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Pengaruh Perubahan Iklim (Climate Change) terhadap Vektor Malaria : Literature Review Nastiti, Niken Irfa; Adnyana, I Made Dwi Mertha; Delfira, Annissa; Asty, Zahra Frizki
JURNAL WIDYA BIOLOGI Vol. 16 No. 02 (2025): Vol. 16 No. 02 (2025) Widya Biologi
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/tagesz57

Abstract

Perubahan iklim memengaruhi dinamika vektor malaria melalui peningkatan suhu, perubahan pola curah hujan, serta modifikasi lingkungan yang berdampak pada distribusi dan kelangsungan hidup nyamuk Anopheles. Literature review ini bertujuan menggambarkan pengaruh perubahan iklim terhadap vektor malaria di Asia dan wilayah lain yang relevan. Pencarian artikel dilakukan melalui Scopus dan PubMed dengan kriteria publikasi tahun 2015-2025 dan diperoleh 9 artikel yang memenuhi syarat untuk dianalisis. Hasil menunjukkan bahwa kenaikan suhu mempercepat perkembangan nyamuk, memperpendek masa inkubasi ekstrinsik parasite, dan memperluas wilayah potensial penularan, sebagaiman ditunjukkan pada An. stephensi, An. gambiae, An. sinensis. Curah hujan merupakan variable lingkungan dominan yang menentukan distribusi An. philippinensis dan An.nivipes, dengan peningkatan luasan habitat di bawah scenario iklim masa depan. Di Indonesia, distribusi vektor dipengaruhi topografi, suhu, kelembaban, dan curah hujan, dengan konsentrasi pada area pesisir, persawahan dan perbukitan. Beberapa studi memprediksi pergeseran spesies dominan serta peningkatan risiko penularan hingga decade mendatang. Secara keseluruhan, perubahan iklim diproyeksikan memperluas wilayah penularan malaria, meningkatkan kelangsungan hidup vektor tertentu, dan mempercepat perkembangan parasit, sehingga berpotensi meningkatkan kejadian malaria di berbagai wilayah endemik maupun non-endemik.
Genetic Diversity and Multiplicity of Plasmodium falciparum Infection in Southeast Asia: New Insights from a Systematic Review Praswitasari, Rengganis; Husada, Dominicus; Hasan, Nur Aini; Adnyana, I Made Dwi Mertha
Journal of Multidisciplinary Applied Natural Science Articles in Press
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.357

Abstract

Plasmodium falciparum caused four million new malaria cases in Southeast Asia in 2023, with heterogeneous transmission patterns and the development of artemisinin resistance. The merozoite surface protein genes (msp-1 and msp-2) serve as genetic markers for analyzing the parasite population structure and multiplicity of infection (MOI). However, a comprehensive synthesis of regional data is limited. This study aimed to determine the genetic diversity and MOI of P. falciparum in Southeast Asia. This systematic review was guided by PRISMA guidelines with searches in the Scopus, PubMed, ProQuest, and Google Scholar databases (2014–2024). The inclusion criterion was observational studies, analyzing the genetic diversity of P. falciparum via msp-1 and msp-2 markers in Southeast Asia. The extracted data included the frequency of msp-1 and msp-2 family alleles, the prevalence of polyclonal infections, and the mean MOI value. Quality assessment was performed via the joanna briggs institute critical appraisal tools with narrative synthesis following the synthesis without meta-analysis (SWiM) guidelines. Fifteen studies; Indonesia (40%), Thailand (26.67%), Myanmar (20%), Vietnam and Malaysia (6.66%) with 1,830 samples successfully genotyped from 2,130 collected samples. The MAD20 (msp-1) allele dominated most locations, with frequencies of up to 100% in Lampung. The distribution of msp-2 alleles showed geographical variation, with FC27 dominating in Papua (96.2%) and 3D7/IC in Vietnam (97.0%). The prevalence of polyclonal infection ranged from 0-84.6%, with MOI values ranging from 1.0-2.93. The hyperendemic areas presented high MOIs (>2.0), whereas the hypoendemic areas presented MOIs close to 1.0, confirming a positive correlation with malaria transmission intensity. The P. falciparum population in Southeast Asia shows high genetic diversity, with geographically variable allele distribution patterns, and MOI values are correlated with malaria endemicity levels. These findings support the need for regional molecular surveillance and a polyvalent approach to the development of msp-based vaccines.
DUKU PEEL INNOVATION: EFFORTS TO IMPROVE CREATIVE HEALTHPRENEURS THROUGH THE DEVELOPMENT OF PLANT-BASED INSECTICIDES Miftahurrahma Miftahurrahma; Tengku Arief Buana Perkasa; Huntari Harahap; Hafizah Hafizah; Denok Tri Hardiningsih; I Made Dwi Mertha Adnyana
BUDIMAS : JURNAL PENGABDIAN MASYARAKAT Vol. 8 No. 1 (2026): BUDIMAS : Jurnal Pengabdian Masyarakat
Publisher : LPPM ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/budimas.v8i1.19448

Abstract

Duku peel is an underutilized agricultural byproduct in Talang Duku Village, a major center of duku production, and is commonly discarded as waste. The community’s heavy reliance on synthetic chemical insecticides presents environmental and health risks, compounded by limited knowledge regarding the processing of agricultural waste into value-added products. This community service program aimed to empower the “A. Khalik Duku Plantation” Farmers Group by converting duku peel waste into a high-value plant-based insecticide in the form of aromatherapy candles, thereby fostering a new generation of creative healthpreneurs. The program applied a participatory community empowerment approach through education, hands-on training, and continuous mentoring. The stages included needs assessment, production and business management training, and evaluation using pre-test and post-test data analyzed with the Wilcoxon and Chi-Square tests. The results showed a significant improvement in participants’ knowledge (P < 0.001), with the median score increasing from 70% to 80% and the number of participants achieving the ≥80% competency threshold rising from 13 to 49. Furthermore, the program successfully facilitated the production of insect-repellent aromatherapy candles and the establishment of the “KUB Duku Lestari” Joint Business Group, which sold more than 50 units within the first three months. In conclusion, this program effectively transformed agricultural waste into a valuable product, promoted sustainable entrepreneurship, and contributed to improving community welfare. It is recommended that the business group standardize product packaging to enhance market competitiveness and that future studies focus on optimizing extraction techniques to improve product efficacy.
A Rare Pediatric Case of Dengue Hemorrhagic Fever with Encephalopathy and Suspected Subdural Hemorrhage Aulia Cempakasari; Tiara Rahmawati; Alief Qobidh Al Bashor Arifin; Dewi Syahputri; Firdha Yekti Hutami; Renata Prameswari; Pramita Anindya Nugraheni; Ronald Pratama Adiwinoto; I Made Dwi Mertha Adnyana
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.262

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is a severe arboviral infection that rarely leads to neurological complications. Dengue encephalopathy, often secondary to metabolic disturbances or shock, presents a significant diagnostic and management challenge in the pediatric population. Case Presentation: We report the case of a 4-year-3-month-old obese girl presenting with fever, gastrointestinal symptoms, and progressively decreasing consciousness (apathetic). Diagnosis of DHF was confirmed by a positive NS1 antigen test, severe thrombocytopenia (nadir 14,000/µL), and hemoconcentration with pleural effusion. Hepatic involvement was noted (SGOT 117.81 U/L). Neurological involvement was characterized by clinical encephalopathy, and a head CT scan revealed hyperdense lesions suspecting subdural hemorrhage (SDH). The patient required multidisciplinary management in the Intensive Care Unit (ICU) for supportive fluid therapy, inotropic support (Dobutamine), and platelet transfusion. The patient showed marked clinical improvement and was discharged on day nine. At a two-week post-discharge follow-up, she demonstrated full cognitive and motor recovery with no neurological sequelae Conclusion: This case highlights the critical need for clinical vigilance for rare, simultaneous neurological complications (encephalopathy and suspected SDH) in pediatric DHF. It underscores that early diagnosis and aggressive, multidisciplinary supportive care can lead to complete recovery even in severe presentations.
Maternal nutritional intervention for preeclampsia prevention: Integrating video-based education and local fish cooking workshops Dea Anenta Veonika; Tia Wida Ekaputri Hz; Niken Irfa Nastiti; Annissa Delfira; I Made Dwi Mertha Adnyana
Community Empowerment Vol. 11 No. 2 (2026)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.15501

Abstract

Preeclampsia remains a primary driver of maternal mortality in Indonesia, highlighting the urgency of addressing maternal nutritional status as a critical, modifiable risk factor through targeted community programs. This community service aims to elevate pregnant women's literacy regarding balanced prenatal nutrition for preeclampsia prevention while mapping their baseline nutritional profiles and risk factors. The program integrated comprehensive health screenings (anthropometric and blood pressure measurements, and medical history assessments) with interactive video screenings and hands-on cooking demonstrations featuring local fish resources. Clinical screenings revealed a high prevalence of metabolic risks: 40% of participants were obese and 35% presented with anemia. A remarkably strong positive correlation was observed between BMI and MUAC (r=0.788; p<0.001). Post-intervention assessments demonstrated a substantial surge in nutritional knowledge, most notably regarding calcium requirements (131.6%) and protein needs (104.8%). Ultimately, combining visual education with experiential cooking workshops serves as an effective, highly practical strategy to improve maternal nutritional literacy and reinforce preeclampsia prevention frameworks at primary healthcare levels.
Multifactorial Predictors of Stunting Among Children Under Five Years: Evidence from Batanghari District, Jambi, Indonesia Huntari Harahap; Armaidi Darmawan; Anggelia Puspasari; Esa Indah Ayudia; I Made Dwi Mertha Adnyana; Asrica Fitri Yonera; Nurul Uswatun Hasanah
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.852

Abstract

Stunting is a public health problem with a high prevalence in Indonesia. The Batanghari District has a stunting rate of 26.3%, exceeding the national target; however, specific regional determinants have not been comprehensively identified. This study aimed to identify multifactorial predictors of stunting in children under five years in Batanghari District. A cross-sectional study was conducted in Batanghari District from August to October 2024, involving 64 children aged 0–60 months selected through purposive sampling. Data were collected via structured questionnaires, anthropometric measurements via WHO standards, and 24 h dietary assessment food recall. Stunting was defined as a height-for-age z score < -2 SD. For statistical analysis, binary logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). The prevalence of stunting was 70.3% (n=45). Inadequate energy density was the strongest predictor (OR = 11.389; 95% CI: 2.906–44.627; p < 0.001), followed by poor drinking water quality (OR = 8.705; 95% CI: 1.668–45.445; p = 0.004), history of problematic pregnancy (OR = 8.250; 95% CI: 0.799–85.165; p = 0.041), poor type of food (OR = 5.123; 95% CI: 1.449–18.110; p = 0.011), calcium density (OR = 4.242; 95% CI: 1.181–15.234; p = 0.021), income below the regional minimum wage (OR = 3.681; 95% CI: 1.146–11.832; p = 0.025), and authoritarian parenting (OR = 3.523; 95% CI: 1.056–11.762; p = 0.036). These findings suggest that stunting in Batanghari District is associated with a complex interplay of nutritional deficiencies, socioeconomic factors, environmental conditions, maternal health, and behavioral factors
Interleukin 10 gene promoter polymorphism –819 T/C modulates IL-10 levels independently of PGE2 in multibacillary leprosy Fitriyanti; Lipinwati; Attiya Istarini; Tia Wida Ekaputri; Niken Irfa Nastiti; I Made Dwi Mertha Adnyana; Rini Pratiwi
Nursing and Health Sciences Journal (NHSJ) Vol. 6 No. 2 (2026): June 2026
Publisher : KHD-Production

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53713/nhsj.v6i2.684

Abstract

The IL-10 –819 T/C promoter polymorphism influences cytokine production in leprosy, yet its functional interplay with serum IL-10 and prostaglandin E2 (PGE2) in Indonesian populations remains undefined. This study investigated its association with multibacillary (MB) leprosy susceptibility and systemic mediator levels. In a case–control design, 35 MB patients and 35 healthy controls from Banyuasin Regency, South Sumatra, were enrolled. PCR-RFLP was used for genotyping, and ELISA was used to quantify serum IL-10 and PGE2. Genotype and allele frequencies did not differ between groups (OR = 1.121; 95% CI: 0.439–2.863; p = 0.811), indicating no susceptibility effect. Serum IL-10 was significantly elevated in patients (median 2.15 pg/mL) versus controls (1.23 pg/mL; p = 0.033). Within cases, IL-10 exhibited a C-allele dose-dependent gradient (TT: 3.82; CT: 4.96; CC: 16.20 pg/mL), though statistically underpowered (H = 0.452; p = 0.798). PGE2 showed no intergroup differences (p = 0.142), nor correlations with genotype (p = 0.915) or IL-10 (rₛ = −0.057; p = 0.639). The IL-10 –819 T/C variant does not predict MB susceptibility but, in a pathogen-context-dependent manner, functionally amplifies IL-10 production. This genetic effect operates independently of systemic PGE2 regulation, highlighting distinct immunomodulatory pathways and supporting the CC genotype as a potential biomarker of immune-suppression severity.
Analisis Kepuasan Mahasiswa terhadap SOP Terintegrasi: Upaya Harmonisasi ISO 45001:2018 dan ISO 14001:2015 Menuju Green Laboratory Kadek Adi Mahendra; I Made Dwi Mertha Adnyana
HORIZON: Indonesian Journal of Multidisciplinary Vol. 4 No. 3 (2026): HORIZON: Indonesian Journal of Multidisciplinary
Publisher : Lembaga Intelektual Muda (LIM) Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54373/hijm.v4i3.5402

Abstract

The Highway Laboratory carries significant occupational safety risks and environmental impacts; however, the implementation of standard operating procedures (SOPs) that integrate occupational safety and environmental management aspects remains suboptimal. This study aims to analyze student satisfaction levels toward integrated SOPs based on ISO 45001 and ISO 14001 as an effort to harmonize toward a green laboratory in the Highway Laboratory. This study employed a descriptive quantitative approach using a survey method involving 150 Civil Engineering students from the 2023 cohort who had completed the full series of laboratory practicum sessions. Data were collected using a structured questionnaire consisting of 30 statement items across six measurement dimensions and analyzed using descriptive statistics. The results revealed that the overall student satisfaction level fell into the "Moderately Satisfied" category, with three dimensions obtaining the lowest scores, namely the implementation of occupational health and safety based on ISO 45001, environmental management based on ISO 14001, and the application of the green laboratory concept. These findings indicate that the existing SOPs have not adequately accommodated occupational safety, health, and environmental sustainability aspects. This study affirms the urgency of developing integrated SOPs that harmonize ISO 45001 and ISO 14001 as the foundation for realizing a safe, healthy, and sustainable green laboratory.
Exploring the Threads of Youth: Stress, BMI, and Menstrual Health in Hang Tuah 2 Senior High School, Sidoarjo Ronald Pratama Adiwinoto; Qulistan Balqis Ulwani; Lena Wijayaningrum; Stefanus Djoni Husodo; Tasalina Yohana Parameswari Gustam; Hanung Prasetya; I Made Dwi Mertha Adnyana
Journal of Current Health Sciences Vol. 5 No. 1: 2025
Publisher : Utan Kayu Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/jchs.202597

Abstract

Background: Menstrual cycle disorders are common problems among adolescent girls and are associated with reproductive health issues. Factors such as Body Mass Index (BMI) and stress are believed to influence menstrual irregularities. This study aims to examine the relationship between BMI, stress, and menstrual cycle irregularities as a preventive measure to maintain optimal menstrual health. Method: This observational analytical study utilized a non-probability sampling technique. Data analysis was conducted using Spearman’s Rho Correlation test and Cross Tabulation test at a significance level of 0.05. Results: The analysis showed a significant positive correlation between BMI and menstrual irregularities (p = 0.010, r = 0.258) and between stress and menstrual irregularities (p = 0.001, r = 0.480). Stress exhibited a stronger association with menstrual irregularities than BMI. Conclusion: This study highlights the relationship between BMI and stress with menstrual irregularities in female adolescents at SMA Hang Tuah 2 Sidoarjo. These findings emphasize the need for targeted interventions addressing nutritional and psychological support to improve menstrual health. Monitoring BMI and managing stress are essential strategies to enhance reproductive health in adolescents. Further research is recommended to explore effective interventions to address these factors and improve adolescent well-being.
Spatio-temporal analysis of dengue virus infection in the Bobonaro Municipality (2022-2024): insight from demographics and risk Zito Viegas da Cruz; I Made Dwi Mertha Adnyana
Berita Kedokteran Masyarakat Vol 42 No 07 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v42i07.28313

Abstract

Purpose: This study aimed to analyze the spatio-temporal patterns of dengue virus infection via kernel density estimation to assess the relative risk distribution and identify transmission hotspots in the Bobonaro municipality. Methods: A retrospective analysis was conducted on confirmed dengue cases (n=311) reported from seven community health centers and one referral hospital in Bobonaro from January 2022 to December 2024. Kernel density estimation with optimal bandwidth selection was employed to map the relative risk distributions and identify spatial clusters. Demographic patterns across age categories were analyzed using negative binomial regression with a quadratic age-rank term, and sex distribution was analyzed using an exact two-proportion binomial test. Results: Annual dengue cases increased by 41.48% over the study period, with significant seasonal patterns observed during the dry and rainy seasons. Case counts increased from the infancy category toward a peak in the youth category (5–14 years, 158 cases, 50.8% of all cases) before declining in older age groups, a pattern confirmed by negative binomial regression with a quadratic age-rank term (incidence rate ratio [IRR] 8.45, 95% CI 2.70–25.37, p<0.001 for the linear term and 0.74, 95% CI 0.65–0.85, p<0.001 for the quadratic term). Females accounted for a slightly higher proportion of cases (51.8%, n=161) than males (48.2%, n=150), a difference that was not statistically significant (p= 0.571). Spatial analysis revealed persistent hotspots in southeastern Bobonaro, with new clusters emerging in the northern regions by 2023 and transmission typically contained within an 80 m radius. Conclusion: This study identified clear demographic vulnerabilities and dynamic spatial patterns of dengue transmission in Bobonaro, demonstrating the utility of GIS-based spatial analysis for strengthening surveillance and guiding targeted vector control in resource-constrained settings.
Co-Authors Agustini, Desak Gede Dwi Al Karina, Citra Alief Qobidh Al Bashor Arifin Alreva Muhazier Jayaputra Anak Agung Komang Suardana Anggelia Puspasari Annissa Delfira Ariastuti, Indria Armaidi Darmawan Artha Budi Susila Duarsa Arundani, Prima Asik Surya Asrica Fitri Yonera Asty, Zahra Frizki Attiya Istarini ATTIYA ISTARINI Aulia Cempakasari Bimantara, Riza Fajar Biutifasari, Verna Budi Utomo Cruz, Zito Viegas da da Cruz , Zito Viegas Dea Anenta Veonika Denok Tri Hardiningsih Dewi Syahputri Dewi, Gusti Ayu Putu Wahyu Purnama Dominicus Husada Dwinka Syafira Eljatin Ekaputri, Tia Wida Eljatin, Dwinka S. Elsa Mega Suryani Erny Kusdiyah Esa Indah Ayudia Farachatus Salwa Salsabila Azhari Firdha Yekti Hutami Fitriyanti Fitriyanti Fitriyanti Hafinuddin Hafinuddin Hafizah Hafizah Hanung Prasetya Herdiyantini, Mita Huntari Harahap I Nyoman Sridana I P. Sudiartawan I Putu Sudiartawan I Wayan Wahyudi, I Wayan I. A. R. Astiti Asih Indrayanti, Ni Komang Rina Irawan Anasta Putra Jundaeng, Jarupat Juniastuti Juniastuti Kadek Adi Mahendra Ketut Merdana Sugiarta Ketut Suniartini Kusman Ibrahim Lena Wijayaningrum Liliawanti Lipinwati Lipinwati ., Lipinwati Luh Nik Armini Lutfian, Lutfian Machado, Filipe de Neri Mahendra, Kadek Adi Maulana, Sidik Maykon Jhuly Martins de Paiva Miftahurrahma Miftahurrahma Muhamad Frendy Setyawan Muhammad Bayu Zohari Hutagalung Muhammad Ridho Akbar Eljatin Muhammad Rizal Muhammad Rizky Pratama N. W. Bogoriani Nadya Aisyah Sasqia Putri Ni Ketut Ayu Juliasih Ni Luh Gede Sudaryati Ni Luh Gede Sudaryati Ni Luh Made Noviana Dewi Niken Irfa Nastiti Niken Irfa Nastiti Niken Irfa Nastiti Nisa Haska Maulina Nuartha, Pande Komang Aditya Ryan Nur Aini Hasan Nurul Qalbi Alrani Nurul Uswatun Hasanah Panduyasa, I Gede Pereira, Abrão J. Prabowo, Sang Kompyang Yudistira Eddy Pramita Anindya Nugraheni Pramita Anindya Nugraheni Prasetya, Hanung Praswitasari, Rengganis Pratama A., Ronald Prima Arundani Putra, I Gede Satya Wijaya Putra, Oki Nugraha Putri, Ida Ayu Govinda Lazenobia De Sanjaya Putu Lakustini Cahyaningrum Putut Dewantha Jenar Putut Dewantha Jenar Qulistan Balqis Ulwani Raza, Syed Meesam Renata Prameswari Rini Pratiwi Ronald Pratama Adiwinoto Ronald Pratama Adiwinoto Ronald Pratama Adiwinoto Sadya Wendra Savitri, Ida Ayu Gede Winda Setiadi M Noor Soedarsono Soedarsono Stefanus Djoni Husodo Suardana, A.A Komang Sudaryati, Ni LG. Sudiartawan, I Putu Sundari, Ni Luh Putu Ari Suwandani, Ni Made Ayu Syed Meesam Raza Tasalina Yohana Parameswari Gustam Tasalina Yohana Parameswari Gustam Tengku Arief Buana Perkasa Tia Wida Ekaputri Tia Wida Ekaputri Hz Tiara Rahmawati Tika, Fanny Eprilia Umar, Tungki Pratama Uswatun Hasanah Widiastiti, Ni Nyoman Widyantari, Dewa Ayu Wyasena, Pande Nyoman Tri Saguna Zito Viegas da Cruz Zuriat Zuriat