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INDONESIA
Indonesian Journal of Biomedicine and Clinical Sciences
Published by Universitas Gadjah Mada
ISSN : -     EISSN : 30323134     DOI : https://doi.org/10.22146/inajbcs.v56i01.11961
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience
Indonesian Journal of Biomedicine and Clinical Sciences (InaJBCS) aims to promote the translational of basic research into clinical studies and of clinical evidence into practice. InaJBCS publishes studies that substantially enhance our standing of disease etiology and physiology; the development of prognostic and diagnostic technologies; trials that test the efficacy of specific interventions and those that compare different treatments. InaJBCS invites authors to submit articles in the fields of biomedical sciences including biomedical genetics, bioinformatics, cardiovascular medicine, endocrinology, gastroenterology, geriatrics, infectious diseases, medical oncology, physiology, pharmacology and toxicology, and phytomedicine medicine.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 105 Documents
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A rare case of syringocystadenoma papilliferum: clinical and histopathological insights Andayani, Raden Roro Rini; Pudjiati, Satiti Retno; Harsono, Erliana Tantri; Rizkiani, Dwinanda Almira; Hanggoro Tri Rinonce; Rita Cempaka; Indra Wahono; Siti Isya Wahdini; Dyah Ayu Mira Oktarina
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17146

Abstract

Syringocystadenoma papilliferum (SCAP) is a rare benign adnexal neoplasm originating from apocrine or eccrine sweat glands, first reported by Stokes in 1917. Clinically, SCAP manifests in various forms such as nodules, plaques, or warts, predominantly affecting the scalp in adolescents or children. Histopathologically, it is characterized by papillary and ductal invaginations lined with a two-layered epithelium. This condition can be present at birth or emerge during puberty. We present a 19-year-old female with a congenital, pinkish-brown, wart-like lesion on her scalp that progressively enlarged and spread to the face. Physical examination revealed a verrucous plaque with central erosion, extending from the temporal scalp to the lateral face. Dermoscopy showed papillary structures with defined lesion borders, while histopathological findings confirmed SCAP. The patient underwent surgical excision, and no new lesions were detected during a 3 mo follow-up. Syringocystadenoma papilliferum is often confused with other neoplasms such as sebaceous nevus or verruca vulgaris, but its definitive diagnosis relies on histopathology. The tumor’s characteristic features include cystic invaginations into the dermis with a two-layered epithelium, differentiating it from other conditions. Surgical excision remains the treatment of choice to prevent potential malignant transformation and improve cosmetic outcomes. Syringocystadenoma papilliferum, though rare, can be effectively managed through timely diagnosis and surgical excision. In this case, the patient’s postoperative outcome was favorable, with no recurrence of the lesion. Histopathological evaluation is crucial for accurate diagnosis and guiding treatment strategies.
Histopathology as a key to identify Sezary syndrome in patient with clinical erythroderma Diovani, Sonia; Irianiwati; Febriana, Sri Awalia; Waskito, Fajar; Rizkiani, Dwinanda Almira; Andayani, Raden Roro Rini; Rifko, Ani
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.17293

Abstract

Sezary syndrome (SS) is a rare and aggressive variant of cutaneous T-cell lymphoma (CTCL), characterized by clonal proliferation of malignant T lymphocytes with skin erythroderma. The incidence of CTCL in the United States from 2000 to 2010 reached 10 cases per million people per year, accounts for only 3% of all cases of cutaneous lymphoma. In Indonesia, lymphoma ranks sixth in terms of malignancies, alongside Hodgkin lymphoma and leukemia. We reported a case of 56 y.o. woman presented with blistering lesions that turned into wounds all over her body. Skin biopsy examination revealed characteristic histopathological features, including basket weave-type orthokeratosis, focal parakeratosis, focal acanthosis, and epidermotropism of atypical lymphoid cells with cerebriform nuclei (Sezary cells). Immunohistochemical examination using CD3, CD4, and CD8 showed positive staining in the membrane and cytoplasm of tumor cells within the dermis and epidermis. Sezary syndrome is characterized by clonal expansion of T-helper memory cells in the skin. Histopathology and immunohistochemistry could not differentiate SS from mycosis fungoides. However, histopathological examination could distinguish SS from other differential diagnoses. The diagnosis of SS can be established based on the triad of 1) generalized exfoliative dermatitis involving more than 80% of the body surface area, 2) lymphadenopathy, and 3) the presence of 5% or more malignant T-cells with cerebriform nuclei (Sezary or Lutzner cells) in peripheral blood lymphocytes. In conclusion, we present a case of SS, diagnosed based on the patient's history, physical examination, peripheral blood examination, histopathology, and immunohistochemistry.
The clinical outcomes and quality of life in patients with Guillain- Barré syndrome: a literature review Rosa De Lima Renita Sanyasi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.19134

Abstract

Guillain-Barre syndrome (GBS) is an immune-mediated condition that targets the roots of the spinal cord and peripheral nerves. While most patients with GBS can achieve complete recovery with appropriate management, some may experience long-term sequelae that adversely impact their quality of life (QoL). Clinical outcomes are measured variables in research to evaluate the effects of interventions or exposures on a particular population’s health. Patients with GBS may experience suboptimal clinical outcomes due to post-GBS disabilities, which may result from complications or residual symptoms of the syndrome. These disabilities can impede daily functioning and significantly lower QoL, often requiring patients to alter their lifestyles, work, and social interactions. Quality of life is a subjective assessment of how individuals perceive their circumstances in relation to their goals, influenced by their cultural and value systems. Various tools are available to assess the quality of life for GBS patients. The clinical outcomes and QoL for post-GBS patients are diverse and shapedby various factors. Through the early identification of these factors, clinicians can enhance management strategies to improve both clinical outcomes and the overall QoL for individuals recovering from GBS.
Comparison of anterior colporrhaphy and vaginal mesh therapy for pelvic organ prolapse: a systematic review and meta-analysis Mukhammad Arif Hadi Khoirudin; Nidia Nursafitri; Mauliya Sri Sukmawati Wahyudi; Muhammad Zainul Fikri; Dita Diana Parti; Wiwien Sugih Utami; Dian Eka Putri Harnandhari
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.19977

Abstract

Pelvic organ prolapse (POP) is a common pelvic disorder among women. Although it is not life-threatening, POP represents significant health concern because it can cause urinary incontinence, decrease sexual function, and impair quality of life. This systematically review was conducted to compare the effectiveness and safety of anterior colporrhaphy with vaginal mesh therapy in the management of POP. The data sources were selected for their reputation in publishing high-quality research in urology and women’s health, including PubMed, Google Scholar, ScienceDirect, and the Cochrane Library, covering publications from 2014 to 2024. We included both randomized and non-randomized studies comparing anterior colporrhaphy with vaginal mesh therapy for stress urinary incontinence (SUI), ensuring a comprehensive review of the available evidence. Data were extracted on sample size, study location, surgical technique, patient satisfaction, reoperation rates, mesh erosion, pain, sexual function, operative time, length of hospital stay, and other complications. A total of 3,528 articles were collected. After removing 2,834 duplicates, 694 unique records remained. Following a quality assessment, six studies met the final inclusion criteria. Analysis of randomized controlled trials and cohort studies revealed no significant differences between the two procedures in terms of erosion rates, SUI incidence, reoperation rates, or patient satisfaction. These findings highlight the importance for urogynecologists to carefully consider patient identification, selection, comorbidities, and the choice of POP repair procedure.
The potential of short-chain fatty acids-producing probiotics as a treatment for liver disease: a systematic review Nur Azizah; Muhamad Rizqy Fadhillah; Nurul Gusti Khatimah; Rizky Clarinta Putri; Clara Riski Amanda; Fadilah, Fadilah; Oswari, Hanifah; Sjatha, Fithriyah
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 3 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i3.20181

Abstract

Recent insights reveal that liver diseases influence not only hepatic function but also disrupt gut microbial balance through the gut–liver axis. The gut–liver axis establishes a bidirectional relationship between the intestines and the liver, allowing microbial by-products such as short-chain fatty acids (SCFAs) to influence liver function and health. Short-chain fatty acids are known to maintain intestinal epithelial integrity, reduce inflammation, and support liver function. Probiotic bacteria including Lactobacillus, Bifidobacterium, and Clostridium, are natural SCFA producers and may offer therapeutic potential for liver disease by targeting the gut-liver axis. This systematic review was conducted using the PRISMA 2020 methodology to identify and evaluate preclinical studies examining the impact of SCFA-producing probiotics on liver disease. We searched PubMed, Scopus, and Google Scholar from August to October 2023, using predefined inclusion criteria based on the PICO framework. The SYRCLE risk of bias tool was employed to evaluate potential biases. A total of 14 animal studies fulfilled the inclusion criteria and were incorporated into the final analysis. The included studies demonstrated that SCFA-producing probiotics improved liver function by reducing serum liver enzymes (ALT, AST), increasing tight junction proteins (occluding, ZO-1), modulating pro-inflammatory cytokines (IL-1β, IL-6, TNF-α,), and improving lipid metabolism. These outcomes were mediated by increases in SCFA levels and improved gut barrier integrity in models of NAFLD, ALD, NASH, and autoimmune hepatitis. These findings support the promising potential of SCFA-producing probiotics as adjunctive therapies for liver disease through modulation of the microbiota-gut-liver axis. Yet, continued research is needed to determine strain-specific efficacy, optimal dosage, long-term safety, and clinical applicability. Future research should also explore personalized probiotic strategies and the integration of probiotic therapy into standard liver disease management.
Diagnostic challenges and clinical insight of medial thigh hemangiolymphangioma in adult: A rare case report Rizkiani, Dwinanda Almira; Trisnowati, Niken; Khalidah, Miya; Anggatama, Marcella; Dyah Ayu Mira Oktarina
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.17129

Abstract

Vascular anomalies are classified into vascular tumors and vascular malformations. Hemangiolymphangioma (HLA) is a rare vascular malformation that contains both blood and lymphatic components, most commonly diagnosed in infancy or early childhood. Adult cases, especially in atypical locations such as the medial thigh, are exceedingly rare and pose diagnostic challenges. A 27 yo female presented with a slowly enlarging, painless lump on the left medial thigh. Initially misdiagnosed as condyloma acuminata, the lesion was subsequently identified as a vascular malformation through dermoscopic visualization of characteristic vascular lacunae. Histopathological and immunohistochemical analyses confirmed the diagnosis of HLA. Surgical excision was performed with clear margins, and no recurrence was observed after 3 mo. Hemangiolymphangiomas are benign but may exhibit local infiltration and recurrence, especially after incomplete resection. Diagnosis requires a multimodal approach including clinical assessment, dermoscopy, histopathology, and immunohistochemistry. Differential diagnosis includes hemangioma, lymphangioma, and malignancies such as lymphangiosarcoma. Complete surgical excision remains the treatment of choice, with other modalities like electrocautery or cryotherapy considered in selected cases. Long-term follow-up is crucial due to the risk of recurrence. In conclusion, this rare adult case of medial thigh HLA highlights the importance of considering vascular malformations in atypical anatomical sites. Early recognition and comprehensive diagnostic evaluation facilitate appropriate management and improve patient outcomes
The effect of 4 weeks chair-based exercise on cognitive function in the elderly Roy Mal; Mariani Santosa; Nawanto Agung Prastowo; Nelson Sudiyono; Ignatio Rika Haryono
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.12067

Abstract

Degenerative processes in the central nervous system contribute to in cognitive function decline in the elderly. Physical exercise may prevent this decline. However, elderly people often require modified forms of activity to ensure both safety and effectiveness. This study aimed to investigate the the effect of chair-based exercise (CBE) on cognitive function in elderly people. This study was conducted a two nursing homes using a two-group pretest and posttest experimental design with a control group. All participants were informed about the procedures of study, provided written informed consent, and underwent an initial cognitive assessment using the mini-mental state examination (MMSE). Participants in the intervention group engaged in CBE sessions over a four-week period. Following the intervention, cognitive function was reassessed in both groups. The Wilcoxon signed-rank test was used to analyze within-group changes, while independent t-tests were used to assess between-group differences in cognitive function scores. A significant improvement in cognitive function was observed in the intervention group after the four-week CBE program (p = 0.008). Moreover, a significant between-group difference in cognitive score changes was found (p = 0.003), favoring the intervention group. In conclusion, a four-week CBE program significantly improved cognitive function among elderly participants. These findings support the use of CBE as an accessible and effective intervention to promote cognitive health in elderly people.
In vivo assay of Gigantochloa apus shoot extract as biolarvicide for myiasis-causing fly larvae Sadana, Aqsa Aufa Syauqi; Istiadi, Hermawan; Halleyantoro, Ryan; Muniroh, Muflihatul
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.16307

Abstract

The use of synthetic insecticides in treating myiasis is associated with adverse side effects and potential disruption of metabolic systems, prompting interest in natural alternatives. This study investigated the in vivo larvicidal efficacy of Gigantochloa apus bamboo shoot extract, formulated as a spray gel. Twenty-five Wistar rats were randomly divided into 5 groups: a negative control group, a positive control (ivermectin), and 3 treatment groups receiving of 1%, 3%, and 5% G. apus bamboo shoot extract. Myiasis was induced by introducing fly larvae into standardized wounds. Treatments were applied topically twice daily for 32 hr, and larval mortality was assessed every 8 hr. Phytochemical screening and GC-MS analysis revealed the presence of bioactive compounds, including alkaloids, flavonoids, tannins, saponins, and hydrogen cyanide, all of which are known for their larvicidal, neurotoxic, and antiproliferative properties. The 5% extract group showed the highest mortality rate (100%) at 32 hr. The LC50 and LC95 values were determined at 1.43% and 6.01%, respectively. Compared to the standard ivermectin treatment, the 5% extract demonstrated a shorter lethal time and more rapid larval death. Morphological examination revealed darker abdominal segments in the dead larvae, indicating a potential interaction with the digestive tract. These findings indicate that G. apus bamboo shoot extract has potential larvicidal activity and can be an effective natural alternative for treating myiasis.
Increasing quantitative estrogen receptor beta expression in meningioma after exogenous hormonal contraception exposure Sakti, Dhimas Hari; Sasongko, Muhammad Bayu; Pawiroranu, Suhardjo; Heriyanto, Didik Setyo; Mahayana, Indra Tri; Respatika, Datu; Widhasari, Idhayu Anggit; Nurlaila, Prima Sugesty; Supartoto, Agus
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.19604

Abstract

Factors influencing estrogen receptor (ER) and progesterone receptor (PR) expression in meningioma are unclear. This study aimed to assess the expression of ER and PR in females with meningioma in relation to patient exogenous hormonal exposure. Cross-sectional study of females with meningioma in Yogyakarta, Indonesia, between 2010 to 2016 was conducted. Histories were obtained through interviews. Expressions of ERa, ERb, and PR were assessed from paraffin blocks containing patients’ meningioma tissue using real-time quantitative polymerase chain reaction (RT-qPCR). The study identified 28 female meningioma patients with a mean age of 45.6 ± 6.8 yr. Increased ERb expression was found in the ³10-yr group of hormonal contraception exposure duration (<10 yr vs ³10 yr = 7.63 (2.3-11.31) vs 12.56 (1.87-42.22), p=0.038). Positive correlation was found between ERb expression and the duration of hormonal contraception exposure (r=0.432; p=0.022), especially progesterone-only contraception (r=0.5; p=0.048), while no significant correlation was found between ERb expression and duration of progesterone-estrogen contraception exposure (r=0.382; p=0.22). No significant analyses were found in ERa and PR. In conclusion, expression of ERβ in meningioma increased in accordance with exogenous hormonal exposure duration, especially progesterone. This finding suggests the importance of ERβ in meningioma and warrants further study as a potential biomarker.
Association between serum endothelin-1 level and major adverse cardiovascular events following percutaneous coronary intervention in stable coronary artery disease Rahayu, Dian Herlusiatri; Anggrahini, Dyah Wulan; Hartopo, Anggoro Budi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.20513

Abstract

Coronary artery disease (CAD) affects greatly the global population, exhibits high mortality and morbidity rates. Major adverse cardiovascular events (MACE), such as stroke, myocardial infarction, heart failure, and death, are the focus of research due to their significant contribution to morbidity and mortality in patients with CAD. Endothelin-1 is identified as a CAD prognostic indicator, especially for heart failure outcome. This study aimed to investigate the association between serum endothelin-1 level and MACE within 1 yr observation in patients with CAD underwent percutaneous coronary intervention (PCI). It was a retrospective cohort study where conducted at Dr. Sardjito General Hospital, Yogyakarta, Indonesia. Subjects were patients with stable CAD who underwent elective PCI. Baseline serum endothelin-1 level was measured by ELISA at the time of elective PCI procedure. The outcome was MACE, which consisted of heart failure, acute coronary syndrome, stroke, and cardiac death, occurred within 1 yr after elective PCI. The ROC curve was designed to determine serum endothelin-1 cut-off value to predict MACE. Sixty-three subjects were enrolled and the endothelin-1 level in serum samples was analyzed. Out of these, 11 (17.5%) experienced MACE within 1 yr post elective PCI. Serum endothelin-1 cut-off value was 1.932 pg/mL, which determined based on ROC curve. There was no significant association between serum endothelin-1 and MACE. There was a trend of higher incidence of MACE, in subjects with above-cut-off endothelin-1 level (≥1.932 pg/mL) (MACE incidence: 23.1% vs. 8.3%; p=0.181). Above-cut-off endothelin-1 level significantly associated with incidence of heart failure (100% vs. 0%; p=0.039) for 1 yr follow-up after elective PCI. Higher serum endothelin-1 level had a trend of higher incidence of 1-yr MACE in patients with stable CAD undergone elective PCI. Among 1-yr MACE, higher serum endothelin-1 associated with increased incidence of heart failure.

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