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Journal : Biota

Modulatory Effects of Fucoidan on Paracetamol-induced Hepatic Damage and Histological Alterations in Rasbora lateristriata Sofyantoro, Fajar; Dafa, Maula Haqul; Primahesa, Alfian; Oktaviana, Shintia; Mayani, Olvita; Simanungkalit, Eben Ezer; Prissandi, Anthera Al Firdaus; Nuriliani, Ardaning; Retnoaji, Bambang; Saragih, Hendry T. S. S. G.; Rohmah, Zuliyati; Widiyanto, Slamet; Wijayanti, Nastiti; Septriani, Nur Indah
Biota Vol 12 No 1 (2026): Jurnal Biota 2026
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/biota.v12i1.27845

Abstract

Paracetamol overdose is a well-documented cause of hepatic injury across vertebrate species, including teleost fish. This study aimed to evaluate the hepatoprotective potential of fucoidan, a sulfated polysaccharide derived from brown algae, against paracetamol-induced liver damage in Rasbora lateristriata. Fish were divided into five experimental groups and exposed to paracetamol (3 mg/L), either alone or in combination with fucoidan at concentrations of 50, 100, or 300 µg/mL, for seven days. Histopathological evaluation of liver tissues was performed using hematoxylin–eosin staining, with semi-quantitative scoring focused on hydropic degeneration, nuclear pyknosis, and necrosis. The results demonstrated that paracetamol exposure induced moderate hepatocellular injury, characterized by cytoplasmic vacuolization, apoptotic nuclear alterations, and necrotic lesions. Co-treatment with fucoidan at 300 µg/mL was associated with reduced severity across all histopathological parameters, indicating partial hepatoprotective effects. In contrast, the 50 µg/mL fucoidan group exhibited paradoxically severe hydropic degeneration despite the absence of pyknosis and necrosis, suggesting a delayed or altered injury profile. Intermediate outcomes were observed at 100 µg/mL. Overall, fucoidan exhibited dose-dependent but inconsistent hepatoprotective effects. The observed histological variability across concentrations suggests that protection may be influenced by factors such as bioavailability, cellular uptake, or interactions with intracellular stress pathways. These findings highlight the need for further mechanistic investigations before fucoidan can be considered a reliable hepatoprotective agent in aquatic toxicology.
Co-Authors Adelfiani, Adelfiani Aeniah, Siti Allimi, Hayu Swari Andi Gita Maulidyah Indraswari Suhri Anita Restu Puji Raharjeng Apriliyani, Tia Ardaning Nuriliani Arief Maulana Sabilillah Ariel Hananya Ariesti, Wiwin Ascarti Adaninggar Dafa, Maula Haqul Della Blatama Devi Anisa Suci Eka Putri Empra, Desi Empra, Desi Eka Putri Endar Pertiwi, Anggita Fajar Sofyantoro Faulana, Arum Fahmi Febrina Nanda Arfiani Halim, Shuha Ma’muriyah Hayu Swari Alimi Hendry Saragih Hendry T.S.S.G. Saragih Hendry Tri Sakti Saragih Hendry Tri Sakti SG Saragih Hurul Ein Illiyin, Sirayya Jerizqa Ayu Fajar Nita Jessy Octavia Harahap Joko Nugroho Wahyu Karyadi Karlina, Ina Karunia Galih Permadani Khasanah, Luthfia Uswatun Khoiruddin Anshori Khoiruddin Anshori Laili Mufli Zusrina Laili Mufli Zusrina Larasshita Putri Adhitya Sani Lathief Al Umami M. Zainuddin Lubis Maharesi, Chesa Ekani Mayani, Olvita Moli Podhi, Felisitas Muhammad Zuchri Zayzda Murtiadi Erlan Supraitno Mustamin, Yusdar Muthia Arrusyda Nastiti Wijayanti Nastiti Wijayanti Nurhidayat, Luthfi Nyan Hayu Widiastuti Oktaviana, Shintia Pradnya Paramita Primahesa, Alfian Prissandi, Anthera Al Firdaus Pusparini, Nur Ainun Oktavia Rahayu, Sekar Rahmadian, Desti Rey, Juniman Ria Vena Septhay Sari Rohmah, Zuliyati Ruth Liananda Citra Dolok Saribu Sadewo, Imran Saeed, Faisal Samparisna Rumansara, Papuani Sandi Francisco Pratama Saragih, Hendry Saragih, Hendry T. S. S. G. Saragih, Hendry Tri Sakti SG Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Septriani, Nur Indah Septriani, Nur Indah Shalihah, Fianicha Sih Kahono Simanungkalit, Eben Ezer Slamet Widiyanto Sofyantoro, Fajar Sri Pujiyati Sularsah, Sais Supraitno, Murtiadi Erlan Susilo Hadi, Susilo T.S.S.G. Saragih, Hendry Tia Apriliyani Yunita, Neri Zulfadhli Zulfadhli Zuliyati Rohmah Zusrina, Laili Mufli