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All Journal Jurnal Ilmiah Farmasi International Journal of Biosciences and Biotechnology Jurnal Farmasi Udayana BIOTROPIA - The Southeast Asian Journal of Tropical Biology Jurnal Sains dan Teknologi Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Karinov Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento Usadha Abdi Samulang : Jurnal Pengabdian Kepada Masyarakat Jurnal Tumbuhan Obat Indonesia Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia
Putu Era Sandhi Kusuma Yuda
Departemen Farmasi Bahan Alam, Fakultas Farmasi, Universitas Mahasaraswati Denpasar, Jl. Kamboja No.11A Denpasar, Indonesia, 80233.
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Antidepressant-Like Activity and Physicochemical Analysis of Essential Oils from Michelia alba and Plumeria alba Flowers Nayaka, Ni Made Dwi Mara Widyani; Swari, Ni Luh Putu; Widnyani, Dewa Ayu Sri Bintang; Sukmayanti, Ni Kadek; Yuda, Putu Era Sandhi Kusuma; Wardani, I Gusti Ayu Agung Kusuma; Sanjaya, Dwi Arymbhi
JST (Jurnal Sains dan Teknologi) Vol. 11 No. 2 (2022)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.576 KB) | DOI: 10.23887/jstundiksha.v11i2.45291

Abstract

Depression is a mental disorder with an increased prevalence. Other than conventional antidepressants, essential oils have been used in aromatherapy as a complementary and alternative medicine to reduce depression. In the current study, the antidepressant-like activity of the inhalation of essential oils from Michelia alba (MAEO) and Plumeria alba (PAEO) flowers was analyzed using the forced swim test. The immobility time of mice from tested groups was evaluated statistically by the non-parametric Kruskal Wallis test, followed by the Mann Whitney post hoc test. Also, the characterization of both essential oils was determined by refractive index, solubility, and Gas Chromatography-Mass Spectrophotometry (GC-MS) analysis. PAEO showed stronger antidepressant-like activity than MAEO (p<0.05) and it was equal to the positive control (essential oil of Lavandula angustifolia) (p>0.05). The GC-MS analysis revealed some calming agents in MAEO and PAEO such as linalool, linalyl acetate, phenylethyl alcohol, and methyl anthranilate.
Fitokimia Minyak Trikatu yang Diproduksi dengan Variasi Suhu dan Waktu Digesti secara GC-MS (Gas Chromatography Mass Spectrometry) Pramitha, Dewa Ayu Ika; Wibawa, Agung Ari Chandra; Yuda, Putu Era Sandhi Kusuma
JST (Jurnal Sains dan Teknologi) Vol. 12 No. 2 (2023): July
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jstundiksha.v12i2.55313

Abstract

Kasa adalah kondisi klinis yang didefinisikan dengan jelas seperti batuk, dan patofisiologisnya terkait erat dengan mekanisme refleks batuk dalam pengobatan modern. Trikatu adalah ramuan yang mengandung tiga bahan herbal dengan rasa pedas, yaitu maricha (black papper), Peepli (long pepper), dan Sunthi (Ginger). Komposisi dari Trikatu terbukti efektif dalam pengobatan Kasa. Perawatan khas dalam mengatasi gejala bronkitis akut, seperti pneumonia dan asma, terbukti tidak efektif, dan Badan Pengawas Obat dan Makanan Amerika Serikat menyarankan untuk tidak menggunakan obat batuk dan pilek pada anak di bawah enam tahun. Pengobatan alternatif perlu dilakukan. Oleh karena itu, pada penelitian ini formula sediaan Trikatu ditransformasikan ke dalam pengobatan Kasa berupa minyak herbal menggunakan VCO, rimpang jahe merah (Zingiber officinale Roxb.), buah kering cabai jawa (Piper retrofractum), dan buah kering merica hitam (Piper nigrum Linn). Formula minyak Trikatu menggunakan metode digesti dengan variasi suhu dan waktu. Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa minyak Trikatu terbentuk akibat variasi suhu dan waktu digesti dengan GC-MS. Senyawa  bioaktif utama yang dihasilkan pada minyak Trikatu dengan variasi suhu dan waktu digesti yaitu octanoic acid, n-decanoic acid, caryophyllene, α-curcumene, dodecanoic acid, zingerone, tetradecanoic acid, n-hexadecanoic acid, α-Monolaurin, oleic acid, dan piperine. Hasil penelitian menunjukkan bahwa suhu dan waktu digesti berpengaruh terhadap keberadaan senyawa dalam pembuatan minyak Trikatu. Semakin lama waktu digesti yang digunakan dalam pembuatan minyak Trikatu, maka kandungan asam lemak tak jenuh dan jenuh akan semakin meningkat.
Peningkatan Produktivitas BumDesa Melalui Pendampingan Perijinan dan pemasaran Produk UMKM Unggulan Desa Pecatu, Bali Sasadara, Maria Malida; Yuda, Putu Era Sandhi Kusuma; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Tirtayasa, Gede Agus Ari
ABDI SAMULANG: Jurnal Pengabdian Kepada Masyarakat Vol 5 No 1 (2026): JANUARI| ABDI SAMULANG
Publisher : Yayasan Habiburrahman Jamalu Bina Ummat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61477/abdisamulang.v5i1.84

Abstract

UMKM Boga Sari Pecatu is a community-based small enterprise fostered by BUMDesa Catu Kwero Sedana Pecatu, specializing in the production of herbal goods. To enhance the productivity of the BUMDesa, the village has designated several flagship products for wider market development, including instant ginger powder to be produced by UMKM Boga Sari Pecatu. Although the UMKM has produced several items, it faces key challenges such as the absence of production permits, limited production facilities that hinder scale‐up, the lack of product branding, and the absence of standardized bookkeeping practices. Through this community service initiative, the implementing team carried out several programs to address these issues, including assistance in fulfilling PIRT registration requirements, procurement of a ginger grater machine to support larger‐scale instant ginger powder production, development of a UMKM logo along with packaging design and labelling, and training on simple bookkeeping practices applicable to small enterprises. The program, conducted by the Faculty of Pharmacy, Universitas Mahasaraswati Denpasar, proceeded smoothly and according to plan. The major focuses included permit facilitation, provision of production equipment, and strengthening of product branding through the development of logos and packaging labels. The outcomes indicate improved partner understanding of PIRT procedures and benefits, although the permit issuance process is still ongoing. In terms of branding, the UMKM now possesses a new logo and compliant packaging label design, enhancing product readiness for broader distribution. Bookkeeping training likewise improved partner knowledge, as reflected in the differences between pre-test and post-test scores
Produksi Ramah Lingkungan Granul Instan Antioksidan dari Kulit Jeruk Bali (Citrus maxima) Menggunakan Ekstraksi Berbantuan Enzim Yuda, Putu Era Sandhi Kusuma; Ni Kadek Lita; Adinda Puspita Elisabet Lian; Ni Putu Jayanti Putri; I Gusti Ayu Sri Candramukhi Devi Dasi; Intan Alfira Kolifay; Erna Cahyaningsih; Maria Malida Vernandes Sasadara
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v4i3.13155

Abstract

Pomelo peel (Citrus maxima) is an agricultural by-product rich in bioactive compounds, particularly flavonoids and phenolic compounds, which have potential antioxidant and anti-aging properties. However, the high pectin content in citrus peels can hinder the release of these active compounds. The objective of this study was to improve the extraction efficiency of bioactive compounds from pomelo peel using an environmentally friendly Enzyme-Assisted Extraction (EAE) method employing pectinase enzymes and to formulate the extract into instant effervescent granules. The granules produced using enzymatic extraction, granules prepared without enzymes, and control granules were evaluated through sensory assessment, physical quality analysis, total phenolic content, antioxidant activity (DPPH method), and crude fiber content. The results showed that enzyme-assisted extraction granules (EEG) exhibited significantly higher free radical scavenging activity (49.57 ± 6.10%) compared to non-enzymatic granules (NEG) (28.48 ± 8.67%). EEG also demonstrated a higher total phenolic content (0.027 g/100 g) than NEG (0.017 g/100 g). In addition, EEG showed better sensory acceptance and physical quality, including a more balanced taste, a stronger citrus aroma, and higher fiber content. These findings indicate that the application of the EAE method can enhance phenolic and fiber content, physical quality, and antioxidant activity of instant pomelo peel granules, suggesting their potential development as an environmentally friendly natural antioxidant product.
Penentuan Kadar Total Flavonoid Pada Ekstrak Bunga Kenop (Gomphrena globosa L.) Dengan Metode Spektrofotometri UV-VIS Cahyaningsih, Erna; Dewi , Ni Luh Kade Arman Anita; Yuda, Putu Era Sandhi Kusuma; Irlangga, I Gusti Ngurah Agustia Adi Surya Taksu
Usadha Vol 4 No 3 (2025): Usadha : Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Flavonoids are phenolic compounds widely distributed in plants and are well known for their antioxidant activity, which plays an important role in preventing degenerative diseases. One plant with potential as a flavonoid source is the globe amaranth flower (Gomphrena globosa L.), which has been traditionally used and reported to exhibit various pharmacological activities. This study aimed to determine the total flavonoid content of globe amaranth flower extract grown in Bali. Extraction was carried out using the maceration method with 96% ethanol at a ratio of 1:10, followed by remaceration. Phytochemical screening was performed to identify the presence of flavonoids, while total flavonoid content was determined using UV-Vis spectrophotometry with quercetin as the standard. Phytochemical screening confirmed the presence of flavonoid compounds in the extract. The determination of total flavonoid content showed a maximum wavelength at 433 nm, with a regression equation of Y = 0.0778X + 0.0012 and a correlation coefficient (r) of 0.9982. The total flavonoid content obtained was 81.808 mgQE/100 g extract. In conclusion, the globe amaranth flower (Gomphrena globosa L.) is a promising natural source of flavonoids and has potential to be developed as a raw material for traditional medicine, particularly as a natural antioxidant.
ETHNOBOTANICAL STUDY OF MEDICINAL PLANT USAGE DURING COVID-19 PANDEMIC: A COMMUNITY-BASED SURVEY IN INDONESIA Nayaka, Ni Made Dwi Mara Widyani; Yuda, Putu Era Sandhi Kusuma; Sanjaya, Dwi Arymbhi; Ernawati, Desak Ketut; Cahyaningsih, Erna; Dewi, Ni Luh Kade Arman Anita; Sasadara, Maria Malida Vernandes
BIOTROPIA Vol. 30 No. 2 (2023): BIOTROPIA Vol. 30 No. 2 August 2023
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11598/btb.2023.30.2.1784

Abstract

Before the availability of a vaccine, Indonesian population relied on traditional medicines to prevent COVID-19. Any species used by indigenous people could lead to further investigations in modern pharmacology, to preserve ancient knowledge, and to plan for plants’ conservation. The study aimed to discover and record species, methods of preparation, route of administration, and motivation in using medicinal plants by the Indonesian population during the COVID-19 pandemic. Participants of survey were selected from the people who live in Java and Bali for responding to an online structured questionnaire. Relative Frequency of Citation (RFC) was employed in the quantitative analysis of the collected data. The pharmacological relevance of the five plants with the highest RFC was further reviewed. The results showed that respondents used 59 plants from 28 families. Five species with the highest RFC were Curcuma longa (0.707), Zingiber officinale (0.674), Cymbopogon citratus (0.269), Kaempferia galanga (0.174), and Curcuma zanthorrhiza (0.165). Most plants were prepared by boiling (77.97%) and administered orally as a single ingredient or mixed with other herbals. Respondents believed that the plants were beneficial as immune-booster (71.26%), maintain good health (24.85%) and stamina (12.28%), and prevent viral infection, including COVID-19 (5.39%). The most commonly used plants might be scientifically based to boost immunity. However, their usage against COVID-19 and the medicinal value of herbal mixtures should be further investigated.
Co-Authors Adinda Puspita Elisabet Lian Agung Ari Chandra Wibawa Agustini, Ni Putu Dewi Anita Dewi, Ni Luh Kade Arman Apriliani, Ni Luh Putri Darmawan, I Wayan Agus Debby Juliadi Desak Ketut Ernawati Dewa Ayu Ika Pramitha Dewi , Ni Luh Kade Arman Anita Dewi, Ni Kadek Dwi Purnama Dwi Arymbhi Sanjaya Elis Suwarni Erna Cahyaningsih Erna Cahyaningsih Gusti Ayu Intan Puspita Dewi Gusti Ayu Made Indah Siantari Gusti Ayu Putri Cantika Dewi Gusti Ayu Putu Yosinta Sasmita Handani, Dewa Ayu Sri I Gusti Ayu Sri Candramukhi Devi Dasi I Made Agus Mahardika I Putu Tangkas Suwantara Indah Muthia Susanthi Indriani, Felia Riska Intan Alfira Kolifay Irlangga, I Gusti Ngurah Agustia Adi Surya Taksu Luh Risma Putri Rahayu Made Agus Deny Mahendra Putra Maria Dewi, Ni Putu Maria Malida Vernandes Sasadara Maria Malida Vernandes Sasadara Megawati , Erna Cahyaningsih Megawati , Fitria Megawati, Fitria Ni Kadek Lita Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Kade Arman Anita Dewi Ni Luh Putu Swari Ni Luh Sintya Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Made Wiwik Setiawati Ni Nyoman Wahyu Udayani Ni Putu Dewanty Suwirtawati Ni Putu Jayanti Putri Ni Putu Siska Sugiantari Ni Putu Udayana Antari Ni Putu Yuni Winariyanthi Ni Wayan Budi Sari Nita, Ni Luh Kade Arman Anita Dewi Perayanthi, Reni Pramesti , Luh Ratih Widhia Puguh Santoso Puguh Santoso Puguh Santoso puguh santoso, puguh Puspita Wati, Ni Putu Putra Hilmi Prayitno Putra, I Made Agus Sunadi Putri, Ni Kadek Dila Pratiwi Putri, Ni Kadek Nisa Leoni Rahadi, I Wayan Surya Sari, Ni Wayan Budi Sasadara, Maria Malida Sasadara, Maria Malida Vernandes Suarnata, I Gede Agus Sugiantari, Ni Putu Siska Sugiyanto, Milyadi Sukmayanti, Ni Kadek Suradnyana, I Gede Made Surya Rahadi, I Wayan Susanthi, Indah Muthia Suwarni, Elis Swari, Ni Luh Putu Tirtayasa, Gede Agus Ari Vernandes Sasadara, Maria Malida Wardani, I Gusti Agung Ayu Kusuma Wardani, I Gusti Ayu Agung Kusuma Widnyani, Dewa Ayu Sri Bintang Widyani Nayaka , Ni Made Dwi Mara Winariyanthi, Ni Putu Yuni Yanti, Ni Kadek Pradnya