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All Journal Jurnal Gizi dan Pangan E-Jurnal Medika Udayana Jurnal Kedokteran Syiah Kuala AL KAUNIYAH Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya MEDISAINS Jurnal Manajemen Kesehatan Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Wikrama Parahita : Jurnal Pengabdian Masyarakat JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA BIOEDUSCIENCE Buletin Farmatera Jurnal Pengabdian Masyarakat AbdiMas Majalah Kedokteran Andalas Jurnal Biomedika dan Kesehatan Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan SULUH: Jurnal Abdimas Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS World Nutrition Journal Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Abdimas Indonesian Journal SEGARA : Jurnal Pengabdian Kepada Masyarakat Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Maria Selvester Thadeus
Universitas Pembangunan Nasional Veteran Jakarta
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Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet Nabila, Inasa; Thadeus, Maria Selvester; Herardi, Ryan
Jurnal Gizi dan Pangan Vol. 18 No. 1 (2023)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2023.18.1.21-30

Abstract

This study aims to determine the effectiveness of parijoto fruit extract (Medinilla speciosa Blume) in improving the condition of fatty liver in male balb/c mice (Mus musculus L.) fed with a high-fat diet. Thirty male balb/c mice weighing 20 to 30 g were randomly divided into six groups, i.e: 1) Standard feed and Carboxymethyl Cellulose Sodium or CMC-Na 0.5% (K1); 2) High-fat diet and CMC-Na 0.5% (K2); 3) High-fat diet and simvastatin 0.026 mg/day (K3); 4) High-fat diet and parijoto fruit extract 5.6 mg/20 g BW (P1); 5) High-fat diet and parijoto fruit extract 8.4 mg/20 g BW (P2); 6) High-fat diet and parijoto fruit extract 11.2 mg/20 g BW (P3). Standard feed, high-fat diet, simvastatin, and parijoto fruit extract were administered for 56 days. On the 57th day, the total of 30 mice were terminated and the livers were then removed for H&E staining histopathological slides. Data on the degree of fatty liver on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Medinilla speciosa Blume extract at a dose of 5.6 mg/20 g BW in group P1 prevent the steatosis degree compared to high-fat feed mice in group K2 (p>0.05). Parijoto fruit extract could act as the potential treatment for fatty liver.
Relationship between Muscle Mass and Fasting Blood Glucose with Vascular Elasticity in Medical Students Purba, Raja Soaloon; Bustamam, Nurfitri; Thadeus, Maria Selvester; Dewiastuti, Marlina
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 17 No 4 (2025): JIKM Vol 17, Issue 4, November 2025
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v17i4.799

Abstract

Background: Low vascular elasticity is one of the key determinants of cardiovascular disease risk. Sedentary lifestyles and high-glucose diets may decrease muscle mass and increase blood glucose levels, potentially reducing vascular elasticity. This study aimed to analyze the relationships among muscle mass, fasting blood glucose levels, and vascular elasticity in medical students. Methods: A cross-sectional study was conducted involving 53 medical students aged 18—22 years using a stratified random sampling technique. Eligible participants were non-smokers, non-alcohol consumers, and had no history of diabetes, hypertension, or the use of medications affecting blood pressure, blood glucose, or cholesterol levels. Muscle mass, fasting blood glucose, and vascular elasticity were measured using a bioelectrical impedance analyzer, capillary blood testing, and an accelerated photoplethysmograph, respectively. Data were analyzed using a Chi-square tests and multivariable Logistic Regression. Results: There were no significant differences in age, blood pressure, BMI, or eating habits between the suboptimal and normal/optimal vascular elasticity groups (p > 0.05). Multivariable analysis showed that muscle mass was significantly associated with vascular elasticity (p = 0.009; OR = 9.656; CI = 1.757–53.075), after adjustment for fasting blood glucose levels (p = 0.386; OR = 2.329; CI = 0.344–15.776). Participants with higher muscle mass were nearly 10 times more likely to have better vascular elasticity. Conclusion: Muscle mass is significantly associated with vascular elasticity in young adults, independent of fasting blood glucose levels. These findings highlight the importance of maintaining adequate muscle mass. Promoting muscle mass through healthy lifestyle habits may help preserve vascular elasticity and reduce the risk of cardiovascular disease.
A Neuroscience Approach to a Virtual Reality (VR) Based Accommodation–Convergence Intervention for Evaluating Intra-Individual Mental Fatigue during Nearwork: A Crossover Experimental Study Concept Hartono, Riyadi; Pasiak, Taufiq Fredrik; Thadeus, Maria Selvester
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.320

Abstract

Introduction: Prolonged nearwork is associated with increased mental fatigue, a neurocognitive state marked by slower processing, reduced accuracy, and diminished executive performance. This condition affects up to 60–70% of students and office workers worldwide. Objective: Analyzing the effect of a VR-based Accommodation–Convergence Intervention on intra-individual mental fatigue parameters during nearwork from a neuroscience perspective. Methods: A crossover experimental study was developed involving 20 healthy male participants (18–25 years) to perform identical 60-minute Pauli test under two conditions: (1) 2D screen-based and (2) 3D VR based (reduce accommodation–convergence by projecting visual object at optical infinity). Mental fatigue was assessed using several biomarkers, including Pauli test performance, P300 amplitude and latency, and EEG Alpha–Theta PSD. Intra-individual differences between conditions were analyzed using a within-subject. The conceptual framework  was supported by a synthesis of 100 peer-reviewed studies (2014–2024) establishing mental fatigue indicators biomarker. Results: Hypothetically, comparisons between 2D screen and 3D VR-based demonstrated improvement in endurance, reflected by a higher Pauli test performance slope, attenuating the increase in P300 latency-amplitude as well as changes in EEG Alpha–Theta indicative of mental fatigue. The results showed a trend of VR exposure across multiple biomarkers, although the confidence intervals were wide in this small-sample pilot study. Conclusion: This study illustrated a neuroscience-based framework demonstrating that accommodation–convergence intervention via VR may influence indicators of mental fatigue. By integrating EEG, P300, and the Pauli test, the approach provides an objective model for assessing intra-individual cognitive endurance.
In Vitro Antifungal Activity of Ethanolic Stem Extract of Tinospora crispa Against Candida albicans and Malassezia furfur Mumtaz, Syifa Afifah; Zulfa, Fajriati; Thadeus, Maria Selvester; Setyaningsih, Yuni
BIOEDUSCIENCE Vol 9 No 3 (2025): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/17984

Abstract

Background: Fungal infections such as candidiasis caused by Candida albicans and pityriasis versicolor caused by Malassezia furfur are highly prevalent in Indonesia. Conventional antifungal treatments often face challenges like resistance and adverse side effects. As an alternative, brotowali stem (Tinospora crispa) extract, rich in alkaloids, flavonoids, and tannins, shows promise as an antifungal agent. This research investigates the in vitro antifungal efficacy of ethanol extract from brotowali stem against C. albicans and M. furfur. Methods: A laboratory experimental design utilizing the well-diffusion method was applied, measuring inhibition zone diameters on Sabouraud Dextrose Agar after 2x24 hours at extract concentrations of 45%, 60%, 75%, and 90%. Results: The ethanol extract of brotowali stem exhibited statistically significant but relatively low antifungal activity based on inhibition zone diameters against C. albicans (0,002) and M. furfur (0,001), with higher concentrations showing greater antifungal. The largest inhibition zones measured 5.93 mm for C. albicans and 3.97 mm for M. furfur. Conclusions: The extract concentrations of 90% concentration exhibited moderate antifungal activity against C. albicans. For M. furfur, all concentrations demonstrated weak antifungal activity.
Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Pelatihan Pembuatan Teh Daun Kelor Kayu Manis pada Ibu-ibu PKK Desa Pangkalan Jati Depok Setyaningsih, Yuni; Tiwuk Susantiningsih; Maria Selvester Thadeus; Mila Citrawati; Hikmah Muktamiroh; Melly kristanti
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2026)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v7i2.16121

Abstract

Kelor memiliki berbagai manfaat bagi kesehatan seperti sebagai antibakteri, antiinflamasi, antioksidan dan lain-lain. Kelor dapat dikonsumsi sebagai sayuran, bubuk, jus atau teh. Kayu manis merupakan rempah yang memiliki manfaat sebagai antioksidan dan antidiabetes. Pemanfaatan daun kelor kayu manis belum pernah dilakukan di Desa Pangkalan Jati, Cinere, Depok, yang merupakan daerah perbatasan dengan ibu kota. Tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan dan keterampilan kader PKK dalam membuat teh daun kelor kayu manis. Metode yang dilakukan dengan melakukan penyuluhan tentang manfaat daun kelor bagi kesehatan dan pelatihan pembuatan teh daun kelor kayu manis dari seduhan langsung dan merebus daun kelor. Hasil pengabdian ini menunjukkan terdapat peningkatan pengetahuan yang bermakna tentang manfaat daun kelor dengan uji Wilcoxon p 0,001. Kader PKK juga dapat melakukan pembuatan teh daun kelor kayu manis dengan baik. Pengabdian yang dilakukan berhasil meningkatkan pengetahuan kader tentang manfaat daun kelor dan meningkatkan keterampilan membuat teh daun kelor kayu manis. Diharapkan kader dapat mengaplikasikan pengetahuan yang sudah didapatkan dalam kehidupan sehari-hari dan memberikan informasi pengetahuan ini kepada masyarakat sehingga dapat meningkatkan kesehatan masyarakat.
Prevention of Anemia in Adolescent Girls in Pangkalan Jati Village, Cinere, Depok Citrawati, Mila; Thadeus, Maria Selvester; Susantiningsih, Tiwuk; Setyaningsih, Yuni
Abdimas Indonesian Journal Vol. 6 No. 1 (2026)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.1518

Abstract

Stunting remains a major public health issue that must be addressed today. Stunting represents a significant nutritional problem that affects social and economic life both within and across communities. There is clear evidence that stunted individuals have higher mortality rates and greater disease incidence. Contributing factors to stunting include inadequate nutritional intake during pregnancy, which leads to fetal growth restriction, marking the beginning of stunting. Stunting prevention education is essentially an activity or effort to convey messages to communities, groups, or individuals with the expectation that they will gain knowledge that can influence their attitudes and behaviors. The youth of the Al Muhajirin Mosque in Pangkalan Jati, Cinere, Depok, have limited knowledge regarding the dangers of anemia among adolescent girls and its link to stunting. The objective of this community service activity was to educate the youth members of Al Muhajirin Mosque about the dangers of anemia and the importance of iron supplementation to reduce the risk of stunting in children. Our finding that this activity can increase adolescents’ understanding of anemia and stunting, thereby contributing to the reduction of anemia and stunting rates in Pangkalan Jati, Cinere, Depok.
Co-Authors Abdullah Rukman Adisaputra, Chantika Zahra Adrian Dharmawan Adyatma, Hilmi Agneta Irmarahayu Akbar, Rafi Thoriq Alyani, Fadhilah Sharfina Annisa Afifah Audrey Alvura Digna Basuki Supartono Cahyaninglatri, Wendi Corlia Cut Fauziah Cut Fauziah Cut Fauziah Dimas Farhan Wibawanto Dinda Nuraini Hanifah Wahab Eko Satrio Bahari Erna Harfiani Fachruddin Perdana Fajriati Zulfa Fajriati Zulfa Familia Bella Rahadiati Giopratiwi, Kusvandita Hany Yusmaini Hardini, Niniek Hartono, Riyadi Hikmah Muktamiroh Husna Bunga Jannati Jannati, Husna Bunga Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Marlina Dewiastuti, Marlina Meiskha Bahar Melly Kristanti Mila Citrawati Muhammad Alif Farhan Muhammad Kevin Auliansyah Akbar Muktamiroh Hikmah Mumtaz, Syifa Afifah Muttia Amalia Nabila, Inasa Nadira Safa Jasmine Nainggolan, Dorlina Nazira, Syarifah Ni Luh Aurial Widjayanti Niniek Hardini Niniek Hardini Noor Az Zhahra Nooramadhani, Tasya Nugrahayu Widyawardani Nunuk Nugrohowati Nurfitri Bustamam Pamuji, Alifia Shafanaura Pasiak, Taufiq Fredrik Prakoso, Luthfi Octafyan Pujangga, Ibnu Wadud Purba, Raja Soaloon Rahadiati, Familia Bella Ramadhansyah, Reza Reinhart Fikram Imam Akbar Retno Yulianti Retno Yuliyanti Rukman Abdullah Ryan Herardi Salman Paris Salman Paris Setyaningsih, Yuni Simanjuntak, Kristina Soroy Lardo Sri Wahyuningsih Sugeng Wiyono Sukrisno, Adi Tiwuk Susantiningsih Tri Faranita, Tri Uswatun Hasanah Uswatun Hasanah Wahab, Dinda Nuraini Hanifah Wibawanto, Dimas Farhan Yanto Sandy Tjang Yudhi Nugraha Yuliyanti, Retno