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All Journal Jurnal Kesehatan Jurnal Sains Teknologi dan Lingkungan (JSTL) Jurnal SOLMA Jambura Journal of Educational Chemistry Jambura Journal of Chemistry Jurnal Mandala Pharmacon Indonesia JURNAL FARMASIMED (JFM) Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Jurnal Kesehatan Madani Medika Jurnal Pengabdian Masyarakat Abdimas Madani Hydrogen: Jurnal Kependidikan Kimia Indonesian Journal of Pharmaceutical Education Jurnal Kolaboratif Sains Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pentagon: Jurnal Matematika dan Ilmu Pengetahuan Alam Damhil: Jurnal Pengabdian kepada Masyarakat Konstanta : Jurnal Matematika dan Ilmu Pengelatuan Alam
Arviani Arviani
Universitas Negeri Gorontalo
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Other

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IDENTIFIKASI TURUNAN ASAM KARBOKSILAT AKAR Acalypha indica SEBAGAI KANDIDAT INHIBITOR GFAT MELALUI LC-HRMS DAN STUDI IN SILICO Arviani; Yuszda K. Salimi; Nurhayati Bialangi; Ahmad Chandra Lakasan; Zifran Nur Rahman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2828

Abstract

Diabetes mellitus remains a major global health challenge, prompting the exploration of natural products as sources of safer antidiabetic agents. This study aimed to identify bioactive compounds from the roots of Acalypha indica and evaluate their potential as inhibitors of glutamine–fructose-6-phosphate amidotransferase (GFAT), an enzyme involved in glucose metabolism. Compound profiling was conducted using liquid chromatography–high resolution mass spectrometry (LC-HRMS), while the inhibitory potential against GFAT was assessed through in silico docking. This integrated approach has not been previously reported. Metabolite profiling using LC-HRMS tentatively identified thirteen carboxylic acid derivatives, including hydroxycinnamic acid, gluconic acid, trans-aconitic acid, and glucoheptonic acid. molecular docking analysis revealed strong binding affinities of several compounds toward GFAT.  Glucoheptonic acid exhibited the lowest binding energy (−8.0 kcal/mol), followed by xylaric acid A (−7.9 kcal/mol) and trans-aconitic acid (−7.5 kcal/mol). These compounds interacted with key active-site residues Gln421, Ser420, Ser422, and Lys675, suggesting a potential enzyme inhibition mechanism. In silico pharmacokinetic analysis indicated that 2-hexylpentanedioic acid exhibited favorable ADME properties, with high gastrointestinal absorption, no major inhibition of CYP450, and low predicted acute toxicity risk. These findings highlight Acalypha indica roots as a promising source of bioactive carboxylic acid derivatives, with glucoheptonic acid emerging as the most promising candidate for further in vitro evaluation as a GFAT inhibitor
Karakterisasi Kitosan dari Cangkang Sotong (Sepia officinalis) dari Pantai Tanjung Kramat Kota Gorontalo: Characterization of Chitosan from Cuttlefish Shells (Sepia officinalis) from Tanjung Kramat Beach, Gorontalo City Stasya Anggriani Talib; Nurhayati Bialangi; Arviani; Yuszda K. Salimi; Deasy Natalia Botutihe
Jurnal Kolaboratif Sains (Special Issue) - Jurnal Kolaboratif Sains (JKS) - Oktober 2025
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v8i10.8866

Abstract

Kitosan, biopolymer kationik alami dari deasetilasi kitin eksoskeleton hewan laut, memiliki sifat biokompatibilitas, biodegradabilitas, dan non-toksisitas yang menarik untuk berbagai aplikasi. Penelitian ini bertujuan untuk mengkarakterisasi kitosan yang diisolasi dari limbah cangkang sotong yang diperoleh dari Pantai Tanjung Kramat, Kota Gorontalo dengan focus rendemen, kadar air, dan analisis Fourier Transform Infrared (FITR). Proses isolasi melibatkan tahap demineralisasi, deproteinasi, dan deasetilasi. Hasil penelitian menunjukkan rendemen kitosan tertinggi 28% pada perlakuan HCl 5%, sedangkan kadar air seluruh sampel berkisar antara 2,00-2,21% dan memenuhi standar SNI 7949:2013 (?12%). Analisis FTIR mengidentifikasi gugus fungsi utama dan derajat deasetilasi (DD) tertinggi mencapai 80,17% pada perlakuan HCl 7%, memenuhi standar mutu (?75%). Penelitian ini memberikan wawasan penting mengenai potensi cangkang sotong sebagai sumber kitosan berkualitas.
Co-Authors Abdullah, Ria Kurniawati Afrilia Ali Ahmad Chandra Lakasan Ahmad Chandra Lakasan Ahmad Kadir Kilo Ahmad, Nur Afni Akram La Kilo Anderson Arnold Aloanis Arsyad , Karlena Astin Lukum Bumulo, Nuraini Daryanti, Edhita Putri Deasy N. Botutihe Deasy Natalia Botutihe Devi Bunga Pagalla Dwi Larasati Dwi Larasati, Dwi Ellaine Nur Danastry Erga Kurniawati Erni Mohamad Ferli Eko Kurniantoro Ferly , Ferli Eko Kurniantoro Frida Maryati Yusuf Haris Munandar Helda Nurfitriana Hendri Iyabu Ishak Isa Jafar La Kilo Julhim S Tangio Karim, Cecy Rahma Kostiawan Sukamto, Kostiawan La Alio La Ode Aman Lubna Hanifah M. Fariez Kurniawan Mardjan Paputungan Maulana Tegar AdityaNugraha Melinda Fitriani Meyrin Hamzah Monik Krisnawati Muhammad Fariez Kurniawan Muksin, Atmal Musa, Weny J.A. Najmah, Najmah Netty Ino Ischak Nita Suleman Nur Silfiah Amin Nurhayati Bialangi Nurul Izza Fersilia Paputungan, Fadilah Alawiya Putri, Luthfi Septianti Artika Rahma Artemisia Rahman, Zifran Nur Ramadhani, Andi Indra Wulan Sari Ramli Utina Roslina Imran Sangkota, Vivi Dia Afrianti Sindy atteri warda Siti Fatimah Stasya Anggriani Talib Suleman Duengo Thayban, Thayban Wenny JA Musa Weny J. A. Musa Wiwin Rewini Kunusa Yuszda K Salimi Yuszda K. Salimi Zifran Nur Rahman