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All Journal Media Penelitian dan Pengembangan Kesehatan Jurnal Biotek Medisiana Indonesia Medical Journal of Indonesia Paediatrica Indonesiana Media Karya Kesehatan J-Kesmas: Jurnal Kesehatan Masyarakat (Indonesian Journal of Public Health) Narra J Indonesian Journal of Health Science The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia Sentra Dedikasi: Jurnal Pengabdian Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rudi Putranto
Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RS Dr. Cipto Mangunkusumo, Jakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Peran heart rate variability dan faktor inflamasi pada sindrom lelah kronik Anwar, Bariani; Faisal, Edward; Irvianita, Vinandia; Putranto, Rudi; Shatri, Hamzah
Indonesian Journal of Health Science Vol 4 No 6 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i6.1139

Abstract

Sindrom kelelahan kronis yang juga dikenal sebagai Myalgic Encephalomyelitis (ME), adalah kondisi kronis kompleks yang ditandai oleh kelelahan parah, disertai nyeri muskuloskeletal, gangguan kognitif, dan sistem autonom. Patofisiologi CFS melibatkan inflamasi kronis, disfungsi mitokondria, dan ketidakseimbangan sistem kekebalan, yang ditunjukkan dengan tingginya kadar sitokin pro-inflamasi. Aktivitas sitokin ini berperan dalam munculnya gejala utama seperti kelelahan, nyeri, dan penurunan kognitif. Diagnosis CFS merupakan proses yang kompleks karena didasarkan pada metode eksklusi dan belum adanya biomarker definitif sehingga menyebabkan banyak pasien tidak terdiagnosis. Heart Rate Variability (HRV) telah diajukan sebagai metode non-invasif untuk menilai disfungsi autonom pada CFS, di mana HRV rendah menunjukkan peningkatan risiko kelelahan dan disfungsi parasimpatis. Penggunaan HRV dan sitokin sebagai biomarker potensial menawarkan pendekatan yang lebih terukur dalam mendiagnosis CFS serta memprediksi prognosis. Namun, heterogenitas dalam hasil penelitian terkait peran sitokin menekankan pentingnya konsistensi metodologis di masa mendatang. Studi lanjutan tentang HRV dan inflamasi pada CFS diharapkan dapat berkontribusi pada strategi terapi yang lebih spesifik.
Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study Putranto, Rudi; Adhiatma, Kresna; Tarigan, Tri Juli Edi; Rumende, Cleopas Martin; Shatri, Hamzah; Rengganis, Iris; Nugroho, Pringgodigdo; Rinaldi, Ikhwan
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237005

Abstract

BACKGROUND The prevalence of type 2 diabetes mellitus (T2DM) is increasing and commonly accompanied by comorbidities, such as depression. Vitamin D levels have been associated with T2DM and depression although the mechanism is uncertain. This study aimed to compare vitamin D levels between patients with T2DM with and without depression in the Indonesian community, where such research is rare. METHODS This cross-sectional study was conducted at Cipto Mangunkusumo Hospital. The participants who met the inclusion criteria on an outpatient basis were screened for depression using the Beck Depression Inventory-II (BDI-II) questionnaire and then divided into 2 groups: patients with T2DM with (BDI-II ≥14) and without (BDI-II <14) depression. Both groups were examined for vitamin D levels using the ELISA method, and an analysis of the mean difference between both groups was performed. RESULTS Of 60 patients, 23 (38%) experienced depression. The median vitamin D levels were 21.8 ng/ml (IQR 14.9–26.6) in the depression group and 26.5 ng/ml (IQR 23.96–34.08) in the non-depression group (p = 0.001). After performing multivariate analysis with confounding variables, the adjusted OR of variables (sex, sun exposure score, and body mass index) was 1.123 (95% CI: 1.003–1.259; p = 0.045). CONCLUSIONS Vitamin D levels were significantly lower in patients with T2DM with depression. Future studies should be carried out to determine the benefits of vitamin D supplementation in patients with T2DM with depression and their pathophysiology.
Hubungan Penggantian Imunosupresan Tidak Terencana dengan Aktivitas Penyakit Lupus Eritematosus Sistemik: Studi Kohort Retrospektif di RSUPN Dr. Cipto Mangunkusumo, Jakarta Amanda, Rosvitha; Koesnoe, Sukamto; Widhani, Alvina; Rinaldi, Ikhwan; Susilo, Adityo; Kurniawan, Juferdy; Putranto, Rudi; Karim, Birry
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease with diverse clinical manifestations. Treatment stabilization is crucial for optimal disease control, but the consistency of immunosuppressive therapy may be affected by non-ideal conditions, including drug unavailability or adverse effects. This study aimed to assess the association between unplanned immunosuppressant switching and increased disease activity in SLE patients. Methods. A retrospective cohort study of SLE patients meeting the inclusion criteria, whose disease activity was evaluated using the MEX-SLEDAI score during immunosuppressant substitution. Participants were grouped into an exposed group undergoing unplanned immunosuppressant switching due to drug unavailability and a comparison group continuing maintenance therapy without switching. Disease activity was assessed using the MEX-SLEDAI score during follow-up. Results. A total of 213 SLE patients were included; 45 patients (21.1%) experienced increased disease activity. Unplanned immunosuppressant substitution was significantly associated with increased disease activity (RR 2.06; 95% CI 1.18–3.60; p=0.011), and remained significant after adjustment for confounders (aRR 1.82; 95% CI 1.05–3.15; p=0.034). Subgroup analysis showed most flares occurred within the first three months after substitution, and mycophenolate-containing replacement regimens were associated with a lower risk of increased disease activity (p=0.025). Conclusions. Unplanned immunosuppressant substitution is associated with increased disease activity in SLE patients. Close monitoring following switching is essential to maintain disease stability.
Co-Authors Achmad Fauzi Achmad Fauzy, Achmad Adhiatma, Kresna Adityo Susilo, Adityo Adli, Mizanul Afistianto, Muhammad Fikri Agus Siswanto Agustin Kusumayati Ahani, Ardhi Rahman Alexander, Reinaldo Alfiah, Elma Alvina Widhani, Alvina Amanda, Rosvitha Andru, Gestana Anwar, Bariani Anwar, Sufyan Ardani, Yanuar Ardhi Rahman Ahani Arfah Husna Ari Fahrial Syam Ari Fahrial Syam Arif Mansjoer Arshita Auliana Aulia Rizka, Aulia Badriul Hegar Bambang Setyohadi Bambang Setyohadi Bambang Subangkit Birry Karim Browijoyo, Isa A. Budi Sampurna Chairani, Aisha Putri Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Cleopas Martin Rumende Cophiadi Irawan Cosphiadi Irawan Dadang Makmun Diah Martina, Diah Dono Antono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Eddy Mart Salim, Eddy Mart Edward Faisal Edward Faisal Eka Ginanjar Em Yunir, Em Erlita, Diana Evy Yunihastuti Faisal, Edward Fiastuti Witjaksono Fita Fitrianti Fitrawan, Ahmad Frastica, Michelle Hapsari, Aljira Fitya Harna, Harna Harry Isbagio Hasan Maulahela Herqutanto - Ika Prasetya Wijaya Ikhwan Rinaldi Imam Subekti Iris Rengganis Irman Firmansyah Irvianita, Vinandia Iskandar Iskandar Jeger, Dian P. Juferdy Kurniawan Jufri , Jufri Kambang Sariadji Kamilia, Nisrina Kemal Fariz Kalista, Kemal Fariz Kosasih, Kartika Anastasia Kuntjoro Harimurti Kurniawan , Ade Laksono Trisnantoro Leonard Nainggolan Luxi Riajuni Marbun, Maruhum Bonar Hasiholan Marcellus Simadibrata Marniati Marniati, Marniati Megantara, Marcelino A. Muh Asrul Irawan, Andi Muhadi Muhadi, Muhadi Muhammad Ali Apriansyah, Muhammad Ali Murdani Abdullah Nabil Mubtadi Falah Nabil Mubtadi Falah, Nabil Mubtadi Nasrun, Martina W. Natali, Veritea nFN Abdurrahman, nFN nFN Sunarno, nFN Noer Endah Pracoyo Noto Dwimartutie Novita, Anisah Nurfitria, Nandika Nurrahmah , Awalia Pane, Meivina Ramadhani Poespitasari, Vinandya Irvianita Pratama, Metra Adi Pringgodigdo Nugroho, Pringgodigdo Putri, Enda Silvia Rachmawati, Elvie Zulka Autzia Raniah, Nida Ratih Arianita Agung Restuti, Ratna Dwi Sabililhaq, Muhammad Adnan Sabrina Munggarani Yusuf Sally A Nasution, Sally A Sariadji Kambang, Sariadji Sihwastuti, Sihwastuti Sinulingga, Dika Sinulingga, Dika I. Siswahyudianto Siti Setiati Suhendro Suwarto, Suhendro Sukamto Koesnoe Sumariyono Sumariyono Suzanna Immanuel Su’udi, Amir Syahrani, Aisyah Syamsuar Manyullei Tri Juli Edi Tarigan Triyani Sukarso Ukkas, Ummu Kalsum Wismandari Wisnu Wulyo Rajabto Yos Hendra Yos Hendra, Yos Yunizaf, Rahmanofa Yusuf, Andi Mukramin Zulkifly, Steven