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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Inovasi Pendidikan IPA Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan Jurnal Penelitian Pendidikan IPA (JPPIPA) LENSA (Lentera Sains): Jurnal Pendidikan IPA Jurnal Penelitian dan Pengkajian Ilmu Pendidikan: e-Saintika Lensa : Jurnal Kependidikan Fisika JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) SECONDARY : Jurnal Inovasi Pendidikan Menengah (JIPM) SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA Jurnal Abdi Masyarakat Indonesia Jurnal Pendidikan Ilmu Pengetahuan Alam (JP-IPA) Inovasi Pendidikan Fisika Prisma Sains: Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram Lensa: Jurnal Kependidikan Fisika Jurnal Abdimas Terapan Kohesi: Jurnal Sains dan Teknologi JIPI (Jurnal IPA dan Pembelajaran IPA) Trigonometri: Jurnal Matematika dan Ilmu Pengetahuan Alam MERDEKA: Jurnal Ilmiah Multidisiplin Jurnal Pendidikan IPA Indonesia Sasambo: Jurnal Abdimas (Journal of Community Service) JURNAL SAINS GEOGRAFI
Ahmad Fauzi Hendratmoko
Universitas Negeri Surabaya
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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Phytochemical Screening and In Silico Prediction of Gynura divaricata Ethanolic Extract as A Potential PIM-1 Inhibitor: Phytochemical and In Silico Prediction of Gynura divaricata Puspitarini , Sapti; Hermanto, Feri Eko; Rohim, Abd; Dliyauddin, Moh; Hendratmoko, Ahmad Fauzi; Budiyanto, Mohammad; Ilhami, Fasih Bintang
Journal of Tropical Life Science Vol. 16 No. 01 (2026)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.16.01.06

Abstract

The pharmacological properties and traditional uses of medicinal plants often correlate with their bioactive constituents, which contribute to diverse therapeutic effects, including anticancer activity. Cancer remains one of the leading causes of mortality worldwide, and the discovery of novel anticancer agents from natural sources continues to be an important research focus. Gynura divaricata is a medicinal herb widely used in traditional Asian medicine for treating diseases. Recent studies have reported that G. divaricata contains several bioactive compounds. such as flavonoids, phenolic acids, terpenoids, and alkaloids, which are known for their antioxidant and anticancer properties. However, despite its traditional use and pharmacological potential, the molecular mechanisms underlying the anticancer activity of G. divaricata remain poorly understood. This study aimed to screen the phytochemical content of the ethanolic leaf extract of G. divaricata and to predict its potential anticancer activity through computational analysis targeting the PIM-1 protein. The DPPH inhibition, total flavonoid content, and total phenolic content of the extract were evaluated. Phytochemical profiling was performed using LC-HRMS. Molecular docking and molecular dynamics simulations were conducted to predict the interactions between the active compounds of G. divaricata and the PIM-1 protein. The extract exhibited 50% DPPH inhibition at a concentration of 2071.01 ppm, with total flavonoid and total phenolic contents of 107.44 ± 4.41 mg QE/g and 10.96 ± 0.49 mg GAE/g, respectively. Identified bioactive compounds, including curcumin, (+)-ar-turmerone, and 4-coumaric acid, were further analyzed through molecular docking to assess their interactions with the PIM-1 kinase. The docking results revealed that these compounds showed favorable binding affinities to the active site of PIM-1, suggesting their potential as anticancer agents. This study is the first to report the potential of G. divaricata active compounds as PIM-1 inhibitors, warranting further validation through both in vitro and in vivo studies.  
Co-Authors ., BINAR AYU DEWANTI Abdul Aziz Khoiri Abdul Kholiq Agustine, Laila Rizky Agustin Ahmad Qosyim Alzena Agatha Araminta Amaturahman Zulfa AN NURIL MAULIDA FAUZIAH AN NURIL MAULIDA FAUZIAH An Nuril Maulida Fauziah Anis Rahma Cahyani Araminta, Alzena Agatha Arnita Yulia Sari Astrid Dwika Anggraini Avina Putri Syahida Az-zahro, Adhelia Carissa Azhar Azhar Azizah, Luluk Nur Desyana Auralia Azizah Dinar Mahdalena Leksana 1 Dliyauddin, Moh DYAH ASTRIANI Dyah Permata Sari Eliza Kristiana Dewi ELOK SUDIBYO Endang Susantini ENDANG SUSANTINI Erika Avenda Putri Khaznah Erman Erman Erna Hayati, Erna Ernita Vika Aulia Fahritsa Salsabila Fasih Bintang Ilhami Fasih Bintang Ilhami, Fasih Bintang FATHARANI, ATIKA Fikky Dian Roqobih Griyanora, Griyanora Hermanto, Feri Eko inayatillah, fafi Intan Permatasari Juliana Putri Ghassani Kamila, Nina Najwa KIKI SEPTARIA Kumalasari, Devi LAILY ROSDIANA Laudia, Stefanie Marla Lia Yuliati liswijaya, liswijaya Lutfiyanti, Rosa Azzahro M. Rosidi Zamroni Mahajeng, Mayang Chris Martini Martini Mashwani, Hazrat Usman Miftahus Sholihin Mochammad Zumar Firdaus Ermawan MOHAMMAD BUDIYANTO Muhamad Arif Mahdiannur Muhammad Hafizh Abdullah Nafila, Faradifa Nagy, Emese K. Nilna Najwa Kamila Noly Shofiyah Norma Yunita Firdaus Nur Faidatul Jannah Nur Safiqoh Arbaatin Nurinnadiyah Rahadatul 'Aisy Nurinnadiyah Rahadatul ’Aisy Obra Jr, Mario R Pramudya Aulia Fadila Puspitarini , Sapti Rahman*, Nanang Rahman, Nanang Rahmawati, Dewi Syamsia Reiza Noor Azizi Rohim, Abd Sa'idah, Zhahirah Indana Safitri Yosita Ratri Salsabila, Putri Avianita Salsabilla Abidah Alfina Santosa, Rizky Putra Sapti Puspitarini Siti Marpuah, Siti Siti Nurul Hidayati Susiyawati, Enny Suwandi, E. Tirta Rohmatain Solikah Titania Zewelya Ray Prameswara Kuswantoro TUTUT NURITA Umatullaila Istiqfarin Ummah, Syifa’ul Vinda Novela Pramudya Wafiq Maula Azizah Wahono Widodo Wahono Widodo WASIS Wasis Wasis Wasis Wiwik Wulandari Zahirah Indana Sa’idah Zahrani Purnita Sari