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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL FARMASIMED (JFM) Eureka Herba Indonesia Indo-MathEdu Intellectuals Journal International Journal of Science and Society (IJSOC) Pharmacy Reports Jurnal Kesehatan dan Pengelolaan Lingkungan Jurnal Lingkar Mutu Pendidikan Jurnal Sehat Indonesia (JUSINDO) Jurnal Praktik Baik Pembelajaran Sekolah dan Pesantren Jurnal Ilmiah Pengabdian dan Inovasi Riemann : Research of Mathematics and Mathematics Education Journal Of Medicine And Health Sciences (Medisci) Murabbi: Pendidikan Guru Madrasah Ibtidaiyah Hexagon: Jurnal Ilmu dan Pendidikan Matematika Hipotenusa: Journal of Mathematical Society Scientific Development Journal Indonesian Journal of Jamu
Kintoko
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Molecular Mechanisms of Sechium edule Based on Network Pharmacology and Molecular Docking on Hypertension Santoso, Rahmat; Kintoko; Sugihartini, Nining
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.14114

Abstract

Chayote is a fruit that has been used for centuries to treat various diseases, including hypertension. However, how the chemical compounds derived from chayote work in treating hypertension remains unclear. Integrating molecular docking and network pharmacology to elucidate the active constituents and potential mechanisms of chayote in treating hypertension. Initially, 50 active compounds from chayote and 97 key targets related to hypertension were identified through network pharmacology analysis. Then, the results of molecular docking and simulations showed: gibberellin A4; gibberellin A7; gibberellin A29; gibberellin A38; gibberellin A44; stigmasta-3,5-dien-7-one; stigmasterol and routinely overcome hypertension through the regulation of ACE, AKT1, ALB, SRC, and TNF genes. These compounds and genes may be key factors of chayote fruit in treating hypertension. Pathway enrichment analysis showed that the antihypertensive effect of chayote is regulated by the gibberellin A7 and TNF signaling pathways. These pathways are primarily associated with anti-oxidative stress, anti-inflammatory responses, and β-cell protection. This study identified the active constituents and potential signaling pathways involved in the antihypertensive effect of chayote. Result: These findings provide a theoretical basis for understanding the mechanism of the antihypertensive effect of chayote. Furthermore, this study may help develop health supplements or natural antihypertensive drugs based on chayote.
Co-Authors Amelia Regina Arsyad Arif Budi Setianto arsyad, regina Astutik, Wiwin Dwi Botutihe, Lisa Agustina Ebenezer Bonyah Eva Kusumahati Fitriana, Eni Hadi Siswanto, Deny Hardi Astuti Witasari Husain, Dewi Putri Husnayanti, Ana Ibrozi, Hardi Astuti Witasari IIN INDAWATI Khrisna Agung Cendekiawan Kristina Warniasih marpaung, Tio Widia A. Moch Saiful Bachri Nining Sugihartini Nurhayati Nuryanto, Abid Nuryanto, Edy Oktaviani, Tristine Pertiwi, Yuniariana Putri, Nadia Maharani Rahmat Santoso, Rahmat Ramadhanie, Bella Rambe, Muhammad Yusuf Rizky Nurdhillah Rohmah, Lely Arbiati Nur Safira, Rizka Sagiran Sapto Yuliani Sapto Yuliani Siska Candra Ningsih Siswanto, Deny Hadi Siti Mutmainah Sri Wiyanah SUGIYANTO Suliyanto Sunanti, Titis Susetyawati , M.M. Endang Susetyawati, M.M. Endang Tio Widia Astuti Marpaung Tsania Taskia Nabila Wahyu Titis Lestariningrum Wahyu Widyaningsih Wardhani, Firdha Aprillia YULIANA, SARI