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A Neuroscience Approach to a Virtual Reality (VR) Based Accommodation–Convergence Intervention for Evaluating Intra-Individual Mental Fatigue during Nearwork: A Crossover Experimental Study Concept Hartono, Riyadi; Pasiak, Taufiq Fredrik; Thadeus, Maria Selvester
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.320

Abstract

Introduction: Prolonged nearwork is associated with increased mental fatigue, a neurocognitive state marked by slower processing, reduced accuracy, and diminished executive performance. This condition affects up to 60–70% of students and office workers worldwide. Objective: Analyzing the effect of a VR-based Accommodation–Convergence Intervention on intra-individual mental fatigue parameters during nearwork from a neuroscience perspective. Methods: A crossover experimental study was developed involving 20 healthy male participants (18–25 years) to perform identical 60-minute Pauli test under two conditions: (1) 2D screen-based and (2) 3D VR based (reduce accommodation–convergence by projecting visual object at optical infinity). Mental fatigue was assessed using several biomarkers, including Pauli test performance, P300 amplitude and latency, and EEG Alpha–Theta PSD. Intra-individual differences between conditions were analyzed using a within-subject. The conceptual framework  was supported by a synthesis of 100 peer-reviewed studies (2014–2024) establishing mental fatigue indicators biomarker. Results: Hypothetically, comparisons between 2D screen and 3D VR-based demonstrated improvement in endurance, reflected by a higher Pauli test performance slope, attenuating the increase in P300 latency-amplitude as well as changes in EEG Alpha–Theta indicative of mental fatigue. The results showed a trend of VR exposure across multiple biomarkers, although the confidence intervals were wide in this small-sample pilot study. Conclusion: This study illustrated a neuroscience-based framework demonstrating that accommodation–convergence intervention via VR may influence indicators of mental fatigue. By integrating EEG, P300, and the Pauli test, the approach provides an objective model for assessing intra-individual cognitive endurance.
In Vitro Antifungal Activity of Ethanolic Stem Extract of Tinospora crispa Against Candida albicans and Malassezia furfur Mumtaz, Syifa Afifah; Zulfa, Fajriati; Thadeus, Maria Selvester; Setyaningsih, Yuni
BIOEDUSCIENCE Vol 9 No 3 (2025): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/17984

Abstract

Background: Fungal infections such as candidiasis caused by Candida albicans and pityriasis versicolor caused by Malassezia furfur are highly prevalent in Indonesia. Conventional antifungal treatments often face challenges like resistance and adverse side effects. As an alternative, brotowali stem (Tinospora crispa) extract, rich in alkaloids, flavonoids, and tannins, shows promise as an antifungal agent. This research investigates the in vitro antifungal efficacy of ethanol extract from brotowali stem against C. albicans and M. furfur. Methods: A laboratory experimental design utilizing the well-diffusion method was applied, measuring inhibition zone diameters on Sabouraud Dextrose Agar after 2x24 hours at extract concentrations of 45%, 60%, 75%, and 90%. Results: The ethanol extract of brotowali stem exhibited statistically significant but relatively low antifungal activity based on inhibition zone diameters against C. albicans (0,002) and M. furfur (0,001), with higher concentrations showing greater antifungal. The largest inhibition zones measured 5.93 mm for C. albicans and 3.97 mm for M. furfur. Conclusions: The extract concentrations of 90% concentration exhibited moderate antifungal activity against C. albicans. For M. furfur, all concentrations demonstrated weak antifungal activity.
Anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit in obesity-induced liver injury Susantiningsih, Tiwuk; Thadeus, Maria Selvester; Citrawati, Mila; Setyaningsih, Yuni
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.30081

Abstract

Background: Hepatic metabolic disorders are closely associated with obesity and are characterized by systemic inflammation and liver injury. Moringa oleifera fruit contains various bioactive compounds with potential anti-inflammatory and hepatoprotective properties. However, evidence regarding its effects on obesity-induced liver injury remains limited..   Objective: This study aimed to evaluate the anti-inflammatory and hepatoprotective effects of Moringa oleifera fruit extract in an obesity-induced rat model..   Methods: This experimental study used 30 male Sprague-Dawley rats divided into five groups: normal control (N), obese control (O), obese rats treated with Moringa oleifera fruit extract at 500 mg/kg body weight once daily (OEMO1), twice daily (OEMO2), and obese rats treated with vitamin C (OC). Systemic inflammation was assessed by measuring serum C-reactive protein (CRP) levels using ELISA, while hepatic changes were evaluated through biochemical markers and histopathological analysis. Data were analyzed using one-way ANOVA followed by post hoc testing.   Results: Obese rats exhibited significantly elevated serum CRP levels and marked hepatic alterations compared to normal controls (p < 0.05). Administration of Moringa oleifera fruit extract significantly reduced CRP levels and improved hepatic histoarchitecture in obese rats, with the greatest effect observed in the twice-daily treatment group (OEMO2) (p < 0.05). The effects were comparable to or greater than those observed with vitamin C. Conclusions: Moringa oleifera fruit extract demonstrates significant anti-inflammatory and hepatoprotective effects in an obesity-induced rat model, suggesting its potential as a natural therapeutic agent for obesity-related liver injury.
Pelatihan Pembuatan Teh Daun Kelor Kayu Manis pada Ibu-ibu PKK Desa Pangkalan Jati Depok Setyaningsih, Yuni; Tiwuk Susantiningsih; Maria Selvester Thadeus; Mila Citrawati; Hikmah Muktamiroh; Melly kristanti
BERNAS: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2026)
Publisher : Universitas Majalengka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jb.v7i2.16121

Abstract

Kelor memiliki berbagai manfaat bagi kesehatan seperti sebagai antibakteri, antiinflamasi, antioksidan dan lain-lain. Kelor dapat dikonsumsi sebagai sayuran, bubuk, jus atau teh. Kayu manis merupakan rempah yang memiliki manfaat sebagai antioksidan dan antidiabetes. Pemanfaatan daun kelor kayu manis belum pernah dilakukan di Desa Pangkalan Jati, Cinere, Depok, yang merupakan daerah perbatasan dengan ibu kota. Tujuan pengabdian kepada masyarakat ini adalah untuk meningkatkan pengetahuan dan keterampilan kader PKK dalam membuat teh daun kelor kayu manis. Metode yang dilakukan dengan melakukan penyuluhan tentang manfaat daun kelor bagi kesehatan dan pelatihan pembuatan teh daun kelor kayu manis dari seduhan langsung dan merebus daun kelor. Hasil pengabdian ini menunjukkan terdapat peningkatan pengetahuan yang bermakna tentang manfaat daun kelor dengan uji Wilcoxon p 0,001. Kader PKK juga dapat melakukan pembuatan teh daun kelor kayu manis dengan baik. Pengabdian yang dilakukan berhasil meningkatkan pengetahuan kader tentang manfaat daun kelor dan meningkatkan keterampilan membuat teh daun kelor kayu manis. Diharapkan kader dapat mengaplikasikan pengetahuan yang sudah didapatkan dalam kehidupan sehari-hari dan memberikan informasi pengetahuan ini kepada masyarakat sehingga dapat meningkatkan kesehatan masyarakat.
Pendidikan Remaja dalam Pencegahan Stunting melalui Pencegahan Pernikahan Dini di Pangkalan Jati, Cinere, Depok Maria Selvester Thadeus; Mila Citrawati; Tiwuk Susantiningsih; Yuni Setyaningsih
Jurnal Penyuluhan dan Pemberdayaan Masyarakat Vol. 5 No. 2 (2026): Jurnal Penyuluhan dan Pemberdayaan Masyarakat
Publisher : CV. Era Digital Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59066/jppm.v5i2.2298

Abstract

Pernikahan dini masih marak terjadi di Indonesia, yang menimbulkan berbagai tantangan kesehatan dan sosial. Kedewasaan yang dibutuhkan untuk menikah tidak hanya mencakup kesiapan biologis, tetapi juga kesiapan psikologis, sosial, mental, dan spiritual. Pernikahan dini memiliki dampak negatif bagi kaum muda dan generasi mendatang. Mengingat kaitannya yang erat dengan tradisi budaya setempat, pencegahan pernikahan dini memerlukan kerja sama yang sinergis antara pemerintah, tokoh agama, tokoh adat, dan masyarakat. Program pengabdian masyarakat ini bertujuan untuk memberikan pemahaman yang lebih mendalam kepada remaja mengenai bahaya pernikahan dini dan kesehatan reproduksi, serta mengedukasi mengenai hubungan antara pernikahan dini dan stunting pada remaja Masjid Al Muhajirin, Pangkalan Jati Cinere Depok. Kegiatan ini dilaksanakan sebagai upaya pencegahan terhadap pernikahan dini dan sebagai strategi konvergensi untuk pencegahan stunting pada remaja. Program ini terdiri dari tiga tahap yaitu pengumpulan data, konseling/sosialisasi, dan evaluasi. Penilaian pengetahuan dilakukan melalui pre-test dan postest untuk mengukur pemahaman peserta mengenai risiko pernikahan dini dan pencegahan stunting. Hasil pengabdian menunjukkan peningkatan pengetahuan dan kesadaran remaja mengenai risiko pernikahan dini serta hubungannya dengan stunting. Kegiatan ini menunjukkan bahwa pendidikan berbasis masyarakat di kalangan kelompok remaja dapat menjadi strategi yang efektif untuk mencegah pernikahan dini dan mengurangi prevalensi stunting dalam jangka panjang.
Management of Men Diagnosed with Schizophrenia Using a Family Medicine Approach Putri Nabila Febrianty; Raihan Akbar Darmawan; Azzahra Roudatul Jannah; Winsca Maghfirda Yasya; Dhia Adhi Perwirawati; Maria Selvester Thadeus; Tiwuk Susantiningsih
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 12 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v12i1.1882

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Background: Family medicine emphasizes comprehensive and sustainable health care for individuals and families. Objective: This study aimed to identify clinical problems in patients with schizophrenia and their families, and to analyze factors influencing schizophrenia-related problems using a family medicine approach.Methods: Management was conducted using a family-centered approach designed to create comprehensive health conditions encompassing physical, mental, social, and emotional aspects. The intervention encouraged a supportive family environment for healthy living behaviors and increased family awareness of disease prevention and health promotion in schizophrenia. Family coaching and education were delivered using RANGKUL promotional media. Results: Family coaching demonstrated improved family understanding of schizophrenia, indicated by an increase in post-test scores of 50 out of 100 compared with pre-test results. Families showed better recognition of symptoms, treatment goals, and the importance of long-term care and medication adherence. Conclusion: Management of a male patient diagnosed with catatonic schizophrenia can be effectively implemented using a family medicine approach. Key supporting factors included high family enthusiasm, openness in providing information for family assessment, and strong commitment to maintaining the patient’s medication compliance. Complicating factors included the parents’ educational level, limited to junior and senior high school, requiring information delivery in simple language.
Grade II Hypertension in a 59-Year-Old Woman: A Case Report Dr. dr. Maria Selvester Thadeus, M. Biomed, Sp.KKLP, Subsp. FOMC; dr. Hikmah Mukhtamiroh, M.MedEd, Sp.KKLP, Subsp. COPC; Audya, Safira Diva; Salsabila Nanda Maharani; Kusuma Jasmine Vicky Sutrisno; Muhammad Pandji Raihan; Nuur Nazhira
Jurnal Ilmu Kedokteran Keluarga Vol. 5 No. 1 (2026): July 2026
Publisher : Family Medicine Department, Faculty of Medicine, Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56674/c6ca3w76

Abstract

This case report describes a 59-year-old woman diagnosed with Grade II hypertension who presented with intermittent headaches. Risk factors included high sodium intake, stress, overweight status, and a significant family history of hypertension and diabetes mellitus. Physical examination revealed blood pressure of 160/100 mmHg without signs of target organ damage. Electrocardiogram and chest radiography results were within normal limits. The diagnosis was established based on repeated elevated blood pressure measurements. The patient received amlodipine and lifestyle modification counseling. Follow-up demonstrated gradual improvement with blood pressure decreasing to 125/85 mmHg. This case highlights the importance of addressing modifiable risk factors and ensuring treatment adherence in hypertensive patients.
Relationship between Muscle Mass and Fasting Blood Glucose with Vascular Elasticity in Medical Students Raja Soaloon Purba; Nurfitri Bustamam; Maria Selvester Thadeus; Marlina Dewiastuti
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 17 No 4 (2025): JIKM Vol 17, Issue 4, November 2025
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52022/jikm.v17i4.799

Abstract

Background: Low vascular elasticity is one of the key determinants of cardiovascular disease risk. Sedentary lifestyles and high-glucose diets may decrease muscle mass and increase blood glucose levels, potentially reducing vascular elasticity. This study aimed to analyze the relationships among muscle mass, fasting blood glucose levels, and vascular elasticity in medical students. Methods: A cross-sectional study was conducted involving 53 medical students aged 18—22 years using a stratified random sampling technique. Eligible participants were non-smokers, non-alcohol consumers, and had no history of diabetes, hypertension, or the use of medications affecting blood pressure, blood glucose, or cholesterol levels. Muscle mass, fasting blood glucose, and vascular elasticity were measured using a bioelectrical impedance analyzer, capillary blood testing, and an accelerated photoplethysmograph, respectively. Data were analyzed using a Chi-square tests and multivariable Logistic Regression. Results: There were no significant differences in age, blood pressure, BMI, or eating habits between the suboptimal and normal/optimal vascular elasticity groups (p > 0.05). Multivariable analysis showed that muscle mass was significantly associated with vascular elasticity (p = 0.009; OR = 9.656; CI = 1.757–53.075), after adjustment for fasting blood glucose levels (p = 0.386; OR = 2.329; CI = 0.344–15.776). Participants with higher muscle mass were nearly 10 times more likely to have better vascular elasticity. Conclusion: Muscle mass is significantly associated with vascular elasticity in young adults, independent of fasting blood glucose levels. These findings highlight the importance of maintaining adequate muscle mass. Promoting muscle mass through healthy lifestyle habits may help preserve vascular elasticity and reduce the risk of cardiovascular disease.
Prevention of Anemia in Adolescent Girls in Pangkalan Jati Village, Cinere, Depok Mila Citrawati; Maria Selvester Thadeus; Tiwuk Susantiningsih; Yuni Setyaningsih
Abdimas Indonesian Journal Vol. 6 No. 1 (2026)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.1518

Abstract

Stunting remains a major public health issue that must be addressed today. Stunting represents a significant nutritional problem that affects social and economic life both within and across communities. There is clear evidence that stunted individuals have higher mortality rates and greater disease incidence. Contributing factors to stunting include inadequate nutritional intake during pregnancy, which leads to fetal growth restriction, marking the beginning of stunting. Stunting prevention education is essentially an activity or effort to convey messages to communities, groups, or individuals with the expectation that they will gain knowledge that can influence their attitudes and behaviors. The youth of the Al Muhajirin Mosque in Pangkalan Jati, Cinere, Depok, have limited knowledge regarding the dangers of anemia among adolescent girls and its link to stunting. The objective of this community service activity was to educate the youth members of Al Muhajirin Mosque about the dangers of anemia and the importance of iron supplementation to reduce the risk of stunting in children. Our finding that this activity can increase adolescents’ understanding of anemia and stunting, thereby contributing to the reduction of anemia and stunting rates in Pangkalan Jati, Cinere, Depok.
Moringa oleifera Fruit Extract Improves Hypothalamic Superoxide Dismutase Activity and Reduces Glial Reactivity in Obese Wistar Rats Dian Ayu Paramitha; Ria Maria Theresa; Maria Selvester Thadeus; Muttia Amalia; Tiwuk Susantiningsih
The Indonesian Biomedical Journal Vol 18, No 3 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i3.4038

Abstract

BACKGROUND: Obesity is linked to chronic low-grade inflammation and increased oxidative stress that may disrupt hypothalamic metabolic homeostasis. Excess nutrient intake activates inflammatory signaling and promotes glial reactivity, contributing to neuroinflammatory remodeling. Superoxide dismutase (SOD) is a key enzymatic antioxidant marker reflecting hypothalamic defense capacity. However, whether natural antioxidants can simultaneously restore SOD activity and attenuate obesity-induced glial reactivity remains unclear. Among many natural antioxidant, Moringa oleifera is rich in bioactive compounds with antioxidant properties that may attenuate neuroinflammation. Therefore, this study was conducted to evaluated the effect of M. oleifera fruit extract (MOFE) on hypothalamic total SOD activity and histopathological features of glial reactivity in obese Wistar rats.METHODS: Male Wistar rats were divided into four groups: normal control, obese control, and two treatment groups. For obese control and treatment groups, obesity was induced for 8 weeks using a high-fat/high-sucrose diet. Fresh M. oleifera fruit pods were macerated to produce MOFE. Following the obesity-induction, the two treatment groups were treated with 500 and 1,000 mg/kgBW/day MOFE for 4 weeks. A hydroxylamine-based assay was employed to measure total SOD activity of hypothalamic tissue homogenate. Meanwhile, hematoxylin-eosin (HE) was used to stain hypothalamic sections for glial reactivity scoring.RESULTS: After the obesity induction, the obesity-induced rats showed elevated Lee Index, but after the treatment with 500 and 1,000 mg/kgBW/day MOFE, the Lee Index decreased for 26.61±3.53% and 26.32±0.93%, respectively, which is greater compared to obese control. MOFE administration was also able to improve hypothalamic SOD activity (64.75±1.29 U/mL and 65.78±0.74 U/mL). MOFE groups also exhibited predominantly milder histopathological changes and glial reactivity than obese controls.CONCLUSION: MOFE administration lowers Lee Index, improves hypothalamic SOD activity, reduces glial reactivity and improves neuroinflammation changes in obese rats, suggesting that MOFE might be potential agent for obesity-related oxidative-inflammatory brain injury. KEYWORDS: Moringa oleifera, obesity, oxidative stress, superoxide dismutase, hypothalamus, gliosis, Wistar rat
Co-Authors Adrian Dharmawan Adyatma, Hilmi Agneta Irmarahayu Akbar, Rafi Thoriq Alyani, Fadhilah Sharfina Annisa Afifah Audrey Alvura Digna Audya, Safira Diva Azzahra Roudatul Jannah Basuki Supartono Chantika Zahra Adisaputra Cut Fauziah Cut Fauziah Cut Fauziah Dhia Adhi Perwirawati Dian Ayu Paramitha Dimas Farhan Wibawanto Dinda Nuraini Hanifah Wahab dr. Hikmah Mukhtamiroh, M.MedEd, Sp.KKLP, Subsp. COPC Eko Satrio Bahari Erna Harfiani Fachruddin Perdana Fajriati Zulfa Fajriati Zulfa Familia Bella Rahadiati Giopratiwi, Kusvandita Hany Yusmaini Hardini, Niniek Hartono, Riyadi Hikmah Muktamiroh Husna Bunga Jannati Jannati, Husna Bunga Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Kusuma Jasmine Vicky Sutrisno Marlina Dewiastuti Meiskha Bahar Melly Kristanti Mila Citrawati Mila Citrawati Muhammad Alif Farhan Muhammad Kevin Auliansyah Akbar Muhammad Pandji Raihan Muktamiroh Hikmah Mumtaz, Syifa Afifah Muttia Amalia Muttia Amalia Nabila, Inasa Nadira Safa Jasmine Nainggolan, Dorlina Nazira, Syarifah Ni Luh Aurial Widjayanti Niniek Hardini Niniek Hardini Noor Az Zhahra Nugrahayu Widyawardani Nunuk Nugrohowati Nurfitri Bustamam Nuur Nazhira Pamuji, Alifia Shafanaura Pasiak, Taufiq Fredrik Prakoso, Luthfi Octafyan Pujangga, Ibnu Wadud Putri Nabila Febrianty Rahadiati, Familia Bella Raihan Akbar Darmawan Raja Soaloon Purba Ramadhansyah, Reza Ratna Puspita Reinhart Fikram Imam Akbar Retno Yulianti Retno Yuliyanti Ria Maria Theresa Rukman Abdullah Ryan Herardi Salman Paris Salman Paris Salsabila Nanda Maharani Setyaningsih, Yuni Simanjuntak, Kristina Soroy Lardo Soroy Lardo Sri Wahyuningsih Sugeng Wiyono Sukrisno, Adi Tasya Nooramadhani Tiwuk Susantiningsih Tiwuk Susantiningsih Tri Faranita, Tri Uswatun Hasanah Uswatun Hasanah Vyona Rizky Mediosepti Wahab, Dinda Nuraini Hanifah Wendi Corlia Cahyaninglatri Wibawanto, Dimas Farhan Winsca Maghfirda Yasya Yanto Sandy Tjang Yudhi Nugraha Yuliyanti, Retno Yuni Setyaningsih Zihono, Yudivaniel