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All Journal International Journal of Public Health Science (IJPHS) Marine Fisheries: Jurnal Teknologi dan Manajemen Perikanan Laut Jurnal Berkala Epidemiologi Journal Of Vocational Health Studies Media Ilmu Kesehatan VIDYA WERTTA : Media Komunikasi Universitas Hindu Indonesia Bio-Inoved : Jurnal Biologi-Inovasi Pendidikan Science Midwifery Jurnal Widya Biologi Indonesian Journal of Global Health research Jurnal Ekologi, Masyarakat dan Sains Widya Kesehatan AgriHealth: Journal of Agri-food, Nutrition and Public Health Journal of Pharmaceutical and Health Research Narra J Journal of Multidisciplinary Applied Natural Science JURNAL VOKASI ILMU-ILMU PERIKANAN (JVIP) Journal of Current Health Sciences Asian Journal of Health Research CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Makara Journal of Health Research Journal of Environment and Sustainability Education Jurnal Kedokteran Meditek Svāsthya: Trends in General Medicine and Public Health Journal of Medicine and Health Technology Education Specialist
Adnyana , I Made Dwi Mertha
Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary Other

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Corticosteroids and glaucoma: How do treatments trigger ocular nerve damage? - A systematic literature review Putra, I Gede Satya Wijaya; Adnyana, I Made Dwi Mertha; Wahyudi, I Wayan; Suardana, Anak Agung Komang; Indrayanti, Ni Komang Rina; Prabowo, Sang Kompyang Yudistira Eddy; Panduyasa, I Gede; Widyantari, Dewa Ayu; Agustini, Desak Gede Dwi; Suwandani, Ni Made Ayu
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 3 (2024): November 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i3.22

Abstract

Corticosteroids are steroid hormone derivatives produced by the adrenal glands. Corticosteroids in the health sector have been widely utilized as anti-inflammatory agents because of their strong and rapid effects. This study aimed to identify the impact of long-term corticosteroid use on eye damage. This study uses a systematic literature review, which is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to the article screening process.  The data of this study, in the form of demographic variables, route of administration, steroid type, comorbidities, and patient risk factors, were descriptively analyzed. As a result, 15 of the 22 articles were selected for analysis. Chronic corticosteroid administration may precipitate optic neuropathy, manifesting as glaucoma, which is characterized by progressive structural degeneration of retinal ganglion cells (RGCs) and concomitant visual function deterioration. The locus of primary pathological insult in glaucomatous conditions is the optic nerve head, specifically at the optic disc. This anatomical site is notable for the abrupt 90-degree angular deviation of RGC axons as they transition from the retinal nerve fiber layer to their trajectory within the optic nerve proper. The use of corticosteroids can damage ocular nerve tissue through an increase in intraocular pressure (IOP) beyond 21 mmHg. This increase in IOP is due to changes in the microstructure of the trabeculum webbing, resulting in increased obstruction to the outflow of aqueous humor.
From silos to systems: Reimagining zoonotic neglected tropical disease management through the lens of one health Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha; Soedarsono, Soedarsono; Gustam, Tasalina Yohana Parameswari
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 3 (2024): November 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i3.61

Abstract

Zoonotic neglected tropical diseases (zNTDs) pose significant global public health challenges, particularly in low-income and middle-income countries. Traditional siloed approaches to zNTD management have proven inadequate for addressing the complex interplay between human, animal, and environmental health factors. This review examined the limitations of fragmented strategies and explored the potential of integrated one-health approaches for more effective zNTD control. This narrative review covered publications from 2000 to 2023, sourced from databases including PubMed and Scopus, emphasizing studies that met inclusion criteria of peer-reviewed research focused on zNTDs through a One Health lens. A comprehensive analysis of the current literature and case studies was conducted to evaluate the multifaceted drivers of zoonotic pathogen spillover, assess the economic and health impacts of zNTDs, and identify successful implementation of the One Health strategy in endemic regions. This review highlights the inadequacies of siloed disease management approaches, which often lead to inefficient resource allocation and missed opportunities for synergistic intervention. Successful case studies have demonstrated the effectiveness of the One Health strategy in improving disease surveillance, enhancing cross-sectoral collaboration, and achieving sustainable health outcomes. The potential of emerging technologies and innovations to support integrated approaches has also been explored. Transitioning from siloed to systemic approaches in zNTD management requires overcoming institutional barriers, fostering cross-sector collaboration, and implementing multitiered frameworks that operate at the local, national, and global levels. Investing in cross-sectoral capacity development and leveraging technological innovations are crucial for building a workforce capable of addressing the complex challenges posed by zNTDs. Adopting the One Health principle offers a promising path toward more comprehensive, efficient, and sustainable strategies for zNTD prevention.
Raising the flag of vigilance on Mpox outbreak in Indonesia: are we prepared? Adnyana, I Made Dwi Mertha; Maulana, Sidik; Lutfian, Lutfian; Adiwinoto, Ronald Pratama
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 2 (2024): September 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i2.63

Abstract

In the wake of the COVID-19 pandemic, the world has become acutely aware of the devastating impact of infectious diseases on public health, economies, and societies. As we gradually recover from the aftermath of COVID-19, another potential threat looms on the horizon, mpox, formerly known as monkeypox. The recent surge in mpox cases worldwide has prompted health authorities to sound an alarm, and Indonesia, as a populous nation with a complex healthcare system, must ask itself: Are we prepared for this emerging challenge?. The question "Are we prepared?" may not have a simple yes or no answer. Instead, it should serve as a reminder of the need for vigilance, adaptation, and continuous improvement in public health systems. As we navigate this new health challenge, the true measure of Indonesia's preparedness is its ability to respond swiftly, effectively, and equitably to protect the health and well-being of all citizens.
Pengaruh Perubahan Iklim (Climate Change) terhadap Vektor Malaria : Literature Review Nastiti, Niken Irfa; Adnyana, I Made Dwi Mertha; Delfira, Annissa; Asty, Zahra Frizki
JURNAL WIDYA BIOLOGI Vol. 16 No. 02 (2025): Vol. 16 No. 02 (2025) Widya Biologi
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/tagesz57

Abstract

Perubahan iklim memengaruhi dinamika vektor malaria melalui peningkatan suhu, perubahan pola curah hujan, serta modifikasi lingkungan yang berdampak pada distribusi dan kelangsungan hidup nyamuk Anopheles. Literature review ini bertujuan menggambarkan pengaruh perubahan iklim terhadap vektor malaria di Asia dan wilayah lain yang relevan. Pencarian artikel dilakukan melalui Scopus dan PubMed dengan kriteria publikasi tahun 2015-2025 dan diperoleh 9 artikel yang memenuhi syarat untuk dianalisis. Hasil menunjukkan bahwa kenaikan suhu mempercepat perkembangan nyamuk, memperpendek masa inkubasi ekstrinsik parasite, dan memperluas wilayah potensial penularan, sebagaiman ditunjukkan pada An. stephensi, An. gambiae, An. sinensis. Curah hujan merupakan variable lingkungan dominan yang menentukan distribusi An. philippinensis dan An.nivipes, dengan peningkatan luasan habitat di bawah scenario iklim masa depan. Di Indonesia, distribusi vektor dipengaruhi topografi, suhu, kelembaban, dan curah hujan, dengan konsentrasi pada area pesisir, persawahan dan perbukitan. Beberapa studi memprediksi pergeseran spesies dominan serta peningkatan risiko penularan hingga decade mendatang. Secara keseluruhan, perubahan iklim diproyeksikan memperluas wilayah penularan malaria, meningkatkan kelangsungan hidup vektor tertentu, dan mempercepat perkembangan parasit, sehingga berpotensi meningkatkan kejadian malaria di berbagai wilayah endemik maupun non-endemik.
A Rare Pediatric Case of Dengue Hemorrhagic Fever with Encephalopathy and Suspected Subdural Hemorrhage Cempakasari, Aulia; Rahmawati, Tiara; Arifin, Alief Qobidh Al Bashor; Syahputri, Dewi; Hutami, Firdha Yekti; Prameswari, Renata; Nugraheni, Pramita Anindya; Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.262

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is a severe arboviral infection that rarely leads to neurological complications. Dengue encephalopathy, often secondary to metabolic disturbances or shock, presents a significant diagnostic and management challenge in the pediatric population. Case Presentation: We report the case of a 4-year-3-month-old obese girl presenting with fever, gastrointestinal symptoms, and progressively decreasing consciousness (apathetic). Diagnosis of DHF was confirmed by a positive NS1 antigen test, severe thrombocytopenia (nadir 14,000/µL), and hemoconcentration with pleural effusion. Hepatic involvement was noted (SGOT 117.81 U/L). Neurological involvement was characterized by clinical encephalopathy, and a head CT scan revealed hyperdense lesions suspecting subdural hemorrhage (SDH). The patient required multidisciplinary management in the Intensive Care Unit (ICU) for supportive fluid therapy, inotropic support (Dobutamine), and platelet transfusion. The patient showed marked clinical improvement and was discharged on day nine. At a two-week post-discharge follow-up, she demonstrated full cognitive and motor recovery with no neurological sequelae Conclusion: This case highlights the critical need for clinical vigilance for rare, simultaneous neurological complications (encephalopathy and suspected SDH) in pediatric DHF. It underscores that early diagnosis and aggressive, multidisciplinary supportive care can lead to complete recovery even in severe presentations.
Genetic Diversity and Multiplicity of Plasmodium falciparum Infection in Southeast Asia: New Insights from a Systematic Review Praswitasari, Rengganis; Husada, Dominicus; Hasan, Nur Aini; Adnyana, I Made Dwi Mertha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.357

Abstract

Plasmodium falciparum caused four million new malaria cases in Southeast Asia in 2023, with heterogeneous transmission patterns and the development of artemisinin resistance. The merozoite surface protein genes (msp-1 and msp-2) serve as genetic markers for analyzing the parasite population structure and multiplicity of infection (MOI). However, a comprehensive synthesis of regional data is limited. This study aimed to determine the genetic diversity and MOI of P. falciparum in Southeast Asia. This systematic review was guided by PRISMA guidelines with searches in the Scopus, PubMed, ProQuest, and Google Scholar databases (2014–2024). The inclusion criterion was observational studies, analyzing the genetic diversity of P. falciparum via msp-1 and msp-2 markers in Southeast Asia. The extracted data included the frequency of msp-1 and msp-2 family alleles, the prevalence of polyclonal infections, and the mean MOI value. Quality assessment was performed via the joanna briggs institute critical appraisal tools with narrative synthesis following the synthesis without meta-analysis (SWiM) guidelines. Fifteen studies; Indonesia (40%), Thailand (26.67%), Myanmar (20%), Vietnam and Malaysia (6.66%) with 1,830 samples successfully genotyped from 2,130 collected samples. The MAD20 (msp-1) allele dominated most locations, with frequencies of up to 100% in Lampung. The distribution of msp-2 alleles showed geographical variation, with FC27 dominating in Papua (96.2%) and 3D7/IC in Vietnam (97.0%). The prevalence of polyclonal infection ranged from 0-84.6%, with MOI values ranging from 1.0-2.93. The hyperendemic areas presented high MOIs (>2.0), whereas the hypoendemic areas presented MOIs close to 1.0, confirming a positive correlation with malaria transmission intensity. The P. falciparum population in Southeast Asia shows high genetic diversity, with geographically variable allele distribution patterns, and MOI values are correlated with malaria endemicity levels. These findings support the need for regional molecular surveillance and a polyvalent approach to the development of msp-based vaccines.
Co-Authors Agustini, Desak Gede Dwi Al Karina, Citra Anak Agung Komang Suardana Annissa Delfira Ariastuti, Indria Arifin, Alief Qobidh Al Bashor Artha Budi Susila Duarsa Arundani, Prima Asik Surya Asty, Zahra Frizki Bimantara, Riza Fajar Biutifasari, Verna Budi Utomo Cempakasari, Aulia Cruz, Zito Viegas da da Cruz , Zito Viegas Dewi, Gusti Ayu Putu Wahyu Purnama Dewi, Ni Luh Made Noviana Dominicus Husada Dwinka Syafira Eljatin Eljatin, Dwinka S. Farachatus Salwa Salsabila Azhari Hafinuddin Hafinuddin Hasan, Nur Aini Herdiyantini, Mita Hutami, Firdha Yekti I P. Sudiartawan I Putu Sudiartawan I Wayan Wahyudi, I Wayan I. A. R. Astiti Asih Indrayanti, Ni Komang Rina Ismail Muhammad Jundaeng, Jarupat Juniastuti Juniastuti Kusman Ibrahim Liliawanti Luh Nik Armini Lutfian, Lutfian Machado, Filipe de Neri Mahendra, Kadek Adi Maulana, Sidik Muhamad Frendy Setyawan Muhammad Bayu Zohari Hutagalung Muhammad Ridho Akbar Eljatin Muhammad Rizal N. W. Bogoriani Nadya Aisyah Sasqia Putri Ni Ketut Ayu Juliasih Ni Luh Gede Sudaryati Niken Irfa Nastiti Nuartha, Pande Komang Aditya Ryan Nugraheni, Pramita Anindya Panduyasa, I Gede Pereira, Abrão J. Prabowo, Sang Kompyang Yudistira Eddy Pramita Anindya Nugraheni Prasetya, Hanung Praswitasari, Rengganis Pratama A., Ronald Prima Arundani Putra, I Gede Satya Wijaya Putra, Oki Nugraha Putri, Ida Ayu Govinda Lazenobia De Sanjaya Putu Lakustini Cahyaningrum Putut Dewantha Jenar Rahmawati, Tiara Raza, Syed Meesam Renata Prameswari Ronald Pratama Adiwinoto Sadya Wendra Savitri, Ida Ayu Gede Winda Setiadi M Noor Soedarsono Soedarsono Sridana, I Nyoman STEFANUS DJONI HUSODO Suardana, A.A Komang Sudaryati, Ni LG. Sudiartawan, I Putu Sugiarta, Ketut Merdana Sundari, Ni Luh Putu Ari Suniartini, Ketut Suwandani, Ni Made Ayu Syahputri, Dewi Syed Meesam Raza Tasalina Yohana Parameswari Gustam Tika, Fanny Eprilia Ulwani, Qulistan Balqis Umar, Tungki Pratama Uswatun Hasanah Widiastiti, Ni Nyoman Widyantari, Dewa Ayu Wijayaningrum, Lena Wyasena, Pande Nyoman Tri Saguna Zuriat Zuriat