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All Journal Jurnal Ilmiah Farmasi Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) JURNAL FARMASIMED (JFM) Eureka Herba Indonesia Indo-MathEdu Intellectuals Journal International Journal of Science and Society (IJSOC) Pharmacy Reports Jurnal Kesehatan dan Pengelolaan Lingkungan Jurnal Lingkar Mutu Pendidikan Jurnal Sehat Indonesia (JUSINDO) Jurnal Praktik Baik Pembelajaran Sekolah dan Pesantren Jurnal Ilmiah Pengabdian dan Inovasi Riemann : Research of Mathematics and Mathematics Education Journal Of Medicine And Health Sciences (Medisci) Murabbi: Pendidikan Guru Madrasah Ibtidaiyah Hexagon: Jurnal Ilmu dan Pendidikan Matematika Hipotenusa: Journal of Mathematical Society Scientific Development Journal Indonesian Journal of Jamu
Kintoko
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Formulasi dan Optimasi Variasi Basis Carbopol dan Emulgator Terhadap Karakteristik Sediaan Emulgel Husain, Dewi Putri; Kintoko; Setianto, Arif Budi
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 2 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/.v7i2.360

Abstract

Emulgel memiliki beberapa kelebihan seperti waktu kontak yang lebih lama, kosistensi yang baik, dapat melembabkan, transparan, mudah penyebaranya, mudah penyerapanya, mudah dihilangkan, dapat bercampur dengan eksipien lain dan larut dalam air. Pembuatan emulgel memerlukan emulgator agar dapat menyatukan dua fase yang berbeda, sediaan dengan emulgator campuran seringkali lebih efektif daripada emulgator tunggal. Penelitian ini bertujuan mengetahui proporsi optimum dari campuran carbopol 940 dan perbandingan konsentrasi tween80 banding span60 sehingga dapat menghasilkan sediaan yang stabil secara fisikokimia. Metode dilakukan dengan memformulasikan sediaan emulgel terlebih dahulu dan diuji fisikokimia meliputi stabilitas, viskositas, daya sebar, daya lekat, nilai pH dan homogenitas. Hasil pengujian didapatkan nilai stabilitas yang baik pada F2 nilai pH sebesar 5.1, viskositas 13.1972 Pa.s, daya sebar 6.05 cm, dan daya lekat 8.80 detik. Analisis data menggunakan One-Way ANOVA dan Kruskal Wallis Test (p<0,05). Berdasarkan nilai rata-rata uji fisikokimia dari setiap pengujian F1, F2, F3, dan F4, dapat disimpulkan bahwa formula optimal yang didapatkan yaitu F2. Hal ini dikarenakan hanya F2 yang memenuhi setiap standar fisikokimia yang telah ditetapkan.
Model Hewan Uji Agen Terapeutik Alami pada Stroke Iskemik Botutihe, Lisa Agustina; Safira, Rizka; Kintoko
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art2

Abstract

Background: Ischemic stroke is an acute neurological injury resulting from focal damage to the central nervous system due to vascular obstruction and subsequent decrease in cerebral blood flow. Numerous animal models of ischemic stroke have been established to investigate its mechanism, pathophysiology, and risk factors. The animal model of ischemic stroke includes a global ischemia model and a focal ischemia model. This article describes various parameters, including hematological, biochemical, cytological, histological, and molecular factors, along with diverse biomarkers, that may support research in the development of novel, safer, and more effective therapeutic agents for ischemic stroke using animal models.Objective: This research seeks to determine the appropriate test animal model and parameters for ischemic stroke experiments.Method: A complete literature search was conducted across multiple databases, including NCBI, PubMed, and additional sources.Results: According to reference studies, the animal model test in the ischemic stroke experiment comprised a focal ischemia model and a global ischemic model. The focal ischemic model is more pertinent to ischemic stroke in humans compared to the global ischemic model. In addition, focal ischemic models, including Middle Cerebral Artery Occlusion (MCAO), have been utilized in over 40% of 2,582 nerve protection trials. The wide variety of test animal models possesses distinct advantages and disadvantages, making it crucial to select the appropriate model. The parameters of ischemic stroke, including hematology, biochemistry, cytology, histology, and molecular analysis, together with their biomarkers, can help in identifying the incidence of ischemic stroke in test animals.Conclusion: The focused ischemia model is a more pertinent animal model for ischemic stroke in relation to humans than the global ischemic model. Parameters utilized for the identification of ischemic stroke encompass hematology, biochemistry, cytology, histology, and molecular biology.
Exploration of the Function of Galactagogue in Fenugreek, Moringa, and Sauropus Androgynus Polyherbal Tea: Systematic Literature Review Eva Kusumahati; Kintoko; Sagiran
Side: Scientific Development Journal Vol. 2 No. 6 (2025): Side: Scientific Development Journal
Publisher : Arbain Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59613/qjxqeb61

Abstract

This study aims to evaluate the effect of polyherbal tea consisting of fenugreek, Moringa oleifera, and Sauropus androgynus on breast milk production and quality, as well as the health of breastfeeding mothers. The method used was a Systematic Literature Review (SLR) based on PRISMA 2020, where studies were identified through a systematic search in the Scopus database using relevant keywords. Data were extracted from studies that met the inclusion criteria and were evaluated to determine the effectiveness and safety of polyherbal teas. The results showed that polyherbal tea supplementation has the potential to increase breast milk production by stimulating the hormones prolactin and oxytocin. Fenugreek and Moringa oleifera significantly increase milk production and change the nutritional profile of breast milk for the better, including increased unsaturated fatty acid content and antioxidant capacity. Sauropus androgynus leaves also show potential as galactogogues and maternal health supporters. In addition, this herbal supplementation provides additional benefits for maternal health, such as improved nutritional status and reduced fatigue. These findings are important because they provide stronger scientific evidence to support the use of herbal supplements in clinical practice, as well as suggesting that polyherbal teas can be an effective natural alternative in improving milk production and quality and supporting the health of breastfeeding mothers. Further research is needed to determine the optimal dosage and long-term effects of these herbal supplements, as well as to understand the synergistic interactions between the herbal ingredients. Relevant keywords for this study included: polyherbal tea, galactagogue, breast milk production, breast milk quality, fenugreek, Moringa oleifera, Sauropus androgynus, and breastfeeding maternal health.
Characterization and The Effects Analysis of Purple-fleshed Sweet Potato Extract (Ipomoea batatas [L.]) Administration on Triglyceride Concentration and Pancreatic Histopathology Profiles of Triton X-100-induced Hyperlipidemia in Rats Kintoko; Hardi Astuti Witasari; Rizky Nurdhillah; Tsania Taskia Nabila
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i2.258

Abstract

Hypertriglyceridemia occurs when the triglyceride levels are increasing from the normal (>150 mg/dL) and it causes pancreatitis at a dose of more than 885 mg/dL. The triglyceride-lowering medicines consumption has several side effects on various organ systems. The plant-based medicine (phytomedicine) alternatives have been observed as the synthetic medicine substitution. Purple-fleshed sweet potato (Ipomoea batatas [L.]) contains anthocyanin that has proven to carry out the antioxidant mechanism and the capability to be used as anti-hypertriglyceridemia. This study aims to identify the activity of purple-fleshed sweet potato extracts on triglyceride levels and the histopathological profile of rats' pancreas-induced Triton X-100. Twenty-five male Wistar rats of week 8th were divided into five groups. The normal (N) group was treated with saline solution, and the treatment (T) groups were a single dose of 100 mg/kg of body weight (BW) Triton X-100 and purple-fleshed sweet potato extracts of 175 (T1); 350 (T2); and 700 (T3) mg/kg BW, while the negative (C-) control group was mere induced by a single-dose Triton X-100 of 100 mg/kg BW. The blood serum was isolated and the pre-and post-test was subsequent conducted. The triglyceride serum levels and histopathological data were analyzed by the Kolmogorov-Smirnov normality test and Kruskal-Wallis post-test statistical analysis. The results showed that Triton X-100-induced treatment could significantly increase the triglyceride levels compared to the normal group (P<0.05). The purple-fleshed sweet potato extracts started to lower the triglyceride level at a dose of 700 mg/kg BW (51.83 ±19.15(%)). The extract doses of 175 and 350 mg/kg BW could not reduce the triglyceride level significantly (3.03±2.77 and 5.63±4.24 (%), respectively). A dose of 700 mg/kg BW did not damage the exocrine gland and Langerhans islet of hyperlipidemia rat pancreas treated by Triton X-100. 
Combination of Essential Oils of Ylang-Ylang (Cananga Odorata), Jasmine (Jasminum Sambac), and Mint Leaves (Mentha Piperita) TestingAphrodisiac on Male Mice Formulated in Candle Forms marpaung, Tio Widia A.; Kintoko; Wahyu Widyaningsih; Moch Saiful Bachri; Amelia Regina Arsyad
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/7q01y176

Abstract

This study explored the potential of Jasminum sambac (jasmine) and Mentha piperita (peppermint) as natural sexual stimulants (aphrodisiacs) to enhance sexual activity in males and females through the use of essential oils. The main objective was to identify the most effective combination of essential oil formulations, which were evaluated through several biological and physiological parameters, including sexual behavior in mice, sperm quality, testicular histopathology, and wax-based formulations as the delivery medium. Three formulations were tested: P1 (3:1:1), P2 (1:3:1), and P3 (1:1:3), administered to mice using a humidifier via inhalation. Sexual behavior was assessed through mounting latency and mounting frequency as indicators of libido. Sperm quality parameters included morphology, motility, viability, and sperm count. Testicular histopathology was examined to evaluate tissue structure and spermatogenesis activity. The results demonstrated that the P1 formulation was the most effective, showing the highest aphrodisiac activity. In the sexual behavior test, P1 recorded an activity value of 21±6.2, indicating enhanced libido. Sperm quality testing also confirmed the superiority of P1, with the lowest sperm abnormalities (5.3±1.53), highest motility (82±7.5), highest viability (85.6±4.58), and the greatest sperm count (53,300±16,653.3). Although testicular histopathology revealed a slight reduction in spermatogenic cells across all treatment groups, the change was not significant in the P1 group compared to the control. Overall, the P1 formulation improved libido and sperm quality more effectively than P3 and the control group, indicating its potential to be developed as an aphrodisiac preparation based on natural essential oils.
Formulation of Emollient Preparation from Rose Essential Oil (Rosa Damascena) Combined with Vanilla Essential Oil (Vanilla Planifolia)in Increasing Body Weight in Baby Rats (Rattus Norvegicus) arsyad, regina; Kintoko; Wahyu Widyaningsih; Tio Widia Astuti Marpaung
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/80n03c83

Abstract

Rose and vanilla essential oils have potential as natural active ingredients in emollient formulations due to their moisturizing and aromatherapeutic relaxation effects. This study aimed to formulate an aromatherapy emollient with four variations in the composition of rose and vanilla essential oils: F1 (0.1 mL:0.4 mL), F2 (0.2 mL:0.3 mL), F3 (0.3 mL:0.2 mL), and F4 (0.4 mL:0.1 mL). Each formula contained a total of 0.5 mL essential oil dissolved in 100 mL sunflower seed oil as the base. Organoleptic evaluation showed that all formulas had a yellowish-white color and liquid texture. The resulting aromas differed among formulas: F1 produced a woody scent, F2 and F3 had an oriental woody fragrance, while F4 exhibited a dominant rose aroma. The pH values ranged from 5.12 to 6.00, which is within the normal skin range. Viscosity values were between 4.92–5.30 cPs, specific gravity ranged from 1.0181–1.0682, and refractive indices were 1.470–1.471, indicating good physical stability. Hedonic testing revealed that Formula F2 was the most preferred by panelists in terms of aroma, texture, and after-feel on the skin. Skin irritation tests on rabbits showed no negative reactions, confirming the formulation’s safety for topical use. Biological activity tests on infant mice demonstrated significant increases in body weight and length compared to the control group. Based on overall results, Formula F2 (0.2 mL rose oil and 0.3 mL vanilla oil) was determined to be the best formulation, offering a balanced aroma, good physical stability, and optimal emollient and relaxation effects.
Dermatological properties of Cosmos caudatus Kunth for photoprotection, anti-aging, and skin brightening applications Husnayanti, Ana; Sugiyanto; Kintoko; Nurhayati
Pharmacy Reports Vol. 5 No. 2 (2025): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.114

Abstract

Cosmos caudatus Kunth, a tropical medicinal herb traditionally used across Southeast Asia, has emerged as a promising botanical ingredient for cosmeceutical applications. This narrative review systematically synthesizes current evidence on its dermatological properties through comprehensive literature search of Scopus and PubMed databases (2015-2025), yielding 25 studies meeting inclusion criteria for skin-relevant bioactivities. Phytochemical characterization consistently identifies flavonoid glycosides, particularly quercetin derivatives (quercitrin, isoquercitrin, rutin), as major bioactive constituents responsible for multifaceted skin benefits. In vitro studies demonstrate potent antioxidant activity (IC₅₀ 17.77-163.6 μg/mL in DPPH assay), significant inhibition of collagenase, elastase, and matrix metalloproteinases underlying anti-aging effects, and superior tyrosinase inhibition (IC₅₀ 6.803 μg/mL) for skin brightening. Photoprotective capacity exhibits remarkable formulation-dependent enhancement, progressing from minimal protection in raw extracts (SPF 3.26) to ultra-protection in optimized cream formulations (SPF 45.59). Advanced delivery systems including nanotechnology (particle size 160-176 nm) and microencapsulation (79.67% flavonoid retention) further enhance stability and bioavailability. Additional antimicrobial activity against Propionibacterium acnes positions C. caudatus uniquely for acne-hyperpigmentation management. Despite robust in vitro evidence, clinical validation through human trials remains a critical research priority. This review establishes C. caudatus as a scientifically validated, multifunctional botanical ingredient with substantial commercial potential in the natural cosmeceutical market.
Ethnopharmacology, LC-MS profiling, and molecular docking of diarrheal-healing plants by the Osing tribe Cendekiawan, Khrisna Agung; Kintoko; Yuliani, Sapto; Wardhani, Firdha Aprillia
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.31315

Abstract

Indonesia has a long history of using medicinal plants, but much of this knowledge, especially among groups like the Osing people in East Java, is not well-documented. This study looks at the plants used by the Osing community to treat diarrhea. This research was conducted through interviews with residents of Banjar and Licin Villages in Banyuwangi Regency. The significance and perceived efficacy of each medicinal plant were evaluated using the ethnobotanical indices Use Value (UV) and Fidelity Level (FL). They also did tests to find the active chemicals in the plants. The most common plants for treating diarrhea were Psidium guajava (UV = 2.44) and Piper betle (UV = 1.11). Psidium guajava had the highest FL value (64.7%). Tests have shown that these plants contain essential chemicals. Further analysis confirmed the presence of quercetin and kaempferol, which are known to help alleviate stomach problems. To support these findings, computer-based tests were done, including Lipinski rule prediction, ADMET profiling, and molecular docking. The results showed quercetin binds well (ΔG = -9.72) and has a good RMSD value (1.83 Å). This suggests quercetin could be a good starting point for making antidiarrheal drugs. Overall, the study underscores the significance of traditional knowledge and recommends further research on plant-based treatments for stomach issues.
Development of English-Based Electronic Module on Three-Variables Linear Equations System for Mathematics Education Students Siska Candra Ningsih; Sri Wiyanah; Kintoko; Ebenezer Bonyah; Kristina Warniasih
Hipotenusa: Journal of Mathematical Society Vol. 7 No. 2 (2025): Hipotenusa: Journal of Mathematical Society
Publisher : Program Studi Tadris Matematika Universitas Islam Negeri (UIN) Salatiga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18326/hipotenusa.v7i2.5162

Abstract

Many Mathematics Education students face difficulties in learning systems of linear equations in three variables, particularly when the material is delivered in English. This study aimed to develop an English-based electronic module that meets the criteria of validity, practicality, and effectiveness. Using the ADDIE development model, the product was evaluated by two validators (material expert and media expert) and implemented with 35 students enrolled in the selected topics in school mathematics course. The validation results showed that the module achieved an average validity score of 91.11% for content feasibility and 88.57% for language feasibility, indicating a ‘very valid’ category. Student responses indicated that the module was practical, with an overall practicality score of 74.17%. Effectiveness testing demonstrated that 77.14% of students met the Minimum Competency Criteria (MCC), placing the module in the effective category. These findings suggest that the English-based electronic module is feasible for use in supporting students’ conceptual understanding and strengthening language-based mathematical literacy, particularly in learning systems of linear equations in three variables.
Quantitative Mapping of Phytochemical Synergy in Psidium guajava and Piper betle for Antidiarrheal Therapy: A Systematic Review and Meta-Analysis Using Radar Chart Analysis and AUC Kintoko; Cendekiawan, Khrisna Agung; Sapto Yuliani; Firdha Aprillia Wardhani
Eureka Herba Indonesia Vol. 7 No. 1 (2026): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v7i1.133

Abstract

Infectious diarrhea constitutes a massive global health burden defined by severe gastrointestinal hypermotility, profound fluid hypersecretion, and aggressive mucosal inflammation. Conventional pharmacotherapy, including antimotility agents and broad-spectrum antibiotics, presents significant clinical limitations, including the exacerbation of antimicrobial resistance and adverse systemic effects. Phytochemical interventions utilizing Psidium guajava and Piper betle offer a robust complementary approach. However, the exact quantitative magnitude of their combined pharmacological synergy requires rigorous statistical integration. A systematic review and meta-analysis were executed utilizing PRISMA protocols. Comprehensive literature screening across major databases identified primary research manuscripts reporting precise quantitative parameters on the antidiarrheal, antimicrobial, and antioxidant properties of the targeted extracts. Extracted data variables included sample sizes, mean outcomes, and standard deviations. The Standardized Mean Difference (SMD) and 95% Confidence Intervals (CI) were calculated using a random-effects model. The multidimensional therapeutic capacity was further mapped and quantified using Radar Chart Analysis (RCA) and geometric Area Under Curve (AUC) mathematical integration. The statistical synthesis indicated that Psidium guajava profoundly suppressed gastrointestinal motility and intestinal fluid accumulation (Pooled SMD = -2.45; 95% CI: -3.10 to -1.80). Concurrently, Piper betle demonstrated immense broad-spectrum bactericidal activity and superlative free radical scavenging capacity (Pooled SMD = 3.85; 95% CI: 2.95 to 4.75). The subsequent AUC integration revealed that combining the specific phytochemical profiles of both botanical sources mathematically expanded the total therapeutic coverage by 42%. The quantitative framework confirms a highly potent synergistic mechanism. Psidium guajava selectively targets the physiological symptoms of hypermotility and secretory failure, while Piper betle aggressively eradicates the underlying pathogenic etiology and neutralizes oxidative tissue damage. This dual-action synergy provides a formidable, evidence-based foundation for the development of advanced botanical therapeutics.
Co-Authors Amelia Regina Arsyad Arif Budi Setianto arsyad, regina Astutik, Wiwin Dwi Botutihe, Lisa Agustina Ebenezer Bonyah Eva Kusumahati Fitriana, Eni Hadi Siswanto, Deny Hardi Astuti Witasari Husain, Dewi Putri Husnayanti, Ana Ibrozi, Hardi Astuti Witasari IIN INDAWATI Khrisna Agung Cendekiawan Kristina Warniasih marpaung, Tio Widia A. Moch Saiful Bachri Nining Sugihartini Nurhayati Nuryanto, Abid Nuryanto, Edy Oktaviani, Tristine Pertiwi, Yuniariana Putri, Nadia Maharani Rahmat Santoso, Rahmat Ramadhanie, Bella Rambe, Muhammad Yusuf Rizky Nurdhillah Rohmah, Lely Arbiati Nur Safira, Rizka Sagiran Sapto Yuliani Sapto Yuliani Siska Candra Ningsih Siswanto, Deny Hadi Siti Mutmainah Sri Wiyanah SUGIYANTO Suliyanto Sunanti, Titis Susetyawati , M.M. Endang Susetyawati, M.M. Endang Tio Widia Astuti Marpaung Tsania Taskia Nabila Wahyu Titis Lestariningrum Wahyu Widyaningsih Wardhani, Firdha Aprillia YULIANA, SARI