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THE EFFECT OF NOISE EXPOSURE ON THE AVERAGE NUMBER OF TEMPORAL LOBUS NEURONS IN ADULT WISTAR RATS Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gde; Witari, Ni Putu Diah; Sumadewi, Komang Trisna; Prima Dewi, A.A.A Asri; Anthony Kerans, Fransiscus Fiano; Kurniawati, Ida
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P09

Noise is defined as unwanted and disruptive sound, considered an environmental stressor and disturbance. Noise encompasses many aspects of modern communities, including work environments. The damaging effects of noise primarily result from the unrestricted production of free radicals into the auditory organs. Exposure to noise causes various health problems, such as hearing impairment, sleep disturbances, and interference with individual performance. Reactive oxygen species (ROS), also known as free oxygen radicals, are normal by-products of cellular aerobic metabolism. These unstable molecules can damage cellular lipids, proteins, and nucleic acids in DNA if the antioxidant balance is disrupted. Acute and chronic exposure to loud noise generates excessive free radicals and disrupts extra-auditory organs such as the nervous, endocrine, and cardiovascular systems. The purpose of this study is to analyze the relationship between noise exposure and the number of neurons in the temporal lobes of Wistar rats. The research design used is a laboratory experimental design, specifically a pure experimental design, implemented with the randomized posttest-only control group design. The research sample consists of 30 male Wistar rats randomized into 2 groups, control and treatment. The treatment group is exposed to 95dB noise for 4 hours per day for 14 days. The rats are then euthanized, and their brain tissue is fixed with 10% neutral buffered formalin. Assessment is performed using Hematoxylin Eosin staining, and analysis is conducted blindly on the average number of neurons in the rat's temporal lobes. Data is subjected to normality testing using the Shapiro-Wilk test and analyzed using independent t-tests for parametric comparison. The results show a significant difference in the mean number of neurons in the temporal lobes between rats exposed to noise and the control group (p <0.005). The conclusion of this study is that noise affects neuron cells in the temporal lobes. Keywords : noise, temporal lobe, neurons.

EVALUATING THE EFFECTIVENESS OF ANATOMY AND HISTOLOGY PRACTICUM DURING COVID-19 PANDEMIC AT FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS WARMADEWA Evayanti, Luh Gde; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Suka Astini, Dewa Ayu Agung Alit; Kerans, Fransiscus Fiano Anthony; Dewi, A.A.Ayu Asri Prima; Ekayani, Ni Wayan Diana
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P11

The implementation of anatomy and histology practical sessions at Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Universitas Warmadewa during the Covid-19 pandemic still has many variations. This difference in implementation will have an influence on the achievement of student learning. This research aims to evaluate the knowledge of anatomy and histology among students by giving asynchronous learning, pre-test, post-test and practicum exam. This study using cross-sectional approach. 124 participants are 3th semester students whose active status at FKIK Universitas Warmadewa. The primary data were collected directly from practical sessions and practicum exam. The pre-test and post-test data were analyzed using paired-T test (p<0.05). The post-test and practicum exam were analyzed using Spearman rho (p<0.05). In anatomical practicum, there is an increase in post-test scores when compared to pre-test although not significant (p = 0.119). Anatomical practicum exam results have a meaningful positive correlation with post-tests (p = 0.013, r = 0.22). In histological practicum there was a significant increase in post-test scores when compared to pre-tests (p = 0.013), although practicum exam results were not significantly correlated with post-test (p = 0.410). Based on this study, improvements are needed related to technical of anatomical and histological practicums, as well as provisions related to practicums so that activities are structured

EKSTRAK ETANOL UMBI UBI JALAR UNGU (Ipomoea batatas L) MENINGKATKAN KETEBALAN ENDOMETRIUM Udiyani, Desak Putu Citra; Jawi, , I Made; Sugiritama, Wayan; Nyoman Arijana, I Gusti Kamasan; Sumadewi, Komang Trisna
E-Jurnal Medika Udayana Vol 12 No 9 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i09.P11

Menopause merupakan salah satu proses yang alami untuk Wanita, dengan terapi Hormone Replacement Therapy (HRT) menimbulkan efek endometriosis dan tromboemboli vena. Umbi ubi jalar ungu (Ipomoea batatas L) merupakan tumbuhan dengan antosianin yang mampu meningkatkan ploriferasi uterus. Tujuan penelitian: penelitian ini membuktikan ekstrak etanol umbi ubi jalar ungu (Ipomoea batatas L) mampu meningkatkan ketebalan endometrium uterus. Metoda penelitian: rancangan penelitian True Experimental-Post Test Only Control Group Design dimana 28 ekor tikus Wistar betina dikelompokkan menjadi 4 kelompok (@7 ekor tikus): P0 merupakan kelompok kontrol, P1 dengan esktrak dosis 10 mg/kgBB, P2 dengan dosis 30 mg/kgBB, dan P3 dosis 100 mg/kgBB diberikan selama 30 hari melalui sonde, pengangkatan uterus pada hari ke 30 dan mengamati ketebalan endometrium uterus. Hasil penelitian: ketebalan endometrium uterus antar kelompok perlakuan dengan rerata berbeda secara signifikan (p=0,000). Kelompok P3 dengan ketebalan endometrium paling tinggi. Kesimpulan: disimpulkan bahwa ekstrak etanol umbi ubi jalar ungu mampu meningkatkan ketebalan endometrium uterus tikus putih yang diovariektomi. Kata kunci: Ekstrak, ubi jalar ungu, antosianin, uterus

IMPROVING CHILDREN'S VISUAL SPATIAL INTELLIGENCE THROUGH DRAWING AT BALI STREET MUMS AND KIDS PROJECT FOUNDATION, DENPASAR Sumadewi, Komang Trisna; Yupardhi, Toddy Hendrawan; Primatanti, Putu Asih; Harkitasari, Saktivi
Community Development Journal Vol 8 No 1 (2024): Community Development Journal
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/cdj.v8i1.5625

Presently, multiple educational options exist for both primary school and higher education. The entire education system is designed to assist students in cultivating a range of abilities or intelligences inherent in each individual, encompassing mental and physical aspects. This concept is usually referred to as "Multiple Intelligences." Spatial visual intelligence is a form of intelligence that can visualize objects and possesses cognitive benefits in processing information through mental imagery. The parenting style employed by parents also influences children's intellectual ability. Based on interviews with foundation managers, it has been seen that due to online learning, youngsters affiliated with the foundation end up reverting to life on the streets, resorting to begging. Before the COVID-19 outbreak, the charity organized various programs and training sessions to enhance street children's skills. Several measures are implemented to diminish the inclination of street children to return to the streets. Nevertheless, given the prevailing circumstances, these activities have significantly reduced, resulting in children reverting to the streets as beggars, often with the consent of their parents. The foundation management anticipates providing training programs to cultivate children's intelligence, encompassing cognitive and emotional aspects. Furthermore, the foundation management seeks to provide parental education to parents of these youngsters. A service program was implemented to address these issues. It involved providing parenting education and teaching children how to draw to enhance their visual-spatial intelligence. The practice yielded a 60.4% increase in parents' knowledge and improved children's drawing skills. All participants attended this activity without exception. Therefore, this service program action was successful.

Pemberdayaan Kader Posyandu Dalam Stimulasi Perkembangan Bayi Melalui Baby Gym di Banjar Tandang Tri Buana, Desa Batur Tengah, Kintamani Sumadewi, Komang Trisna; Asri Prima Dewi, Anak Agung Ayu; Anthony Kerans, Fransiscus Fiano; Diah Witari, Ni Putu; Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gede; Kurniawati, Ida
Warmadewa Minesterium Medical Journal Vol. 3 No. 3 (2024): September 2024
Publisher : Warmadewa University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Gangguan perkembangan pada bayi dan anak menjadi perhatian pemerintah karena dampak yang dapat ditimbulkan. Gangguan perkembangan motorik banyak ditemukan pada bayi usia 3-5 bulan. Gangguan ini berupa keterlambatan perkembangan yang tidak sesuai dengan usianya. Kondisi ini terjadinya karena dipengaruhi oleh berbagai faktor, salah satunya rendahnya stimulus yang diberikan. Berdasarkan wawancara bersama kader Posyandu di Banjar Tandang Tribuana, Desa Batur Tengah, Kecamatan Kintamani, Kabupaten Bangli, didapatkan bahwa pemberian informasi mengenai perkembangan anak masih rendah, pelatihan mengenai pemberian stimulasi bayi dan anak juga masih jarang dilakukan, serta belum pernah dilakukan pelatihan mengenai baby gym. Melihat permasalahan tersebut, maka solusi yang dapat dilakukan antara lain memberikan edukasi mengenai tumbuh kembang serta stimulasi anak berdasarkan usia, dan pelatihan mengenai baby gym yang dapat membantu perkembangan bayi dan anak. Program ini bertujuan untuk meningkatkan pengetahuan mitra mengenai tumbuh kembang anak, stimulasi perkembangan sesuai usia, mengenali keterlambatan perkembangan serta meingkatkan keterampilan mitra dalam melakukan baby gym. Mellalui kegiatan ini didapatkan hasil berupa peningkatan pengetahuan mitra mengenai tumbuh kembang dan stimulasi anak sebesar 51.17%, peningkatan keterampilan mitra dalam memberikan stimulasi serta melalukan baby gym. Kehadiran peserta 100% dengan pastisipasi aktif melalui respon yang diberikan oleh peserta. Kesimpulannya, program ini terlaksana dengan lancar dan dapat memenuhi indikator keberhasilan program yang sudah ditetapkan oleh tim pengabdian.

Relationship between Vitiligo Disease and Quality of Life of Patients at Sanjiwani Gianyar Regional General Hospital Prasanthi Dewi, Ratih; Puspasari, Ni Made Indah; Sumadewi, Komang Trisna
Muhammadiyah Medical Journal Vol. 6 No. 1 (2025): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mmj.6.1.31-40

Background: Vitiligo is an idiopathic skin disorder of acquired depigmentation that burdens patients’ lives. This disorder often causes problems that can affect the psychological and social well-being of patients and ultimately affect their quality of life. Purposes: This study aims to determine the relationship between vitiligo disease and patients’ quality of life at Sanjiwani Gianyar Hospital. Methods: This type of research is analytically observational with a cross-sectional approach. Data were collected by filling out the DLQI questionnaire. All data collected was analyzed using univariate and bivariate analysis. The research results are declared significant if the p-value is <0.05 and not significant if the p-value is >0.05. Results: The results showed that most vitiligo patients were in the age range of 30-39 years (30%), female (26%), high school education level (28%), unmarried (38%), self-employed and traders (20%), and generalized vitiligo classification (80%). The PR value of 3.33 (95% CI: 1.614-6.879) indicates vitiligo patients have at least a moderate to considerable influence on their quality of life by three times and at most six times. Based on the results of bivariate statistical tests using chi-square, the p-value = 0.000 (p < 0.05), which means the result is significant. Conclusion: Vitiligo disease is significantly related to patients' quality of life at Sanjiwani Gianyar Regional General Hospital.

The Effect of Pilocarpine Hydrochloride on The Occurrence of Temporal Lobe Epileptic Seizures in White Mice (Mus musculus L.) BALB/C Strain Audria, Intan Safira; Harkitasari, Saktivi; Diah Witari, Ni Putu; Ningrum, Rima Kusuma; Putra Parwati, Tjok Istri; Sumadewi, Komang Trisna; Wiranatha, I Gede; Pratiwi, Cokorda Agung
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.67-72

The objective of this research was to determine the effective dosage of pilocarpine hydrochloride to provoke epileptic seizures in animal models. In this study, a true-experimental method was utilized, employing a post-test only control group design. A total of 32 white mice (Mus musculus Linnaeus UICC 524) BALB/c strains were divided into four different groups for this study. The experimental groups were subjected to varying dosages of pilocarpine hydrochloride: 220 mg/kgBW as group I, 320 mg/kgBW as group II, and 350 mg/kgBW as group III. On the other hand, the control group was administered a saline solution (NaCl 0.9%) at a dosage of 0.16% ml/kgBW. Both pilocarpine hydrochloride and saline solution (NaCl 0.9%) were injected intraperitoneally (i.p) into mice. In group I, none of the mice experienced epileptic seizures, and they all survived. In contrast, in group III, all the mice experienced epileptic seizures, but none of them survived. The Man-Whitney Test showed significant differences in seizure occurrence across doses (p<0.01). The effective dose of pilocarpine hydrochloride for inducing epileptic seizures associated with temporal lobe epilepsy (TLE) in this study appears to be in the range of 320 mg/kgBW to 350 mg/kgBW.

Hematology Profiles in Colorectal Cancer Patients in Bali Kurniawati, Ida; Dewi, Anak Agung Ayu Asri Prima; Kerans, Fransiscus Fiano Anthony; Witari, Ni Putu Diah; Adyasputri, A A I Ayesa Febrinia; Sueta, Made Agus Dwianthara; Sumadewi, Komang Trisna; Evayanti, Luh Gde; Astini, Dewa Ayu Agung Alit Suka
Jurnal Ilmiah Kesehatan Vol 18 No 01 (2025): Jurnal Ilmiah Kesehatan (Journal of Health Science)
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/jhs.v18i01.6936

Colorectal cancer is a leading cause of cancer-related deaths worldwide. This study explores blood profile and cancer staging in colorectal cancer patients in Bali. It was a descriptive-analytical study that collected demographic and clinical data from medical records of colorectal cancer patients at Prof. Dr. I.G.N.G. Ngoerah Hospital. The results of the study showed the basic characteristics and hematology profiles of 100 colorectal cancer patients. The average age of patients was 55.6 ± 11.4 years, with 54% of the total sample being male. The average body mass index (BMI) was 21.1 ± 3.6 kg/m², with an average height of 161.9 ± 6.1 cm and an average weight of 55.3 ± 10.0 kg. Laboratory tests revealed an average hemoglobin (Hb) level of 11.0 ± 3.6 g/dL, red blood cell count of 4.0 ± 0.9 million/μL, white blood cell count of 11.2 ± 7.3 thousand/μL, and platelet count of 302.8 ± 154.8 thousand/μL. The average hematocrit (HCT) level was 33.7 ± 6.6 L/L. Liver function parameters indicated average aspartate aminotransferase (AST/SGOT) levels of 45.6 ± 63.6 U/L and alanine aminotransferase (ALT/SGPT) levels of 24.6 ± 29.4 U/L. Renal function was described by an average blood urea nitrogen (BUN) level of 21.8 ± 21.0 mg/dL, urea levels of 21.9 ± 21.2 mg/dL, and creatinine levels of 2.3 ± 11.5 mg/dL. Our study highlights the importance of hematology profiles in colorectal cancer patients as part of cancer screening examination. Further study with a larger number of samples and more diverse populations is needed to analyze the relation between variables.

Edukasi Gangguan Tumbuh Kembang dan Stimulasi Kemampuan Bicara Berbasis Keluarga dalam Program Community Oriented Medical Education di Desa Bresela, Gianyar Sumadewi, Komang Trisna; Yupardhi, Toddy Hendrawan; Satriya Wibawa, I Komang
Jurnal Pengabmas Masyarakat Sehat Vol 7, No 2 (2025): APRIL
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jpms.v7i2.2850

Anak usia ≤ 2 tahun merupakan periode emas perkembangan otak. Pada periode ini, kebutuhan gizi anak harus terpenuhi dengan baik. Kurangnya nutrisi pada anak meningkatkan risiko terjadinya gangguan pertumbuhan dan perkembangan. Anak dengan stunting memiliki risiko lebih tinggi mengalami gangguan perkembangan. Selain gizi, kurangnya stimulasi juga menjadi faktor yang dapat menyebabkan gangguan perkembangan. Berdasarkan wawancara bersama orang tua, didapatkan permasalahan prioritas antara lain kurangnya pemahaman mengenai tahapan tumbuh kembang anak, adanya keterlambatan bicara pada anak serta kurangnya keterampilan dalam memberikan stimulasi bicara. Program edukasi pertumbuhan dan perkembangan serta stimulasi kemampuan bicara bertujuan untuk menambah wawasan orang tua dalam melakukan skrining serta deteksi dini gangguan tumbuh kembang serta memberikan stimulasi yang benar sesuai usia. Metode yang digunakan dalam program pengabdian ini meliputi edukasi mengenai tumbuh kembang anak, pengenalan Kuisioner Pra Skrining Pengembangan (KPSP), serta demonstrasi pemberian stimulasi bicara pada anak. Dari pelaksanaan program pengabdian ini didapatkan adanya peningkatan pengetahuan mitra sebesar 66,7% berdasarkan nilai pretest dan posttest. Disamping itu, dari observasi tampak adanya peningkatan mitra dalam melakukan skrining tumbuh kembang menggunakan KPSP serta bentuk stimulasi yang dapat dilakukan. Dengan demikian, dapat disimpulkan kegiatan pengabdian ini berjalan lancar. Akan tetapi, perlu dilakukan monitoring secara berkelanjutan untuk mengetahui implementasi program ini dalam kehidupan sehari-hari.

Edukasi Gangguan Tumbuh Kembang dan Stimulasi Kemampuan Bicara Berbasis Keluarga dalam Program Community Oriented Medical Education di Desa Bresela, Gianyar Sumadewi, Komang Trisna; Yupardhi, Toddy Hendrawan; Satriya Wibawa, I Komang
Jurnal Pengabmas Masyarakat Sehat Vol 7, No 2 (2025): APRIL
Publisher : Poltekkes Kemenkes Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33992/jpms.v7i2.2850

Anak usia ≤ 2 tahun merupakan periode emas perkembangan otak. Pada periode ini, kebutuhan gizi anak harus terpenuhi dengan baik. Kurangnya nutrisi pada anak meningkatkan risiko terjadinya gangguan pertumbuhan dan perkembangan. Anak dengan stunting memiliki risiko lebih tinggi mengalami gangguan perkembangan. Selain gizi, kurangnya stimulasi juga menjadi faktor yang dapat menyebabkan gangguan perkembangan. Berdasarkan wawancara bersama orang tua, didapatkan permasalahan prioritas antara lain kurangnya pemahaman mengenai tahapan tumbuh kembang anak, adanya keterlambatan bicara pada anak serta kurangnya keterampilan dalam memberikan stimulasi bicara. Program edukasi pertumbuhan dan perkembangan serta stimulasi kemampuan bicara bertujuan untuk menambah wawasan orang tua dalam melakukan skrining serta deteksi dini gangguan tumbuh kembang serta memberikan stimulasi yang benar sesuai usia. Metode yang digunakan dalam program pengabdian ini meliputi edukasi mengenai tumbuh kembang anak, pengenalan Kuisioner Pra Skrining Pengembangan (KPSP), serta demonstrasi pemberian stimulasi bicara pada anak. Dari pelaksanaan program pengabdian ini didapatkan adanya peningkatan pengetahuan mitra sebesar 66,7% berdasarkan nilai pretest dan posttest. Disamping itu, dari observasi tampak adanya peningkatan mitra dalam melakukan skrining tumbuh kembang menggunakan KPSP serta bentuk stimulasi yang dapat dilakukan. Dengan demikian, dapat disimpulkan kegiatan pengabdian ini berjalan lancar. Akan tetapi, perlu dilakukan monitoring secara berkelanjutan untuk mengetahui implementasi program ini dalam kehidupan sehari-hari.

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