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Corticosteroids and glaucoma: How do treatments trigger ocular nerve damage? - A systematic literature review Putra, I Gede Satya Wijaya; Adnyana, I Made Dwi Mertha; Wahyudi, I Wayan; Suardana, Anak Agung Komang; Indrayanti, Ni Komang Rina; Prabowo, Sang Kompyang Yudistira Eddy; Panduyasa, I Gede; Widyantari, Dewa Ayu; Agustini, Desak Gede Dwi; Suwandani, Ni Made Ayu
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 3 (2024): November 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i3.22

Abstract

Corticosteroids are steroid hormone derivatives produced by the adrenal glands. Corticosteroids in the health sector have been widely utilized as anti-inflammatory agents because of their strong and rapid effects. This study aimed to identify the impact of long-term corticosteroid use on eye damage. This study uses a systematic literature review, which is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to the article screening process.  The data of this study, in the form of demographic variables, route of administration, steroid type, comorbidities, and patient risk factors, were descriptively analyzed. As a result, 15 of the 22 articles were selected for analysis. Chronic corticosteroid administration may precipitate optic neuropathy, manifesting as glaucoma, which is characterized by progressive structural degeneration of retinal ganglion cells (RGCs) and concomitant visual function deterioration. The locus of primary pathological insult in glaucomatous conditions is the optic nerve head, specifically at the optic disc. This anatomical site is notable for the abrupt 90-degree angular deviation of RGC axons as they transition from the retinal nerve fiber layer to their trajectory within the optic nerve proper. The use of corticosteroids can damage ocular nerve tissue through an increase in intraocular pressure (IOP) beyond 21 mmHg. This increase in IOP is due to changes in the microstructure of the trabeculum webbing, resulting in increased obstruction to the outflow of aqueous humor.
From silos to systems: Reimagining zoonotic neglected tropical disease management through the lens of one health Adiwinoto, Ronald Pratama; Adnyana, I Made Dwi Mertha; Soedarsono, Soedarsono; Gustam, Tasalina Yohana Parameswari
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 3 (2024): November 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i3.61

Abstract

Zoonotic neglected tropical diseases (zNTDs) pose significant global public health challenges, particularly in low-income and middle-income countries. Traditional siloed approaches to zNTD management have proven inadequate for addressing the complex interplay between human, animal, and environmental health factors. This review examined the limitations of fragmented strategies and explored the potential of integrated one-health approaches for more effective zNTD control. This narrative review covered publications from 2000 to 2023, sourced from databases including PubMed and Scopus, emphasizing studies that met inclusion criteria of peer-reviewed research focused on zNTDs through a One Health lens. A comprehensive analysis of the current literature and case studies was conducted to evaluate the multifaceted drivers of zoonotic pathogen spillover, assess the economic and health impacts of zNTDs, and identify successful implementation of the One Health strategy in endemic regions. This review highlights the inadequacies of siloed disease management approaches, which often lead to inefficient resource allocation and missed opportunities for synergistic intervention. Successful case studies have demonstrated the effectiveness of the One Health strategy in improving disease surveillance, enhancing cross-sectoral collaboration, and achieving sustainable health outcomes. The potential of emerging technologies and innovations to support integrated approaches has also been explored. Transitioning from siloed to systemic approaches in zNTD management requires overcoming institutional barriers, fostering cross-sector collaboration, and implementing multitiered frameworks that operate at the local, national, and global levels. Investing in cross-sectoral capacity development and leveraging technological innovations are crucial for building a workforce capable of addressing the complex challenges posed by zNTDs. Adopting the One Health principle offers a promising path toward more comprehensive, efficient, and sustainable strategies for zNTD prevention.
Raising the flag of vigilance on Mpox outbreak in Indonesia: are we prepared? Adnyana, I Made Dwi Mertha; Maulana, Sidik; Lutfian, Lutfian; Adiwinoto, Ronald Pratama
Svāsthya: Trends in General Medicine and Public Health Vol. 1 No. 2 (2024): September 2024
Publisher : PT. Mega Science Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70347/svsthya.v1i2.63

Abstract

In the wake of the COVID-19 pandemic, the world has become acutely aware of the devastating impact of infectious diseases on public health, economies, and societies. As we gradually recover from the aftermath of COVID-19, another potential threat looms on the horizon, mpox, formerly known as monkeypox. The recent surge in mpox cases worldwide has prompted health authorities to sound an alarm, and Indonesia, as a populous nation with a complex healthcare system, must ask itself: Are we prepared for this emerging challenge?. The question "Are we prepared?" may not have a simple yes or no answer. Instead, it should serve as a reminder of the need for vigilance, adaptation, and continuous improvement in public health systems. As we navigate this new health challenge, the true measure of Indonesia's preparedness is its ability to respond swiftly, effectively, and equitably to protect the health and well-being of all citizens.
Co-Authors Agustini, Desak Gede Dwi Al Karina, Citra Anak Agung Komang Suardana Ariastuti, Indria Artha Budi Susila Duarsa Arundani, Prima Asik Surya Bimantara, Riza Fajar Biutifasari, Verna Budi Utomo Cruz, Zito Viegas da da Cruz , Zito Viegas Dewi, Gusti Ayu Putu Wahyu Purnama Dewi, Ni Luh Made Noviana Dwinka Syafira Eljatin Eljatin, Dwinka S. Farachatus Salwa Salsabila Azhari Hafinuddin Hafinuddin Herdiyantini, Mita I P. Sudiartawan I Putu Sudiartawan I Wayan Wahyudi, I Wayan I. A. R. Astiti Asih Indrayanti, Ni Komang Rina Ismail Muhammad Jundaeng, Jarupat Juniastuti Juniastuti Kusman Ibrahim Liliawanti Luh Nik Armini Lutfian, Lutfian Machado, Filipe de Neri Mahendra, Kadek Adi Maulana, Sidik Muhamad Frendy Setyawan Muhammad Bayu Zohari Hutagalung Muhammad Ridho Akbar Eljatin Muhammad Rizal N. W. Bogoriani Nadya Aisyah Sasqia Putri Ni Ketut Ayu Juliasih Ni Luh Gede Sudaryati Nuartha, Pande Komang Aditya Ryan Panduyasa, I Gede Pereira, Abrão J. Prabowo, Sang Kompyang Yudistira Eddy Pramita Anindya Nugraheni Prasetya, Hanung Pratama A., Ronald Prima Arundani Putra, I Gede Satya Wijaya Putra, Oki Nugraha Putri, Ida Ayu Govinda Lazenobia De Sanjaya Putu Lakustini Cahyaningrum Putut Dewantha Jenar Raza, Syed Meesam Ronald Pratama Adiwinoto Sadya Wendra Savitri, Ida Ayu Gede Winda Setiadi M Noor Soedarsono Soedarsono Sridana, I Nyoman STEFANUS DJONI HUSODO Suardana, A.A Komang Sudaryati, Ni LG. Sudiartawan, I Putu Sugiarta, Ketut Merdana Sundari, Ni Luh Putu Ari Suniartini, Ketut Suwandani, Ni Made Ayu Syed Meesam Raza Tasalina Yohana Parameswari Gustam Tika, Fanny Eprilia Ulwani, Qulistan Balqis Umar, Tungki Pratama Uswatun Hasanah Widiastiti, Ni Nyoman Widyantari, Dewa Ayu Wijayaningrum, Lena Wyasena, Pande Nyoman Tri Saguna Zuriat Zuriat