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Rohama, Rohama
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Uji Aktivitas Antibakteri Ekstrak Daun Pulutan (Urena lobata L) Terhadap Bakteri Staphylococcus aureus: Antibacterial Activity Test of Pulutan Leaf Extract (Urea lobata L) Againt Staphylococcus aureus Fitriani, Dyah; Rohama, Rohama; Darsono, Putri Vidiasari; Hakim, Ali Rakhman
Jurnal Surya Medika (JSM) Vol. 10 No. 3 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i3.9006

Abstract

Penyakit infeksi merupakan suatu penyakit yang disebabkan karena virus, bakteri, protozoa ataupun jamur. Penggunaan antibiotik dalam pengobatan infeksi dapat menimbulkan efek samping dan resistensi. Daun pulutan secara empiris digunakan sebagai penurun panas, rematik, luka, bisul, dan sebagai antiseptik. Daun pulutan mengandung metabolit sekunder alkaloid, saponin, dan flavonoid yang diduga memiliki aktivitas antibakteri. Penelitian ini bertujuan untuk menguji aktivitas antibakteri ekstrak daun pulutan (Urena lobata L) terhadap bakteri Staphylococcus aureus, menentukan Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) ekstrak daun pulutan (Urena lobata L) Terhadap bakteri Staphylococcus aureus. Metode yang digunakan pada penelitian ini adalah true experimental. Pengujian aktivitas antibakteri menggunakan metode difusi cakram dan dilusi cair. Kemudian data dianalisis menggunakan Kruskal-Wallis dan Mann Whitney. Hasil ekstrak daun pulutan memiliki aktivitas antibakteri pada konsentrasi 100% zona hambat 14,09 mm dan konsentrasi 80% zona hambat 11,09 mm. Nilai KHM terdapat pada konsentrasi 80% dan tidak memiliki nilai KBM. Hasil uji statistik menunjukan terdapat perbedaan bermakna p value 0,004 pada Kruskall Wallis dan pada Mann Whitney menunjukan p value 0,025. Dapat disimpulkan Daun Pulutan (Urena lobata L) memiliki aktivitas antibakteri kategori kuat. Nilai KHM terdapat pada konsentrasi 80% dan tidak memiliki nilai KBM terhadap bakteri Staphylococcus aureus.
P Profil Kromatografi Dan Penetapan Kadar Flavonoid Total Fraksi Etil Asetat Daun Kalangkala (Litsea Angulata Blum) Menggunakan Spektrofotometri Uv-Vis: Profil Kromatografi Dan Penetapan Kadar Flavonoid Total Fraksi Etil Asetat Daun Kalangkala (Litsea Angulata Blum) Menggunakan Spektrofotometri Uv-Vis Mardlatillah, Mardlatillah; Rohama, Rohama; Kurniawati, Darini
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.276

Abstract

Background: Kalangkala is a fruit plant typical of Kalimantan and belongs to the species of the genus Litsea which is thought to have potential as a natural antioxidant. Empirically, some people in South Kalimantan use the kalangkala plant, especially the seeds of the fruit, to treat boils. One of the compounds that have antioxidant and antibacterial content is flavonoids.Objectives: To determine the thin layer chromatography profile of the total flavonoid compound of the ethyl acetate fraction and to calculate the total flavonoid content of the ethyl acetate fraction of the leaf extract of Kalangkala (Litsea angulata Blum).Method: Thin Layer Chromatography Profile and Determination of Total Flavonoid Content of the Ethyl Acetate Fraction of Kalangkala Leaf Extract using the UV-Vis Spectrophotometry method. The data were then analyzed qualitatively and quantitatively.Results: The chromatographic profile of the total flavonoids of the ethyl acetate fraction of Kalangkala leaf eluent that was most optimal was Ethyl acetate : n-Hexane (3:7) because it showed the most stains, namely 5 stains. And in the uv-vis spectrophotometry method, the total flavonoid content of the ethyl acetate fraction of Kalangkala leaves (Litsea angulata Blum) was 0.9 mg QE/g.Conclusion: Kalangkala leaf extract on the TLC profile using ethyl acetate : n-Hexane (3:7) showed a total of 5 stains. And the value of the total flavonoid content of the ethyl acetate fraction of kalangkala leaves was 0.9 mg QE/g.
F Formulasi dan Antibakteri Sediaan Sabun Cair Ekstrak Daun Sembung (Blumea Balsamifera) terhadap bakteri Staphylococcus aureus: Formulasi dan Evaluasi Romadhina, Rodhiatul; Budi, Setia; Rohama, Rohama
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.400

Abstract

Background: The skin is a part that is susceptible to exposure to chemical, physical substances as well as bacteria, fungi and viruses. The bacteria that is often found on the skin is Staphylococcus aureus. To overcome this, soap making needs to be done, one of which uses sembung leaf extract which has biological activity as antibacterial. Objective: Extracting sembung leaves and making formulations of antibacterial liquid soap preparations of sembung leaf extracts and analyzing antibacterial preparations of liquid soap preparations of sembung leaf extracts Methods: The research method method used is experimental with true experimental design and the research design uses post test only with control group design. Making 3 kinds of antibacterial liquid soap formulations sembung leaf extract with concentrations of 5%, 7%, and 10%. Then evaluation includes pH, organoleptic, high foam, viscosity, and antibacterial test. Results: Based on the results of the organileptic test, there was no difference between each formulation of liquid soap extract from Sembung (Blumea balsamifera) leaf extract. Then in the pH test, it is included in the vulnerable pH of liquid soap, namely pH 8-11. After that, in the foam height test, the results of the foam height test were included in the foam height test vulnerable, namely 13-220 mm. Then, the viscosity test results obtained that the viscosity test is included in the viscosity test vulnerability, namely 400-4000 cPs. Finally, the anti-bacterial test obtained clear results of the diameter of the inhibition zone in each formulation. Conclusion: All formulations meet the SNI standard for liquid soap for pH testing, organoleptic testing, high foam testing, and viscosity testing. In antibacterial testing against Staphylococcus aureus bacteria using the disc method the best formula was obtained, namely a concentration of 5%.
U Uji Aktivitas Antibakteri Ekstrak Daun Pulutan (Urena lobata L) Terhadap Bakteri Streptococcus pyogenes Pusvita, Shela; Rohama, Rohama; Yuwindry, Iwan; Darsono, Putri Vidiasari
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.420

Abstract

Background: Pharyngitis or sore throat has a fairly high prevalence rate in Indonesia caused by Streptococcus pyogenes bacteria. Pulutan has experience as a medicine for sore throat, rheumatic fever, antipyretic, fracture, antifertility, and vaginal discharge. Based on research on ethanol extract that was done previously, pulutan leaf extract has antibacterial activity. Objective: To determine the antibacterial activity of pulutan leaf extract (Urena lobata L) which has the potential as an antibacterial against the growth of Streptococcus pyogenes and to determine the minimum inhibitory concentration and minimum killing concentration. Methods: This type of true experimental research design, namely research methods that look for causal relationships between independent and dependent variables. Antibacterial testing using disc diffusion and dilution methods. With concentrations of 100%, 75%, 50%, 25%, positive control amoxicillin and DMSO negative control. Results: The results of the disc diffusion test were able to inhibit the growth of the Streptococcus pyogenes bacteria which was indicated by the presence of a clear zone around the disc paper. The results of the dilution test obtained the MIC value at a concentration of 50% indicated by the media tube which looks clear. There was no KBM value at all the concentrations of the extracts tested, indicated by the growth of bacteria in the test medium. Conclusion: Pulutan leaf extract (Urena lobata L) has antibacterial activity which is indicated by the presence of an inhibition/clear zone around the disc paper. MIC results found at a concentration of 50%, KBM results on pulutan leaf extract (Urena lobata L) did not have killing power at all concentrations. Keywords: Antibacterial, Pulutan Leaf Extract (Urena lobata L), Streptococcus pyogenes.
A Aktivitas Antioksidan dan Penetapan Kadar Flavonoid Daun Sirih Merah (Piper crocatum Ruiz & Pav) Dengan Variasi Ukuran Partikel Serbuk Simplisia Oktavia, Rissa; Rohama, Rohama; Saputri, Rina
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 1 (2023): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i1.422

Abstract

Background: Red betel (Piper crocatum Ruiz & Pav) is a medicinal plant that is used empirically by the people of Tehang, Central Kalimantan for wound healing. The ability of red betel leaves to heal wounds is associated with the anti-inflammatory properties of the secondary metabolites of the flavonoid class contained therein which also have a role as a source of antioxidants. Particle size will affect the amount of bioactive compounds in an extract. Objective: To determine the difference in antioxidant activity and flavonoid content ethanol extract of red betel leaf in a variation of particle size simplisia powder. Methods: True experimental quantitative research which divided into two experimental groups, namely red betel leaf extract with a mesh particle size of 40/60 and 60/80. Testing of antioxidant activity with the DPPH method and determining the levels of flavonoids with the UV-Vis Spectrophotometry method. Results: The results of antioxidant activity based on IC50 values at 40/60 and 60/80 mesh particle sizes is 5.96 ppm and 2.74 ppm. The results of flavonoid content determination at 40/60 and 60/80 mesh particle size is 1.448 mg QAE/g and 3.5 mg QAE/g. Statistical analysis with the Mann Whitney test showed a significant difference (p value 0.025 <0.05). Conclusion: There is a significant difference with the variation of particle size on the antioxidant activity and levels of flavonoids. The highest antioxidant activity and flavonoid levels were observed in extracts with a mesh particle size of 60/80. The smaller the particle size, the stronger the antioxidants and the higher the levels of flavonoids.
E Etnomedicine Tumbuhan Obat di Masyarakat Desa Belangian, Kalimantan Selatan: Syahfitri, Laili Shinta Ayu; Nastiti, Kunti; Kurniawati, Darini; Rohama, Rohama
Jurnal Pelayanan Kefarmasian dan Sains Vol 4 No 2 (2024): Journal of Pharmaceutical Care and Sciences (JPCS)
Publisher : LPPM Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/jpcs.v4i2.549

Abstract

Background: The diversity of tribes and cultures in Indonesia makes culturaldifferences and traditional knowledge, one of which is in utilizing plants for thetreatment of a disease. One of the widespread tribes on the island of Kalimantanthat is thick with traditional medicine is the Banjar Tribe located in BelangianVillage, South Kalimantan. Ethnomedisin is a treatment by certain ethnicities basedon hereditary traditions in traditional medicine, in this case the use of medicinalplants.Objective: The purpose of this study was to determine the ethnomedicine ofmedicinal plants used by the Banjar Tribe of Belangian Village, Aranio District,South Kalimantan Province.Methods: This research is descriptive using qualitative and quantitative methods.Quantitative analysis with Fidelity Level (FL) calculations for each type ofmedicinal plant.Result: Based on the results of research from 38 informants, 58 species with 36families were obtained. There are 50 diseases that can be treated from 58 types ofmedicinal plants. The most popular method of processing is boiled 56.89 then drunk72.41%. The most widely used part of medicinal plants is the leaf part of 41.73%.Five types of plants with the highest FL values that stated effectiveness for treatmentwere Cymbopogon citratus 86.84%, Zingiber officinale 78.94%, Jatropha multifidaL 73.64%, Peronema canescens jack 68.42%, Syzygium polyanthum 65.78%. Thetradition of treatment with medicinal plants by the Banjar Tribe has been passeddown for generations with the value of local wisdom in its use.Conclusion: There are 58 types of medicinal plants that can be used as medicineor relief for certain diseases by the people of the Banjar Tribe, Belangian Village.With the highest FL value of five is found in Cymbopogon citratus plants 86.84%,Zingiber officinale 78.94%, Jatropha multifida L 73.64%, Peronema canescensjack 68.42%, Syzygium polyanthum 65.78%.
Co-Authors Ali Rakhman Hakim Amalia, Ghina Rezki Amalia, Putri Rizky Ananda, Hesti Aulia Andriani, Ine Anggraini, Livani Aryzki, Saftia Caroline, Putricia D, Putri Vidiasari Dari, Kristina Wulan Dede Mahdiyah, Dede Deviani, Norma Elieser, Michael Fauzah Fauzah, Fauzah Fawwaz, Muhammad Taufiq Febriani, Agnesia Febriani, Carolina Fitriani, Dyah Fuaddah, Munawarah Gusnianti, Elva Hastika, Febby Yulika Husna, Hafizatul Ida Ayu Putu Sri Widnyani Indah Purnamasari Intan Intan Irawan, Angga Ismiadi, Rahmad Jannah, Ghina Raudhatul Khairunnisa Khairunnisa Khairunnisa, Aisya F. Khuluqia, Munirah Kristiana, Isha Desty Kristina, Isha Desty Kurniawati, Darini Kusnia, Risha I. K. Kusuma D, Muhammad Chandra Hadi Mahmudah Mahmudah Mardlatillah, Mardlatillah Martha, Dhea Yolanda Mawarid, M.T.F. Melviani, Melviani Mia Audina, Mia Nabila, Putri Nabila, Yasmin Nastiti, Kunti Ningsih, Gusria Surya Ningtias, Radita Dia Ayu Noor Latifah Nor Erpiana, Indah Noval Noval Nugraha, Dyan Fitri Octavia, Mutia Oktavia, Helda Oktavia, Rissa Pawestri, Hasna Priadi, Ota Puspita, Melinda Dian Pusvita, Shela Putra, Dedy Karmadi Putri Vidiasari Darsono, Putri Vidiasari Rahayu, Desi Dwi Rahmadani Rahmadani Rahmawati, Rahmawati Rianti, Nur Addina Rina Safitri Rina Saputri Romadhina, Rodhiatul Sadlia, Fitri Setia Budi Shinta, Laili Shinta Ayu Siti Aisyiyah, Siti Syahfitri, Laili Shinta Ayu Tumanggor, Agustina Hotma Uli Tuti Alawiyah Uljanati, Khairi Witin, Rafelita Septania B. Yanti, Novita Yuwindry, Iwan