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All Journal Pharmaciana: Jurnal Kefarmasian JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Al Ishlah Jurnal Pendidikan Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Ilmu Kefarmasian Indonesia Pharmaceutical Journal of Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Bangun Desa : Jurnal Pengabdian Masyarakat Journal of Psychological Research
Kusumawardani, Nurul
Program Studi S1 Farmasi; Fakultas Ilmu-Ilmu Kesehatan; Universitas Alma Ata
Religion Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Analysis of total phenolic content and antioxidant activity of mahogany seed infusion (Swietenia mahagoni (L.) Jacq.) Pratiwi, Sindi; Emelda, Emelda; Kusumawardani, Nurul; Munir, Muhammad Abdurrahman; Azizah, Abibatul; Pothitirat, Werayut
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 4, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(4).262-272

Abstract

Background: The mahogany plant (Swietenia mahagoni) is a plant used in medicine. Mahogany seeds are also efficacious as antiseptics, antioxidants, and antimicrobials. This plant contains flavonoids, saponins, tannins, essential oils, alkaloids, and anthraquinones. The higher the phenolic content in a plant, the higher the antioxidant activity. According to previous studies, it was stated that the methanol extract of mahogany seeds has good antioxidant properties, and the phenolic compounds contained in mahogany seeds can be the main contributors to antioxidant activity.Objectives: This study aims to analyze the total phenolic content, measure the inhibition concentration 50% (IC50) and determine the antioxidant activity of mahogany (Swietenia mahagoni) seed infusion.Methods: This type of research is experimental which begins with extraction using the infusion method at a temperature of 900C for 15 minutes followed by measuring the total phenolic content by reacting the infusion preparation and the Gallic acid respectively with the Follin-ciocalteu reagent. The antioxidant activity test was carried out using the DPPH (,-diphenyl--picrylhydrazyl) free radical scavenging method. Each absorbance was measured using UV-Vis Spectrophotometry. The phenolic test was measured by making a linear regression between concentration and absorbance, followed by calculating the total phenolic content. Meanwhile, the absorbance obtained for the antioxidant test was calculated by calculating the percent inhibition. The IC50 is determined by calculating the linear regression of the relationship between concentration and percent inhibition.Result: The results of the phenolic content were 2.531 ± 0.029 mg GAE/g, the IC50 value for gallic acid was 5.54 ppm, and for mahogany seed extract, the IC50 value was 47.04 ppm, which is a very strong antioxidant.Conclusion: This study concluded that the phenolic content of mahogany seed infusion extract contained phenolic compounds equivalent to 2.531 ± 0,029 mg GAE/g of gallic acid and that mahogany seed extract had very strong antioxidant activity.
Co-Authors Ahmad Salim Akrom, Akrom Amalia, Latifa Amukti, Danang Amukti, Danang ANAFRIN YUGISTYOWATI Apristina, Ana Avista, Agriva Devaly Azizah, Abibatul Basuki, Adriyanto Rochmad Danang Prasetyaning Amukti Daru Estiningsih Dwinta, Eliza emelda, emelda Endang Darmawan Endang Darmawan Estiningsih, Daru Eva Nurjanah Herlina, Tetie Husnul Khatimah Iftita Nuratika Ramadhanti Jasmine Amira Hatisuci Lestari, Masbani Ajeng Maulida, Milati Nurul Muh. Mustakim Muh. Mustakim, Muh. Muhammad Abdurrahman Munir Muhammad Fakhrurrozi Munarsih, Dena Nabila , Lathifa Nandy Agustin Syakarofath Nawawi, Bismi Ratu Fortuna Ninisita Sri Hadi Nurinda, Eva Nurwanti, Esti Nuryanti, Sundari Desi Pothitirat, Werayut Pothitirat, Werayut Pratama, Aditya Mandala Pratama, Haka R Pratami, Ria Indah Pratiwi, Sindi Pratiwi, Sindi Prillia, Wiwi Kustio Puspitasari, Ade Rahma Sakti Oktavia Rahmawati, Dewi Astri Ratih Nugraeni ratih ratih Rizal Fauzi Rosa Nikmatul Fajri Rusiyono, Ruwet Rusny Istiqomah Sujono Silvianita, Novi Sri Suprapti Suat, Winda Dheananda Sukma Ananda , RA Dewinta Sulistiari Retnowati Suminingtyas, Ifa Aris Tri Rochmadi Trisna Styawaty Very Ainun Fauziah Vitara, Debby Wahyudi, Andi Wahyuningsih Wahyuningsih Wardani, Astin Eka Wulandari, Ari Susiana Wulandari, Metha Yanhari, Apriza Dwi Yulinda Kurniasari Zahro, Siti