) against Staphylococcus aureus and Propionibacterium acnes bacteria. Methods: Making extracts was done by maceration method  using  96% ethanol. The concentrations of extracts  used  were 5%, 10% and  15%,  with chloramphenicol and clindamycin as positive controls and distilled water as negative controls. Antibacterial activity was tested by the Cup-plate technique. Results: The antibacterial activity of kacapiring leaves ethanol extract to S. aureus showed that at concentrations of 5%, 10% and 15% the inhibitory power diameters values were respectively 5.58 mm, 9.3 mm and 11.41 mm while the antibacterial activity of extracts kacapiring leaves ethanol to P. acnes bacteria at concentrations of 5%, 10% and 15% had inhibitory power diameters of 6.33 mm, 9.25 mm and 11 mm respectively. Conclusion: Ethanol extract of kacapiring leaves has antibacterial activity against Staphylococcus aureus and Propionibacterium acnes bacteria. At a concentration of 5% and 10%, it shows the moderate category and at a concentration of 15% shows a strong category.Keywords: antibacterial, cup-plate technique , gardenia jasminoides
Uji Antidiabetik Ekstrak Buah Pare (Momordica charantia L.) terhadap Penurunan Kadar Glukosa Darah pada Mencit yang Diinduksi Streptozotocin Parawansah Parawansah; Nuralifah Nuralifah; Andi Noor Kholidha
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 1 (2017)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.321 KB) | DOI: 10.46496/medula.v5i1.3889

Abstract

ABSTRACT Diabetes mellitus is a chronic disease in which the patient has excess glucose levels in the blood. Pare (Momordica charantia L.) is one of the plants that have efficacy in treating various diseases one of them is antidiabetes. Activity of active substances from the pare may play a role in lowering blood sugar levels. This research is done to know the effect of increasing concentration of pare extract to decrease blood glucose level in mice induced by streptozotocin.This study was experimental laboratory, the study was done by measured  the initial blood sugar level in mice, sugar content after induction of steptozotosin, and after administration of 100 mg / kgBW extract test, 250 mg / kgBW and 400 mg / kgBW with observation time for 7 days , as well as gave metformin suspension as a positive control.The results showed that the optimum value of antidiabetic activity of ethanol extract of pare fruit at a concentration of 400 mg / kgBW and had an average decrease of 122 mg / dl.Keywords: Antidiabetes, Momordica charantia L., Streptozotocin
The Activity of Notika Leaves (Archboldiodendron calosericeum KOBUSKI) Against Tumors Necrosis Factor Alpha (TNF-) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.23816

Abstract

Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum KOBUSKI). This research was conducted to determine the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-a) in wistar mice. This study used a post test only control group design. Using 5 treatment groups, namely positive control (diclofenac sodium), negative control (NaCMC 0.5%), 100 mg/kgBW extract test group, 200 mg/kgBW extract group and 300 mg/kgBW extract group. In vivo tests were carried out by induction of inflammatory substances, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). The conclusion obtained is that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-a) in Wistar rats based on the reduction in levels with negative control and the best dose was 100 mg/kgBW.
Co-Authors Akib, Nurlliyin Alya Zuhriyah Amirudin Eso Antrie, Geong Anwar, Irvan Arba, Muhammad Arfan Arfan Arfan Arfan Ariani, Eno Retno Arismawati, A Armadany, Fery Indradewi Asriulah Jabar Aswani, Aswani Damu, Rusliati Dewi, Pahtma Purnama Sari Dian Munasari Solo Dinata, Ade Sundari Eso, Amiruddin Fadhliyah Malik Feri Indradewi Ferry Sandra Fery Indradewi Armadani Fery Indradewi Armadany Fitrawan, L.O.M. Fitrawan, La Ode Muhammad Fitriani Sonaru Fristiohady, Adryan Gemini Alam Halim, Hikma Lestari Hasniar, Wa Ode Helma Yanda Serah Hikmah, Nurull I Putu Sudayasa I Putu Sudayasa Iko, Ria Agus Indah Amalia Lestari Indah Purnamasari Irma Jabbar, Asriullah Jabbar, Asriullah Jamsir, Asmaidah Jannah, Sitti Raodah Nurul Karmilah Kasmawati, Henny La Ode Muhammad Fitrawan Loly Subhiaty Idrus Malina, Rachma Mardiani, Siti Mesi Leorita, Mesi Mesrawati Trisetya Muhammad Hajrul Malaka Muhammad Ilyas Y Muhammad Ilyas Yusuf Mulyawati, Sufiah Asri Munasari, Dian Murniaty Mursyidah Apriatin Muslihin, Sari Melyana Ni Nyoman Fitri Astari Ningsih, Warda Ayu Nining Yulianti Nita Trinovitasari Nur illiyyin Akib Nur, Hasniana Nurramadhani A. Sida Nurramadhani Asida Nurrokhmadhani, Wa Ode Sitti Nurul Febrina Rahmawati Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah Parawansah, Parawansah Parawansah, P Parawansah, P Pascayantri, Asniar Pratiwi, Aulif Puteri Febriyanthi Rachman Rahmat Ramadhan Rahmawati Rahmawati Rifa’atul Mahmudah Rini, Risky Sesa Rosdiana Natzir Sabarudin Sabarudin Sabarudin, S Sari, Anita Puspita Satriana Nasrun Septiyana, Wanda Siti Hajar Sitti Fazrianti Saputri Sofianti Tarta Sri oktaviani Sudiman, Aswan Sunandar Ihsan Sunandar Ihsan, Sunandar Suryani Suryani Syarifin, Andi Noor Kholidha Syasna, Annisa Tomy Nurtamin Trinovitasari, Nita Ulan Dwi Shintia Wa Ode Arlina Misnaeni Wa Ode Nurmayanti Wa Ode Siti Rahayu Fathanah Wa Ode Sitti Asfiah Udu, Wa Ode Sitti Asfiah Wa Ode Tika Ertia Wahid Wahyuni Wahyuni Yulfa Yulfa Zubaydah, Wa Ode Sitti