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Evaluation of Definitive Antibiotic Therapy Effectiveness in Sepsis Patients at Tabanan Hospital, Indonesia Luh Rai Maduretno Asvinigita; Ketut Tunas; Ida Ayu Alit Widhiartini; Agata Widatama; Rini Noviyani
Medica Hospitalia : Journal of Clinical Medicine Vol. 12 No. 1 (2025): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v12i1.1210

Abstract

BACKGROUND : The study evaluated the use of definitive antibiotics and examined the association between the causative bacteria, resistance patterns, and antibiotic regimens with clinical outcomes in sepsis. AIMS :  To assess the suitability of definitive antibiotics in sepsis patients at Tabanan Hospital, focusing on the correlation between bacterial type, antibiotics, and resistance profiles with clinical outcomes, aiming to improve sepsis management and reduce antibiotic resistance. METHOD : The observational cross-sectional study analyzed data descriptively to evaluate antibiotic-pathogen compatibility retrospectively. Chi-square tests were used for bivariate analysis of mortality-related variables. Survival analysis employed the Kaplan-Meier method. RESULT : Among 112 sepsis patient records (Jan 2020 - Dec 2022), 62% received antibiotics based on bacterial sensitivity test contradiction to another 38% who were given inappropriately antibiotic. Empiric antibiotic treatment was associated with increased mortality (OR=4.379; CI 95% 1.274-15.052; P=0.022). Bacterial type and resistance status showed no significant association with mortality (OR=0.417; CI 95% 0.030-5.708; P=1.000 and OR=1.500; CI 95% 0.156-14.420; P=1.000, respectively). CONCLUSION : Definitive antibiotic use for sepsis patients at Tabanan Hospital was mostly appropriate, and the empiric antibiotics treatment was associated with mortality, while the causal bacteria and resistance status were not significantly associated with mortality.  Findings highlight the importance of transitioning from empiric to targeted therapy to potentially reduce mortality in sepsis management.
PENGARUH KOMBINASI SODIUM LAURIL SULFAT DAN NATRIUM KLORIDA TERHADAP KARAKTERISTIK SAMPO EKSTRAK LIDAH BUAYA Andriani, Luh Nela; Putra, I Gusti NAWW; Tunas, I Ketut
Jurnal Riset Kefarmasian Indonesia Vol. 4 No. 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.304

Abstract

The shampoo industry in Indonesia is growing. The shampoo formulation contains 2 main ingredients, namely sodium lauryl sulfate (SLS) and sodium chloride (NaCl). One example of natural ingredients in the manufacture of shampoo is Aloe Vera (Aloe vera L.). This study aims to determine the effect of variations in the concentration of SLS and NaCl on the physical and chemical properties of shampoo. This research is an experimental study with 8 formulas. Includes organoleptic test, homogeneity test, viscosity test, foam height test, specific gravity test, and pH test. Making shampoo preparations by weighing all ingredients according to each formulation, leaving the shampoo for 1 day before testing for 4 weeks of storage.The results showed that the organoleptic test and the homogeneity test of NaCl and SLS had no effect on shampoo. In the specific gravity test and the pH test of NaCl and SLS there was no dominant influence on the specific gravity of shampoo. In the foam height test, the SLS coefficient value is higher than NaCl so that SLS dominantly affects the height of the shampoo foam. In the viscosity test the coefficient value of NaCl is higher than SLS so that NaCl dominantly affects the viscosity of the shampoo. The conclusion from this research is that NaCl has a dominant influence on the physical properties, namely viscosity, while SLS has a dominant influence on the physical properties, namely the height of the shampoo foam.
Co-Authors ., Ni Putu Ayu Laksmini Agata Widatama Anak A. A. W. P. Dewi Andriani, Luh Nela Budiana, Nyoman Damayanti, Cokorda Istri Dewa Ayu Agus Sri Laksemi Dewa Ayu Agus Sri Laksmi Dewi Puspita Apsari Dewi, Anak A. A. W. P. Dewi, Ni Ketut Cintya Dhiancinantyan Windydaca Brata Putri Farmani, Putu Ika Karma Gayatri, Ni Kadek Weni Diah I Gusti Kamasan Arijana I Gusti NAWW Putra I Kadek Swastika I Ketut Suwiyoga I Made Sudarmaja I Made Sudarmaja I Nyoman Gede Budiana I Nyoman Mahayasa Adiputra I Nyoman Mangku Karmaya I Putu Darma Wijaya I Putu Prisa Jaya . I Putu Riska Ardinata I. Lesmana Ida Ayu Alit Widhiartini Ida Ayu Dewi Wiryantini Intan Puspa Kurniastuti, A.A. Ayu Komang Indah Luh Nela Andriani Luh Putu Ratna Sundari Luh Rai Maduretno Asvinigita Made Ary Pradnyawati Made Karma Maha Wirajaya Manuaba, I.A. Ratih Wulansari Mulana, Victorinus Alfred Saptiono Mulana, Viktorinus Alfred Saptiono Ni Luh Ariwati Ni Luh Gde Ari Natalia Yudha Ni Luh Putu Eka Diarthini Ni Luh Rustini Ni Luh Rustini Ni Made Linawati Ni Made Sudiari Ni Putu Aryati Suryaningsih Ni Putu Widya Astuti Ni Wayan Mita Arisia Nurwiyanti, . Nyoman Titin Brimantari Nyoman Trisna Aryanata Oktayanti, Leny Prapti Wujani, Ni Luh Gede Puspa, Intan Putra, I Gusti NAWW Putu Ayu Asri Damayanti Putu Ayu Asri Damayanti Putu Ayu Indrayathi Putu Ika Farmani Putu Indah Budi Apsari R. Niruri Rasmaya Niruri Rasmaya Niruri Rasmaya Niruri Rini Noviyani Rini Noviyani Sagun Chandra Yowani Sanjaya, I Putu Maheswara Dharma Septiari, I Gusti Ayu Agung Sri Laksemi, Dewa Ayu Agus Suadnyana, Ida Ayu Astiti Teri, Komang Triastawan, I Komang Agus Viktorinus Alfred Saptiono Mulana Vitalia Fina Carla Rettobjaan Widowati, I Gusti Ayu Rai - Widyani, Ni Made Wimpie I Pangkahila Wintariani, Ni Putu Wirajaya, Karma Maha Yudha, A.A. Ngurah Bagus Arista Yuniantari, Ni Wayan