Article Per Year (5 Year)
p-Index From 2020 - 2025
3.608
P-Index
This Author published in this journals
All Journal Acta Biochimica Indonesiana JURNAL KAJIAN VETERINER Cendana Medical Journal
Amat, Anita Lidesna Shinta
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health Veterinary

Published : 24 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 24 Documents
Search

 1   2   3 
Hubungan Durasi Dan Posisi Penggunaan Smartphone Terhadap Nyeri Leher Pada Mahasiswa Preklinik Fakultas Kedokteran Universitas Nusa Cendana lai, gloria harpazo; Kareri, Dyah Gita Rambu; Amat, Anita Lidesna Shinta; Setiawan, I Made Buddy; Sasputra, I Nyoman
Cendana Medical Journal Vol 11 No 2 (2023): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v11i2.13907

Abstract

Background : Neck pain is an uncomfortable and painful feeling on the neck and the upper back. Neck pain are generally known by two definition, spesific neck pain and non spesific neck pain. Non spesific neck pain is caused by an injured muscle, joints, or bone in the neck area due to bad posture. Medical students used smartphones in a long duration for social media activities and learning purposes. Smartphone usage in a long duration with static and non ergonomic body position is one of the factors causing non spesific neck pain. Objective : This research’s objective is to analyze the correlation of duration and position of smartphone usage on preclinical students of The Faculty of Medicine, Universitas Nusa Cendana. Methods : This research is an analytical observational research with cross sectional approach. The samples on this research was 179 people that was obtained using stratified random sampling technique. The data was analyzed using Spearman correlation test. Results : Data from 179 respondents showed that 45.8% experienced mild neck pain, 33.0% experienced moderate neck pain, 5.0% experienced severe neck pain and 16.2% did not experience neck pain. For the duration of smartphone use, 97.8% had a high duration of smartphone use, 2.2% had a moderate duration of smartphone use and none had a low duration of smartphone use. For the position of smartphone use, 1.1% have a very high risk level, 7.8% have a high risk level, 91.1% have a medium risk level and none have a low risk level. The results of the bivariate analysis with the Spearman correlation test showed p value = 0.162 for the relationship between the duration of smartphone use and neck pain, and p = 0.538 for the relationship between the position of smartphone use and neck pain. Conclusion: There is no significant relationship between duration and position of smartphone usage on preclinical students of The Faculty of Medicine, Universitas Nusa Cendana
A study on the hepatoprotective effect of turmeric (Curcuma longa) extract on the liver histopathology of albino rats induced by sodium diclofenac Hibur, Grasia Intan Praskawati; Amat, Anita Lidesna Shinta; Riwu, Magdarita; Telussa, Arley Sadra
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.209

Abstract

Background: Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), causes significant hepatotoxicity through oxidative stress mechanisms. Turmeric (Curcuma longa L.), rich in curcuminoid antioxidants, may offer hepatoprotection. Objective: To evaluate the hepatoprotective effects of turmeric extract against diclofenac sodium-induced liver injury in rats. Methods: Twenty-eight male Sprague Dawley rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg BW for 7 days), and two treatment groups receiving diclofenac sodium followed by turmeric extract at 100 or 200 mg/kg BW for 14 days. Liver histopathology was assessed using hematoxylin-eosin staining. Data were analyzed descriptively. Results: Turmeric extract attenuated hepatocellular damage in a dose-dependent manner. The 200 mg/kg BW dose completely prevented necrosis, demonstrating superior hepatoprotection compared to 100 mg/kg BW. Conclusion: Turmeric extract exerts hepatoprotective effects against diclofenac-induced liver injury through attenuation of histopathological damage.
Effect of turmeric (Curcuma longa L.) extract on gastric histopathology of diclofenac sodium-induced rats Lie, Melania; Amat, Anita Lidesna Shinta; Woda, Rahel Rara; Lidia, Kartini
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.210

Abstract

Background: Prolonged use of diclofenac sodium can cause gastric mucosal damage through cyclooxygenase inhibition and oxidative stress. Turmeric (Curcuma longa L.) contains curcumin and other bioactive compounds with potential gastroprotective properties. Objective: To determine the dose-dependent gastroprotective effect of turmeric extract against diclofenac sodium-induced gastric mucosal injury in rats. Methods: This experimental study used 28 male Sprague-Dawley rats randomly allocated into four groups (n=7): normal control, negative control (diclofenac 10 mg/kgBW for 7 days), and two treatment groups receiving turmeric extract at 100 mg/kgBW (P1) or 200 mg/kgBW (P2) for 14 days following diclofenac induction. Gastric tissues were evaluated histopathologically using a qualitative description. Results: The negative control group showed severe erosion and inflammatory infiltration. Both treatment groups demonstrated gastroprotective effects with minimal epithelial damage and no inflammatory changes. The 200 mg/kgBW dose showed superior protection compared to 100 mg/kgBW. Conclusion: Turmeric extract provides dose-dependent gastroprotection against diclofenac-induced gastric injury, with 200 mg/kgBW demonstrating superior efficacy.
Effect of turmeric extract on glutathione levels in diclofenac-induced oxidative stress in rats Jumba, Cynthia Benedikta; Amat, Anita Lidesna Shinta; Pakan, Prisca Deviani; Rini, Desi Indria
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.222

Abstract

Background: Glutathione (GSH), the primary endogenous antioxidant, protects cells against oxidative stress. Diclofenac sodium, a commonly prescribed nonsteroidal anti-inflammatory drug (NSAID), depletes GSH through hepatic metabolic byproducts, causing oxidative damage. Objective: To evaluate the protective effect of turmeric extract (Curcuma longa L.) on glutathione levels in rats subjected to diclofenac-induced oxidative stress. Methods: Twenty-eight male Wistar rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg body weight [BW]), and two treatment groups receiving turmeric extract (100 mg/kg BW or 200 mg/kg BW) following diclofenac induction. Diclofenac was administered for 7 days; turmeric extract was given orally for 14 days. Cardiac blood glutathione levels were measured spectrophotometrically. Results: Turmeric extract significantly increased glutathione levels in diclofenac-induced rats compared to negative controls (p<0.05). The 200 mg/kg BW dose produced superior protection, elevating GSH levels significantly above all groups (p<0.001), demonstrating a dose-dependent antioxidant effect. Conclusion: Turmeric extract demonstrates significant dose-dependent antioxidant activity against diclofenac-induced oxidative stress, with the 200 mg/kg BW dose achieving superior GSH elevation (p < 0.001), suggesting potential as a protective agent against NSAID-induced oxidative damage.
Co-Authors Aji Winarso, Aji Anjani, Ratih Anu, Helena Vaustina Artawan, I Made Asan, Maria Ignatia De Loyola Ina Peni Br Damanik, Efrisca Meliyuta Corputty, Dian Yelisa Damanik, Efrisca M. Br. Deri Riskiyanti Tallo Manafe Dewanti, Intan Putri Djahi, Sri Nur Nur Saidah Djunaidi, Savitry R. Maudy E D, Maria Agnes Folamauk, Conrad Liab Hendricson Gue, Ronaldo Osario Lau Hibur, Grasia Intan Praskawati Jumba, Cynthia Benedikta Kapitan, Irene Krisanti Kareri, Dyah Gita Rambu Kause, Marthen Keba, Diorita Sely lai, gloria harpazo Lidia, Kartini Lie, Melania Ly, Elsye Jasicha Magdarita Riwu Maria Agnes Etty Dedy Mukin, Patricia Flamli Uma Nurina, Rr. Listyawati PAKAN, PRISCA DEVIANI Pao, Ressa Patricia PRISCA DEVIANI PAKAN Ratu, Kristian Rini, Desi Indria Riwu, Magdarita Sasputra, I Nyoman Setianingrum, Elisabeth Levina Sari Setiawan, I Made Buddy Sianturi, Elaine Courtesy So’o, Rosina Wiwin Sunarno, Martinus Ezra Tandang, Fransiskus Telussa, Arley Sadra Toby, Tarsisius Ryang Wahyuningrum, Stefany Adi Woda, Rahel Rara Wungouw, Herman Pieter Louis