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All Journal International Journal of Public Health Science (IJPHS) Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Kesehatan Manarang Biolearning Journal Jurnal Abdimasa PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Science Midwifery Jurnal Promotif Preventif Mitra Mahajana: Jurnal Pengabdian Masyarakat Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO International Journal of Health, Economics, and Social Sciences (IJHESS) Jurnal EduHealth Jurnal Sains dan Teknologi Sci-Tech Journal Jurnal Sains dan Kesehatan Jurnal Ilmiah Ilmu Terapan Universitas Jambi Journal of Pharmaceutical and Sciences. Jurnal Etnofarmasi Jurnal Mahasiswa Ilmu Kesehatan Journal of Public Health and Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmu Kesehatan Jurnal Etnofarmasi
Lukman Hardia
Program Studi Farmasi, Fakultas Farmasi, Universitas Pendidikan Muhammadiyah Sorong
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Studi In Vivo Efek Nefroprotektif Ekstrak Etanol Batang Tali Kuning (Anamirta cocculus (L.) Wight & Arn.) terhadap Profil Kreatinin Serum Mencit Dian Nur Khofifah; A. M. Muslihin; Lukman Hardia
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1522

Abstract

Background: Nephrotoxicity due to the use of drugs such as gentamicin can cause kidney damage characterized by increased creatinine levels. The use of medicinal plants as nephroprotective agents is a potential alternative; one such plant is yellow rope stem (Anamirta cocculus (L.) Wight & Arn.), known to contain antioxidant compounds. Objective: This study aims to assess the nephroprotective activity of yellow rope stem ethanol extract and determine the optimal dose for reducing gentamicin-induced increases in creatinine levels in mice. Method: The study was conducted experimentally with a pre-test and post-test design using the maceration method with 70% ethanol solvent. Mice were divided into six groups, namely negative control, positive control (vitamin E), healthy control, and three treatment groups with varying extract doses. Creatinine levels were measured using the Jaffe method with a UV-Vis spectrophotometer. Results: The results showed that the yellow rope stem ethanol extract at a dose of 77 mg/kgBW was able to reduce creatinine levels significantly (p<0.05), while lower doses did not show a significant difference. Conclusion: Ethanol extract of yellow rope stems has nephroprotective activity at an optimal dose of 77 mg/kgBW, thus having the potential to be developed as a herbal agent to protect kidney function.
Research Trends of Stunting Related to Insulin-Like Growth Factor-1: Bibliometric Analysis Lukman Hardia; Agus Sangka Pratama; A. M. Muslihin
Jurnal Penelitian Pendidikan IPA Vol 9 No SpecialIssue (2023): UNRAM journals and research based on science education, science applic
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9iSpecialIssue.6903

Abstract

Stunting is a condition in which a person's height is less than normal based on age and gender. The prevalence of stunting in Indonesia in 2021 is 24.4%. This illustrates that stunting is still a problem that cannot be resolved in Indonesia. Research on the incidence of stunting was carried out to determine its relationship with insulin-like growth factor-1 (IGF-1) levels. Search results on the Pubmed database obtained 446 English-language articles published from 1993 – April 12, 2023. The results of bibliometric analysis and VOSViewer show that new research trends began to be seen in 2018 to 2023 even though there had been publications previously in 1993 and 2000, but very minimal amount. The most dominating document types were journal articles with 310 publications (69.51%) and reviews with 89 publications (19.96%). The most trending keywords are humans (268), female (176), male (145), animals (142), insulin-like growth factor i/metabolism (94), child (74), adult (60), mice (56), pregnancy (47) and child preschool (43). The publishing journals that published the most articles were Frontiers in Endochronolgy (22 publications), International Journal of Molecular Sciences (19 publications), Scientific Reports (13 publications). The highest number of author collaborations is from the USA with 78 articles being the country with the most collaboration on both SCP and MCP with an MCP to SCP ratio of 0.244. China ranks second with the number of articles of 63 with an MCP ratio of 0.190.
Anthocyanin Compounds from Ethanol Extract of Red Fruit (Pandanus conideus L.): A Functional Group Analysis Indah Amelia Rizky; Angga Bayu Budiyanto; Lukman Hardia
Jurnal Penelitian Pendidikan IPA Vol 10 No 11 (2024): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i11.9321

Abstract

Red Fruit (Pandanus conoideus L.) is a typical Papuan plant that is rich in bioactive compounds such as anthocyanins, which have the potential to act as antioxidants. This research aims to analyze the chemical structure of anthocyanin compounds from red fruit ethanol extract using Fourier Transformed Infrared (FTIR) spectroscopy. FTIR is a spectroscopic tool widely used to characterize or detect functional groups and qualitatively identify compounds in samples. Anthocyanins act as antioxidants and have various biological activities such as preventing cancer, cardiovascular disease, and diabetes. Extraction was carried out using the maceration method using 70% ethanol solvent, and characterization was performed using FTIR in the wave range 4000-450 cm⁻¹. The results of the research that has been carried out show that the ethanol extract of red fruit contains secondary metabolites such as flavonoids, alkaloids, and saponins. The FTIR results of red fruit extract show the presence of functional groups characterized by the presence of the O-H, C-O-C, C-O, and C=C functional groups which are important indicators of the antioxidant properties of anthocyanins. This research confirms the potential of Red Fruit as a natural source of anthocyanins which are useful as antioxidants
Analysis of administrative-pharmaceutical completeness on patient prescriptions at Puskesmas X, Sorong City Carmel Josuhua Paulus; Lukman Hardia; Angga Bayu Budiyanto
Science Midwifery Vol 14 No 2 (2026): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i2.2374

Abstract

Prescription completeness is an important indicator in pharmaceutical services because it is related to therapeutic accuracy and patient safety. Incomplete prescriptions may increase the risk of medication errors during drug preparation and administration. This study aimed to determine the level of administrative and pharmaceutical completeness of patient prescriptions at Puskesmas X, Sorong City. This research used a descriptive observational method with a retrospective approach involving 1,572 patient prescriptions selected using a total sampling technique. The assessment was conducted based on the standards of the Indonesian Ministry of Health Regulation Number 73 of 2016 and Number 58 of 2014. The results showed that all prescriptions (100%) were categorized as incomplete. In the administrative aspect, patient name and prescription date reached 100% completeness, while patient height, doctor’s practice license number, and doctor’s phone number showed 0% completeness. Doctor’s initials/signature were found in 60.8% of prescriptions. In the pharmaceutical aspect, drug name, stability, and compatibility reached 100% completeness, while dosage form and drug strength reached 70.6% and 69.3%, respectively. The study concluded that pharmaceutical completeness was better than administrative completeness; however, prescription writing at Puskesmas X, Sorong Citis still, did not meet pharmaceutical service standards.
Efektivitas Kulit Buah Naga Merah (Hylocereus Polyrhizus) sebagai Antikolesterol Lukman Hardia; Rizqi Fadil Nadila; Wahyuni Watora
Jurnal Sains & Kesehatan Vol 5 No 1 (2026): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v5i1.1698

Abstract

Hypercholesterolemia is a condition where blood cholesterol levels exceed normal limits, becoming a risk factor for coronary heart disease. The skin of the red dragon fruit (Hylocereus polyrhizus) contains flavonoids, betayanin, and dietary fiber that have the potential to lower cholesterol levels. This study aims to determine the effectiveness and optimal dose of red dragon fruit peel extract as a cholesterol lowering in white rats of the Wistar strain (Rattus novergicus) induced by high cholesterol feed. This study used the pretest and post-test with control group design method, with 25 mice divided into 5 groups: negative control, positive control (simvastatin 10mg) and treatment groups with extract doses of 15, 30, and 60 mg/kg BB. The results showed that red dragon fruit peel extract had the effectiveness of hypercholesterolemia with a dose of 60mg/kgBB providing the most optimal reducing effect. Conclusion: Ethanol extract of red dragon fruit peel can significantly lower cholesterol levels in rats with hypercholesterolemia.
Evaluation of Herbal Honey with Black Cumin and Curcuma xanthorriza as an Antioxidant Supplement for Stunting Prevention Lukman Hardia; Akrom Akrom; Titiek Hidayati; Nanik Sulistyani
Journal of Public Health and Pharmacy Vol. 5 No. 1 (2025)
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i1.5549

Abstract

Introduction: Honey has been widely used as a nutritional supplement and medicine. Many herbal honey products are developed as nutritional supplements that are combined with SFM to make them more effective, but there are still many shortcomings due to the unpleasant taste produced, unattractive physical appearance, and high susceptibility to oxidation reactions that cause severe damage to the quality of honey, especially in the content of active substances, viscosity, and pH, which can cause the effectiveness of honey to decrease and result in product failure as nutritional supplements to treat stunting problems. We have developed an herbal honey multi-nutrient supplement that combines honey with black cumin oil and Curcuma xanthorriza extract called HBCX. Adding Curcuma xanthorriza extract and black cumin oil to honey is expected to increase honey's benefits as an antioxidant. This study aims to determine the physicochemical characteristics (pH and viscosity), heavy metal contamination content, polyphenols, and antioxidant activity. Methods: This experimental laboratory research was conducted at the Pharmacy Lab, Faculty of Pharmacy, UAD. The viscosity and pH of HBCX were observed using an Ostwald viscometer and a pH meter. Total phenol determined by Folin-Ciocalteau reagent and gallic acid standard. Determination of antioxidant activity using the DPPH method. The data are presented in a quantitative descriptive manner and matched with the SNI honey standard. Results: The results showed that HBCX herbal honey had a higher viscosity than the sampled honey from the market but was still lower than the SNI requirements. HBCX honey has a lower pH than sample honey products from the market but still complies with national standards. HBCX honey is safe from heavy metal contamination and contains polyphenols. The antioxidant activity of HBCX honey is relatively high, with IC50=54.78 ppm. Conclusion: HBCX has high polyphenol content, is safe from heavy metal contamination, and has sufficient antioxidant activity.
Pengaruh Konsentrasi Ekstrak Etanol Metimun (Cucumis sativus L.) Terhadap Konsentrasi Antioksidan dalam Sediaan Masker Gel Peel Off Gilda Fransiska; Wahyuni Watora; Lukman Hardia
Jurnal Sains & Kesehatan Vol 4 No 2 (2025): Jurnal Sains dan Kesehatan
Publisher : Politeknik Baubau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57151/jsika.v4i2.1590

Abstract

Salah satu tanaman yang berpotensi sebagai sumber antioksidan alami adalah mentimun (Cucumis sativus L.). Kandungan air yang tinggi serta keberadaan vitamin C dan flavonoid di dalam mentimun berperan dalam aktivitas antioksidan dengan mekanisme menghambat, menangkap, maupun memutus reaksi radikal bebas yang bersifat sangat reaktif dan dapat memicu terbentuknya radikal bebas baru. Berdasarkan hasil uji fitokimia, ekstrak mentimun diketahui mengandung beberapa senyawa metabolit sekunder, seperti alkaloid, flavonoid dan saponin. Pemanfaatan bahan tersebut sebagai sediaan kosmetik berbentuk masker gel peel off dinilai sangat tepat. Jenis masker ini memiliki keunggulan dari segi kepraktisan karena setelah mengering dapat dilepaskan langsung dari permukaan kulit tanpa harus dibilas terlebih dahulu. Penelitian ini bertujuan untuk menganalisis pengaruh perbedaan konsentrasi ekstrak etanol mentimun (Cucumis sativus L.) yang diformulasikan dalam masker gel peel off terhadap aktivitas antioksidan yang dihasilkan. Metode yang digunakan adalah metode DPPH (2,2-diphenyl-1-picrylhydrazil atau 1,1-diphenyl-2-picrylhydrazil). Sediaan masker gel peel off diformulasikan dengan variasi konsentrasi ekstrak, yaitu 0,5% pada formula I, 1% pada formula II, dan 1,5% pada formula III. Nilai IC₅₀ yang diperoleh dari pengujian masker gel peel off pada F1 dengan konsentrasi ekstrak 0,5% menunjukkan hasil bernilai negatif sehingga IC₅₀ tidak dapat ditentukan, sedangkan ekstrak 1% (F2) memiliki nilai IC₅₀ sebesar 230,7 ppm dan ekstrak 1,5% (F3) sebesar 79,29 ppm, yang menunjukan peningkatan aktivitas antioksidan seiring dengan meningkatnya konsentrasi ekstrak dalam sediaan masker.
Analgesic effectiveness test of kitolod leaf ethanol extract (isotoma longiflora l.) against male white mice (mus musculus) Inda Dwi Yanti; Angga Bayu Budiyanto; Lukman Hardia
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2227

Abstract

This study aims to evaluate the analgesic effectiveness of ethanol extract of Kitolod leaves (Isotoma longiflora L.) in male white mice (Mus musculus). Kitolod leaves are traditionally used as herbal remedies for pain, yet scientific evidence regarding their analgesic potential remains limited. This true experimental research employed a pre- and post-test with control group design, involving five groups: negative control (Na-CMC 1%), positive control (diclofenac sodium 50 mg), and three treatment groups administered Kitolod leaf extract at doses of 56 mg/kgBW, 112 mg/kgBW, and 224 mg/kgBW. Extract preparation was carried out using maceration with 96% ethanol, followed by phytochemical screening which confirmed the presence of flavonoids, alkaloids, tannins, and steroids. Analgesic activity was assessed using the tail flick method by measuring latency response to thermal stimuli at intervals of 30, 60, 90, 120, 150, and 180 minutes post-treatment. The results showed that Kitolod leaf extract increased pain response latency, with the 112 mg/kgBW and 224 mg/kgBW doses demonstrating the strongest analgesic effects comparable to diclofenac sodium. Statistical analysis using independent sample t-test and one-way ANOVA indicated significant differences (p < 0.05) between treatment and control groups. These findings suggest that Kitolod leaf ethanol extract possesses promising analgesic properties and may serve as a potential natural alternative for pain management.
Analisis Pemakaian BMHP pada Pasien Persalinan Normal, Operasi Caesar Umum, Dan BPJS di RSUD Sorong Levina Virginia; Lukman Hardia; Wahyuni Watora
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 5 (2025): Oktober 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i5.6395

Abstract

Disposable Medical Materials play an important role in maternity services and their use is influenced by the type of delivery and the patient's payment method. This study aims to analyze the influence of both on the use of disposable medical materials in the Emergency Department Pharmacy and the Medical Depot of Dr. J.P. Wanane Regional General Hospital, Sorong Regency, and to comparing the use of disposable medical materials between caesarean section patients of the social security administration and general normal delivery. This quantitative cross-sectional study used a total sampling of 108 delivery patients from January 2025 to June 2025. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests (α=5%). The Kruskal-Wallis test results showed a significant difference in the use of medical consumables between patient groups based on the combination of delivery type and payment method (p = 0.011). Caesarean section patients from the Social Security Administration used the most medical consumables, while patients with normal delivery used the least. Mann-Whitney analysis confirmed that the use of medical consumables was higher among Caesarean section patients from the Social Security Administration compared to normal delivery (p = 0.007). Thus, the type of delivery and payment method had a significant influence, with the highest use of medical consumables among Caesarean section patients from the Social Security Administration. It was concluded that the type of delivery and payment method had a significant effect, with the highest use of disposable medical materials in the social security administration caesarean section patients.
Pengaruh Variasi Pelarut Ekstrak Daun Bungkus (Smilax rotundifolia) Sebagai Antibakteri Muh. Dahlan Wael; Irwandi Irwandi; Lukman Hardia
Jurnal Promotif Preventif Vol 9 No 1 (2026): Februari 2026: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v9i1.2441

Abstract

Daun bungkus (Smilax rotundifolia) adalah tanaman jenis flora yang tumbuh di Indonesia, khususnya pada daerah timur papua. Daun bungkus (S. rotundifolia) sering dikenal dengan khasiatnya sebagai obat kejantanan. Daun bungkus (S. rotundifolia) mempunyai kemiripan dengan daun sirih, namun tidak memiliki bau. metode kuantitatif dengan desain True eksperimental. Penelitian ini menggunakan variasi pelarut yaitu pelarut etanol dan kloroform, masing-masing dengan konsentrasi 10% dan 15%. Data yang diperoleh kemudian dianalisis menggunakan ANOVA (Analisis Varians) Selanjutnya, untuk mengetahui perbedaan nilai rata-rata (mean) antar data, analisis dilanjutkan menggunakan uji LSD (Least Significant Difference). Hasil penelitian ini memperlihatkan bahwa kedua jenis ekstrak daun bungkus (S. rotundifolia) memiliki aktivitas antibakteri terhadap S. aureus. Hal tersebut tampak pada ekstrak etanol maupun kloroform pada konsentrasi 10% dan 15% yang masing-masing menghasilkan zona hambat di sekitar kertas cakram sesuai konsentrasi ekstrak yang digunakan. Sebaliknya, pada uji terhadap E. coli tidak ditemukan adanya aktivitas penghambatan. Kondisi ini ditunjukkan oleh tidak terbentuknya zona bening di area sekitar cakram sehingga dapat disimpulkan bahwa pertumbuhan E. coli tidak terpengaruh oleh perlakuan tersebut. Pada analisis data, ekstrak etanol dan kloroform terhadap bakteri S. aureus dengan nilai sig. >0,05, namun pada bakteri E. coli tidak menunjukkan efektivitas pada ekstrak etanol dan kloroform daun bungkus
Co-Authors A. M. Muslihin Achmad Noerkhaerin Putra Adriyani E. G. Sitanggang Agus sangka pratama Akrom Akrom Akrom, Akrom Alyssa Mileta Aponno Angga Bayu Budianto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Angga Bayu Budiyanto Anisa, Meilinda Arif Budi Setianto Arif Radhika Mentari Arni, Veni Zafi Assem, Vincentia Santy Astuti, Ratih Arum Aulia Mifthakul Jannah Azzahra Vivin Mahdiya Afandy Budianto, Angga Bayu Carmel Josuhua Paulus Darmayanti Tumpu Diah Wulandari Dian Nur Khofifah Dika Rahayu Dion Fahcrul Rozi Eka Savira Ni'ma Arfiani Erawati, Rika Ernifan Ernifan Eva Maya Sari Fabanyo, Syahrul H. Fajar Maulana fania, vikafania Gilda Fransiska Hikmahtul Putri Utami Ica Damayanti Ikhwan Dahlan Rais Inda Dwi Yanti Indah Amelia Rizky Indah Diah Ningrum Innal Saitis Innal Saitis Irene Eunike Tanod Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Irwandi Jannah, Aulia Mifthakul Justitia Cahyani Fadli Laela Hayu Nurani Lanipi, Retna Parica Lanipi, Retna Paricca Levina Virginia M Natsir Djide M. Yogi Riyantama Isjoni Mansyur Arief Marzella Dea Rossardy Meilinda Anisa Mika Tri Kumala Swandari Muh Ishar Difinubun Muh. Dahlan Wael Muslih Anwar Nanik Sulistyani Nanik Sulistyani Nazila Galela Nazla Wati Sanaky Ningrum, Indah Diah Nuhidayah Sarifuddin Nuhidayah Sarifuddin Nur ‘Azah Nurkhasanah Nurkhasanah Nurul Maghfirah1 Nurwahyuni Paulus, Johan Kartino Prasasti Bintarum Pratama, Agus Sangka putri puspitawati, devyana Rahayu, Dika Rasi Fitri Yanti Tuasikal Retna Parica Lanipi Retna Parica Lanipi Retna Paricca Lanipi Risanyel Elsan Tuturop Rizqi Fadil Nadila SALIM, MUH.AGUS Sanaky, Nazla Wati Sarifuddin, Nuhidayah Selfiana Iek Serlin Marsela Sintya Sari Dwi Kusumaningrum Siska Siska Siti Fatma Z.F. Siti Rahmadani Sitti Hadija Samual Sun, Suny Syahrul H. Fabanyo Titiek Hidayati Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tuasikal, Rasi Fitri Yanti Tunnazilah, Nurhikmah Tutuhatunewa, Priscillia Ryani ulandari, clarista windi Umpain, Agnes Nesa Vincentia Santy Assem Wa Ode Nurwahida Wahyuni Watora Wasaraka, Fadila Alfiah Wiwik Triyani Wiwik Wiwik, Wiwik Triyani Wiwit Ayu Fitrianti Yapsenang, Amar Jansen Yuniatri, Nur Khusna Yusnita La Goa Zf, Siti Fatma