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From silos to systems: Reimagining zoonotic neglected tropical disease management through the lens of one health Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha; Soedarsono, Soedarsono; Gustam, Tasalina Yohana Parameswari
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 3 (2024): November 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i3.61

Abstract

Zoonotic neglected tropical diseases (zNTDs) pose significant global public health challenges, particularly in low-income and middle-income countries. Traditional siloed approaches to zNTD management have proven inadequate for addressing the complex interplay between human, animal, and environmental health factors. This review examined the limitations of fragmented strategies and explored the potential of integrated one-health approaches for more effective zNTD control. This narrative review covered publications from 2000 to 2023, sourced from databases including PubMed and Scopus, emphasizing studies that met inclusion criteria of peer-reviewed research focused on zNTDs through a One Health lens. A comprehensive analysis of the current literature and case studies was conducted to evaluate the multifaceted drivers of zoonotic pathogen spillover, assess the economic and health impacts of zNTDs, and identify successful implementation of the One Health strategy in endemic regions. This review highlights the inadequacies of siloed disease management approaches, which often lead to inefficient resource allocation and missed opportunities for synergistic intervention. Successful case studies have demonstrated the effectiveness of the One Health strategy in improving disease surveillance, enhancing cross-sectoral collaboration, and achieving sustainable health outcomes. The potential of emerging technologies and innovations to support integrated approaches has also been explored. Transitioning from siloed to systemic approaches in zNTD management requires overcoming institutional barriers, fostering cross-sector collaboration, and implementing multitiered frameworks that operate at the local, national, and global levels. Investing in cross-sectoral capacity development and leveraging technological innovations are crucial for building a workforce capable of addressing the complex challenges posed by zNTDs. Adopting the One Health principle offers a promising path toward more comprehensive, efficient, and sustainable strategies for zNTD prevention.
Raising the flag of vigilance on Mpox outbreak in Indonesia: are we prepared? Adnyana, I Made Dwi Mertha; Maulana, Sidik; Lutfian, Lutfian; Adiwinoto, Ronald Pratama
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 2 (2024): September 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i2.63

Abstract

In the wake of the COVID-19 pandemic, the world has become acutely aware of the devastating impact of infectious diseases on public health, economies, and societies. As we gradually recover from the aftermath of COVID-19, another potential threat looms on the horizon, mpox, formerly known as monkeypox. The recent surge in mpox cases worldwide has prompted health authorities to sound an alarm, and Indonesia, as a populous nation with a complex healthcare system, must ask itself: Are we prepared for this emerging challenge?. The question "Are we prepared?" may not have a simple yes or no answer. Instead, it should serve as a reminder of the need for vigilance, adaptation, and continuous improvement in public health systems. As we navigate this new health challenge, the true measure of Indonesia's preparedness is its ability to respond swiftly, effectively, and equitably to protect the health and well-being of all citizens.
Pengaruh Perubahan Iklim (Climate Change) terhadap Vektor Malaria : Literature Review Nastiti, Niken Irfa; Adnyana, I Made Dwi Mertha; Delfira, Annissa; Asty, Zahra Frizki
JURNAL WIDYA BIOLOGI Vol. 16 No. 02 (2025): Vol. 16 No. 02 (2025) Widya Biologi
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/tagesz57

Abstract

Perubahan iklim memengaruhi dinamika vektor malaria melalui peningkatan suhu, perubahan pola curah hujan, serta modifikasi lingkungan yang berdampak pada distribusi dan kelangsungan hidup nyamuk Anopheles. Literature review ini bertujuan menggambarkan pengaruh perubahan iklim terhadap vektor malaria di Asia dan wilayah lain yang relevan. Pencarian artikel dilakukan melalui Scopus dan PubMed dengan kriteria publikasi tahun 2015-2025 dan diperoleh 9 artikel yang memenuhi syarat untuk dianalisis. Hasil menunjukkan bahwa kenaikan suhu mempercepat perkembangan nyamuk, memperpendek masa inkubasi ekstrinsik parasite, dan memperluas wilayah potensial penularan, sebagaiman ditunjukkan pada An. stephensi, An. gambiae, An. sinensis. Curah hujan merupakan variable lingkungan dominan yang menentukan distribusi An. philippinensis dan An.nivipes, dengan peningkatan luasan habitat di bawah scenario iklim masa depan. Di Indonesia, distribusi vektor dipengaruhi topografi, suhu, kelembaban, dan curah hujan, dengan konsentrasi pada area pesisir, persawahan dan perbukitan. Beberapa studi memprediksi pergeseran spesies dominan serta peningkatan risiko penularan hingga decade mendatang. Secara keseluruhan, perubahan iklim diproyeksikan memperluas wilayah penularan malaria, meningkatkan kelangsungan hidup vektor tertentu, dan mempercepat perkembangan parasit, sehingga berpotensi meningkatkan kejadian malaria di berbagai wilayah endemik maupun non-endemik.
Genetic Diversity and Multiplicity of Plasmodium falciparum Infection in Southeast Asia: New Insights from a Systematic Review Praswitasari, Rengganis; Husada, Dominicus; Hasan, Nur Aini; Adnyana, I Made Dwi Mertha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.357

Abstract

Plasmodium falciparum caused four million new malaria cases in Southeast Asia in 2023, with heterogeneous transmission patterns and the development of artemisinin resistance. The merozoite surface protein genes (msp-1 and msp-2) serve as genetic markers for analyzing the parasite population structure and multiplicity of infection (MOI). However, a comprehensive synthesis of regional data is limited. This study aimed to determine the genetic diversity and MOI of P. falciparum in Southeast Asia. This systematic review was guided by PRISMA guidelines with searches in the Scopus, PubMed, ProQuest, and Google Scholar databases (2014–2024). The inclusion criterion was observational studies, analyzing the genetic diversity of P. falciparum via msp-1 and msp-2 markers in Southeast Asia. The extracted data included the frequency of msp-1 and msp-2 family alleles, the prevalence of polyclonal infections, and the mean MOI value. Quality assessment was performed via the joanna briggs institute critical appraisal tools with narrative synthesis following the synthesis without meta-analysis (SWiM) guidelines. Fifteen studies; Indonesia (40%), Thailand (26.67%), Myanmar (20%), Vietnam and Malaysia (6.66%) with 1,830 samples successfully genotyped from 2,130 collected samples. The MAD20 (msp-1) allele dominated most locations, with frequencies of up to 100% in Lampung. The distribution of msp-2 alleles showed geographical variation, with FC27 dominating in Papua (96.2%) and 3D7/IC in Vietnam (97.0%). The prevalence of polyclonal infection ranged from 0-84.6%, with MOI values ranging from 1.0-2.93. The hyperendemic areas presented high MOIs (>2.0), whereas the hypoendemic areas presented MOIs close to 1.0, confirming a positive correlation with malaria transmission intensity. The P. falciparum population in Southeast Asia shows high genetic diversity, with geographically variable allele distribution patterns, and MOI values are correlated with malaria endemicity levels. These findings support the need for regional molecular surveillance and a polyvalent approach to the development of msp-based vaccines.
DUKU PEEL INNOVATION: EFFORTS TO IMPROVE CREATIVE HEALTHPRENEURS THROUGH THE DEVELOPMENT OF PLANT-BASED INSECTICIDES Miftahurrahma Miftahurrahma; Tengku Arief Buana Perkasa; Huntari Harahap; Hafizah Hafizah; Denok Tri Hardiningsih; I Made Dwi Mertha Adnyana
BUDIMAS : JURNAL PENGABDIAN MASYARAKAT Vol. 8 No. 1 (2026): BUDIMAS : Jurnal Pengabdian Masyarakat
Publisher : LPPM ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/budimas.v8i1.19448

Abstract

Duku peel is an underutilized agricultural byproduct in Talang Duku Village, a major center of duku production, and is commonly discarded as waste. The community’s heavy reliance on synthetic chemical insecticides presents environmental and health risks, compounded by limited knowledge regarding the processing of agricultural waste into value-added products. This community service program aimed to empower the “A. Khalik Duku Plantation” Farmers Group by converting duku peel waste into a high-value plant-based insecticide in the form of aromatherapy candles, thereby fostering a new generation of creative healthpreneurs. The program applied a participatory community empowerment approach through education, hands-on training, and continuous mentoring. The stages included needs assessment, production and business management training, and evaluation using pre-test and post-test data analyzed with the Wilcoxon and Chi-Square tests. The results showed a significant improvement in participants’ knowledge (P < 0.001), with the median score increasing from 70% to 80% and the number of participants achieving the ≥80% competency threshold rising from 13 to 49. Furthermore, the program successfully facilitated the production of insect-repellent aromatherapy candles and the establishment of the “KUB Duku Lestari” Joint Business Group, which sold more than 50 units within the first three months. In conclusion, this program effectively transformed agricultural waste into a valuable product, promoted sustainable entrepreneurship, and contributed to improving community welfare. It is recommended that the business group standardize product packaging to enhance market competitiveness and that future studies focus on optimizing extraction techniques to improve product efficacy.
Hierarchical Risk Factors for Stunting in Urban Indonesian Children (0–59 Months): A Case‒Control Study from Jambi, Indonesia Harahap, Huntari; Putra, Irawan Anasta; Maulina, Nisa Haska; Kusdiyah, Erny; Adnyana, I Made Dwi Mertha; Alrani, Nurul Qalbi
AgriHealth: Journal of Agri-food, Nutrition and Public Health Vol 6, No 2 (2025): October
Publisher : Research and Development Center for Food, Nutrition and Public Health (P4GKM) LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/agrihealth.v6i2.107534

Abstract

Stunting affects 149.2 million children globally, with Indonesia reporting a prevalence of 21.6%, despite a decline in trends. Urban-specific risk factors remain poorly characterized, which limits the development of effective intervention strategies for metropolitan areas. This study aimed to identify the risk factors associated with stunting in children aged 0 to 59 months in Jambi, Indonesia. This case-control study involved 108 children aged 0 to 59 months from five community health centers in Jambi City from December 2024 to January 2025. The cases (n = 54) were children with height-for-age z scores of less than 2 standard deviations (SD), and the controls (n = 54) had standard growth patterns. Data collection involved anthropometric measurements and structured maternal interviews, which were analyzed via chi-square tests with 95% confidence intervals. Low birth length had a very high odds ratio (OR = 45.69, 95% CI = 5.88 to 354.70; p < 0.001), whereas inadequate complementary feeding resulted in a perfect prediction (OR = 5.33, 95% CI = 3.20 to 8.88; p < 0.001). Incomplete immunization (OR = 37.81, 95% CI = 8.32 to 171.71; p < 0.001) and maternal educational deficit (OR = 6.53, 95% CI = 1.76 to 24.18; p = 0.002) were identified as the primary modifiable determinants. Multisectoral strategies targeting maternal nutrition, universal immunization, and education-based interventions are necessary to reduce stunting in Indonesia’s urban population sustainably.
The Relationship Between Feeding Patterns and Maternal Knowledge about Nutrition with the Incidence of Stunting in Children Age 0-5 Years in the Working Area of the Gedongan Health Center, Mojokerto City Putri, Nadya Aisyah Sasqia; Adiwinoto, Ronald Pratama; Arundani, Prima; Nugraheni, Pramita Anindya; Adnyana, I Made Dwi Mertha
AgriHealth: Journal of Agri-food, Nutrition and Public Health Vol 5, No 1 (2024): April
Publisher : Research and Development Center for Food, Nutrition and Public Health (P4GKM) LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/agrihealth.v5i1.83808

Abstract

Stunting is a prolonged state of chronic malnutrition. This disorder is characterized by having a body length-for-age or body height-for-age measurement that falls below the -2 standard deviation established by the World Health Organization (WHO). The etiology of stunting is multifaceted, encompassing factors such as nutrition, feeding practices, infectious illnesses, and household income. Maternal understanding of nutrition, including dietary factors, is also associated with the occurrence of stunting. This study aimed to establish the relationship between feeding habits and maternal knowledge of nutrition with the prevalence of stunting in the operational region of the Gedongan Health Center, located in Mojokerto City. This study is an observational analytical study employing a cross-sectional design. The study’s population consisted of all women with children residing in the working area of the Gedongan Health Center. This study encompassed 144 participants who completed the Child Feeding Questionnaire (CFQ) regarding eating practices and a questionnaire assessing maternal knowledge of nutrition. The objective was to examine the relationship between these factors to height and age. The chi-square test results indicate a statistically significant association between feeding practices and stunting (p = 0.0001) and maternal knowledge about nutrition and stunting (p = 0.0001). The survey revealed that most children had been provided with appropriate feeding patterns, and most moms had a commendable nutritional understanding. The study’s findings indicate a noteworthy relationship between feeding behaviors and mothers’ nutrition knowledge.
Co-Authors Agustini, Desak Gede Dwi Al Karina, Citra Alrani, Nurul Qalbi Anak Agung Komang Suardana Annissa Delfira Ariastuti, Indria Artha Budi Susila Duarsa Arundani, Prima Asik Surya Asty, Zahra Frizki Bimantara, Riza Fajar Biutifasari, Verna Budi Utomo Cruz, Zito Viegas da da Cruz , Zito Viegas Denok Tri Hardiningsih Dewi, Gusti Ayu Putu Wahyu Purnama Dewi, Ni Luh Made Noviana Dominicus Husada Dwinka Syafira Eljatin Eljatin, Dwinka S. Erny Kusdiyah Farachatus Salwa Salsabila Azhari Hafinuddin Hafinuddin Hafizah Hafizah Hasan, Nur Aini Herdiyantini, Mita Huntari Harahap I P. Sudiartawan I Putu Sudiartawan I Wayan Wahyudi, I Wayan I. A. R. Astiti Asih Indrayanti, Ni Komang Rina Irawan Anasta Putra, Irawan Anasta Jundaeng, Jarupat Juniastuti Juniastuti Kusman Ibrahim Liliawanti Luh Nik Armini Lutfian, Lutfian Machado, Filipe de Neri Mahendra, Kadek Adi Maulana, Sidik Maulina, Nisa Haska Miftahurrahma Miftahurrahma Muhamad Frendy Setyawan Muhammad Bayu Zohari Hutagalung Muhammad Ridho Akbar Eljatin Muhammad Rizal N. W. Bogoriani Ni Ketut Ayu Juliasih Ni Luh Gede Sudaryati Niken Irfa Nastiti Nuartha, Pande Komang Aditya Ryan Nugraheni, Pramita Anindya Panduyasa, I Gede Pereira, Abrão J. Prabowo, Sang Kompyang Yudistira Eddy Prasetya, Hanung Praswitasari, Rengganis Pratama A., Ronald Putra, I Gede Satya Wijaya Putra, Oki Nugraha Putri, Ida Ayu Govinda Lazenobia De Sanjaya Putri, Nadya Aisyah Sasqia Putu Lakustini Cahyaningrum Putut Dewantha Jenar Raza, Syed Meesam Ronald Pratama Adiwinoto Sadya Wendra Savitri, Ida Ayu Gede Winda Setiadi M Noor Soedarsono Soedarsono Sridana, I Nyoman STEFANUS DJONI HUSODO Suardana, A.A Komang Sudaryati, Ni LG. Sudiartawan, I Putu Sugiarta, Ketut Merdana Sundari, Ni Luh Putu Ari Suniartini, Ketut Suwandani, Ni Made Ayu Syed Meesam Raza Tasalina Yohana Parameswari Gustam Tengku Arief Buana Perkasa Tika, Fanny Eprilia Ulwani, Qulistan Balqis Umar, Tungki Pratama Uswatun Hasanah Widiastiti, Ni Nyoman Widyantari, Dewa Ayu Wijayaningrum, Lena Wyasena, Pande Nyoman Tri Saguna Zuriat Zuriat