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All Journal Jurnal Biologi Tropis Acta Biochimica Indonesiana Biopendix: Jurnal Biologi, Pendidikan dan Terapan JURNAL KAJIAN VETERINER Journal of Health Community Service Cendana Medical Journal
Anita Lidesna Shinta Amat
Universitas Nusa Cendana
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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A study on the hepatoprotective effect of turmeric (Curcuma longa) extract on the liver histopathology of albino rats induced by sodium diclofenac Hibur, Grasia Intan Praskawati; Amat, Anita Lidesna Shinta; Riwu, Magdarita; Telussa, Arley Sadra
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.209

Abstract

Background: Diclofenac sodium, a widely used nonsteroidal anti-inflammatory drug (NSAID), causes significant hepatotoxicity through oxidative stress mechanisms. Turmeric (Curcuma longa L.), rich in curcuminoid antioxidants, may offer hepatoprotection. Objective: To evaluate the hepatoprotective effects of turmeric extract against diclofenac sodium-induced liver injury in rats. Methods: Twenty-eight male Sprague Dawley rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg BW for 7 days), and two treatment groups receiving diclofenac sodium followed by turmeric extract at 100 or 200 mg/kg BW for 14 days. Liver histopathology was assessed using hematoxylin-eosin staining. Data were analyzed descriptively. Results: Turmeric extract attenuated hepatocellular damage in a dose-dependent manner. The 200 mg/kg BW dose completely prevented necrosis, demonstrating superior hepatoprotection compared to 100 mg/kg BW. Conclusion: Turmeric extract exerts hepatoprotective effects against diclofenac-induced liver injury through attenuation of histopathological damage.
Effect of turmeric (Curcuma longa L.) extract on gastric histopathology of diclofenac sodium-induced rats Lie, Melania; Amat, Anita Lidesna Shinta; Woda, Rahel Rara; Lidia, Kartini
Acta Biochimica Indonesiana Vol. 8 No. 1 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.210

Abstract

Background: Prolonged use of diclofenac sodium can cause gastric mucosal damage through cyclooxygenase inhibition and oxidative stress. Turmeric (Curcuma longa L.) contains curcumin and other bioactive compounds with potential gastroprotective properties. Objective: To determine the dose-dependent gastroprotective effect of turmeric extract against diclofenac sodium-induced gastric mucosal injury in rats. Methods: This experimental study used 28 male Sprague-Dawley rats randomly allocated into four groups (n=7): normal control, negative control (diclofenac 10 mg/kgBW for 7 days), and two treatment groups receiving turmeric extract at 100 mg/kgBW (P1) or 200 mg/kgBW (P2) for 14 days following diclofenac induction. Gastric tissues were evaluated histopathologically using a qualitative description. Results: The negative control group showed severe erosion and inflammatory infiltration. Both treatment groups demonstrated gastroprotective effects with minimal epithelial damage and no inflammatory changes. The 200 mg/kgBW dose showed superior protection compared to 100 mg/kgBW. Conclusion: Turmeric extract provides dose-dependent gastroprotection against diclofenac-induced gastric injury, with 200 mg/kgBW demonstrating superior efficacy.
Effect of turmeric extract on glutathione levels in diclofenac-induced oxidative stress in rats Jumba, Cynthia Benedikta; Amat, Anita Lidesna Shinta; Pakan, Prisca Deviani; Rini, Desi Indria
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.222

Abstract

Background: Glutathione (GSH), the primary endogenous antioxidant, protects cells against oxidative stress. Diclofenac sodium, a commonly prescribed nonsteroidal anti-inflammatory drug (NSAID), depletes GSH through hepatic metabolic byproducts, causing oxidative damage. Objective: To evaluate the protective effect of turmeric extract (Curcuma longa L.) on glutathione levels in rats subjected to diclofenac-induced oxidative stress. Methods: Twenty-eight male Wistar rats were randomly divided into four groups (n=7): normal control, negative control (diclofenac sodium 10 mg/kg body weight [BW]), and two treatment groups receiving turmeric extract (100 mg/kg BW or 200 mg/kg BW) following diclofenac induction. Diclofenac was administered for 7 days; turmeric extract was given orally for 14 days. Cardiac blood glutathione levels were measured spectrophotometrically. Results: Turmeric extract significantly increased glutathione levels in diclofenac-induced rats compared to negative controls (p<0.05). The 200 mg/kg BW dose produced superior protection, elevating GSH levels significantly above all groups (p<0.001), demonstrating a dose-dependent antioxidant effect. Conclusion: Turmeric extract demonstrates significant dose-dependent antioxidant activity against diclofenac-induced oxidative stress, with the 200 mg/kg BW dose achieving superior GSH elevation (p < 0.001), suggesting potential as a protective agent against NSAID-induced oxidative damage.
Dose-dependent nephroprotective effects of turmeric extract against diclofenac-induced kidney injury in rats Amapiran, Renya Rosari; Amat, Anita Lidesna Shinta; Indriarini, Desi; Hietingwati, Syeben HE; Nugraheni, Tri
Acta Biochimica Indonesiana Vol. 8 No. 2 (2025): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Non-steroidal anti-inflammatory drugs, particularly diclofenac sodium, are widely prescribed but can cause nephrotoxicity through oxidative stress mechanisms. Turmeric (Curcuma longa L.) contains curcumin and other bioactive compounds with potent antioxidant properties that may protect against drug-induced kidney damage. Objective: To evaluate the dose-dependent effects of turmeric ethanol extract on kidney histopathology in rats with established diclofenac sodium-induced nephrotoxicity. Methods: Twenty-eight male Sprague Dawley rats were randomly divided into four groups: normal control, diclofenac (10 mg/kg for 7 days), and two treatment groups receiving diclofenac followed by turmeric extract at 100 mg/kg or 200 mg/kg for 14 days. Kidney histopathology was assessed using the Arsad scoring system by a blinded pathologist. Results: Significant differences existed between groups (p < 0.001). The negative control exhibited severe kidney damage with hydropic degeneration, granular casts, and cellular casts (mean score: 2.78 ± 0.24). Treatment with 100 mg/kg showed partial improvement (1.65 ± 0.31), while 200 mg/kg demonstrated substantial improvement approaching normal histology (0.52 ± 0.18) with only minimal residual damage. Conclusion: Turmeric extract demonstrates significant dose-dependent nephroprotective effects against diclofenac-induced kidney damage, with 200 mg/kg providing superior protection, suggesting potential therapeutic applications in mitigating NSAID-induced nephrotoxicity.
The Relationship of Knowledge Levels About COVID-19 With COVID-19 Prevention Behavior In Oebobo Village Community Kupang Devina, Vania Carla; Wungouw, Herman Pieter; Amat, Anita Lidesna Shinta; Minggu, Dominikus
Cendana Medical Journal Vol 13 No 1 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i1.16326

Abstract

Introduction: COVID-19 is a virus that can be transmitted from human to human (human to human transmission). This virus has spread widely in China and even to other countries. This virus can spread because of the travel history of people who have been infected with the corona virus. The increase in COVID-19 in Indonesia is also based on the lack of public knowledge about COVID-19. The existence of correct information can help people to increase their knowledge. Misinformation can make people's understanding also change. Therefore, the level of community knowledge greatly influences people's behavior. Behavior is an action that can also be interpreted as all activities carried out by someone which is the result of external stimuli that explain the knowledge they have. Community behavior in preventing COVID-19 can help reduce the increase in the incidence of COVID-19. Purpose: The purpose of this study was to determine the relationship between the level of knowledge about COVID-19 and COVID-19 prevention behavior in the community in Oebobo Village, Kupang. Methods: This type of research was an observational analytic using amethod cross sectional conducted on the people of Oebobo Village, Kupang City. . Data were obtained by filling out the Knowledge Questionnaire about COVID-19 and the COVID-19 Prevention Behavior Questionnaire by 100 respondents who met the inclusion criteria. Sampling was done by using purposive random sampling technique. The results were analyzed univariately and bivariately using thecorrelation test Spearman. Results: Data from 100 respondents showed, 64.0% had a good level of knowledge, 32.0% had a sufficient level of knowledge and 4.0% had a poor level of knowledge. For preventive behavior, 68.0% had good behavior, 32.0% had moderate behavior and none had bad behavior. The results of the bivariate analysis with the correlation test Spearman showed the results of p= 0.114 (p> 0.05) Conclusion: There is no significant relationship between the level of knowledge about COVID-19 and COVID-19 prevention behavior in the community in Oebobo Kupang Village
Hubungan Tingkat Stres Akademik Dengan Keteraturan Siklus Menstruasi Pada Mahasiswi Preklinik Fakultas Kedokteran Universitas Nusa Cendana Salmay, Helenri Juntari; Amat, Anita Lidesna Shinta; Trisno, Idawati
Cendana Medical Journal Vol 13 No 1 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i1.16329

Abstract

Latar Belakang : Menstruasi merupakan suatu perubahan fisiologis pada tubuh wanita secara berkala yang dipengaruhi oleh hormon reproduksi. Siklus menstruasi seorang wanita dapat terjadi secara teratur dan tidak teratur, seperti polimenore, oligomenore, dan amenore. Salah satu faktor yang dapat mempengaruhi keteraturan siklus menstruasi adalah stres. Sumber stres yang paling banyak dialami oleh mahasiswa adalah stres dalam bidang akademik. Mahasiswa kedokteran memiliki stres yang lebih tinggi dibandingkan dengan kelas lain karena tuntutan akademik yang tinggi dan kurikulum yang berbeda. Tujuan : Penelitian ini bertujuan untuk mengetahui hubungan tingkat stres akademik dengan keteraturan siklus menstruasi pada mahasiswa praklinis Fakultas Kedokteran Universitas Nusa Cendana. Metode : Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional yang dilakukan pada mahasiswa praklinis Fakultas Kedokteran Universitas Nusa Cendana. Pengumpulan data dilakukan dengan pengisian Medical Student Stresor Questionnaire (MSSQ) dan kuesioner keteraturan siklus menstruasi oleh 100 responden angkatan 2018, 2019 dan 2020 yang memenuhi kriteria inklusi. Pengambilan sampel dilakukan dengan teknik stratified random sampling . Hasilnya dianalisis secara univariat dan bivariat dengan menggunakan uji korelasi koefisien kontingensi. Hasil : Dari 100 responden, 51 responden mengalami stres berat, 31 responden mengalami stres sedang, 13 responden mengalami stres sangat berat, dan 5 responden mengalami stres ringan. Untuk keteraturan siklus menstruasi, 70 responden memiliki siklus menstruasi normal, 30 responden memiliki siklus menstruasi tidak normal, 28 responden mengalami oligomenore dan 2 orang mengalami polimenore. Hasil uji analisis bivariat dengan uji korelasi koefisien kontingensi menunjukkan hasil p = 0,151 (p>0,05) Kesimpulan : Tidak terdapat hubungan yang signifikan antara tingkat stres akademik dengan keteraturan siklus menstruasi pada mahasiswa praklinis Fakultas Kedokteran Universitas Nusa Cendana. Kata Kunci : Tingkat stres akademik, keteraturan siklus menstruasi, mahasiswa kedokteran
PENGARUH EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) TERHADAP GAMBARAN HISTOPATOLOGI OTOT JANTUNG TIKUS (Rattus norvegicus) DIINDUKSI ALOKSAN Lerrick, Riky Alberth; Damanik, Efrisca Meliyuita Br.; Amat, Anita Lidesna Shinta; Nurina, Rr. Listyawati
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.22056

Abstract

Introduction: Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, saponins, and tannins, which have antidiabetic properties. Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or action, leading to increased production of Reactive Oxygen Species (ROS). The antioxidants in red betel leaf extract are expected to reduce ROS formation and protect cardiac muscle from DM-induced damage.. Methods: This laboratory experimental study used a true experimental post-test only control group design. Thirty rats were divided into five groups: positive control (KK+), negative control (KK−), and treatment groups (KP1, KP2, KP3), each consisting of six rats. Histopathological features of cardiac muscle, including interstitial fibrosis, ventricular myocyte hypertrophy, and intramyocyte lipid deposits, were assessed. Data were analyzed using the Kruskal-Wallis test and Post Hoc LSD. Results: There was a significant difference in ventricular myocyte hypertrophy between groups (p = 0.009), but no significant differences were observed in interstitial fibrosis (p = 1.000) and intramyocyte lipid deposits (p = 0.866). Discussion: Red betel leaf extract at 150 mg/kg body weight effectively reduced ventricular myocyte hypertrophy in diabetic rats Conclusion: Red betel leaf extract significantly reduced ventricular myocyte hypertrophy but had no effect on fibrosis or intramyocyte lipid deposits.
Perbedaan Kejadian Astenopia Antara Pegawai Administrasi Dan Non Administrasi Fakultas Kedokteran Dan Kedokteran Hewan Universitas Nusa Cendana Daruranto, Bryan Davidson; Amat, Anita Lidesna Shinta; Telussa, Arley; Nikita, Hyasinta Arlette
Cendana Medical Journal Vol 13 No 2 (2025): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v13i2.27141

Abstract

Administrative employees have a high risk of experiencing asthenopia due to long-term use of computers, but non-administrative employees with less duration of computer use can also experience asthenopia. incidence of asthenopia.Various symptoms of asthenopia were noted more frequently in workers using VDT (Visual Display Terminal) i.e. administrative employees than in workers who did little or no work using VDT, i.e. non-administrative employees. Knowing the difference in the incidence of asthenopia between administrative and non-administrative employees of the Faculty of Medicine and Veterinary Medicine, University of Nusa Cendana. This is a quantitative study with a case control design on employees of the University of Nusa Cendana. total sampling technique is used in this research. The sample was divided into administrative and non-administrative employees. Astenopia data were collected using a Computer Vision Syndrome questionnaire. Bivariate test using chi square showed a significant difference between administrative and non-administrative employees (p=0.000). Administrative employees have an average CVS score of 10.1 while non-administrative employees have 3.45. There is a significant difference in the incidence of asthenopia between administrative and non-administrative employees.
Antibacterial Effectiveness Test of Sandalwood Leaf Extract (Santalum album) Against Pathogenic Bacteria Escherichia coli and Staphylococcus aureus Amiroh, Jasmine Kiran; Amat, Anita Lidesna Shinta; Iswaningsih, Iswaningsih; Setiawan, I Made Buddy
BIOPENDIX: Jurnal Biologi, Pendidikan dan Terapan Vol 13 No 1 (2026): Biopendix: Jurnal Biologi, Pendidikan & Terapan
Publisher : Program Studi Pendidikan Biologi FKIP Unpatti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biopendixvol13issue1page14-20

Abstract

Infectious diseases are diseases caused by organisms such as bacteria, viruses, fungi or parasites. One of the causes of most infectious diseases comes from bacterial infections, including Escherichia coli and Staphylococcus aureus. Treatment for bacterial infections is generally by administering antibiotics. Treatment using plants containing antibacterials is an alternative that is being widely studied as an effort to kill bacteria other than the use of antibiotics. One of the plants cultivated and used as a medicinal plant is sandalwood (Santalum album). This research was carried out to evaluate the antibacterial activity of sandalwood leaf extract (Santalum album) against Escherichia coli and Staphylococcus aureus. The research utilized a true experimental framework with a posttest-only control group design, featuring treatment groups consisting of a Ciprofloxacin positive control, a sterile aquadest negative control, and varying concentrations of sandalwood leaf extract (ranging from 3.12% to 100%), each replicated three times against Escherichia coli and Staphylococcus aureus strains. Data analysis used the Kruskal-Wallis statistical test with a 95% degree of confidence. Based on the results of testing the antibacterial potential of sandalwood leaf extract on the growth of Escherichia coli and Staphylococcus aureus bacteria, it was shown that the extract had antibacterial potential. Analysis of the Kruskal-Wallis test showed that p = 0.002 was smaller than α = 0.05, showing there was a significant variation in the mean diameter of the inhibition zones between the different treatment groups. There is an antibacterial effectiveness of sandalwood leaf extract (Santalum album) against Escherichia coli and Staphylococcus aureus bacteria
The Relationship Between Formula Feeding and Incidence of Diarrhea Among Infants Ages 0-6 Months at Sikumana Public Health Center, Kupang City Suban, Irenne Sovia Lestari; Amat, Anita Lidesna Shinta; Wardani, Nimas Prita Rahajeningtyas Kusuma; Woda, Rahel Rara
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10989

Abstract

Diarrhea remains one of the leading causes of morbidity and mortality among infants in Indonesia. Formula feeding is often associated with diarrhea, especially among infants under six months of age. Based on 2024 data from the Kupang City Health Office, Sikumana Public Health Center ranked second in diarrhea cases among children under five, with 1,376 reported cases. This study employed an analytical observational design with a cross-sectional approach. The population included all infants aged 0–6 months residing in the Sikumana Public Health Center area. A total of 120 infants were selected using a consecutive sampling technique according to inclusion and exclusion criteria. Data were collected through structured questionnaires administered to parents and verified with information from the Maternal and Child Health (KIA) book. Data were analyzed using the Chi-square test with a significance level of p<0.05. Among the 120 respondents, 21 infants (17.5%) received formula, while 99 infants (82.5%) did not receive formula. A total of 45 infants (37.5%) experienced diarrhea, and 75 infants (62.5%) did not. Data analysis indicated no meaningful connection between formula feeding and the occurrence of diarrhea (p = 0.352). There was no significant association between formula feeding and the rates of diarrhea in infants aged 0–6 months at the Sikumana Public Health Center located in Kupang City.
Co-Authors Aji Winarso, Aji Amapiran, Renya Rosari Amiroh, Jasmine Kiran Anjani, Ratih Anu, Helena Vaustina Arley Sadra Telussa Artawan, I Made Asan, Maria Ignatia De Loyola Ina Peni Ballo, Natasya Detami Sheline Br Damanik, Efrisca Meliyuta Br. Damanik, Efrisca Meliyuita Corputty, Dian Yelisa Damanik, Efrisca M. Br. Damanik, Efrisca Meliyuita Br. Daruranto, Bryan Davidson Deri Riskiyanti Tallo Manafe Devina, Vania Carla Dewanti, Intan Putri Djahi, Sri Nur Nur Saidah Djunaidi, Savitry R. Maudy E D, Maria Agnes Efrisca Damanik Folamauk, Conrad Liab Hendricson Gue, Ronaldo Osario Lau Haning, Andre Januar Dwi Putra Herman Pieter Louis Wungouw Hibur, Grasia Intan Praskawati Hietingwati, Syeben HE Idawati Trisno Indriarini, Desi Iswaningsih, Iswaningsih Jumba, Cynthia Benedikta Kapitan, Irene Krisanti Kareri, Dyah Gita Rambu Kause, Marthen Keba, Diorita Sely Koamesah, S.M.J lai, gloria harpazo Lenggu, Claritha Kaci Louis Lerrick, Riky Alberth Lidia, Kartini Lie, Melania Liwu, Apolonia Nogo Ly, Elsye Jasicha Magdarita Riwu Maria Agnes Etty Dedy Maria Fransiska Priska Yulianti Mau Meta, Maria Chrisanti Minggu, Dominikus Mukin, Patricia Flamli Uma Ngara, Cydri Anggreny Rade Dendo Nikita, Hyasinta Arlette Nugraheni, Tri Nurina, Rr. Listyawati PAKAN, PRISCA DEVIANI Pao, Ressa Patricia PRISCA DEVIANI PAKAN Prisca Deviani Pakan Ratu, Kristian Regina Marvina Hutasoit Rini, Desi Indria Riwu, Magdarita Salmay, Helenri Juntari Sasputra, I Nyoman Setianingrum, Elisabeth Levina Sari Setiawan, I Made Buddy Sianturi, Elaine Courtesy So’o, Rosina Wiwin Suban, Irenne Sovia Lestari Sunarno, Martinus Ezra Tandang, Fransiskus Telussa, Arley Toby, Tarsisius Ryang Wahyuningrum, Stefany Adi Wardani, Nimas Prita Rahajeningtyas Kusuma Woda, Rahel Rara Wungouw, Herman P L Wungouw, Herman Pieter Wungouw, Herman Pieter Louis