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Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet Nabila, Inasa; Thadeus, Maria Selvester; Herardi, Ryan
Jurnal Gizi dan Pangan Vol. 18 No. 1 (2023)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2023.18.1.21-30

Abstract

This study aims to determine the effectiveness of parijoto fruit extract (Medinilla speciosa Blume) in improving the condition of fatty liver in male balb/c mice (Mus musculus L.) fed with a high-fat diet. Thirty male balb/c mice weighing 20 to 30 g were randomly divided into six groups, i.e: 1) Standard feed and Carboxymethyl Cellulose Sodium or CMC-Na 0.5% (K1); 2) High-fat diet and CMC-Na 0.5% (K2); 3) High-fat diet and simvastatin 0.026 mg/day (K3); 4) High-fat diet and parijoto fruit extract 5.6 mg/20 g BW (P1); 5) High-fat diet and parijoto fruit extract 8.4 mg/20 g BW (P2); 6) High-fat diet and parijoto fruit extract 11.2 mg/20 g BW (P3). Standard feed, high-fat diet, simvastatin, and parijoto fruit extract were administered for 56 days. On the 57th day, the total of 30 mice were terminated and the livers were then removed for H&E staining histopathological slides. Data on the degree of fatty liver on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Medinilla speciosa Blume extract at a dose of 5.6 mg/20 g BW in group P1 prevent the steatosis degree compared to high-fat feed mice in group K2 (p>0.05). Parijoto fruit extract could act as the potential treatment for fatty liver.
Relationship between Muscle Mass and Fasting Blood Glucose with Vascular Elasticity in Medical Students Purba, Raja Soaloon; Bustamam, Nurfitri; Thadeus, Maria Selvester; Dewiastuti, Marlina
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 17 No 4 (2025): JIKM Vol 17, Issue 4, November 2025
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v17i4.799

Abstract

Background: Low vascular elasticity is one of the key determinants of cardiovascular disease risk. Sedentary lifestyles and high-glucose diets may decrease muscle mass and increase blood glucose levels, potentially reducing vascular elasticity. This study aimed to analyze the relationships among muscle mass, fasting blood glucose levels, and vascular elasticity in medical students. Methods: A cross-sectional study was conducted involving 53 medical students aged 18—22 years using a stratified random sampling technique. Eligible participants were non-smokers, non-alcohol consumers, and had no history of diabetes, hypertension, or the use of medications affecting blood pressure, blood glucose, or cholesterol levels. Muscle mass, fasting blood glucose, and vascular elasticity were measured using a bioelectrical impedance analyzer, capillary blood testing, and an accelerated photoplethysmograph, respectively. Data were analyzed using a Chi-square tests and multivariable Logistic Regression. Results: There were no significant differences in age, blood pressure, BMI, or eating habits between the suboptimal and normal/optimal vascular elasticity groups (p > 0.05). Multivariable analysis showed that muscle mass was significantly associated with vascular elasticity (p = 0.009; OR = 9.656; CI = 1.757–53.075), after adjustment for fasting blood glucose levels (p = 0.386; OR = 2.329; CI = 0.344–15.776). Participants with higher muscle mass were nearly 10 times more likely to have better vascular elasticity. Conclusion: Muscle mass is significantly associated with vascular elasticity in young adults, independent of fasting blood glucose levels. These findings highlight the importance of maintaining adequate muscle mass. Promoting muscle mass through healthy lifestyle habits may help preserve vascular elasticity and reduce the risk of cardiovascular disease.
A Neuroscience Approach to a Virtual Reality (VR) Based Accommodation–Convergence Intervention for Evaluating Intra-Individual Mental Fatigue during Nearwork: A Crossover Experimental Study Concept Hartono, Riyadi; Pasiak, Taufiq Fredrik; Thadeus, Maria Selvester
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.320

Abstract

Introduction: Prolonged nearwork is associated with increased mental fatigue, a neurocognitive state marked by slower processing, reduced accuracy, and diminished executive performance. This condition affects up to 60–70% of students and office workers worldwide. Objective: Analyzing the effect of a VR-based Accommodation–Convergence Intervention on intra-individual mental fatigue parameters during nearwork from a neuroscience perspective. Methods: A crossover experimental study was developed involving 20 healthy male participants (18–25 years) to perform identical 60-minute Pauli test under two conditions: (1) 2D screen-based and (2) 3D VR based (reduce accommodation–convergence by projecting visual object at optical infinity). Mental fatigue was assessed using several biomarkers, including Pauli test performance, P300 amplitude and latency, and EEG Alpha–Theta PSD. Intra-individual differences between conditions were analyzed using a within-subject. The conceptual framework  was supported by a synthesis of 100 peer-reviewed studies (2014–2024) establishing mental fatigue indicators biomarker. Results: Hypothetically, comparisons between 2D screen and 3D VR-based demonstrated improvement in endurance, reflected by a higher Pauli test performance slope, attenuating the increase in P300 latency-amplitude as well as changes in EEG Alpha–Theta indicative of mental fatigue. The results showed a trend of VR exposure across multiple biomarkers, although the confidence intervals were wide in this small-sample pilot study. Conclusion: This study illustrated a neuroscience-based framework demonstrating that accommodation–convergence intervention via VR may influence indicators of mental fatigue. By integrating EEG, P300, and the Pauli test, the approach provides an objective model for assessing intra-individual cognitive endurance.
In Vitro Antifungal Activity of Ethanolic Stem Extract of Tinospora crispa Against Candida albicans and Malassezia furfur Mumtaz, Syifa Afifah; Zulfa, Fajriati; Thadeus, Maria Selvester; Setyaningsih, Yuni
BIOEDUSCIENCE Vol 9 No 3 (2025): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/17984

Abstract

Background: Fungal infections such as candidiasis caused by Candida albicans and pityriasis versicolor caused by Malassezia furfur are highly prevalent in Indonesia. Conventional antifungal treatments often face challenges like resistance and adverse side effects. As an alternative, brotowali stem (Tinospora crispa) extract, rich in alkaloids, flavonoids, and tannins, shows promise as an antifungal agent. This research investigates the in vitro antifungal efficacy of ethanol extract from brotowali stem against C. albicans and M. furfur. Methods: A laboratory experimental design utilizing the well-diffusion method was applied, measuring inhibition zone diameters on Sabouraud Dextrose Agar after 2x24 hours at extract concentrations of 45%, 60%, 75%, and 90%. Results: The ethanol extract of brotowali stem exhibited statistically significant but relatively low antifungal activity based on inhibition zone diameters against C. albicans (0,002) and M. furfur (0,001), with higher concentrations showing greater antifungal. The largest inhibition zones measured 5.93 mm for C. albicans and 3.97 mm for M. furfur. Conclusions: The extract concentrations of 90% concentration exhibited moderate antifungal activity against C. albicans. For M. furfur, all concentrations demonstrated weak antifungal activity.
Co-Authors Abdullah Rukman Adisaputra, Chantika Zahra Adrian Dharmawan Adyatma, Hilmi Agneta Irmarahayu Akbar, Rafi Thoriq Alyani, Fadhilah Sharfina Annisa Afifah Audrey Alvura Digna Basuki Supartono Cahyaninglatri, Wendi Corlia Cut Fauziah Cut Fauziah Cut Fauziah Dimas Farhan Wibawanto Dinda Nuraini Hanifah Wahab Eko Satrio Bahari Erna Harfiani Fachruddin Perdana Fajriati Zulfa Fajriati Zulfa Familia Bella Rahadiati Giopratiwi, Kusvandita Hany Yusmaini Hardini, Niniek Hartono, Riyadi Hikmah Muktamiroh Husna Bunga Jannati Jannati, Husna Bunga Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Marlina Dewiastuti, Marlina Meiskha Bahar Mila Citrawati Muhammad Alif Farhan Muhammad Kevin Auliansyah Akbar Muktamiroh Hikmah Mumtaz, Syifa Afifah Muttia Amalia Nabila, Inasa Nadira Safa Jasmine Nainggolan, Dorlina Nazira, Syarifah Ni Luh Aurial Widjayanti Niniek Hardini Niniek Hardini Noor Az Zhahra Nooramadhani, Tasya Nugrahayu Widyawardani Nunuk Nugrohowati Nurfitri Bustamam Pamuji, Alifia Shafanaura Pasiak, Taufiq Fredrik Prakoso, Luthfi Octafyan Pujangga, Ibnu Wadud Purba, Raja Soaloon Rahadiati, Familia Bella Ramadhansyah, Reza Reinhart Fikram Imam Akbar Retno Yulianti Retno Yuliyanti Rukman Abdullah Ryan Herardi Salman Paris Salman Paris Setyaningsih, Yuni Simanjuntak, Kristina Soroy Lardo Sri Wahyuningsih Sugeng Wiyono Sukrisno, Adi Tiwuk Susantiningsih Tri Faranita, Tri Uswatun Hasanah Uswatun Hasanah Wahab, Dinda Nuraini Hanifah Wibawanto, Dimas Farhan Yanto Sandy Tjang Yudhi Nugraha Yuliyanti, Retno