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All Journal Jurnal Ilmiah Farmasi MPI (Media Pharmaceutica Indonesiana) Pharmascience Farmasains : Jurnal Ilmiah Ilmu Kefarmasian SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Kreativitas PKM JCPS (Journal of Current Pharmaceutical Sciences) Pharmacoscript Lumbung Farmasi : Jurnal Ilmu Kefarmasian Borneo Journal Of Pharmascientech SPIN: Jurnal Kimia & Pendidikan Kimia Jurnal Mandala Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Community Journal Journal Borneo Jurnal Bakti Untuk Negeri Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Sains Medisina Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Parapemikir Jurnal Ilmiah Farmasi Jurnal Farmasi dan Farmakoinformatika Borneo Journal of Pharmacy Jurnal Sains dan Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Fitriyanti, Fitriyanti
Fakultas Farmasi, Universitas Borneo Lestari, Banjarbaru, Kalimantan Selatan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Borneo Journal Of Pharmascientech

 1 
UJI POTENSIASI EFEK SEDATIF-HIPNOTIK EKSTRAK ETANOL KANGKUNG AIR (Ipomoea aquatic) ASAL GAMBUT KALIMANTAN SELATAN Potential Test Of Sedative-Hypnotic Effect Extract Ethanol Ipomoea Aquatica Form Gambut, South Kalimantan. Karunita Ika Astuti; Fitriyanti Fitriyanti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 2 No 2 (2018): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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Abstract

UJI POTENSIASI EFEK SEDATIF-HIPNOTIK EKSTRAK ETANOL KANGKUNG AIR (Ipomoea aquatic) ASAL GAMBUT KALIMANTAN SELATAN Potential Test Of Sedative-Hypnotic Effect Extract Ethanol Ipomoea Aquatica Form Gambut, South Kalimantan. Karunita Ika Astuti* dan Fitriyanti STIKES Borneo Lestari, Kelapa Sawit 8 Bumi Berkat, Banjarbaru, Indonesia *karunitaika@gmail.com ABSTRAK Pengobatan Sedatif-hipnotik menggunakan golongan obat depresan Susunan Saraf Pusat (SSP) yang relatif tidak selektif namun obat dari golongan ini jika digunakan berkepanjangan dapat bersifat toksik dan menyebabkan kematian. Kangkung air (Ipomoea aquatic) memiliki efek antioksidan yang baik. Tujuan dari penelitian ini adalah untuk mengetahui kandungan senyawa kimia dan efek tanaman Kangkung air terhadap Uji sedative-Hipnotik. Sebanyak 30 mencit dalam 5 kelompok uji yaitu Kelompok control negatif, control positif dengan pemberian diazepam 10 mg/KgBB secara oral, Kelompok perlakuan dengan ekstrak Kangkung Air dosis 1 mg/KgBB, 2 mg/KgBB, dan $ mg/KgBB dengan metode rotaryroad dan Fireplace Test. Data yang didapat dianalisis dengan Shapiro-Wilk, kemudian dilanjutkan uji one way ANOVA dan Post Hoc Tests. Hasil menunjukkan adanaya efek sedasi ekstrak etanol kangkung air pada dosis 4 mg/20 BB. Kata kunci: SedatiF-Hipnotik, kangkung air, rotarod. ABSTRACT Treatment Sedatives-hypnotics using the class of depressants of Central Nervous System (CNS) are relatively not selective. However, drugs of this class if used prolonged can be toxic and cause death. Ipomoea aquatica has a good antioxidant effect. The aim of the test are to the show contains chemical coumpound and the effect of sedative-hypnotic test. Twenty five male mice divided into 5 group (N=5) which is called as negative control group, positive control group will be given Diazepam at dose 10mg/KgBW p.o and 3 treatment groups will be given Ipomea Aquatica Ectract (EKA) ad dose 1 mg/KgBW(I); 2 mg/kgBW(II); and 4mg/KgBW(III) p.o, In this study used rotarod and Fireplace method. Data were analyzed using Saphiro Wilk Test then One ways ANOVA and post hoc test. There is a sedation effect of Ipomea aquatica Extract at 4 mg/20 BB dose. Keywords: Sedative-Hypnotive Test, Ipomoea Aquatica, rotarod
KAJIAN FARMAKOGNOSTIK KULIT BATANG BALIK ANGIN (Mallotus paniculatus (Lam.) Mull. Arg) Fitriyanti; Nopita; Revita Saputri
BORNEO JOURNAL OF PHARMASCIENTECH Vol 3 No 2 (2019): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

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Abstract

ABSTRACTIndonesia is rich with natural products that can be used as a medicine. One of thenatural resources used traditionally in Borneo is Balik Angin stem bark as amedicine for diarrhea and swollen gums. In terms of its potential, it is necessaryto research to provide a scientific basis for qualitatively describingpharmacognostic which includes organoleptic, macroscopic and microscopic anddetermining the identification of chemical compounds contained through reactiontests and thin layer chromatography profiles of ethanol extract 70%. Theorganoleptic test has the results in the form of a distinctive odor, brown color,and a feeling of tightness. In the macroscopic observation of the Stem bark hasthick bark with a hard, coarse and cracked texture with a thin outer surface darkbrown easy to peel and red gummy. Microscopic observations have identifiable fragments in the form of epidermal cells, cortex, and crystal oxalate. Theidentification of chemical compounds showed positive effects on tannins,saponins, flavonoids, triterpenoids, and quinones. Profile of TLC obtained 5stains separated by eluent ethyl acetate: methanol: water with (7: 2: 1). Keywords : Mallotus paniculatus (Lam.) Mull. Arg, Pharmacognostic study,ethanol extract 70%.
UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL 96% HERBA PUTRI MALU (Mimosa pudica L.) TERHADAP MENCIT JANTAN YANG DIINDUKSI Oleum ricini Karunita Ika Astuti; Fitriyanti; Nur Huda
BORNEO JOURNAL OF PHARMASCIENTECH Vol 4 No 1 (2020): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v4i1.276

Abstract

Mimosa pudica L. is one of plants which is used as antidiarrhea by the common people in the society. The objectives of this research is to determine the compounds and antidiarrhea activity of ethanolic 96% Mimosa pudica L extract by using masers method. The method is divided 5 groups and its has 5 mices, which negatif group is given by NaCMC 0,5%, positive group given by Loperamide HCL with doses 0,0052 mg/20g, and the ethanol extract with doses (100, 200, dan 400 mg/kgBB). After 30 minutes treatment to animal study, it is continued by Oleum ricini p.o. Observation is done during 4 hours by observed some parameter such as frequency of diarrhea and weight of feses. The result of compound Mimosa pudica L. extract such as alkaloid, flavonoid, tanin, saponin, and steroid. The data is analyzed by using Man Whitney showed Mimosa pudica L extract doses 400 mg/kgBB is efectives doses such as antidiarrhea which is able to decrease the frequency of diarrhea (P>0,585) and weight of feses (P>0,754).
Uji Daya Hambat Ekstrak Etanol 96% Daun Jeruk Purut (Citrus Hystrix D.C. ) Terhadap Propionibacterium Acnes Fitriyanti Fitriyanti; Syaid Nofal Assegaf; Karunita Ika Astuti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 6 No 2 (2022): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v6i2.471

Abstract

Acne is a disease on the surface of the skin that often causes pain and leaves red, pus-filled spots. The plant that can be developed as an antibacterial is the citrus tribe which is also useful as a flavor enhancer in cooking, namely kaffir lime leaves (Citrus hystrix D.C). The purpose of this study was to test the activity of 96% ethanol extract of kaffir lime leaves against the inhibition of the acne-causing bacteria Propionibacterium acnes. In testing the antibacterial activity of this study using a good method. Based on the results of phytochemical screening, the extract was positive for flavonoids, saponins, tannins, and steroids. Based on the test results of measuring the diameter of the inhibition zone of kaffir lime leaf extract at a concentration of 100%; 80%; 60%; 40%; 20%; and 10% by 22.133 mm; 19,333 mm; 17,266 mm; 15,933 mm, 14.9 mm; and 12.133 mm. Data were analyzed using SPSS with Mann Whitney to obtain a significant value for each concentration variation, with a value of sig <0.05, which means that there are significant differences in each treatment group.
Uji Aktivitas Antibakteri Ekstrak Metanol Daun Ramania (Bouea. macrophylla Griffith) Terhadap Bakteri Escherichia coli hairunnisa nisa; Fitriyanti Fitriyanti; Putri Kartika Sari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.463

Abstract

Ramania (B. macrophylla Griffith) can beused as an antibacterial in the gastrointestinal tractOne of the bacteria in the digestive tract is Escherichia coli. The purpose of this study was to determine the group of compounds contained in ramania leaf methanol extract (B. macrophylla Griffith) and the activity of ramania leaf methanol extract (B. macrophylla Griffith) in inhibiting the growth of E. coli bacteria. Using the maceration method with methanol solvent and extract amendment of 8.6019%. Ramania leaf methanol extract (B. macrophylla Griffith) contains secondary metabolite compounds namely alkaloids, flavonoids, saponins, tannins, and steroids. Antibacterial activity test was carried out by the welling method with a concentration of methanol extract of ramania leaves (B. macrophylla Griffith) which is 1,024 mg / ml; 2,048 mg/ml; 4,096 mg/ml; 8.192 mg/ml; 16,384 mg/ml; 32,760 mg/ml; positive control of ciprofloxacin 5μg/disk, and negative control of Na-CMC 0.5%. The results of the antibacterial activity test of ramania leaf methanol extract (B. macrophylla Griffith) showed that the concentration of 2.048 mg / ml included the inhibition zone of the weak category, namely 3.33 mm;, while the concentration of 32,760 mg / ml included the moderate inhibition zone, namely mm; 8.48 mm and the positive control of ciprofloxacin 5μg / disk was included in the category of very strong inhibition zone, namely 22.8 mm. Based on the spss results using the Man-Whitney test the positive control and control had no difference due to the sig value (<0.05). It can be concluded that ramania leaf methanol extract (B. macrophylla Griffith) has antibacterial activity against E. coli bacteria and has secondary metabolite compounds found in ramania leaves (B. macrophylla Griffith) are Alkaloids, Flavonoids, Tannins, Saponins and Steroids.
Uji Aktivitas Antibakteri “Ekstrak Metanol Daun Sungkai (Peronema canescens Jack) Terhadap Bakteri Propionibacterium acnes. Shelin Shelin; Fitriyanti Fitriyanti; Muhammad Saufi
BORNEO JOURNAL OF PHARMASCIENTECH Vol 7 No 2 (2023): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v7i2.489

Abstract

The Sungkai plant (P. canescens Jack) is known to have medicinal properties in the traditional treatment of skin diseases. The aim of this research is to identify groups of phytochemical compounds contained in the methanol extract from Sungkai leaves, as well as evaluate the ability of the methanol extract to inhibit the growth of P. acnes bacteria. In the first stage, phytochemical screening was carried out from the methanol extract of Sungkai leaves. The results of this screening show that the methanol extract of Sungkai leaves contains alkaloids, flavonoids, phenols, triterpenoids and tannins. In the antibacterial activity test, the diffusion method with the well technique was used at extract concentrations of 1%, 5%, 10%, 15% and 20%. As a comparison, the positive control used clindamycin with a concentration of 2 µg/disk, while the negative control used Na-CMC with a concentration of 0.5%. The results of the antibacterial activity test showed that at a concentration of 1%, the methanol extract of Sungkai leaves had an inhibition zone with moderate intensity. However, at a concentration of 20% as well as in the positive control clindamycin with a concentration of 2 µg/disc, there was a stronger zone of inhibition. Thus, these findings indicate that methanol extract from Sungkai leaves has the potential to inhibit the growth of P. acnes, which is often associated with skin problems. The phytochemical compounds contained in this extract can be the basis for potential development in natural-based skin
Uji Aktivitas Antibakteri Ekstrak Etanol 70% Daun Ginseng Jawa (Talinum paniculatum (Jacq.) Gaertn) Terhadap Bakteri Shigella dysenteriae Riwanda Oktaviani; Fitriyanti Fitriyanti; Putri Kartika Sari
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 1 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i1.502

Abstract

Shigellosis is a digestive tract infection that can be caused by S dysenteriae bacteria. Javanese ginseng (T. paniculatum (Jacq.) Gaertner) is a plant known to have antibacterial potential. This study aims to determine the content of the class of compounds contained in the 76% ethanol extract of Javanese ginseng leaves and to observe the antibacterial activity of the 70% ethanol extract of Javanese ginseng leaves against S. dysenteriae based on the diameter of the inhibition zone. Antibacterial testing using the disc diffusion method with six variations of extract concentrations including 5%, 10%, 20%, 40%, 60% and 80% for positive and negative controls used Azithromycin 15µg/disk and 0.5% Na-CMC. Identification of the content of secondary metabolites was carried out on alkaloids, phenols, flavonoids, quinones, saponins, steroids/triterpenoids and tannins. The results of the screening test for 70% ethanol extract of Javanese ginseng leaves contained flavonoids, phenols, saponins, steroids and tannins. Antibacterial testing at the smallest concentration, namely 5% of the inhibition zone, is considered weak with an average inhibition diameter of 4.01 mm and at the largest concentration, namely 10%, the inhibition zone is considered strong with an average inhibition zone diameter of 11.26 mm.
Uji Aktivitas Antibakteri Ekstrak Etil Asetat Daun Tigaron (Crataeva nurvala Buch.Ham) Terhadap Bakteri Propionibacterium acnes Dengan Metode Difusi Sumuran Sari, Putri Kartika; Sari, Novita; Fitriyanti, Fitriyanti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 9 No 1 (2025): Borneo Journal Of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59053/bjp.v9i1.559

Abstract

Tigaron (C. nurvala buch.Ham.) is a plant can be found in India, Africa, Australia, Japan, Myanmar, Sri Lanka, Malaysia, India and China. Traditionally, the bark, leaves, flowers and root are used in traditional medicine to cure various disease conditions. The leaves of this plant used to treat abscesses, wounds and skin diseases. This study aims to determine of secondary metabolite and antibacterial activity test from ethyl acetate extract of tigaron leaves (C. nurvala buch.Ham.) in inhibiting growth of Propionibacterium acnes with varying concentration which are 0.31 mg/ml, 1.55 mg/ml, 7.75 mg/ml, 38.75 mg/ml, 193.75 mg/ml, negative control Na-CMC 0, 5% and positive control antibiotic clindamycin. Tigaron leaves were extracted using the maceration method using ethyl acetate solvent, secondary metabolite compounds detected using phytochemical screening method and antibacterial activity test using the well diffusion method. The final yield of ethyl acetate extract of tigaron leaves (C. nurvala buch. Ham.) was obtained at 1%. The secondary metabolite contained are alkaloids, flavonoids and steroids. The results showed that concentration of 0.31 mg/mL was included in the weak category inhibition zone (4.97 mm), 1.55 mg/mL (5.97 mm), 7.75 mg/mL (7.08 mm), 38.75 mg/mL (10.02 mm) which was included in the medium category inhibition zone and concentration of 193.75 mg/mL which is included in the strong category inhibition zone, clindamycin antibiotic as a positive control showed a strong zone of inhibition (16.5 mm). Ethyl acetate extract of tigaron leaves (C. nurvala buch.Ham.) can inhibit the growth of Propionibacterium acnes.
Co-Authors Abdurrazaq Abdurrazaq Abdurrazaq Abdurrazaq, Abdurrazaq Ahmad Ahmad Ahmad Ridha Akbar, Depy Oktavian Alista, Siti Ari Surya Pratama Aristha Novyra Putri Astuti, Karunita Ika Ayunda, Feradella Azmi Yunarti Azwarina Nuke Azzahra, Tania Nasyawa Bella Rosalina Endah Chandra, M. Andi Depy Oktavian Akbar Didik Rio Pambudi Dini Amelia, Safitri Dyera Forestryana Eka Sandra Era Habibah Faradilla Iedliany Gunawan Gunawan Gusti Khairunnisa Hadirvika Tjuthiyanda Hafiz Ramadhan Hafiz Ramadhan hairunnisa nisa Helmina Wati Hidayati Rahmi Iedliany, Faradilla Jamaludin, Wahyudin Bin Karunika Ika Astuti Khairunnisa, Gusti Khairunnisa, Gustii Liana Fitriani Hasyim Liana Fitriani Hasymi M. Andi Chandra M. Fahrul Ricky NorHavid Malik Yustika Marlia Fatwa Muammaroh Muhammad Hafizudin Muhammad Hidayattullah Muhammad Nazarudin Muhammad Nazarudin, Muhammad Muhammad Nur Rahman Hendrawan Muhammad Reza Fahlevi Muhammad Saufi Murniati . Muthia Rahmi, Muthia Nashrul Wathan Noor Hayati, Noor Nopita Norazizah, Ufairah Norhasanah Norhasanah Novita Sari Nur Huda Nur Laili Nurbidayah Nurul Hikmah Nurul Mardiati Pasaribu, Cindy Putri Indah Sayakti Putri Kartika Sari Putri Kartika Sari Rahmadina, Aprillia Rahmayanti Fitriah Rahmi Muthia Ratna Restapaty Rina Helmina Riwanda Oktaviani Rizaldi, Gusti Rizka D.A. Widianti Rusida, Esty Restiana Saputri, Revita Sari Wahyunita Sauqi, Muhammad Setyo Yogi Shelin Shelin Siti Khalida Assyifa, Dayanti Siti Kholilah Siti Kholilah Susiani, Eka Fitri Syaid Nofal Assegaf Syamratul Qalbiyah Syifa Syifa Tia Mariati Risma Melati Vebruati Vebruati Vebruati Vebruati Wahyudin Bin Jamalludin Wahyudin Bin Jamaludin Wahyudin Bin Jamaludin Yuni Fahriana Yusmalina Yusmalina Yusrina Conitaty Zannah, Meryatul