Article Per Year (5 Year)
p-Index From 2021 - 2026
3.923
P-Index
This Author published in this journals
All Journal Jambura Journal of Health Sciences and Research Jurnal Ners International Journal Of Science, Technology & Management (IJSTM) Jurnal Kesehatan: Jurnal Ilmu- Ilmu Keperawatan, Kebidanan, Farmasi dan Analis Kesehatan Jurnal Kesehatan Tambusai JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Sains dan Teknologi Jurnal Rumpun Ilmu Kesehatan Jurnal Kesehatan Amanah PCJN Pharmaceutical and Clinical Journal of Nusantara Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences. Jurnal Sains Student Research Jurnal Novem Medika Farmasi Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Sains Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Muhammad Yunus
Prodi Apoteker Universitas Prima Indonesia, Medan. Sumatera Utara, Indonesia.
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

Published : 28 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 28 Documents
Search

 1   2   3 
Hubungan Tingkat Pengetahuan Pasien Hipertansi Terhadap Kepatuhan Minum Obat Pada Pasien Rawat Jalan Di Rumah Sakit Royal Prima Adelia Pratiwi; Muhammad Yunus; Roy Indrianto Bangar
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3416

Abstract

Hypertension s a chronic condition with a high prevalence that can lead to cardiovascular complications if patients do not adhere to medication regimens and the medication adherence is on of the primary key to therapeutic success. However, low adherence rates remain a significant challenge, often linked to insufficient patient understanding. This study aimed to analyze the relationship between the level of knowledge of hypertensive patients and their medication adherence at Royal Prima Hospital. This research method employed a quantitative correlational design with a cross-sectional approach involving 78 outpatient respondents selected through purposive sampling. Demographic data were analyzed using the Chi-Square Test, while the relationship between the main variables was tested with Spearman Correlation. The results showed that the majority of respondents had a sufficient level of knowledge (52.6%) and moderate adherence (48.7%). The Spearman Correlation test yielded a coefficient value (rₛ) of 0.803 with p < 0.001, indicating a very strong and significant positive relationship between the level of knowledge and medication adherence. Conversely, the Chi-Square Test results showed no significant association between demographic characteristics and adherence. It is concluded that knowledge is a crucial determinant influencing treatment adherence among hypertensive patients.
Formulasi dan Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Daun Sirsak (Annona Muricata L.) terhadap Bakteri Pseudomonas Aeruginosa Cristin Natali Rouli; Muhammad Yunus; Asyrun Alkhairi Lubis
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 4 No. 1 (2026): Januari: OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v4i1.2090

Abstract

Soursop leaves (Annona muricata L.) are known to contain secondary metabolites such as alkaloids, flavonoids, tannins, saponins, and polyphenols, which have antibacterial potential. This study aimed to formulate soursop leaf extract into a gel dosage form and to evaluate its antibacterial activity against Pseudomonas aeruginosa. This research was conducted as an experimental laboratory study. Soursop leaf extract was obtained using the maceration method with 96% ethanol as the solvent and then formulated into gel preparations with extract concentrations of 5%, 10%, and 15%. Physical evaluation of the gel preparations included organoleptic test, homogeneity, pH, spreadability, and viscosity. Antibacterial activity was evaluated using the well diffusion method on Nutrient Agar medium. The results showed that all gel formulations met the physical requirements for topical preparations. The antibacterial activity test demonstrated that the soursop leaf extract gel inhibited the growth of Pseudomonas aeruginosa, with the 15% concentration producing the largest inhibition zone of 10 mm compared to other concentrations. In conclusion, soursop leaf extract gel has potential to be developed as a topical antibacterial agent against Pseudomonas aeruginosa.
Skrining Fitokimia Dan Profil Total Fenol Serta Flavonoid Pada Ekstrak Daun Seledri (Apium graveolens L.) Carmenita M. Cindy Tiara Situmorang; Muhammad Yunus; Novitaria Br Sembiring
Jurnal Novem Medika Farmasi Vol. 5 No. 1 (2026): volume 5 issue 1 2026
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v5i1.2174

Abstract

ABSTRAK Daun seledri (Apium graveolens L.) merupakan salah satu tanaman herbal yang diketahui mengandung senyawa metabolit sekunder yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui golongan senyawa yang terkandung serta menentukan kadar total fenol dan flavonoid pada ekstrak daun seledri. Simplisia daun seledri diekstraksi menggunakan etanol 96% dengan metode maserasi. Skrining fitokimia dilakukan untuk mengidentifikasi kandungan senyawa metabolit sekunder. Penetapan kadar total fenol menggunakan metode Folin–Ciocalteu dengan baku pembanding asam galat dan pengukuran pada panjang gelombang 765 nm. Penetapan kadar total flavonoid menggunakan metode kompleksasi AlCl3 dengan baku kuersetin pada panjang gelombang 434 nm. Hasil penelitian menunjukkan bahwa ekstrak daun seledri mengandung flavonoid, alkaloid, polifenol, tanin, sterol, dan triterpenoid. Kadar total fenol sebesar 209,79 mg GAE/g ekstrak dan kadar total flavonoid sebesar 12,50 mg QE/g ekstrak.
Efikasi Gel Ekstrak Daun Seledri (Apium graveolens L.) terhadap Gambaran Makroskopik Ulkus pada Model Tikus Diabetes induksi Aloksan Tamy Yolanda Putri; Muhammad Yunus; Novitaria Br Sembiring
Jurnal Novem Medika Farmasi Vol. 5 No. 1 (2026): volume 5 issue 1 2026
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v5i1.2175

Abstract

Diabetes melitus masih menjadi penyakit dengan angka penderita yang terus meningkat setiap tahun dan masih menjadi masalah utama dalam kesehatan di seluruh dunia. Tanaman herbal yang digunakan sebagai alternatif pengobatan yaitu daun seledri (Apium graveolens L.). Penelitian ini bertujuan untuk melihat pengaruh perbedaan konsentrasi ekstrak daun seledri dalam sediaan gel terhadap proses penyembuhan ulkus pada model tikus diabetes yang diinduksi aloksan. Penelitian ini dibagi dalam enam kelompok. Kelompok ini terbagi atas : Kelompok normal, kelompok negatif, kelompok positif, kelompok perlakuan 1 dengan pemberian ekstrak daun seledri konsentrasi 5 %, kelompok perlakuan 2 dengan pemberian ekstrak daun seledri 10 %, dan kelompok perlakuan 3 dengan pemberian ekstrak daun seledri konsentrasi 15 %. Parameter pengamatan yang digunakan adalah diameter ulkus selama 14 hari. Hasil penelitian menunjukkan bahwa evaluasi maksroskopik paling baik terdapat pada kelompok perlakuan 2 dengan gel daun seledri konsentrasi 10 % dan kelompok perlakuan 3 dengan gel daun seledri konsentrasi 15 %. Hal ini membuktikan bahwa gel ekstrak daun seledri (Apium graveolens L.) memiliki potensi sebagai alternatif terapi penyembuhan ulkus pada kondisi diabetes akibat induksi aloksan.
Uji Aktivitas Antioksidan Ekstrak Etanol Herba Sirih Cina (Peperomia pellucida L.) dengan Metode DPPH Jecika Stefany Br Tumanggor; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6142

Abstract

Free radicals are reactive compounds that can cause damage to cells, enzymes, lipids, and even DNA, thus triggering various degenerative diseases. Antioxidants neutralize free radicals and prevent oxidative damage. Chinese betel herb (Peperomia pellucida L.) is known to contain phenol and flavonoid secondary metabolite compounds that act as natural antioxidants. This study aims to test the antioxidant activity of ethanol extract of Chinese betel herb with DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Extraction was done by maceration method using 80% ethanol solvent. Antioxidant activity was tested by reacting the extract against DPPH solution and measuring the absorbance using UV-Vis spectrophotometry. The results showed an IC₅₀ value of 32.97 ppm, which is classified as very strong antioxidant activity. These results indicate that ethanol extract of Chinese betel herb has great potential as a source of natural antioxidants.  
Uji Aktivitas Antioksidan Ekstrak Etanol Daun Pepaya (Carica papaya L.) dengan Metode DPPH Anggun Pratiwi; Razoki Razoki; Muhammad Yunus; Daimah Wirdatus Sanaun Harahap
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6231

Abstract

Oxidative stress is a condition resulting from an imbalance between free radicals and the body's antioxidant system, which can damage cells and trigger degenerative diseases such as diabetes, cancer, atherosclerosis and heart disease. Antioxidants play an important role in neutralizing free radicals to prevent cell damage. Papaya leaves (Carica papaya L.) are known to contain bioactive compounds that have potential as a source of natural antioxidants. This study aims to test the antioxidant activity of papaya leaf ethanol extract using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method, with quercetin as a comparator. Extraction was done by maceration using 80% ethanol. Antioxidant activity was measured based on the decrease in absorbance of DPPH solution at a wavelength of 517 nm using UV-Vis spectrophotometer. The results showed that papaya leaf extract had strong antioxidant activity with IC₅₀ value of 21.35 ppm, while quercetin was 4.84 ppm. Thus, the ethanol extract of papaya leaves showed high potential as an effective natural antioxidant.  
Perbandingan Efektivitas Penggunaan Obat Oral Antiabetik Tunggal dan Kombinasi pada Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit Umum Royal Prima Medan Ega Yos Sanda; Muhammad Yunus; Erida Novriani
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 2 (2025): Juli : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i2.6857

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, with a high prevalence in Indonesia. Pharmacological therapy using oral antidiabetic medications (OAD), either singly or in combination, is a primary approach to managing type 2 DM. Evaluating the effectiveness of therapy is essential to ensure the achievement of glycemic targets and to prevent complications. This study aims to compare the effectiveness of using single and combination oral antidiabetic medications in reducing blood glucose levels in patients with type 2 Diabetes Mellitus at Royal Prima General Hospital Medan. This study is a non-experimental observational study, utilizing a retrospective descriptive design with a cross-sectional approach. A sample of 60 patients with type 2 DM who were hospitalized between January - June 2024, consisted of 30 patients on single therapy and 30 patients on combination therapy. Data was taken from medical records, and the effectiveness was assessed based on the decrease in blood sugar levels over six days of treatment. The results of this study show that the average percentage decrease in blood sugar levels over 6 days for single oral antidiabetics was 28.87%, and the average reduction in blood sugar levels for combination antidiabetics was 31.34%. Combination therapy shows higher effectiveness in reducing blood sugar levels compared to single therapy. There is a difference in effectiveness between single OAD therapy and combination therapy in patients with T2DM. Combination therapy tends to be more effective and can be a rational alternative for patients who do not reach glycemic targets with monotherapy.
Evaluasi Formulasi Sediaan Floating Mikroenkapsulasi yang Mengandung Ekstrak Etanol Daun Pepaya (Carica Papaya L.) Glory Stevi Natasia Saragih; Razoki Razoki; Muhammad Yunus; Hariyadi Dharmawan Syahputra
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 1 (2025): Maret : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i1.7052

Abstract

Microencapsulation is a technology that uses controlled release of active ingredients to increase bioavailability and reduce gastrointestinal irritation. This study aims to evaluate the microencapsulation formulation of ethanol extract of papaya leaf (Carica papaya L.) by testing its stability, moisture content, and floating in the stomach and intestinal medium. Mardikasari et al (2020) showed the release of chitosan-alginate microencapsulation of 8,811 mg/L (acid) and 79,908 mg/L (base). Microencapsulation was performed by adding sodium alginate and chitosan as polymers, CaCl2 as a cross-linking, and three variations of extract concentration in F1 without extract, F2 of 0,25%, F3 of 0,5%, and F4 of 0,75%. The results showed that all formulas remained stable during the storage cycle in terms of color, aroma, taste, and texture. The average moisture content of the microencapsulated formulations was 24%, 20,5%, 28%, and 18,7%. The microencapsulated preparations were able to maintain their stability in the acidic conditions in the stomach, but showed a decrease in floating under acidic conditions in the intestine.
Co-Authors Adelia Pratiwi Adinda Silvani Ginting Afika, Nur Angelia Vega Anggun Pratiwi Asyrun Alkhaira Lubis Asyrun Alkhairi Lubis Asyrun Alkhairi Lubis Asyrun lkhairi Lubis Brian Elberth Halu Caniago, Indri M. Clearesta Carmenita M. Cindy Tiara Situmorang Cindy Ronaldo Munthe Cristin Natali Rouli Daimah Wirdatus Sanaun Harahap Desmina Nur Cahaya Simanjuntak Edy Fachrial Ega Yos Sanda Elfia Neswita Elfia Neswita Erida Novriani Fira Safitri Ginting, Astriani Natalia Br Glory Stevi Natasia Saragih Hariyadi Dharmawan Syahputra Henny Yolanda Ardilla Hindri Syahputri Jecika Stefany Br Tumanggor Jefri Naldi Jefri Naldi Keliat, Elsa Nova Q Pani Kiki Rawitri Magdalena Tiara V Manihuruk Melnihati Laia Muhammad Amin Nasution Muhammad Andry Muhtamilatur Rahma Novitaria Br Sembiring Novriani , Erida Nurasni Octavian Ashido Nababan Pricella Ginting Purba, Helprida GM Razoki Razoki Razoki Reh Malem Br Karo Roy Indrianto Bangar S Sari, Syilvi Rinda Sembiring, Novitaria Sitanggang, Titin Krisdayanti Siti Nurkholifah Sri Wahyuni Suci Della Tafonao, Rachel Julia Tamy Yolanda Putri Tiara Fortuna A.R Tuti Putri Waruwu Wahyuni Sihombing Yolanda Eliza Putri Lubis Zulmai Rani