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All Journal Biospecies Journal of Mathematical and Fundamental Sciences JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Biologi Tropis Jurnal Maternitas Kebidanan Jurnal Keperawatan Priority PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Jurnal Ners Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Kesehatan Tambusai PRIMER (Prima Medical Journal) Ahmar Metastasis Health Journal (AMHJ) Jurnal Impresi Indonesia Journal of Social Research GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Buletin Kedokteran dan Kesehatan Prima International Journal of Public Health Excellence (IJPHE) International Journal of Health and Pharmaceutical (IJHP) Jurnal Pendidikan Indonesia (Japendi) Journal of Pharmaceutical and Sciences. JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Indonesian Journal of Sport Science and Coaching
Yolanda Eliza Putri Lubis
Fakultas Kedokteran, Kedokteran Gigi, Dan Ilmu Kesehatan Universitas Prima Indonesia
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Uji Daya Hambat Kombinasi Ekstrak Daun Nanas (Ananas Comosus (L.) Merr.) dan Daun Sirih Hijau (Piper Betle L.) Terhadap Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Zuhra, Layla; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62296

Abstract

Jerawat vulgaris merupakan kondisi inflamasi kronis pada kelenjar pilosebasea yang ditandai dengan berbagai jenis lesi. Bakteri utama yang berperan dalam patogenesis jerawat adalah Propionibacterium acnes dan Staphylococcus aureus. Terapi antibiotik konvensional dapat menimbulkan efek samping dan resistensi, sehingga diperlukan alternatif antimikroba dari bahan alam. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri kombinasi ekstrak etanol daun nanas (Ananas comosus (L.) Merr.) dan daun sirih hijau (Piper betle L.) terhadap bakteri P. acnes dan S. aureus. Ekstrak dibuat dengan metode maserasi menggunakan etanol 96% pada konsentrasi 20%, 40%, dan 60%. Uji antibakteri dilakukan menggunakan metode difusi cakram (Kirby-Bauer) pada media Nutrient Agar, dengan klindamisin sebagai kontrol positif dan aquadest sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa kombinasi ekstrak pada semua konsentrasi mampu membentuk zona hambat terhadap P. acnes (diameter rata-rata: 20,23 mm; 22,69 mm; 24,85 mm) dan S. aureus (diameter rata-rata: 20,51 mm; 20,23 mm; 24,74 mm), dengan zona hambat terbesar pada konsentrasi 60%. Analisis statistik menunjukkan perbedaan signifikan pada P. acnes (p = 0,016), namun tidak pada S. aureus (p = 0,284). Temuan ini mendukung potensi kombinasi ekstrak daun nanas dan sirih hijau sebagai alternatif agen antibakteri topikal untuk pengobatan jerawat, khususnya terhadap P. acnes. Penelitian lebih lanjut diperlukan untuk mengkaji mekanisme kerja dan keamanan penggunaannya.
Gambaran Penggunaan Obat Proton Pump Inhibitor Pada Pasien Tukak Peptikum Di Rs Royal Prima Medan Periode Januari 2022 – April 2025 Doladave, Miguelle Franklin; Handayani, Putri; Lubis, Yolanda Eliza Putri
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62357

Abstract

Peptic ulcer disease is a gastrointestinal disorder characterized by mucosal lesions in the stomach or duodenum. Proton Pump Inhibitors (PPIs) are the main therapy by inhibiting gastric acid secretion. To describe the use of PPI drugs in patients with peptic ulcer disease at Royal Prima Hospital Medan from January 2022 to April 2025. This descriptive retrospective study used secondary data from medical records. Samples were selected using total sampling technique, involving 96 patients who met the inclusion and exclusion criteria. Data were analyzed univariately and presented in frequency distribution. Most patients were over 50 years old (62.5%) and female (56.2%). The most commonly used PPI was lansoprazole (62.5%), with dosage of 2x1 daily (78.1%), treatment duration of 7-30 days (53.1%), and the most frequent clinical symptom was nausea (45.8%). The use of PPIs in peptic ulcer patients at Royal Prima Hospital Medan was largely in accordance with the principles of appropriate indication and dosage, with lansoprazole being the most frequently used drug.
The Effect of Administration of Rosella Flower (Hibiscus Sabdariffa) Extract Gel on The Expression Of TNF-α And Caspase-3 Expression in An In Vivo Study of Wistar Strain Rats Exposed to Ultraviolet B-Lights Purboningtyas, Dyah Nisma; Lumbantobing, Christina J.R.E.; Lubis, Yolanda Eliza Putri
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.753

Abstract

UV rays are oxidative because they can produce Reactive Oxygen Species and free radical compounds. The dangers of sun exposure can cause skin disorders such as aging at an early age (photoaging). Rosella flower petals can be used in medicine, jams, and natural food coloring because they contain flavonoids as antioxidants or free radical scavengers. The research aimed to determine the effect of administering Rosella (Hibiscus sabdariffa L.) flower extract gel on TNF-α expression and Caspase-3 expression in an in vivo study of Wistar mice exposed to UVB. This research is an experimental study. The sample for each treatment group consisted of 6 individuals, so the total research sample was 24. Data analysis used descriptive, normality, and homogeneity tests with data analysis processing using SPSS 25.0 for Windows. The study found that administration of rosella flower extract gel with a concentration of 15% effectively reduced the expression of TNF-α and Caspase-3 in mice exposed to UVB light and produced filled and dense collagen. So, it can be concluded that rosella flower extract gel can act as an antioxidant that inhibits the growth of TNF-α and Caspase-3 expression.
EVALUASI PENGGUNAAN OBAT DAN IDENTIFIKASI DRUG RELATED PROBLEM (DRP) PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM ROYAL PRIMA MEDAN Tafonao, Rachel Julia; Yunus, Muhammad; Lubis, Yolanda Eliza Putri
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32447

Abstract

Pengelolaan diabetes melitus tipe 2 sering kali kompleks dan membutuhkan penggunaan lebih dari satu jenis obat, yang dapat menyebabkan Drug Related Problems (DRP). Penelitian ini bertujuan untuk mengevaluasi penggunaan obat dan mengidentifikasi Drug Related Problem (DRP) yang kemungkinan terjadi pada pasien diabetes melitus tipe 2. Penelitian ini adalah penelitian deskriptif dengan pendekatan prospektif, yang dilakukan di Rumah Sakit Umum Royal Prima Medan dari September hingga November 2023. Data yang digunakan adalah 450 resep pasien rawat jalan yang berusia 18 tahun dan didiagnosis dengan diabetes melitus tipe 2, baik dengan atau tanpa komplikasi, serta menggunakan obat antidiabetes oral. Dari hasil penelitian, karakteristik pasien diabetes melitus tipe 2 yang paling banyak adalah kelompok usia dewasa (19-59 tahun) dengan 55.33% dan jenis kelamin perempuan dengan 60.44%. Metformin adalah obat antidiabetes yang paling umum digunakan dengan persentase 36.74%. Potensi DRP yang paling sering ditemukan adalah interaksi obat (97%) dan overdosis (3%). Identifikasi dan manajemen DRP yang tepat sangat penting untuk meningkatkan efektivitas terapi dan kualitas hidup pasien. Disarankan juga adanya edukasi berkelanjutan bagi pasien dan pelatihan bagi tenaga medis untuk meminimalkan risiko DRP.
Ekstrak Granul Nanopartikel Kulit Jeruk Sunkist (Citrus Sinensis (L.) Osbeck) Dan Ekstrak Kulit Jeruk Nipis (Citrus Aurantifolia) Terhadap Gambaran Perlemakan Hati Pada Tikus (Rattus Norvegicus) Model Diabetes) Mutia, Maya Sari; Nabila, Putri; Hamsi, Ulpah Zahara; Lubis, Yolanda Eliza Putri
Jurnal Maternitas Kebidanan Vol. 9 No. 2 (2024): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v9i2.5623

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck have a high content of anthocyanins (95% of which are cyanidin-3-glucoside and cyanidine-3-6"-malonyl-glucoside), flavanone (hesperidin and narirutin), as well as hydroxynamic acid (caffeic acid, cumaric acid, cinnamic acid, and ferulic acid), carotenoids, sugars, minerals, and fiber, considered a good food source of bioactive substances with beneficial effects on health. This study aims to examine the potential for liver improvement in mice with a diabetes model after the administration of nanoparticle granules combining sunkist orange peel and lime peel. The design of this experimental research is Post Test Only Control Group Design. Twenty-five male rats of the wistar strain were used which were divided into 5 groups at random, namely the negative control group (aloxan), the positive control group (aquadest), Treatment 1 (aloxan + nanoparticle granules 50mg/kgBB), Treatment 2 (aloxan + nanoparticle granules 100mg/kgBB) Treatment 3 (aloxan + nanoparticle granules 200mg/kgBB). The liver organ was prepared for observation with 10x ocular magnification and 40x objective lens magnification. Liver improvement had an effect on the decrease of SGPT, SGOT, and Histopathological picture of the liver in diabetic model mice after the administration of nanoparticle granules combined with sunkist orange peel and lime peel at concentrations of 50 mg/KgBB, 100 mg/KgBB and 200 mg/KgBB showed significant differences. The best liver improvement is by administering nanoparticle granules a combination of sunkist orange peel and lime peel at a concentration of 200 mg/KgBB. Keyword: Diabetes Mellitus, Sunkist orange and lime peel extracts, fatty live.  
UJI EFEKTIVITAS EKSTRAK RIMPANG KUNYIT TERHADAP BAKTERI BACILLUS CEREUS DENGAN PEMBANDING CIPROFLOXACIN Maulidi, Risyad Rizki; Pangaribuan, Novita Helshinta Dewi; Ginting, Frisdayanti Br; Sheridan, Princessa Fath; Lubis, Yolanda Eliza Putri
Biospecies Vol. 13 No. 1 (2020): Januari 2020
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.703 KB) | DOI: 10.22437/biospecies.v13i1.8389

Abstract

This research aims to find out effectiveness test of turmeric rhizome in concentration of 25%, 50%, 75% and 100% toward Bacillus cereus bacterial and Ciprofloxacin the same concentration as the comparison. Bacillus cereus Bacteria is a gram-positive rod-shaped bacteria and it is dangerous for humans. This research was conducted with an experimental method with post-test only design and sampling using purposive sampling method. The effectiveness test of turmeric rhizome extract toward Bacillus cereus bacteria was carried out by diffusion using disc paper by calculating the diameter of the bacterial inhibition zone against disc paper that had been moistened with turmeric rhizome extract or Ciprofloxacin solution. The results obtained in this research were carried out with the Post Hoc test, the test was found that there were significant differences from each treatment given with a 95% confidence index. In bacteria treated with 25% ciprofloxacin toward Bacillus cereus, the effectiveness was above 50% turmeric rhizome extract and under 75% turmeric extract. Turmeric extract of 75% 10.6 mm had bacterial effect as Ciprofloxacin 25% of 10.1 mm toward the growth of Bacillus cereus bacterial.
- Uji Efektivitas Ekstrak Bunga Pepaya (Carrica papaya L.) Terhadap Kadar Gula Darah Mencit (Mus musculus L.) Jantan Yang Diinduksi Sukrosa: Uji Efetivitas Ekstrak Bunga Pepaya (Carrica Papaya L.) Terhadap Kadar Gula Darah Mencit (Mus Musculus L.) Jantan Yang Diinduksi Sukrosa Marpaung, Febri Sri; Tampubolon, Ester Juanita br.; Andika, Muhammad Insan; Lubis, Yolanda Eliza Putri; Mutia, Maya Sari
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11175

Abstract

The papaya (Carica papaya L) flower contain flavonoids, tannins, and triterpenoid steroids which function as antidiabetic. This study was conducted to determine the antidiabetic effect of papaya (Carica papaya L) flower extract on sucrose-induced male mice. In this study, mice were made diabetic by inducing them with sucrose at a dose of 160 mg/kg BW. A total of 25 mice were grouped homogeneously into 5 groups, consisting of a negative control group (CMC 0.5%), a positive control group (no administration), a group with a dose of 200 mg/kg BW, a group with a dose of 400 mg/Kg. BW, and the group with a dose of 500 mg/Kg BW. Measurement of blood sugar levels of mice was carried out before administration of sucrose, after administration of sucrose and after administration of papaya flower extract. The results showed that the three doses had an antidiabetic effect, and the administration of papaya flower extract at a dose of 200 mg/Kg BW showed a better effect than the negative control.
- Uji Efektivitas Ekstrak Etanol Kulit Jeruk Sunkist (Citrus sinensis (L.) Osbeck) Terhadap Kadar Gula Darah Tikus Wistar (Rattus norvegicus) dengan Hiperkolesterolemia yang di Induksi Streptozotocin. : UJI EFEKTIVITAS EKSTRAK ETANOL KULIT JERUK SUNKIST (Citrus sinensis (L.) Osbeck) TERHADAP KADAR GULA DARAH TIKUS WISTAR (Rattus norvegicus) DENGAN HIPERKOLESTEROLEMIA YANG DI INDUKSI STREPTOZOTOCIN Depari, Sania Angelisa F; Rambe, Daffa Jihan Azmi; Meilando, Rifki; Lisya, Cut; Mutia, Maya Sari; Lubis, Yolanda Eliza Putri
Biospecies Vol. 14 No. 1 (2021): Januari 2021
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/biospecies.v14i1.11250

Abstract

The Condition of high blood sugar levels in people with diabetets appears to trigger an increase in LDL and decrease HDL level where in people with diabetes the energy obtained by the body comes from the decomposition of fat and protein metabolism.”Sunkist orange peel (Citrus sinensis (L.) Osbeck) is reported to have antidiabetic, anti-hypercholesterolemia, anti-inflammatory and antioxidant activities. This study aims to find out the effectiveness of Sunkist orange peel ethanol extract (Citrus sinensis (L.) Osbeck) on blood sugar levels at doses of 500, 750 and 1000 mg/kgBB. This study used the True Experimental Pre-Test and Post-Test Control Group as research design where sunkist orange peel was extracted by maceration method and was given orally for 14 days to streptozotocin induced wistar rat with hypercholesterolemia. Statistical test results showed that ethanol extract of Sunkist orange peel was able to lower blood sugar levels and cholesterol levels of h streptozotocin induced wistar rat with hypercholesterolemia (p<0.05). The most effective dose of Sunkist orange peel ethanol extract in lowering blood sugar levels and cholesterol levels of streptozotocin induced wistar rat with hypercholesterolemia is 1000mg/kgBB.
Medical Record Management Analysis Of Inpatient Patients Based On Standards Of Medical Record Services In Government Hospital In Medan Hasan Basri Nasution, Muhammad; Girsang, Ermi; Eliza Putri Lubis, Yolanda; Napiah Nasution, Ali
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 3 (2022): August 2022
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v2i3.75

Abstract

Inpatient medical records have an important role as a source of data and health information for inpatients related to treatment and care planning. The main factor that causes problems in inpatient medical records is the undisciplined factor of the person in charge who handles patients in filling out medical records. This can cause inpatient medical record management, not in accordance with medical record service standards. This study aimed to analyze inpatient medical record management based on medical record service standards. This research is a quantitative analytic study with a cross-sectional approach. The study was conducted at the Government Hospital in Medan. The research population was 126 people and all of them were used as samples. Sampling by means of total sampling. Data analysis used univariate, bivariate with chi-square test, and multivariate with multiple logistic regression at 95% confidence level (0.05). The results showed that inpatient medical record management implementation based on medical record service standards at the Government Hospital in Medan was influenced by work motivation (p = 0.001) and supervision (p = 0.000). While the variables that have no effect are length of work (p = 1,000), education (p = 0.848), teamwork (p = 0.241), and completeness of infrastructure (p = 0.760). The supervision variable is the most dominant variable or has the greatest influence with the value of Exp(B)/OR = 19,542. Medical record employees who state that supervision is carried out well by superiors will improve the implementation of inpatient medical record management well, compared to those who state that supervision is still not good. It is recommended that the leadership carry out inherent supervision (waskat) to all medical record employees and provide motivation through motivational seminars to improve the implementation of inpatient medical record management based on medical record service standards.
Motivasi Pengendalian Tekanan Darah dan Kualitas Hidup Pasien Hipertensi di Poli Rawat Jalan RS Harapan Bunda Batam Arie Vonikartika; Thomson Parluhutan Nadapdap; Yolanda Eliza Putri Lubis
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.54250

Abstract

Hipertensi merupakan tantangan kesehatan global yang serius dan sering kali tidak menunjukkan gejala hingga terjadi komplikasi berat. Pengendalian penyakit kronis ini sangat bergantung pada faktor internal pasien, terutama motivasi dalam menjalankan perawatan mandiri. Penelitian ini bertujuan untuk menganalisis hubungan antara motivasi pengendalian tekanan darah dengan kualitas hidup pasien hipertensi di Poli Rawat Jalan Rumah Sakit Harapan Bunda Batam. Metode penelitian menggunakan desain deskriptif analitik dengan pendekatan cross-sectional terhadap 230 responden yang dipilih melalui teknik purposive sampling. Data dikumpulkan menggunakan kuesioner TSRQ untuk mengukur motivasi dan WHOQOL-BREF untuk kualitas hidup. Hasil penelitian menunjukkan bahwa mayoritas responden memiliki motivasi tinggi (94,4%) dan kualitas hidup yang baik (96,5%). Uji statistik Spearman Rank menghasilkan nilai p = 0,000 dengan koefisien korelasi (r) sebesar 0,337. Hal ini membuktikan adanya hubungan yang signifikan dengan arah positif namun berkekuatan lemah antara motivasi pengendalian tekanan darah dengan kualitas hidup. Kesimpulan dari penelitian ini adalah semakin tinggi motivasi pasien dalam mengontrol tekanan darah, maka semakin baik pula kualitas hidup yang mereka rasakan. Tenaga kesehatan diharapkan dapat terus memperkuat aspek psikososial pasien guna menjaga stabilitas motivasi tersebut.
Co-Authors Abrianus Sarumaha Adjani Buaya Agnes Rya Sianturi Aisyah Mughni Muchtar Aleksander Marganda Sidebang Ali Napiah Nasution Ananda, Rayhan Khozin Aulia Andika, Muhammad Insan Anggi Sri Ananda Aipin Annisa Alsadilla Zahra Annisa Amalia Arie Vonikartika Aulia, Nathasyia Bayu Ramazata Br Sitepu, Rachel Maria Cruz Jovanca Charles Manurung Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Chrismis Novalinda Ginting Christine Wira Dika Juliana Halawa Claudya Claudya Delfian, Taufik Dendy Teguh Kurniawan Depari, Sania Angelisa F Dessy Series Ulina Ginting Diaz F. Izdihar Dita Anisa Ismardi Doladave, Miguelle Franklin Dwi Surya Artie Edlin Edlin Edlin Nadi Ermi Girsang Ermi Girsang Ermi Girsang Ermi Girsang Evan charista ziraluo Faridahanum, Faridahanum Febri Sri Astuti Marpaung Gideon Nadeak Ginting, Chrismis Novalinda Ginting, Frisdayanti Br Girsang, Ermi Grace Dewani Silaban Gurusinga, Fransisco Bastanta Hamsi, Ulpah Zahara Hanjaya Hasan Basri Nasution, Muhammad Hendy Million I Nyoman Ehrich Lister Ica Yulianti Pulungan Jansen Jansen Juliana Lina Karmila Kaban Katherine Gunawan Lawrence, Christopher Layla Zuhra Lisbetaria Laia Lisya, Cut Lumbantobing, Christina J.R.E. Manao, Oktoriadi Mangatas Silaen Marpaung, Febri Sri Marpaung, Febri Sri Astuti Maulidi, Risyad Rizki Maya Sari Mutia Maya Sari Mutia Maya Sari Mutia Meilando, Rifki Monica, Veny Muhammad Hasan Basri Nasution Muhammad Husni Lubis Muhammad Raihan Ishak Muhammad Yunus Mutia, Maya Sari Nabila, Putri Napiah Nasution, Ali Nardi, Leo Nasution, Masdalena Nathasyia Aulia Nazara, Niscaya Aprian Nova Elisabeth Lumban Gaol Pangaribuan, Novita Helshinta Dewi Pearlie, Michelle Maydelaine Pratomo, Fransiskus Aryo Purboningtyas, Dyah Nisma Putranto Manalu Putri Handayani Putri Handayani Putri, Shafyra Mahdyah Radhitya Qowiyyul Davin Rahmi Arianti Rama Atma Negara Ramadhini, Amelya Putri Rambe, Daffa Jihan Azmi Reghita Claudia Malau Rena Meutia Rizal Rizal Rizky, Muhammad Irvan Roland Daniel Theodore Amudi Matondang Rudolf Alponso Santy Siregar Sari, Ajeng Mestika Sheridan, Princessa Fath Silitonga, Impola Dinita Felicia Sitepu, Bintang Darma M Soekardi, Adi Sri Lestari Sri Lestari Nasution Sri Wahyuni Stevenie - Suandy Suandy Suandy Suandy Suandy, Suandy Suhartomi Susan Gabriella Br Sinulingga Tafonao, Rachel Julia Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Therry Prosperita K. Wau Thomson Parluhutan Nadapdap Wahyu Setia Widodo Wahyu Widowati Widya Yanti Sihotang Yeni Puspawani Yeni Puspawani Yulizal, Ok Zuhra, Layla