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All Journal JPMS (Jurnal Pendidikan Matematika dan Sains) Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Biosfer: Jurnal Tadris Biologi Biogenesis: Jurnal Ilmiah Biologi Jurnal Bioterdidik: Wahana Ekspresi Ilmiah BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Jurnal Florea DIDAKTIKA BIOLOGI: Jurnal Penelitian Pendidikan Biologi Biosfer: Jurnal Pendidikan Biologi Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Biosilampari: Jurnal Biologi JPBIO (Jurnal Pendidikan Biologi) BIOSFER : Jurnal Biologi dan Pendidikan Biologi Education and Human Development Journal Jurnal Metaedukasi : Jurnal Ilmiah Pendidikan BIO-EDU: Jurnal Pendidikan Biologi Journal of Tropical Ethnobiology Eduproxima : Jurnal Ilmiah Pendidikan IPA Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Bioeduca : Journal of Biology Education Bioscientist : Jurnal Ilmiah Biologi JIPB (Jurnal Inovasi Pembelajaran Biologi) International Journal of Multidisciplinary: Applied Business and Education Research LEARNING : Jurnal Inovasi Penelitian Pendidikan dan Pembelajaran EDUTECH : Jurnal Inovasi Pendidikan Berbantuan Teknologi SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA SOCIAL : Jurnal Inovasi Pendidikan IPS PSEJ (Pancasakti Science Education Journal) Jurnal Pijar MIPA Inornatus: Biology Education Journal Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) Maximus: Journal of Biological and Life Sciences Biodik: Jurnal Ilmiah Pendidikan Biologi Jurnal Pendidikan MIPA Bioma : Jurnal Biologi dan Pembelajaran Biologi
Hernawati, Diana
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Physics Social Sciences Transportation Other

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Journal : JPBIO (Jurnal Pendidikan Biologi)

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In silico analysis: Activity of active compounds in passiflora foetida to diabetes Soendoess, Khadizah; Hernawati, Diana; Putra, Rinaldi Rizal
JPBIO (Jurnal Pendidikan Biologi) Vol 9, No 1 (2024): April 2024
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v9i1.2974

Abstract

Plants contain good compounds that are simple to complex including medicinal plants. Herbs are all plant species that are around settlements, cultivated, wild plants that are known to have medicinal properties. An example is the rambusa plant (Passiflora foetida L.). Rambusa leaves are efficacious in relieving fever, insomnia, colds, headaches, diabetes, and asthma. The purpose of this study is to find out physicochemical & pharmacokinetic predictions, toxicity levels, and the affinity of active compounds and a comparison of toxicity levels and affinity of rambusa plants or Passiflora foetida L. with metformin. The method used in this study is qualitative descriptive. Molecular docking with in silico  approach between active compound Passiflora foetida L. with target protein Alpha-glucosidase subunit B to inhibit blood sugar levels (diabetes). The compound that has the best pharmacokinetic profile compared to metformin is Passifloricin A. 5-Hydroxy-7,4'-dimethoxyflavone, Deidaclin, Linamarin, Volkenin, (1S,4S)-Tetraphyllin B (S)-Tetraphyllin A and Passifloricin A compounds are relatively safer, not mutagen and not toxic to the liver, except Passifloricin A is toxic to the liver, because the compound has a safer level of toxicity compared to the comparison medicine, metformin.
Co-Authors Abu Bakar Chaniago, Otis Aprillia Aradea Aripin Asep Marwan, Asep Asep Suryana Abdurrahmat Ave Suakanila Fauzisar, Ave Suakanila Azizah, Gina Luthfi AZIZAH, RISMA BADRIAH , LIAH Badriah, Liah Cahyawati, Yani Dani Ramdani, Dani Dewi, Resti Aulia DEWI, YULIA ROSMALA Diella, Dea Diki Muhamad Chaidir Dina Maulina Dita Agustian Endang Surahman Fadzillah, Sania Nur Fauzi, Fahmi Muhamad Fauziyah, Naila Nurul Fazriah, Ade Tias Nur FIRDAUS, FIRDA MAULIDA Fitriani, Rita Hardin, Arimbi Rizki Hastuti, Aris Hidayatuloh, Anang Iliyani, Shopiya Indriani, Yayu Azmi K, PURWATI KUSWARINI Komarudin Komarudin Lengkana, Dewi LISTIANI, FITRI M, ROMY FAISAL Meriyana, Reni Mimien Henie Irawati Mohamad Amin Muhtar, Epi Nurul Bariyah Mustofa, Romy Faisal Mutiara, Frista Nadiyawati, Sambung Nana, Nana Nuralam, Malina Mega NURUL HIDAYAH Nuryadin, Egi Priyo Wibowo, Priyo Pujiyanti, Resti Purwati K Suprapto Purwati Kuswarini Suprapto, Purwati Kuswarini Rakhmawati, Ismi Rinaldi Rizal Putra, Rinaldi Rizal Rismawati, Noneng Riyani, Siti Rosidah Ruganda, Ernita Ryandita, Fira Regina Sembiring, Rinawati Sendi Sendi Siva Fauziah, Siva Soendoess, Khadizah Sofia, Ismi Daru Sri Endah Indriwati Sriwenda, Winda Sumantri, Agus Supriatna, Asep Yudi Vita Meylani WAFA, ASRI SOFIA Wahidin Wahidin Widiyawati, Eka WISNU JULI WIONO, WISNU JULI Yanti, Aulia Fuji Yanty, Desty Zahra Fauziah Syuhada, Mutiara