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Journal : JURNAL ILMIAH MAKSITEK

PERBANDINGAN EFEKTIVITAS NEFROPROTEKTOR EKSTRAK JINTAN HITAM (NIGELLA SATIVA) DENGAN EKSTRAK TEMULAWAK (CURCUMA XANTHORRHIZA) TERHADAP GAMBARAN HISTOPATOLOGI GINJAL TIKUS (RATTUS NOVERGICUS) YANG DIINDUKSI PARASETAMOL KARTIKA HANDAYANI; DES SURYANI; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Over-use of paracetamol can cause nephrotoxicity. Black cumin and curcuma contain antioxidants that can ward off freeradicals produced by paracetamol metabolism. To compare the effectiveness of nephroprotector of black cumin extract andcurcuma extract on the histopathological picture of rats induced by paracetamol. True experimental, Post Test Only ControlDesign. 24 rats were divided into 4 groups: negative control standard diet and aquades, positive group paracetamol dose500 mg / kgBB, treatment 1 extract of black cumin extract 500 mg / kgBB, and treatment 2 curcuma extract 500 mg / kgBB.After 30 minutes P1 and P2 were given a dose of paracetamol 500 mg / kg. Rats were dissected for kidney removal andhistopathological preparations were made. Degeneration, necrosis and bleeding of the proximal tubules were assessed byscoring, comparison of scores between groups was assessed by the kruskal wallis test. There were nephroprotector effectsof black cumin and curcuma, with the same effectiveness on kidney damage induced by paracetamol. Black cumin can bedeveloped further as a nephroprotector.
PREVALENSI DAN FAKTOR - FAKTOR YANG TERKAIT DENGAN PERKEMBANGAN KEJADIAN PENYAKIT TUBERKULOSIS MULTIDRUG RESISTANT DI KOTA MEDAN RIFQY IMSYA AL AYYUBI LUBIS; HUMAIRAH MEDINA LIZA LUBIS
JURNAL ILMIAH MAKSITEK Vol 6 No 2 (2021): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Multidrugs resistant tuberculosis is a type of TB bacterial resistance to at least two first-line anti-TB drugs, namely Isoniazidand Rifampin which are the two most effective TB drugs.1 A global total of 186,772 cases of MDR / RR-TB were detectedand known in 2018, up from 160,684 in 2017, 156,071 cases were registered in treatment, up from 139,140 in 2017. Theestimated incidence of drug-resistant TB cases in Indonesia was 24,000 in 2018, but in 2018 only 9180 TB RR patients werefound and only 49% of TB patients were confirmed. RR initiating second-line TB treatment. The aim of this study was tocollect data on the prevalence and factors associated with the development of the incidence of multidrug resistanttuberculosis in the city of Medan. This study was a descriptive analytic study with a cross section design. The researchsample consisted of 28 MDR TB patients at Puskesmas Helvetia and RSUD Pirngadi Medan, which were taken by totalsampling method. This study was tested with the Pearson correlation test. The results of this study showed that the riskfactors for the sample of this study were male gender 15 people (53.6%), mean age above 40 years 21 people (75.0%) 26people (92.9%) married status, 25 people with high school education level (89.3%), 9 self-employed people (32.1%), monthlyincome less than 1,000,000 15 people (53.6%), history of use Previous OAT OAT line 1 (complete) 11 people (39.3%), ahistory of smoking 14 people (50.0%), a history of not consuming alcohol 23 people (82.1%), patient knowledge about MDRTB was less or bad 18 people (53.6%), patient compliance in taking medicine was good 17 people (60.7%), 16 people wereless motivated to take medication (57.1%) and the patient's daily habits were good 14 people (50.0%). The relationshipbetween several risk factors such as previous drug use history with the level of patient adherence to MDR TB, the level ofmedication adherence and motivation to take medication and vice versa. meanwhile, daily habits such as smoking andalcohol consumption had no relationship with previous history of drug use, patient adherence to MDR TB, level of medicationadherence and motivation to take medication.
Co-Authors Afelita, Tia Afif Fadhilah Irsyad Afifah Endah Dwi Purianti Aini, Rahma Ainur Rofiq Ainur Rofiq Aisyah Salsabila Alamsyah, Tegar Alfarisi, Bunail Isna Amanda Farra Assyfah Aminuyati Amira Fazhira Ance Roslina ANNISA . ANNISA FITRI HENDEWI Annisa Rifqa Hestiana Annissa Ambaravista Nasution Anriani, Dwi Arifin, Salsalina Dwi Atika Dwiyanti Atika Rahmi Atmaja, Pramudia Barasa, Neza Farach Addiba Berkah Tania Sawitri Bunail Isna Alfarisi Ceri Permata Ayuni Charisma Yani Roza Cindy, Tiara Safira Cindykia, Assyifa DEA YULIA LUBIS Delyuzar, Delyuzar Des Suryani Des Suryani DEWI AGUSTIN HAKIM HARAHAP Dilma Ayu Khairani DIWA AULIA AHMAD Dwiyanti, Atika Fadillah, Akram Fadlina, Shofiah Dina Fayyaza, Nesya Alya Febryandani, Silvy Claresta Filzah, Rahmah Fitri Nur Malini Frina Aeni Putri Galang Ramadhan Hasanah, Nurul HENDRA SUTYSNA Herian, M. Fauzan Alfatin Hervina, Hervina Hestiana, Annisa Rifqa Hidayatullah, Muhammad Rafli HSB, Fatur M Ahmad Hutabarat, Siti Rahmah IBNU AFIF ARMADI Ilham Hariaji Indyra Mahrani Lubis Irsyad, Afif Fadhilah Islami, M. Dian Isnaini Ulfa Jamilah, Qurratu Kasturi KARTIKA HANDAYANI Kesuma, Ilham Jaya KHAIRATUL FITHRIYAH Khairunisa, Zafira Kirana Arum Indra Laden Laden, Laden LITA SEPTINA Lubita, Mardiyah M. Dian Islami Malini, Fitri Nur MEIZLY ANDINA Muhammad Al Anas Muhammad Farouq Hilmi Harahap Muhammad Fathurridha Arabia Salim Muhammad Rafli Hidayatullah Muhammad Zikri Agung Ramadhan Muhammad Zulfikar Karim Chan Nasution, Annissa Ambaravista Nasution, Reyhan Khaira Helmita Nesya Alya Fayyaza Noviardy, Arya Nurcahaya Sinaga Nurfadly, Nurfadly Oche Axena Yulhan Parinduri, Saskya Nabila Prayoga, M. Iqbal Purwoningsih, Emni Qatrunnada Medina Salim Qatrunnada Medina Salim Rafa Nabila Haifa Rafa Nabila Haifa Rahma Rifda F.S. Lubis Rahmah Filzah Raihana Zavira Ramadhan, Galang Ramadhan, Reza Mukti Ratih Yulistika Utami Riaulina, Nasha RIFQY IMSYA AL AYYUBI LUBIS Rizkitha Martono Putri Rizky Yusfasari Robitah Asfur Salsabila, Aisyah Salsabila, Asya Salsabila, Salsabila Sari, Indah Permata Sembiring, Khairul Rasyid Septiady, Teuku Baihaqi Shaik Hussain, Basrah Bee Binte SITI MIRHALINA Siti Mulyani Sitompul, Asma Dwi Nantika Sri Rezeki Arbaningsih Tania Mulia Utami Tegar Alamsyah Teuku Baihaqi Septiady USWATUL KHOIROT Utami, Tania Mulia Widya Yustika Yulhan, Oche Axena Yusmawati Yusran Yustika, Widya Zavira, Raihana Zulkarnain, Rizki Chairani