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All Journal Biospecies Journal of Mathematical and Fundamental Sciences JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Jurnal Penelitian Pendidikan IPA (JPPIPA) Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Biologi Tropis Jurnal Maternitas Kebidanan Jurnal Keperawatan Priority PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Prima Medika Sains Journal of Telenursing (JOTING) AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Jurnal Kesehatan Tambusai PRIMER (Prima Medical Journal) Ahmar Metastasis Health Journal (AMHJ) Jurnal Impresi Indonesia Journal of Social Research GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Buletin Kedokteran dan Kesehatan Prima International Journal of Public Health Excellence (IJPHE) International Journal of Health and Pharmaceutical (IJHP) Jurnal Pendidikan Indonesia (Japendi) Journal of Pharmaceutical and Sciences. JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Indonesian Journal of Sport Science and Coaching
Yolanda Eliza Putri Lubis
Universitas Prima Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Uji Daya Hambat Kombinasi Ekstrak Daun Nanas (Ananas Comosus (L.) Merr.) Dan Daun Sirih Hijau (Piper Betle L.) Terhadap Bakteri Propionibacterium Acnes Dan Staphylococcus Aureus Zuhra, Layla; Eliza Putri Lubis, Yolanda; Suandy , Suandy
Jurnal Impresi Indonesia Vol. 4 No. 10 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i10.7127

Abstract

Acne vulgaris is a chronic inflammatory condition of the pilosebaceous glands characterized by various types of lesions, commonly affecting adolescents and young adults. Among the principal causative bacteria are Propionibacterium acnes and Staphylococcus aureus. Conventional topical antibiotic therapy may lead to side effects such as skin irritation and antibiotic resistance, which points to the importance of alternative antimicrobial agents sourced from natural products. This experimental study aimed to evaluate the antibacterial activity of a combination of ethanol extracts of pineapple leaves (Ananas comosus (L.) Merr.) and green betel leaves (Piper betle L.) against P. acnes and S. aureus. The extracts were prepared using the maceration method with 96% ethanol and tested at concentrations of 20%, 40%, and 60%. Antibacterial activity was determined by the disk diffusion method (Kirby-Bauer) on Nutrient Agar, using clindamycin as the positive control and sterile aquadest as the negative control. The results demonstrated that all concentrations of the extract combination produced inhibition zones against P. acnes (mean diameters: 20.23 mm, 22.69 mm, and 24.85 mm) and S. aureus (mean diameters: 20.51 mm, 20.23 mm, and 24.74 mm), with the greatest effects observed at 60% concentration. Statistical analysis indicated a significant difference in inhibition against P. acnes (p = 0.016), but not against S. aureus. These findings support the potential use of pineapple and green betel leaf extract combinations as alternative topical antibacterial agents for acne treatment, particularly against P. acnes, and warrant further research into their use as natural anti-acne formulations.
Hubungan Konsumsi Kopi Dengan Kadar Asam Urat, Kolestrol, dan Body Mass Index (BMI) di Warkop Asli Medan Ananda, Rayhan Khozin Aulia; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62247

Abstract

Coffee consumption has become part of people's lifestyle, especially among the productive age group. Coffee contains active compounds known to affect purine metabolism, lipid profile, and nutritional status. This study aims to analyze the relationship between coffee consumption and uric acid levels, cholesterol, and Body Mass Index (BMI) among consumers at Warkop Asli Medan. This study employed a descriptive observational design with a cross-sectional approach conducted from May to August 2025. A total of 96 respondents were selected using purposive sampling technique. Data were collected through questionnaires and direct examinations including uric acid levels, cholesterol, and BMI measurements. Data analysis used chi-square test with significance level of α = 0.05. The majority of respondents were male (65.6%) with moderate coffee consumption (59.4%). Examination results showed 81.3% of respondents had normal uric acid levels, 76.0% had normal cholesterol levels, and 60.4% had normal BMI. Bivariate analysis showed no significant relationship between coffee consumption and uric acid levels (p=0.426), BMI (p=0.160), and cholesterol (p=0.905). There is no significant relationship between coffee consumption and uric acid levels, cholesterol, and BMI among consumers at Warkop Asli Medan.
Uji Daya Hambat Kombinasi Ekstrak Daun Nanas (Ananas Comosus (L.) Merr.) dan Daun Sirih Hijau (Piper Betle L.) Terhadap Bakteri Propionibacterium Acnes dan Staphylococcus Aureus Zuhra, Layla; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62296

Abstract

Jerawat vulgaris merupakan kondisi inflamasi kronis pada kelenjar pilosebasea yang ditandai dengan berbagai jenis lesi. Bakteri utama yang berperan dalam patogenesis jerawat adalah Propionibacterium acnes dan Staphylococcus aureus. Terapi antibiotik konvensional dapat menimbulkan efek samping dan resistensi, sehingga diperlukan alternatif antimikroba dari bahan alam. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri kombinasi ekstrak etanol daun nanas (Ananas comosus (L.) Merr.) dan daun sirih hijau (Piper betle L.) terhadap bakteri P. acnes dan S. aureus. Ekstrak dibuat dengan metode maserasi menggunakan etanol 96% pada konsentrasi 20%, 40%, dan 60%. Uji antibakteri dilakukan menggunakan metode difusi cakram (Kirby-Bauer) pada media Nutrient Agar, dengan klindamisin sebagai kontrol positif dan aquadest sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa kombinasi ekstrak pada semua konsentrasi mampu membentuk zona hambat terhadap P. acnes (diameter rata-rata: 20,23 mm; 22,69 mm; 24,85 mm) dan S. aureus (diameter rata-rata: 20,51 mm; 20,23 mm; 24,74 mm), dengan zona hambat terbesar pada konsentrasi 60%. Analisis statistik menunjukkan perbedaan signifikan pada P. acnes (p = 0,016), namun tidak pada S. aureus (p = 0,284). Temuan ini mendukung potensi kombinasi ekstrak daun nanas dan sirih hijau sebagai alternatif agen antibakteri topikal untuk pengobatan jerawat, khususnya terhadap P. acnes. Penelitian lebih lanjut diperlukan untuk mengkaji mekanisme kerja dan keamanan penggunaannya.
Gambaran Penggunaan Obat Proton Pump Inhibitor Pada Pasien Tukak Peptikum Di Rs Royal Prima Medan Periode Januari 2022 – April 2025 Doladave, Miguelle Franklin; Handayani, Putri; Lubis, Yolanda Eliza Putri
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62357

Abstract

Peptic ulcer disease is a gastrointestinal disorder characterized by mucosal lesions in the stomach or duodenum. Proton Pump Inhibitors (PPIs) are the main therapy by inhibiting gastric acid secretion. To describe the use of PPI drugs in patients with peptic ulcer disease at Royal Prima Hospital Medan from January 2022 to April 2025. This descriptive retrospective study used secondary data from medical records. Samples were selected using total sampling technique, involving 96 patients who met the inclusion and exclusion criteria. Data were analyzed univariately and presented in frequency distribution. Most patients were over 50 years old (62.5%) and female (56.2%). The most commonly used PPI was lansoprazole (62.5%), with dosage of 2x1 daily (78.1%), treatment duration of 7-30 days (53.1%), and the most frequent clinical symptom was nausea (45.8%). The use of PPIs in peptic ulcer patients at Royal Prima Hospital Medan was largely in accordance with the principles of appropriate indication and dosage, with lansoprazole being the most frequently used drug.
The Effect of Administration of Rosella Flower (Hibiscus Sabdariffa) Extract Gel on The Expression Of TNF-α And Caspase-3 Expression in An In Vivo Study of Wistar Strain Rats Exposed to Ultraviolet B-Lights Purboningtyas, Dyah Nisma; Lumbantobing, Christina J.R.E.; Lubis, Yolanda Eliza Putri
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.753

Abstract

UV rays are oxidative because they can produce Reactive Oxygen Species and free radical compounds. The dangers of sun exposure can cause skin disorders such as aging at an early age (photoaging). Rosella flower petals can be used in medicine, jams, and natural food coloring because they contain flavonoids as antioxidants or free radical scavengers. The research aimed to determine the effect of administering Rosella (Hibiscus sabdariffa L.) flower extract gel on TNF-α expression and Caspase-3 expression in an in vivo study of Wistar mice exposed to UVB. This research is an experimental study. The sample for each treatment group consisted of 6 individuals, so the total research sample was 24. Data analysis used descriptive, normality, and homogeneity tests with data analysis processing using SPSS 25.0 for Windows. The study found that administration of rosella flower extract gel with a concentration of 15% effectively reduced the expression of TNF-α and Caspase-3 in mice exposed to UVB light and produced filled and dense collagen. So, it can be concluded that rosella flower extract gel can act as an antioxidant that inhibits the growth of TNF-α and Caspase-3 expression.
EVALUASI PENGGUNAAN OBAT DAN IDENTIFIKASI DRUG RELATED PROBLEM (DRP) PADA PASIEN RAWAT JALAN DIABETES MELITUS TIPE 2 DI RUMAH SAKIT UMUM ROYAL PRIMA MEDAN Tafonao, Rachel Julia; Yunus, Muhammad; Lubis, Yolanda Eliza Putri
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.32447

Abstract

Pengelolaan diabetes melitus tipe 2 sering kali kompleks dan membutuhkan penggunaan lebih dari satu jenis obat, yang dapat menyebabkan Drug Related Problems (DRP). Penelitian ini bertujuan untuk mengevaluasi penggunaan obat dan mengidentifikasi Drug Related Problem (DRP) yang kemungkinan terjadi pada pasien diabetes melitus tipe 2. Penelitian ini adalah penelitian deskriptif dengan pendekatan prospektif, yang dilakukan di Rumah Sakit Umum Royal Prima Medan dari September hingga November 2023. Data yang digunakan adalah 450 resep pasien rawat jalan yang berusia 18 tahun dan didiagnosis dengan diabetes melitus tipe 2, baik dengan atau tanpa komplikasi, serta menggunakan obat antidiabetes oral. Dari hasil penelitian, karakteristik pasien diabetes melitus tipe 2 yang paling banyak adalah kelompok usia dewasa (19-59 tahun) dengan 55.33% dan jenis kelamin perempuan dengan 60.44%. Metformin adalah obat antidiabetes yang paling umum digunakan dengan persentase 36.74%. Potensi DRP yang paling sering ditemukan adalah interaksi obat (97%) dan overdosis (3%). Identifikasi dan manajemen DRP yang tepat sangat penting untuk meningkatkan efektivitas terapi dan kualitas hidup pasien. Disarankan juga adanya edukasi berkelanjutan bagi pasien dan pelatihan bagi tenaga medis untuk meminimalkan risiko DRP.
Ekstrak Granul Nanopartikel Kulit Jeruk Sunkist (Citrus Sinensis (L.) Osbeck) Dan Ekstrak Kulit Jeruk Nipis (Citrus Aurantifolia) Terhadap Gambaran Perlemakan Hati Pada Tikus (Rattus Norvegicus) Model Diabetes) Mutia, Maya Sari; Nabila, Putri; Hamsi, Ulpah Zahara; Lubis, Yolanda Eliza Putri
Jurnal Maternitas Kebidanan Vol. 9 No. 2 (2024): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v9i2.5623

Abstract

Sunkist oranges (Citrus sinensis (L.) Osbeck have a high content of anthocyanins (95% of which are cyanidin-3-glucoside and cyanidine-3-6"-malonyl-glucoside), flavanone (hesperidin and narirutin), as well as hydroxynamic acid (caffeic acid, cumaric acid, cinnamic acid, and ferulic acid), carotenoids, sugars, minerals, and fiber, considered a good food source of bioactive substances with beneficial effects on health. This study aims to examine the potential for liver improvement in mice with a diabetes model after the administration of nanoparticle granules combining sunkist orange peel and lime peel. The design of this experimental research is Post Test Only Control Group Design. Twenty-five male rats of the wistar strain were used which were divided into 5 groups at random, namely the negative control group (aloxan), the positive control group (aquadest), Treatment 1 (aloxan + nanoparticle granules 50mg/kgBB), Treatment 2 (aloxan + nanoparticle granules 100mg/kgBB) Treatment 3 (aloxan + nanoparticle granules 200mg/kgBB). The liver organ was prepared for observation with 10x ocular magnification and 40x objective lens magnification. Liver improvement had an effect on the decrease of SGPT, SGOT, and Histopathological picture of the liver in diabetic model mice after the administration of nanoparticle granules combined with sunkist orange peel and lime peel at concentrations of 50 mg/KgBB, 100 mg/KgBB and 200 mg/KgBB showed significant differences. The best liver improvement is by administering nanoparticle granules a combination of sunkist orange peel and lime peel at a concentration of 200 mg/KgBB. Keyword: Diabetes Mellitus, Sunkist orange and lime peel extracts, fatty live.  
Gambaran Karakteristik Klinis pada Pasien Hepatitis Akut di RSU Royal Prima Medan Tahun 2022-2025 Laia, Lisbetaria; Handayani, Putri; Lubis, Yolanda Eliza Putri
Jurnal Pendidikan Indonesia Vol. 6 No. 10 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i10.8689

Abstract

Hepatitis akut merupakan kondisi medis yang dapat menyebabkan gangguan fungsi hati serta berpotensi berkembang menjadi penyakit hati kronis. Penelitian ini bertujuan untuk mendeskripsikan gambaran karakteristik klinis pada pasien hepatitis akut yang dirawat di RSU Royal Prima Medan pada tahun 2022-2025. Penelitian observasional dengan desain cross-sectional dilakukan dengan menggunakan teknik total sampling. Seluruh pasien yang terdiagnosis hepatitis akut dengan data rekam medis yang lengkap di RSU Royal Prima Medan pada periode 2022-2025 dijadikan sampel dengan total 34 responden. Hasil penelitian menunjukkan mayoritas responden adalah laki-laki (55,9%) dengan kelompok usia dominan kategori dewasa 20-60 tahun (91,2%). Gejala utama yang paling banyak dialami adalah demam (67,6%) dan ikterus (50%). Pemeriksaan laboratorium menunjukkan peningkatan signifikan pada SGOT (70,6%), SGPT (91,2%), bilirubin direct (67,7%), bilirubin indirect (64,8%), dan total bilirubin (70,6%). Penelitian ini memberikan gambaran komprehensif mengenai karakteristik klinis pada pasien hepatitis akut di RSU Royal Prima Medan yang diharapkan dapat mendukung upaya diagnosis dini, manajemen yang tepat, serta pencegahan komplikasi yang lebih lanjut.
Antimicrobial Activity Test of The Combination of Pineapple Leaf Extract (Ananas Comosus) and Green Betel Leaf Extract (Piper Betle L) Against Candida Albicans Buaya, Adjani; Lubis, Yolanda Eliza Putri; Suandy, Suandy
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2841

Abstract

Candida albicans is an opportunistic fungus that can cause infections, especially in individuals with low immune systems. Efforts to control this fungal infection can be done by utilizing natural ingredients as an alternative antifungal. Pineapple leaves (Ananas comosus) and green betel leaves (Piper betle L) are known to contain active compounds with antimicrobial properties. This study aims to determine the inhibitory power of a combination of pineapple leaf and green betel leaf extracts on the growth of Candida albicans and to compare their effectiveness at various concentrations. This research is a laboratory experimental study using the disc diffusion method. Three groups of extract concentration combinations were used: 20%, 40%, and 60%. The diameter of the inhibition zone was measured in millimeters, and data were analyzed using a one-way ANOVA test followed by a Tukey HSD test. The results showed that the 20% concentration produced the largest average inhibition zone diameter of 38.32 mm, while the 40% and 60% concentrations produced 28.46 mm and 28.31 mm, respectively. The ANOVA test showed a significant difference between groups (p < 0.05), and the Tukey HSD test showed that the 20% concentration was significantly different from the other two groups. The combination of pineapple leaf and green betel leaf extracts at a concentration of 20% was the most effective concentration in inhibiting the growth of Candida albicans compared to concentrations of 40% and 60%.
The Relationship Between Compulsive-Impulsive Behavior and Online Shopping Among Medical Students Suandy, Suandy; Aulia, Nathasyia; Lubis, Yolanda Eliza Putri
Jurnal Keperawatan Priority Vol. 8 No. 1 (2025)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v8i1.6417

Abstract

Compulsive and impulsive buying behaviors have become increasingly prevalent in modern society, particularly among medical students who have easy access to online shopping. This study aims to explore the relationship between compulsive and impulsive buying tendencies and online shopping behaviors among students from the Faculty of Medicine at Universitas Prima Indonesia, specifically the Class of 2023. Using an analytical survey method and a cross-sectional approach, data were collected from a purposive sample of 100 students. Questionnaires were administered to assess the levels of compulsive and impulsive buying. The results indicated a significant moderate positive correlation between compulsive and impulsive buying behaviors and online shopping, with a correlation coefficient of r=0.445 (p<0.001). This research aims to enhance the understanding of shopping behavior in the digital era and to assist in developing strategies to prevent unhealthy shopping habits.
Co-Authors Aleksander Marganda Sidebang Alponso, Rudolf Ananda, Rayhan Khozin Aulia Andika, Muhammad Insan Anggi Sri Ananda Aipin Annisa Amalia Arianti, Rahmi Aulia, Nathasyia Br Sitepu, Rachel Maria Cruz Jovanca Buaya, Adjani Chrismis Novalinda Ginting Chrismis Novalinda Ginting Christine Wira Dika Juliana Halawa Claudia Malau, Reghita Claudya Claudya Davin, Radhitya Qowiyyul Delfian, Taufik Depari, Sania Angelisa F Dewani Silaban, Grace Diaz F. Izdihar Doladave, Miguelle Franklin Dwi Surya Artie Edlin, Edlin Ermi Girsang Evan charista ziraluo Faridahanum, Faridahanum Ginting, Chrismis Novalinda Ginting, Frisdayanti Br Girsang , Ermi Girsang, Ermi Gurusinga, Fransisco Bastanta Hamsi, Ulpah Zahara Hanjaya Hasan Basri Nasution, Muhammad Husni Lubis, Muhammad I Nyoman Ehrich Lister Ishak, Muhammad Raihan Ismardi, Dita Anisa Jansen, Jansen Juliana Lina Kaban, Karmila Katherine Gunawan Laia, Lisbetaria Lawrence, Christopher Lestari Nasution, Sri Lisya, Cut Lumban Gaol, Nova Elisabeth Lumbantobing, Christina J.R.E. Manao, Oktoriadi Manurung, Charles Marpaung, Febri Sri Marpaung, Febri Sri Astuti Maulidi, Risyad Rizki Maya Sari Mutia Maya Sari Mutia Meilando, Rifki Million, Hendy Monica, Veny Mughni Muchtar, Aisyah Muhammad Yunus Mutia, Maya Sari Nabila, Putri Nadeak, Gideon Nadi, Edlin Napiah Nasution, Ali Nardi, Leo Nasution, Masdalena Nazara, Niscaya Aprian Pangaribuan, Novita Helshinta Dewi Pearlie, Michelle Maydelaine Pratomo, Fransiskus Aryo Pulungan, Ica Yulianti Purboningtyas, Dyah Nisma Puspawani , Yeni Puspawani, Yeni Putranto Manalu Putri Handayani Putri, Shafyra Mahdyah Ramadhini, Amelya Putri Ramazata, Bayu Rambe, Daffa Jihan Azmi Rena Meutia Rizal Rizal Rizky, Muhammad Irvan Roland Daniel Theodore Amudi Matondang Rya Sianturi , Agnes Sari Mutia, Maya Sari, Ajeng Mestika Sarumaha, Abrianus Sheridan, Princessa Fath Silitonga, Impola Dinita Felicia Sitepu, Bintang Darma M Soekardi, Adi Sri Astuti Marpaung, Febri Sri Lestari Sri Wahyuni Stevenie - Suandy , Suandy Suandy, Suandy Suhartomi Tafonao, Rachel Julia Tampubolon, Ester Juanita Tampubolon, Ester Juanita br. Teguh Kurniawan, Dendy Therry Prosperita K. Wau Wahyu Setia Widodo Wahyu Widowati Wahyuni Nasution, Sri Widya Yanti Sihotang Zahra, Annisa Alsadilla Zuhra, Layla