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Hanif Amrulloh
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Journal of Multidisciplinary Applied Natural Science
Published by Pandawa Institute
ISSN : -     EISSN : 27743047     DOI : 10.47352/jmans
Core Subject : Science, Education, Agriculture, Social, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Physics
Journal of Multidisciplinary Applied Natural Science (abbreviated as J. Multidiscip. Appl. Nat. Sci.) is a double-blind peer-reviewed journal for multidisciplinary research activity on natural sciences and their application on daily life. This journal aims to make significant contributions to applied research and knowledge across the globe through the publication of original, high-quality research articles in the following fields: 1) biology and environmental science 2) chemistry and material sciences 3) physical sciences and 4) mathematical sciences. The J. Multidiscip. Appl. Nat. Sci. is an open-access journal containing original research articles, review articles, and short communications in the areas related to applied natural science. The J. Multidiscip. Appl. Nat. Sci. publishes 2 issues in a year on January (first issue) and July (second issue). This journal has adopted a double-blind reviewing policy whereby both the referees and author(s) remain anonymous throughout the process.
Arjuna Subject : Umum - Umum
Articles 25 Documents
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Search results for , issue "Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science" : 25 Documents clear
Application of Photoacoustic Spectroscopy for Glucose Level Measurement: A Literature Review Pratama, Buky Wahyu; Widyaningrum, Rini; Setiawan, Andreas; Mitrayana, Mitrayana
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.260

Abstract

This study addresses the critical need for effective glucose level measurement in managing diabetes mellitus (DM). DM is a serious, economically influential disease that has no cure at present, highlighting the magnitude of prevention, control, and monitoring of blood glucose levels. This study systematically examined 79 articles from Google Scholar and PubMed databases, focusing on non-invasive glucose measurement using the photoacoustic system. After eliminating duplicates, 27 articles were reviewed. Glucose solution was predominantly used as the primary sample. Fixed and tunable lasers, especially near-infrared (NIR) lasers, were highlighted due to their superior penetration and accuracy in glucose measurements. Signal-purification techniques were used to guarantee accurate detection by removing noise. The evaluation involved regression analysis and machine learning integration to determine glucose levels statistically. The choice of sampling sites in volunteers was a critical factor affecting measurement accuracy. The study demonstrated meaningful progress in the development of photoacoustic methods, particularly in monitoring DM.
Modification of the QuEChERS Method for Drug Analysis in Biological Sample: A Review Rivai, Sitty Nurqomariah; Kristianto, Sonny; Putri, Rury Eryna; Fatiqin, Awalul; Abidin, Mohamad Hamdi Zainal
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.261

Abstract

Drug analysis in biological samples remains a significant challenge due to the complex matrix composition that can interfere with extraction and detection processes. The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method, initially developed for pesticide residue analysis, has been increasingly adapted for forensic toxicology, particularly in drug extraction from biological matrices. This review explores various modifications of the QuEChERS method applied to blood, urine, and liver samples, focusing on the effectiveness of different solvents, buffer salts, and sorbents in enhancing extraction efficiency. Furthermore, it highlights current challenges such as matrix effects and the critical importance of method validation to ensure reliability and reproducibility. By analyzing recent developments and trends in QuEChERS applications, this review offers valuable insights into optimizing extraction protocols for forensic purposes. The findings aim to support the advancement of more efficient, robust, and accessible analytical techniques in forensic toxicology, ultimately contributing to more accurate and reliable drug detection in complex biological samples.
In Vitro Anti-Acne Activity and Bioactive Compound Analysis of Sargassum cristaefolium Ethanolic Extract from Teluk Awur Jepara Kristiani, Theresia Adven Dea; Husni, Amir; Isnansetyo, Alim
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.262

Abstract

Acne is a prevalent skin disorder, particularly among adolescents, causing significant physical and psychological impacts. Ongoing efforts are dedicated to acne treatment by developing therapeutic agents with enhanced effectiveness while minimizing side effects. In this study, we aimed to assess the potential of Sargassum cristaefolium sourced from Teluk Awur Jepara, extracted using ethanol, in combating acne through its in vitro antibacterial and antioxidant attributes. Utilizing the disk diffusion method, our findings demonstrated the extract's efficacy against Cutibacterium acne, Staphylococcus epidermidis, and Staphylococcus aureus. The minimum inhibitory concentration and minimum bactericidal concentration were determined to be 50 and >100 mg mL-1 against C. acnes, 25 and 100 mg mL-1 against S. epidermidis, and 25 and 100 mg mL-1 against S. aureus, respectively. Additionally, bacteriolytic assays confirmed the extract's ability to partially lyse bacterial cells, particularly S. aureus and S. epidermidis at 2× MIC, while C. acne exhibited partial lysis until the 6th hour, followed by an increase in absorbance, possibly due to cellular debris aggregation or bacterial persistence due to incomplete lysis. Furthermore, the extract exhibited notable free radical scavenging properties against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), with IC50 values of 645.35 ± 9.52 and 574 ± 33.52 µg mL-1, respectively. The S. cristaefolium ethanol extract exhibited a total phenol content of 14.17 ± 0.39 mg GAE g-1 and a sulfate content of 10.99 ± 0.45%. Liquid chromatography-mass spectrometry (LC-MS) analysis identified bioactive compounds, including carotenoids, terpenoids, steroids, flavonoids, chromenols, and fatty acids, all of which demonstrate substantial potential as antioxidants and antibacterial agents against acne-causing bacteria. Therefore, ethanolic extract of S. cristaefolium demonstrates potential as an anti-acne treatment due to its antibacterial and antioxidant properties.
Molecular Phylogeny of rDNA-ITS on Native Dendrobium in Lampung Mahfut, Mahfut; Syarif, Admi; Wahyuningsih, Sri
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.263

Abstract

Dendrobium, a flagship collection of the Liwa Botanical Garden, is an endemic flora of the Southern Sumatra that requires preservation. One of the challenges in its conservation and potential development is the molecular identification. This molecular identification utilizes DNA barcoding with the rDNA-ITS marker as a practical, rapid, accurate, effective, and efficient alternative, complementing previous species-level identification results based on morphological characteristics. Amplification results from 5 selected samples showed specific bands measuring 300 bp. Sequence data analysis using BioEdit and MEGA V.11.0.11 software with 1000 bootstraps grouped all accessions into the same main cluster with a similarity range of 94–100%. Phylogenetic analysis revealed that accession D2 is similar to D. signatum from Japan (AB593662.1), and accession D3 to D. densiflorum (HQ114255), D4 to D. nobile (LC011413.1), accession D6 to D. trigonopus (KF143730.1), and accession D12 to D. faciferum (LC192955.1) from China. The results of this study will enrich the taxonomic and phylogenetic data of Dendrobium, which is essential for conservation and serves as a foundation for its development as a medicinal herbal plant.
Optimizing Cork Oak (Quercus suber) Acorn Growth and Survival: Influence of Harvest Timing and Nursery Conditions in Morocco Mabrouk, Achraf; Souileh, Ayoub; Oubrahim, Hayat; Magri, Najib; El Antry, Salwa; Abidi, Fatima; Zekhnini, Oussama; Abbas, Younes; Ouajdi, Mohamed
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.264

Abstract

Cork oak (Quercus suber) forests are vital for maintaining ecological balance and supporting socio-economic stability in Morocco. However, these forests face significant degradation driven by climate change, human activities, and inadequate regeneration practices. A critical factor influencing successful cork oak regeneration is the timing of acorn harvesting, which directly impacts germination rates and seedling quality. This study aimed to determine the optimal acorn harvesting periods to maximize germination and produce robust seedlings suitable for nursery and field planting. Conducted at the Center for Innovation, Research and Training under the National Agency for Water and Forests, the research involved collecting acorns from the Maâmora forest across six harvesting periods: August, September, early-October, mid-October, November, and December. The methodology included acorn sorting, phytosanitary treatments, and standardized nursery substrate preparation. Key parameters such as germination rate, seedling height, collar diameter, survival rate, and root system development were systematically monitored. Results indicated that acorns harvested in mid-October and November yielded the highest germination rates (86% and 85%, respectively), superior seedling growth (average heights of 21.40 cm and 10.09 cm), and better survival rates (95% and 75%). In contrast, acorns harvested in August showed the lowest germination (50%) and reduced seedling vigor, reflecting the detrimental effect of immature acorns. Early harvests in August and September corresponded with slower growth and lower survival. The findings underscore the critical influence of harvest timing on cork oak regeneration success. Acorns collected during mid-October and November demonstrated faster germination, enhanced seedling vigor, and robust root development. The study recommends focusing on these optimal harvesting windows, combined with proper storage and nursery management, to improve reforestation efforts and support the sustainable restoration of Morocco’s cork oak ecosystems.
Bioremediation of Profenofos-Contaminated Soil using Bio-Slurry, Exogenous, and Indigenous Microorganism Formulation from Puntukdoro Farmland, Indonesia Pujiati, Pujiati; Sholikhah, Oktaviariesta Habibatus; Utami, Sri; Fatimah, Fatimah; Ramadhan, Rico; Ni'matuzahroh, Ni'matuzahroh
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.265

Abstract

Pesticide residues in soil present significant environmental and health risks, especially in regions with heavy organophosphate used in vegetable farming. This study examines bioaugmentation, an eco-friendly method for degrading soil pesticide residues, utilizing both indigenous and exogenous microorganisms, as well as bio-slurry from biogas production. Puntukdoro Village, Magetan, Indonesia, generates a substantial quantity of bio-slurry waste, which presents a promising solution to local agricultural challenges, including low crop yields and soil degradation. Puntukdoro Village produces a significant amount of bio-slurry waste, which offers a promising solution to local agricultural issues, including poor crop yield and soil degradation. The study aims to identify and formulate microorganisms from Puntukdoro using bio-slurry and exogenous cellulolytic mold formulations. This involves extracting and characterizing indigenous bacteria, preparing external supplements, and conducting ex situ bioaugmentation with seven different treatments. Ten mold isolates, including Penicillium, Monilia, Aspergillus, and Trichoderma, and eight bacterial isolates, including Micrococcus, Pseudomonas, and Bacillus, were identified. Bioremediation assays showed that both indigenous and exogenous microorganisms improved soil quality and reduced pesticide levels. The most effective treatment, P7, with 10% bio-slurry, 10% biofostik, and 10% indigenous microorganisms applied for 28 d (W4), reduced profenofos from 4.718 to 0.000 mg/kg. In contrast, treatment P2W1, with 30% biofostik for 7 d, reduced profenofos by 0.293 mg/kg. These findings indicate that exogenous and indigenous microorganisms can effectively enhance profenofos bioremediation.
Global Perspectives on Environmental Microbiome Research: Current Status and Future Directions Putri, Wahyu Aristyaning; Subiastuti, Aprilia Sufi; Wulandari, Cahyo; Rachman, Mifta Pratiwi; Sebastian, Alfino; Siregar, Abdul Rahman; Himawan, Tyas Ikhsan; Priyono, Dwi Sendi; Sofyana, Neng Tanty; Purwestri, Yekti Asih; Nugrahapraja, Husna; Wibowo, Anjar Tri
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.266

Abstract

The environmental microbiome plays an important role in various ecosystems around the world, influencing nutrient cycling, disease dynamics and ecosystem stability. This bibliometric analysis provides a comprehensive overview of the current state and future directions of environmental microbiome research from a global perspective from 2009–2024. Through systematic examination of Scopus publications, 2154 documents were found. The results show a significant increase in the number of publications since 2017 and a peak in 2024. The most cited document was "The hidden world within plants: Ecological and evolutionary considerations for defining functioning of microbial endophytes" with 1887 citations and “Structure and function of the global ocean microbiome” with 1843 citations. The most productive countries in environmental microbiome research are the United States (n = 748), China (n = 533), India (n = 308), Germany (n = 172) and the United Kingdom (n = 157). Microbiome, microbial community, microfolora, microbiota, microbiology, bacteria, and bacterium are the most popular topics that will continue to develop in the future. Although the United States has published the highest total number of papers, more recent studies have predominantly been published from China, indicating shift in the centre of study from the United States to China. Insights gained from this analysis contribute to a deeper understanding of the environmental microbiome research landscape, guiding future research priorities and collaborations in the field.
Enhancing Electrical Characteristics in a High-Power Seawater Battery: Solutions with Acid Zinc Anolyte and Alumina-Carbon-Cement Separator Pauzi, Gurum Ahmad; Surtono, Arif; Suciyati, Sri Wahyu; Syafriadi, Syafriadi; Samosir, Ahmad Saudi; Sulistiyanti, Sri Ratna; Simanjuntak, Wasinton
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.267

Abstract

The potential of seawater as a source of galvanic cell energy has not been fully realized due to significant challenges, particularly anode degradation in single-compartment high-power seawater batteries. This study addresses these limitations by introducing a novel two-compartment system, utilizing an acid zinc anolyte and an alumina-carbon-cement separator designed to enhance both the electrical performance and longevity of the battery. Experimental results demonstrate a remarkable increase in current output (97.81 times) and a substantial boost in power (5.25 times) compared to conventional single-compartment cells. Furthermore, the internal resistance of the system is reduced by 95.7%, indicating improved energy transfer efficiency. The use of the alumina-carbon-cement separator effectively mitigates anode corrosion, a common issue that limits the operational lifespan and reliability of seawater batteries. These findings suggest that the proposed two-compartment configuration not only overcomes critical technical barriers but also offers a promising and sustainable alternative for renewable energy generation from seawater. The enhanced performance and durability of this system highlight its potential for practical applications in marine and coastal energy harvesting, contributing to the advancement of clean energy technologies.
Investigation of Potential Molecular Targets of Zanthoxylum acanthopodium in Ovarian Cancer Using Network Pharmacology Assessments Wijaya, Johanna Fransiska; Chiuman, Linda; Syahputra, Hariyadi Dharmawan; Kaban, Vera Estefania; Razoki, Razoki; Ginting, Chrismis Novalinda; Iksen, Iksen
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.268

Abstract

Ovarian cancer is a serious disease that affects the ovaries, and its early detection is challenging due to vague symptoms often dismissed as minor ailments. Currently, natural sources have gained attention for their potential role in anticancer treatment. This study aimed to utilize network pharmacology to explore the potential targets and mechanisms of Zanthoxylum acanthopodium in the treatment of ovarian cancer. This study utilized the KNApSAcK and Swiss Target Prediction to identify active compounds and target genes. Additionally, ovarian cancer-specific target genes were sourced from the GEO database. To identify possible key target genes, the network interaction between protein-protein using the STRING database and visualized them in Cytoscape. Subsequent analysis using Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enabled us to focus on primary therapeutic targets. Our investigation into Zanthoxylum acanthopodium revealed 10 active compounds that pass Lipinski rule of five and oral bioavailability with acceptable pharmacokinetic profiles, 88 therapeutic targets, and identified 5 hub genes: SRC, CCNB2, MMP9, PTGS2, and PTPRC, which are strongly associated with ovarian cancer progression. Pathway enrichment analysis highlighted several pathways significantly related to the pathogenesis of ovarian cancer. This study elucidates the therapeutic potential and mechanisms of action of Z. acanthopodium as a promising candidate for ovarian cancer treatment. However, further research, including both in vitro and in vivo studies, is necessary to understand its molecular mechanisms comprehensively.
Monte Carlo Mathematical Model Simulation: An Evaluation of The Probability of Construction Project Acceleration Pratama R, Alfandi Rizki; Djakfar, Ludfi; Negara, Kartika Puspa
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 2 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.269

Abstract

Complex projects such as road infrastructure require reliability and risk analysis for safety and economic sustainability. This study divides the concept of comprehensive risk identification into several variables with several indicators. Indicators refer to findings that occur in the field during acceleration. The simulation was conducted with the help of the @Risk program in Microsoft Excel using standard settings, and the distribution used was triangular. The population in this study is all project stakeholders related to determining the implementation time of the Djuanda FO construction, which is currently underway in the 46th week. The population consisted of 22 experts who were involved in scheduling the FO Djuanda construction project. Since the population size is limited in the study, all population members were sampled. The sampling technique is census or saturated sampling, in which all population members are used as samples. The respondents asked to complete a questionnaire and answer questions about implementing the FO Djuanda development project. Sampling is limited to top management with expertise in decision-making to determine the duration of project implementation in scheduling. This study obtained interval data, with interval data in the form of a Likert scale (scale 1–5). Based on the research results, risk evaluation can be adopted well through Monte Carlo mathematical model simulation. The risks in the acceleration of the FO Djuanda development project, based on the order of risk levels from the largest to the smallest, are direct costs, work calendar schedule, logistics, external, field constraints, health and safety, indirect costs, community relations, environment, construction contracts, traffic, and construction.

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