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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Search results for , issue "Vol 8 No 1 (2025)" : 12 Documents clear
Hemolisis pada Produk Packed Red Cells dari Pendonor Obesitas Artini, Dyah; Danarsih, Dwi Eni; Purnamaningsih, Nur'Aini
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.55-63

Abstract

Background Obesity may affect the quality of transfused blood while it's being stored in the blood bag, according to studies. Through various pathways, obesity can alter the metabolism of red blood cells, increasing their vulnerability to hemolysis. Obese donors are currently not prohibited from donating blood by the Blood Transfusion Unit's donor selection examination. Therefore, there is still a substantial chance that blood products from obese donors will degrade in quality. The rate of hemolysis of blood components increases in direct proportion to the rise in the donor's body mass index (BMI). By using hemolysis as the primary metric, this study aims to investigate how obesity impacts the storage quality of PRC blood products. Methods The primary objective of this experimental study is to investigate the effect of fat donors on the quality of PRC blood products at the PMI Blood Donor Unit in Sleman Regency. The study included eight donors, divided into two groups: obese and non-obese. 350 cc of blood from each donor was processed into a platelet-rich plasma (PRC) component. The PRC component was subsequently examined hemologically and found to be hemolyzed. The Student T-Test was then used to explore the exam outcomes for each group. Results Both groups' PRC samples' hemolysis values and plasma hemoglobin levels increased during storage. There was an increase in plasma hemoglobin of 0.41 g/dL and a hemolysis value of 0.59% in the blood sample from the obese donor. When compared to the increase in the non-obese group, which was 0.34 g/dL and 0.47%, the value of this increase was higher. The analysis's results showed that there was no statistically significant difference between the sample groups' increase in hemolysis (p value = 0.732). Conclusions The study's findings showed that there is no statistically significant relationship between obesity and hemolysis in PRC products.
Efektifitas Ekstrak Daun Sirsak (Annona muricata L) Dalam Terapi Kanker Payudara Pada Jalur Apoptosis Ramadhani, Nadhira Tsurayya; Maharani, Putri; Wahono, Shafira; Maharani, Tasya Aulia; Adenina, Masayu Syarinta
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.79-86

Abstract

Breast cancer is one of the leading causes of cancer-related mortality in Indonesia. The number of new breast cancer cases has reached 68,858 cases (16.6%) out of a total of 396,914 new cancer cases. Conventional approaches to cancer therapy include surgery, radiation, and chemotherapy. However, these treatments are often expensive and associated with significant side effects. As a result, various preventive and therapeutic efforts have been developed, including the use of herbal plants with potential anticancer properties such as Annona muricata L. Therefore, a more in-depth review of this compound is needed. This article is based on data retrieved from databases such as PubMed, ScienceDirect, ClinicalKey, and Google Scholar using the keywords: “Annona muricata L.”, “breast cancer”, “acetogenin”, “apoptosis”, and “oxidative stress”. Articles in English or Indonesian within the last 10 years were included. The literature review revealed that Annona muricata L. contains active compounds, primarily acetogenins, which exhibit cytotoxic activity through the induction of apoptosis. Acetogenins act by inhibiting mitochondrial complex I (NADH dehydrogenase), resulting in decreased adenosine triphosphate (ATP) production, energy stress, and subsequently, apoptosis induction. In addition, acetogenins affect the intrinsic apoptotic pathway by downregulating anti-apoptotic proteins such as Bcl-2 and Bcl-xL, while upregulating p53 gene expression, which plays a key role in activating the extrinsic apoptosis pathway. Another mechanism is its ability to reduce oxidative stress by enhancing the activity of antioxidant enzymes, thereby protecting normal cells from free radical-induced damage. However, to date, studies of Annona muricata L. as an adjuvant therapy for breast cancer remain limited—especially regarding its long-term use and effects on normal cells. Therefore, Annona muricata L. holds potential as an adjunct therapy in the treatment of breast cancer. Further research is needed to determine the appropriate dosage, long-term effectiveness, and potential side effects, particularly in breast cancer patients.
Perbedaan Fungsi Sistolik Ventrikel Kanan antara Hipertensi Arteri Pulmonal dan Hipertensi Vena Pulmonal Rayhansyah, Vito; Yanni, Mefri; Irramah, Miftah; Hamdani, Rita; Revilla, Gusti; Linosefa, Linosefa
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.14-25

Abstract

Background Pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) are both associated with increased right ventricular (RV) afterload, potentially leading to RV systolic dysfunction. Despite its prognostic value in predicting right heart failure (RHF), echocardiographic evaluation of RV function remains underutilized in the routine assessment of patients with PAH and PVH. Methods This study aims to evaluate differences in RV systolic function between PAH and PVH patients. A total of 116 patients (58 PAH and 58 PVH) were selected through consecutive sampling from medical records at RSUP Dr. M. Djamil Padang. Echocardiographic parameters were analyzed using appropriate statistical tests based on data distribution and type, including Chi-square, Fisher’s exact, and Mann-Whitney U tests. Results Significant differences were observed between PAH and PVH groups in terms of tricuspid regurgitation (TR) severity (p = 0.003), tricuspid annular plane systolic excursion (TAPSE) (p = 0.013), and tissue Doppler-derived systolic velocity of the tricuspid annulus (S′) (p = 0.001). No significant differences were found in ejection fraction (EF), systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP), or TR velocity (TR Vmax). Overall, RV systolic function differed significantly between the PAH and PVH groups (p = 0.006). Conclusions The findings demonstrate a statistically significant difference in RV systolic function between patients with PAH and PVH. These results underscore the need for more comprehensive and routine echocardiographic evaluation of RV function in these populations to enhance risk stratification and management.
Perbandingan Hasil Biometri dan Tajam Penglihatan pada Katarak Anak, Sebelum dan Sesudah Operasi Katarak Uirianto, Meiliana Angeline; Umboh, Anne; Rares, Laya; Witjaksana, Riani
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.45-54

Abstract

Background Lens disorders in pediatrics include cataracts and abnormalities in the shape, size, and location of the lens. These abnormalities are a significant source of visual impairment in children. Cataracts are responsible for nearly 10% of all childhood vision loss worldwide. Cataracts in children cause over one million cases of Blindness among Asian children. The purpose of this study is to analyze the differences in axial length (AL)—corneal curvature, and best-corrected visual acuity (BCVA) before and after surgery in pediatric cataract eyes. Methods This study used a comparative experimental analytical research design with a Pretest-Posttest on a single group without control, utilizing ocular biometry instruments and BCVA examination in pediatric cataract eyes before and after surgery. Results The BCVA and AL in 8 children showed significant differences. The average BCVA with logMAR decreased from 1.98 to 1.36 one month after surgery, with a paired t-test yielding a t-value of 2.595 and p-value of 0.018 < 0.05. Moreover, the initial BCVA average of 1.98 improved to 0.79 three months after surgery, with a t-value of 5.574 and a p-value of 0.001 (< 0.05). As for the AL, it increased from 22.21 mm to 22.57 mm one month after surgery, with a t-value of -2.475 and p-value of 0.021 < 0.05. Furthermore, the initial AL average of 22.21 mm increased to 22.75 mm three months after surgery, with a t-value of -4.375 and p-value of 0.003 < 0.05. Conclusions There were significant differences in BCVA and AL in the sample before pediatric cataract surgery, as well as one and three months after the surgery.
Pengaruh Latihan Keseimbangan Terhadap Keseimbangan Postural pada Lansia Widiyanta, Fauzyah Azzahra; Sidarta, Nuryani
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.6-13

Abstract

Background The elderly have a higher potential for injury due to reduced body stability. In Indonesia, the incidence of elderly falls is 12.9%. Factors contributing to the increased risk of falls include biological changes such as aging and sedentary lifestyle habits. Balance training is one form of exercise that is considered effective in improving postural stability in the elderly. However, the success of this exercise is highly dependent on the duration of its application. Therefore, in this study, we aimed to evaluate the effect of balance training on postural stability with a two-week training program. Methods This study used a quasi-experimental design involving 25 elderly individuals aged more than 60 years. Consecutive non-random sampling technique was applied in the selection of participants. The balance training program was implemented three times per week for a period of two weeks. The exercise protocol was based on the guidelines released by the American College of Sports Medicine (ACSM). To assess postural stability, the Timed Up and Go Test instrument was used, which was administered before and after the exercise program. Data analysis was performed using the Wilcoxon test method with a significance limit of p<0.05. Results The findings of this study indicated that the elderly group over 70 years old dominated the study participants, with the proportion of women at 56% and men at 44%. The results of the postural balance evaluation revealed that 64% of the subjects showed a low level of balance, especially in the elderly over 70 years old with female gender. Bivariate analysis gave a p value = 0.00, indicating a significant effect of a balance training program performed three times a week with an interval of days for two consecutive weeks on improving postural stability in the elderly. Conclusions Balance training 3 times a week with alternate days for 2 consecutive weeks has an effect on improving postural balance in the elderly.
Hubungan Antropometri dengan Sindrom Metabolik pada Pekerja Kantor di Universitas Trisakti: Studi Potong Lintang Trilaksmi, Antin; Nazma, Diani; Soesilo, Christian; Sari, Meiriani; Mahardieni, Karlina; Panduwati, Lira
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.26-34

Abstract

Background Metabolic syndrome is a disease with an increasing prevalence and a high health burden. Most individuals with metabolic syndrome have a sedentary lifestyle, such as office workers who rarely undergo health check-ups. Therefore, this study aims to investigate the profile and correlation of anthropometric indices and metabolic syndrome parameters among office workers at Trisakti University. Methods Office workers from the Faculty of Medicine, Trisakti University, were recruited for this study, and informed consent was obtained. Subsequently, data on blood pressure, laboratory tests including glucose levels and lipid profiles, as well as anthropometric measurements such as weight, height, body mass index (BMI), waist circumference, and hip circumference were collected. The data were statistically analyzed using univariate analysis and bivariate correlation analysis with Spearman's test, as well as intergroup difference tests using the Kruskal-Wallis test and ANOVA. Results The average age of the subjects was 41.46±9.87 years. The data showed that approximately 43.33% had hypertension, with a concentration of data in the profiles of grade I obesity, normotension, normal triglyceride levels, normal blood glucose levels, and normal high-density lipoprotein (HDL) levels. The analysis revealed a significant difference in HDL levels between the normal BMI group and the overweight BMI group (MD: 9.534; 95% CI: 1.68-17.39; p = 0.018). A very weak and non-significant correlation was found between BMI and metabolic syndrome parameters. Conclusions Anthropometric indices reflect central obesity as well as the characteristics of metabolic syndrome among employees at the Faculty of Medicine, Trisakti University.
Keefektifan Injeksi Toksin Botulinum Tipe A (BTX-A) untuk Terapi Neuralgia Pasca Herpes: Sebuah Tinjauan Pustaka Wijaya, Edward; Winaya, Ketut Kwartantaya; Utami, Desak Nyoman Trisepti
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.87-97

Abstract

Postherpetic neuralgia (PHN) is a common and debilitating complication of shingles, characterized by persistent pain that lasts for months to years after the resolution of the herpes zoster rash. While various treatments, such as anticonvulsants and opioids, are commonly used, they often fail to provide adequate pain relief and are associated with significant side effects. Botulinum toxin type A (BTX-A), traditionally used for muscle spasticity, has emerged as a promising treatment for PHN due to its ability to reduce pain through its neurotoxic effects. This literature review evaluates the safety and efficacy of BTX-A in treating PHN by reviewing 30 studies sourced from databases such as PubMed, Medline, and PubMed Central. The results indicate that BTX-A injections significantly alleviate PHN-associated pain, with many patients experiencing a reduction of up to 70% in pain severity. Additionally, BTX-A has been shown to improve patients' quality of life by enhancing sleep quality and reducing the need for oral medications. Although the results are promising, the review calls for further research to determine optimal dosing protocols and the long-term effects of BTX-A. Despite its limitations, BTX-A presents a potential therapeutic option for managing PHN, particularly for patients who do not respond well to traditional treatments.
Definisi Ketidakstabilan Mikrosatelit pada Kanker: apa yang harus diketahui Abdallah, Mays Talib; Al-Shakarchi, Ola E; Hussein, Asmaa A; Abdulmuttaleb, Mohammed Essam; Alsammarraie, Ahmed Zuhair; Aziz, Ismail H; Dawood, Noor Jabbar; Kadhom, Mohammed
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.98-110

Abstract

Microsatellite instability (MSI) is the result of flaws in the DNA mismatch repair (MMR) system that cause insertions or deletions in repetitive DNA sequences known as microsatellites. A hallmark of Lynch syndrome, MSI affects 8–22% of sporadic cancers, including colorectal, gastric, and endometrial carcinomas. Clinically, MSI predicts immune checkpoint inhibitor (ICI) treatment; MSI-high (MSI-H) tumors show better response rates than others. Treatment results, prognosis, and chemotherapy sensitivity among MSI-H patients show notable variation, though.  Next-generation sequencing (NGS), which concurrently evaluates tumor mutational burden (TMB) and actionable mutations, immunohistochemistry (IHC) for MMR protein loss, and PCR-based fragment analysis, defines MSI detection. Although IHC is affordable for Lynch screening, NGS provides more extensive genomic profiling. Though they need verification, new technologies such as artificial intelligence-based histomorphological analysis and single-molecule molecular inversion probes (smMIPs) are encouraging. The prognostic effect of MSI differs by cancer kind and stage. MSI-H in early-stage colorectal cancer (CRC) is linked to better survival, but less advantage from 5-fluorouracil chemotherapy. Confounding variables like BRAF mutations cloud the prognostic function in metastatic CRC. Apart from CRC, MSI-H forecasts good results in prostate, gastric, and ovarian cancers but a bad prognosis in breast cancer. Emphasizing its dual function as a diagnostic, prognostic, and therapeutic biomarker, this paper combines MSI's molecular mechanisms, detection techniques, and clinical relevance. Among the difficulties are test standardization and immunotherapy response heterogeneity resolution. Future studies should look at liquid biopsies and combination treatments to maximize precision cancer driven by MSI.
Studi Banding in-vitro terakit Efikasi Antelmintik Ekstrak Daun Pegagan (Centella asiatica) dan Daun Putri Malu (Mimosa pudica) terhadap Cacing Ascaris suum Cliffton, Cliffton; Situmorang, Evi Ulina Margareta; Dewi, Rita; Joprang, Freggy Spicano
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.35-44

Abstract

Background Nematode infections result in 60.000 deaths each year. The majority of these infections are dominated by Ascaris Lumbricoides, which is asymptomatic and is currently treated with albendazole. However, prolonged use increases the risk of drug resistance. Research on herbal anthelmintics is very much needed. Herbs like C. asiatica and M. pudica (a wild tropical plant), have proven to possess antiparasitic properties due to their anthelmintic content. Methods This research used in-vitro experiments to compare the effectiveness of M. pudica and C. asiatica herbal extracts and their concentrations on the death time of A. suum worms. Herbal extracts were obtained through remaceration techniques, and each herb was made in concentrations of 10%, 20%, and 50%. Each experimental group was given 5 A. suum worms, which were observed every hour for 24 hours. Results A total of 53.3%, 86.6%, and 93.3% of the worms died in the C. asiatica group using 10%, 20%, and 50% concentration. Meanwhile,  60%, 73.3%, and 100% of the worms died in the M. pudica group using the same concentrations. By using two-way anova to compare the effectiveness of each concentration and also to compare the two plants, it could be concluded that there was no significant difference between C. asiatica and M. pudica either in their respective concentrations (p=0.0588) or between herbs (p=0.1670). The post-hoc test carried out also showed that there was no difference in the lethal effect of the two extracts. Conclusions Both extracts exhibited similar anthelmintic effects (p > 0.05), with LC50 of 8.91% for C. asiatica and 9.33% for M. pudica.
Efektivitas Pemberian Probiotik Bifidobacterium longum Terhadap Pertumbuhan Pseudomonas aeruginosa Pada Mencit (Mus musculus) Adrian, Adrian; Wiriansya, Edward Pandu; Ikram, Dzul; Muchtar, Amrizal; Anshary, Suci Noviyanah; Karim, Marzelina; Fazdlurrahman, Fazdlurrahman; Ahmad, Izhar Fitrah; Faisal, M. Fathir; Usman, Muh. Muflih; Ilham, Muhammad
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.64-72

Abstract

Background Pseudomonas aeruginosa is an opportunistic, Gram-negative bacterium that can cause infections both acutely and chronically. Antibiotics are essential for treating acute bacterial infections. The use of probiotics is one effort to reduce the number of resistant antibiotics. One of the probiotics derived from microorganisms is Bifidobacterium longum. This study was conducted to determine the effectiveness of Bifidobacterium longum on the growth of Pseudomonas aeruginosa in mice (Mus musculus). Methods This study was conducted using the True Experimental Post-test method. The population used was 3- to 4-month-old mice, with a body weight of 20 to 40 grams, as determined by the Federer formula. The mice were fed standard food and given sterile distilled water. A total of 30 mice were tested and divided into five treatment groups. The test carried out is a test of the distribution of the number of colonies. Results Of the five groups studied, the administration of Bifidobacterium longum combined with the antibiotic ceftriaxone in the probiotic intervention group yielded an effective result (p < 0.05), as did the group that received only Bifidobacterium longum probiotics (p < 0.05). at the same time, the other group did not show an effective result (p >0.05). Conclusions Based on the study, it was explained that the administration of Bifidobacterium longum was effective as a supportive and curative group, but not as a preventive measure against the growth of Pseudomonas aeruginosa in mice.

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