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All Journal Jurnal Gizi dan Pangan E-Jurnal Medika Udayana Jurnal Kedokteran Syiah Kuala AL KAUNIYAH Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Manajemen Kesehatan Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Wikrama Parahita : Jurnal Pengabdian Masyarakat JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Buletin Farmatera Jurnal Pengabdian Masyarakat AbdiMas Majalah Kedokteran Andalas Jurnal Biomedika dan Kesehatan Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan SULUH: Jurnal Abdimas Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS World Nutrition Journal Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat SEGARA : Jurnal Pengabdian Kepada Masyarakat
Maria Selvester Thadeus
Universitas Pembangunan Nasional Veteran Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Hepatoprotective Effect of Parijoto Fruit Extract (Medinilla speciosa Blume) on Male Mice Fed with High-Fat Diet Nabila, Inasa; Thadeus, Maria Selvester; Herardi, Ryan
Jurnal Gizi dan Pangan Vol. 18 No. 1 (2023)
Publisher : The Food and Nutrition Society of Indonesia in collaboration with the Department of Community Nutrition, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25182/jgp.2023.18.1.21-30

Abstract

This study aims to determine the effectiveness of parijoto fruit extract (Medinilla speciosa Blume) in improving the condition of fatty liver in male balb/c mice (Mus musculus L.) fed with a high-fat diet. Thirty male balb/c mice weighing 20 to 30 g were randomly divided into six groups, i.e: 1) Standard feed and Carboxymethyl Cellulose Sodium or CMC-Na 0.5% (K1); 2) High-fat diet and CMC-Na 0.5% (K2); 3) High-fat diet and simvastatin 0.026 mg/day (K3); 4) High-fat diet and parijoto fruit extract 5.6 mg/20 g BW (P1); 5) High-fat diet and parijoto fruit extract 8.4 mg/20 g BW (P2); 6) High-fat diet and parijoto fruit extract 11.2 mg/20 g BW (P3). Standard feed, high-fat diet, simvastatin, and parijoto fruit extract were administered for 56 days. On the 57th day, the total of 30 mice were terminated and the livers were then removed for H&E staining histopathological slides. Data on the degree of fatty liver on histopathological slides were collected and analyzed using the Kruskal-Wallis test and followed by the Mann-Whitney test. The histopathological analysis showed Medinilla speciosa Blume extract at a dose of 5.6 mg/20 g BW in group P1 prevent the steatosis degree compared to high-fat feed mice in group K2 (p>0.05). Parijoto fruit extract could act as the potential treatment for fatty liver.
Association of Muscle Mass and Fasting Blood Glucose with Vascular Elasticity in Medical Students Purba, Raja Soaloon; Bustamam, Nurfitri; Thadeus, Maria Selvester; Dewiastuti, Marlina
Jurnal Ilmiah Kesehatan Masyarakat : Media Komunikasi Komunitas Kesehatan Masyarakat Vol 17 No 4 (2025): JIKM Vol 17, Issue 4, November 2025
Publisher : Public Health Undergraduate Program, Faculty of Health Science, Universitas Pembangunan Nasional Veteran Jakarta

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Abstract

Background: Low vascular elasticity is one of the key determinants of cardiovascular disease risk. Sedentary lifestyles and high-glucose diets may decrease muscle mass and increase blood glucose levels, potentially reducing vascular elasticity. This study aimed to analyze the relationships among muscle mass, fasting blood glucose levels, and vascular elasticity in medical students. Methods: A cross-sectional study was conducted involving 53 medical students aged 18—22 years using a stratified random sampling technique. Eligible participants were non-smokers, non-alcohol consumers, and had no history of diabetes, hypertension, or the use of medications affecting blood pressure, blood glucose, or cholesterol levels. Muscle mass, fasting blood glucose, and vascular elasticity were measured using a bioelectrical impedance analyzer, capillary blood testing, and an accelerated photoplethysmograph, respectively. Data were analyzed using a Chi-square tests and multivariable Logistic Regression. Results: There were no significant differences in age, blood pressure, BMI, or eating habits between the suboptimal and normal/optimal vascular elasticity groups (p > 0.05). Multivariable analysis showed that muscle mass was significantly associated with vascular elasticity (p = 0.009; OR = 9.656; CI = 1.757–53.075), after adjustment for fasting blood glucose levels (p = 0.386; OR = 2.329; CI = 0.344–15.776). Participants with higher muscle mass were nearly 10 times more likely to have better vascular elasticity. Conclusion: Muscle mass is significantly associated with vascular elasticity in young adults, independent of fasting blood glucose levels. These findings highlight the importance of maintaining adequate muscle mass. Promoting muscle mass through healthy lifestyle habits may help preserve vascular elasticity and reduce the risk of cardiovascular disease.
Co-Authors Abdullah Rukman Adisaputra, Chantika Zahra Adrian Dharmawan Adyatma, Hilmi Agneta Irmarahayu Akbar, Rafi Thoriq Alyani, Fadhilah Sharfina Annisa Afifah Audrey Alvura Digna Basuki Supartono Cahyaninglatri, Wendi Corlia Cut Fauziah Cut Fauziah Cut Fauziah Dimas Farhan Wibawanto Dinda Nuraini Hanifah Wahab Eko Satrio Bahari Erna Harfiani Fachruddin Perdana Fajriati Zulfa Fajriati Zulfa Familia Bella Rahadiati Giopratiwi, Kusvandita Hany Yusmaini Hardini, Niniek Hikmah Muktamiroh Husna Bunga Jannati Jannati, Husna Bunga Kristina Simanjuntak Kristina Simanjuntak Kristina Simanjuntak Marlina Dewiastuti, Marlina Meiskha Bahar Mila Citrawati Muhammad Alif Farhan Muhammad Kevin Auliansyah Akbar Muktamiroh Hikmah Muttia Amalia Nabila, Inasa Nadira Safa Jasmine Nainggolan, Dorlina Nazira, Syarifah Ni Luh Aurial Widjayanti Niniek Hardini Niniek Hardini Noor Az Zhahra Nooramadhani, Tasya Nugrahayu Widyawardani Nunuk Nugrohowati Nurfitri Bustamam Pamuji, Alifia Shafanaura Prakoso, Luthfi Octafyan Pujangga, Ibnu Wadud Purba, Raja Soaloon Rahadiati, Familia Bella Ramadhansyah, Reza Reinhart Fikram Imam Akbar Retno Yulianti Retno Yuliyanti Rukman Abdullah Ryan Herardi Salman Paris Salman Paris Setyaningsih, Yuni Simanjuntak, Kristina Soroy Lardo Sri Wahyuningsih Sugeng Wiyono Sukrisno, Adi Tiwuk Susantiningsih Tri Faranita, Tri Uswatun Hasanah Uswatun Hasanah Wahab, Dinda Nuraini Hanifah Wibawanto, Dimas Farhan Yanto Sandy Tjang Yudhi Nugraha Yuliyanti, Retno