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All Journal Jurnal Biologi Tropis Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Window of Health : Jurnal Kesehatan Jurnal Biomedika dan Kesehatan UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO INDONESIAN JOURNAL OF HEALTH Jurnal Ilmiah Kesehatan (JIKA) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh jpki
Karim, Marzelina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Changes HDL and LDL Levels After Using Olive Oil and Figs Extract on White Rats with A High-Fat Diet Alhumaerah, Musdalifah; Syamsu, Rachmat Faisal; Karim, Marzelina; Nurmadilla, Nesyana; Murfat, Zulfitriani
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6536

Abstract

Hypercholesterolemia often initiates the pathogenesis of atherosclerosis which can occur slowly. As free radicals increase, the need for antioxidants also increases. Reducing LDL and increasing HDL levels is the target of therapy for hyperlipidemia patients with the main goals of lifestyle changes and drug therapy. Olive oil and fig extract have therapeutic benefits as alternative treatments from MUFA content dominated by oleic acid and phenolic compounds. The polyphenol content is known to inhibit the formation of atherosclerosis and inhibit the increase in MCP-1 levels in white mice on a high-fat diet. Therefore, it is hoped that the administration of figs extract and olive oil can overcome dyslipidemia, especially changes in HDL and LDL levels in white mice. To determine changes in HDL and LDL levels. The research conducted was a true experimental research was used with a Pre-Post control group research design and test statistical analysis with Microsoft Office 2013. Showed there was an effect of fig extract (Ficus Carica L) on changes in HDL levels and the effect of olive oil (Olea europea L) on changes in LDL levels in white rats (Rattus novergicus) fed a high-fat diet. The intervention of fig extract and olive oil had a significant effect on the group given the single intervention.
Comparison of The Effectiveness of E-C Positive Pressure Ventilation Technique and Modified Chinlift Positive Pressure Ventilation Technique in Mppd at Ibnu Sina Hospital Maulidya, Dhinda Lunizar; Dwimartyono, Fendy; Maharani, Ratih Natasha; Sommeng, Faisal; Karim, Marzelina
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6634

Abstract

Mask ventilation skills are essential competencies for MPPD to master. According to SKDI, these skills include competency 4A, which is the ability to perform independently by mastering the theory, principles, indications, and steps. To date, there have been few studies evaluating the effectiveness of modified chinlift and E-C techniques regarding the tidal volume delivered (TV). Therefore, the researchers were interested in comparing the effectiveness of the E-C method and modified chinlift positive pressure ventilation technique in mask ventilation (MV) use. This study is a quantitative research with an observational analytical cross-sectional design. Researchers observed the treatments given by MPPD, totaling 22 individuals, to 6 research subjects. Data analysis for this research used Mann-Whitney and chi-square tests as Independence Tests. After applying the E-C technique, 43.8% out of 100% were successful, and 56.3% were not successful. Meanwhile, with the MCL technique, out of 100%, 40.6% were successful, and 59.4% were not successful. The E-C technique showed better results compared to the Modified Chinlift technique in MV, although statistically, the test results for the difference in success scores between the two techniques did not show any significant difference.
The Effect of Olive Oil and Tin Leaf Extract on GDP Levels in White Rats Jannah, Reza Miftahul; Syamsu, Rachmat Faisal; Karim, Marzelina; Julyani, Sry; Kartika, Andy Visi
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7293

Abstract

Diabetes Mellitus is a chronic condition characterized by fasting blood glucose levels of less than 126 mg/dl, which are above the normal range. DM is otherwise called the quiet executioner since it is frequently not understood and when it is found complexities have happened. Monounsaturated fatty acids (MUFA), which have anti-diabetic properties, can be found in olive oil, a functional food. Fig leaves contain flavonoid compounds, β-setosterol, and these polyphenols are accounted for to work as antidiabetics. The point of this study was to decide the impact of directing olive oil and fig leaf separate on fasting blood glucose levels in white rodents. This study employs a Pretest-Posttest Control Group Design and quantitative experimental research methods. The examples utilized were 24 mice. The independent t-test was used to process the results, and One Way Annova was used to carry on. According to the findings of the study, the group that received olive oil had a fasting blood glucose of 41.00 mg/dL (p0.004), the group that received fig leaf extract had a p value of 37.25 mg/dL (p0.005), and the group that received a mixture of olive oil and fig leaf extract had a p value of 39.00 mg/dL (p0.004). Olive oil and fig leaf extract both have an effect on the blood glucose levels of mice induced by Aloxan, but the combination yields more significant results. This is the study's conclusion.
Effectiveness Test of Saliara Leaf Extract (Lantana camara) on Escherichia coli Bacteria Kirby Bauer Disc Method Baba, Firda; Karim, Marzelina; Sam, Andi Dhedie Prasatia; Sodiqah, Yani; Hatta, Dhian Karina
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7294

Abstract

Death due to infection is the most common cause and is a challenge in the health sector. In 2019, 7.7 deaths were due to bacterial infections, 90 to 100 cases were urinary tract infections and Escherichia coli bacteria contributed to 90% of urinary tract infections. This research uses the Kirby Bauer Disc method to determine the effectiveness of Saliara (Lantana camara) leaves against Escherichia coli bacteria. The type of research is a Laboratory experiment using the Kirby Bauer disc method with a post-test-only control group design. Data analysis uses recording of identifying the inhibition zones formed The research showed that a sample's concentration can influence the inhibition zone's resulting diameter. Saliara leaf extract with concentrations of 100%, 150%, and 200% produced an inhibition zone of 8.55 mm; 9.59mm; 12.34 mm in the proliferation of Escherichia coli bacteria. The positive control with the antibiotic ciprofloxacin produced an inhibition zone of 19.56 mm on the growth of Escherichia coli bacteria. Control with negative distilled water does not create an inhibition zone because it does not have antibacterial activity. The conclusion is moderate inhibitory activity in Saliara (Lantana camara L.) leaf extract at concentrations of 100% and 150%. It is strong at a concentration of 200% against the growth of Escherichia coli bacteria.
Isolation and Identification of Bacteria in the Integrated Laboratory of the Faculty of Medicine, Moslem Indonesia of University Karim, Marzelina; Hattah, Dhian Karina Aprilani; Haris, Haslianti H.; Churiani, Churiani
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8219

Abstract

The integrated laboratory is one of the learning facilities at the university, especially to support the implementation of practicum. In laboratories that are full of activities, bacterial contamination often occurs which can interfere with the smooth running of research and practicum. This contamination is often caused by a lack of sterility in the work process and less than optimal indoor air quality. Therefore, it is important to know the type and number of bacteria found in the laboratory to prevent further spread of contamination. This study aims to isolate and identify bacteria in the Integrated Laboratory of the Faculty of Medicine, Universitas Muslim Indonesia. The method used in this study was descriptive research with a laboratory observational design, which was carried out by macroscopic and microscopic means to determine the type of microorganisms and the number of bacterial colonies. The results showed four types of bacteria found, namely Staphylococcus sp., Klebsiella pneumoniae, Staphylococcus epidermidis, and Bacillus sp., which were isolated from air and swab results. Airborne bacteria had the highest number of colonies at 14 CFU, while swab bacteria were found at 200 CFU. Although bacterial colonies were found in the laboratory, this number is still considered safe for the number of bacteria in the laboratory. Based on these findings, it is recommended that laboratory facilities pay more attention to aspects of cleanliness and sanitation as a whole. 
TOKSISITAS SENYAWA DMBA (7,12 DIMETHYLBENZ[A]ANTHRACENE) SEBAGAI LARUTAN KARSINOGENESIS KANKER KOLOREKTAL PADA TIKUS PUTIH (RATTUS NOVERGICUS) Rifai B, Muh.; Syamsu, Rachmat Faisal; Karim, Marzelina; Gani, Azis Beru; Hasbi, Berry Erida
Jurnal Kesehatan Tambusai Vol. 4 No. 4 (2023): DESEMBER 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i4.22209

Abstract

Kanker kolorektal (colorectal cancer/CRC) merupakan masalah kesehatan masyarakat yang ada di Indonesia dan saat ini menempati urutan keempat kanker tertinggi. Kanker merupakan penyakit yang disebabkan akibat proliferasi sel multiseluler sehingga menimbulkan perubahan sifat sel yang tidak terkendali. Kadar Malondialdehyde (MDA) merupakan salah satu marker biokimia yang digunakan untuk penelitian profil kanker. Senyawa DMBA (7,12-Dimethylbenz[a]anthracene) adalah salah satu agen Polycyclic Aromatic Hydrocarbon (PAH) yang banyak digunakan untuk mempelajari karsinogenesis. Reagen DMBA dilarutkan dengan minyak jagung dan diinduksikan 1 kali dalam seminggu secara subkutan pada tikus. Tujuan dari penelitian ini adalah untuk mengetahui toksisitas senyawa DMBA (7,12-dimethylbenz[a]anthracene) sebagai larutan karsinogenesis kanker kolorektal pada tikus putih (rattus novergicus). Penelitian yang dilakukan adalah penelitian true experimental dengan menggunakan rancangan pre dan post-test control group design untuk melihat perbedaan pada sampel sebelum dan setelah pemberian perlakuan. Hasil dari penelitian ini menunjukkan senyawa DMBA dengan dosis 20 mg/kgBB memiliki dosis letal karena pada minggu ke-3 terjadi mortalitas yang paling tinggi dari minggu sebelumnya, yaitu pada minggu ke-1 angka kematian tikus putih mencapai 4 ekor, minggu ke-2 terdapat 9 ekor tikus putih yang mati, minggu ke-3 terdapat 10 tikus ekor yang mati dan minggu ke-4 terdapat 5 ekor tikus yang mati. Selain itu senyawa DMBA juga dapat menurunkan berat badan secara signifikan, dimana hasil uji Analisa one way Anova didapatkan nilai P-value 0,000. Senyawa DMBA juga dapat meningkatkan kadar MDA darah pada tikus putih, dari hasil uji Analisa Mann whitney U test didapatkan nilai p-value 0,001. Senyawa DMBA (7,12-dimethylbenz[a]anthracene) sebagai larutan karsinogenesis kanker kolorektal memiliki efek toksisitas pada tikus putih (rattus novergicus).
Analisis Hubungan Faktor-Faktor Kepuasan Pasien terhadap Bed Occupancy Rate (BOR) pada Instalasi Bedah RSP Ibnu Sina Puspita, Andi Adelia; Jaya, Muhammad Alim; Karim, Marzelina; Harahap, Wirawan; Hasbi, Berry Erida
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 5 No. 1 (2026): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Februari 2
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat kepuasan pasien dan Bed Occupancy Rate (BOR) pada pelayanan rawat inap Instalasi Bedah RS Ibnu Sina YW–UMI Makassar. Penelitian ini merupakan studi epidemiologi analitik korelasional dengan pendekatan potong lintang (cross-sectional) yang menggunakan data primer dan sekunder. Data primer diperoleh melalui kuesioner kepuasan pasien berbasis SERVQUAL yang mencakup lima dimensi, yaitu tangible, empathy, reliability, responsiveness, dan assurance, sedangkan datasekunder berupa laporan BOR rumah sakit Triwulan I Tahun 2025. Sampel penelitian berjumlah 89 responden yang dipilih menggunakan teknikpurposive sampling. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Korelasi Spearman. Hasil penelitian menunjukkan bahwa nilai BOR Instalasi Bedah sebesar 70,85%, yang berada dalam kategori ideal sesuai standar Kementerian Kesehatan Republik Indonesia. Sebagian besar pasien menyatakan puas terhadap pelayanan yang diberikan, dengan tingkat kepuasan tertinggi pada dimensi reliability dan terendah pada dimensi responsiveness. Namun, hasil analisis bivariat menunjukkan bahwa tidak terdapat hubungan yang signifikan antara seluruh dimensi kepuasan pasien dan BOR (p > 0,05) dengan kekuatan hubungan yang sangat lemah. Penelitian ini menyimpulkan bahwa pencapaian BOR lebih dipengaruhi oleh faktor manajerial dan operasional rumah sakit dibandingkan persepsi kepuasan pasien, sehingga peningkatan mutu pelayanan dan pengelolaan BOR perlu dilakukan melalui pendekatan yang terintegrasi.
Antibacterial Extract of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract against ESBL-Producing Klebsiella pneumoniae Rivaldy, Naufal; Kartika, Andy Visi; Karim, Marzelina; Sodiqah, Yani; Anggita, Dwi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1560

Abstract

The rising prevalence of infections caused by Extended-Spectrum Beta-Lactamase (ESBL)-producing Klebsiella pneumoniae necessitates the search for alternative antibacterial agents. Red dragon fruit (Hylocereus polyrhizus) peel is a potential source of bioactive compounds. This study aimed to evaluate the in vitro antibacterial activity of red dragon fruit peel extract against ESBL-producing K. pneumoniae. The bacteria were isolated and identified via culture on MacConkey agar, Gram staining, and biochemical tests. The peel was extracted using 96% ethanol via maceration. Antibacterial activity was assessed using the disk diffusion method on Mueller-Hinton agar with extract concentrations of 20%, 40%, 60%, 80%, and 100% (v/v), with three replicates per concentration. Meropenem (10 µg) and DMSO served as positive and negative controls. The extract exhibited concentration-dependent antibacterial activity, with mean inhibition zone diameters increasing from 5,6 ± 0,3 mm at 20% to 6,1 ± 0,2 mm at 100%. The positive control produced a 30,2 ± 0,5 mm zone, while the negative control showed no inhibition. One-way ANOVA confirmed significant differences between groups (p-value < 0,05). Red dragon fruit peel extract demonstrated promising in vitro antibacterial activity against ESBL-producing K. pneumoniae, although its potency was considerably lower than meropenem.
The Effect Of Applying Virgin Coconut Oil (VCO) Ointment On the Healing Of Vulnus Scissum In Mice (Mus Musculus) Tahir, Sugiarti; Wahid, Syarifuddin; Hasbi, Berry Erida; Purnamasari, Reeny; Karim, Marzelina
Syifa'Medika Vol 16, No 2 (2026): Syifa Medika: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i2.10167

Abstract

Penyembuhan luka merupakan proses kompleks yang melibatkan beberapa tahap biologis, inflamasi, proliferasi, dan maturasi. Salah satu terapi yang berpotensi mempercepat penyembuhan luka adalah penggunaan Virgin Coconut Oil (VCO), yang diketahui memiliki sifat anti-inflamasi dan anti-mikroba. Penelitian ini bertujuan untuk mengevaluasi efek salep VCO terhadap penyembuhan vulnus scissum pada mencit (Mus musculus). Penelitian eksperimental ini menggunakan desain true experimental dengan tiga kelompok, yaitu dua kelompok perlakuan yang masing-masing diberi salep VCO dengan dosis 1,5 ml dan 2 ml dan kelompok kontrol yang tidak diberi VCO selama 14 hari. Hasil penelitian menunjukkan bahwa pemberian salep VCO dosis 1,5 ml dan 2 ml secara signifikan mempercepat penyembuhan luka dibandingkan dengan kelompok kontrol. Kelompok dengan dosis 2 ml menunjukkan penyusutan luka yang lebih cepat, dengan panjang luka pada hari ke-14 menjadi lebih kecil 0,6 mm hingga 0,0 mm. Hasil uji Mann Whitney menunjukkan perbedaan signifikan antara kelompok kontrol dan kelompok perlakuan (p = 0.000). Penelitian ini menyimpulkan bahwa salep VCO efektif dalam mempercepat penyembuhan luka vulnus scissum pada mencit, dengan dosis 2 ml memberikan hasil yang optimal. Penelitian lebih lanjut diperlukan untuk mengeksplorasi dosis lebih optimal dan aplikabilitas klinis pada manusia.
“Antibacterial Activity of Olive Oil Against Salmonella Typhi.” Fauziyah, Nailatul; Syamsu, Rachmat Faisal; Sodiqah, Yani; Karim, Marzelina; Arifuddin Karim, Abdul Mubdi Ardiansar
Syifa'Medika Vol 16, No 2 (2026): Syifa Medika: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v16i2.10374

Abstract

Salmonella typhi merupakan penyebab utama demam tifoid yang sering memerlukan pengobatan antibiotik, namun masalah resistensi bakteri terhadap antibiotik menjadi tantangan besar dalam pengobatan. Penelitian ini bertujuan untuk menguji efek antimikroba dari tiga jenis minyak zaitun: Extra Virgin Olive Oil (EVOO), Extra Light Olive Oil (ELOO), dan Olive Pomace Oil (OPO) terhadap pertumbuhan Salmonella typhi. Metode yang digunakan adalah uji difusi cakram selama tiga hari di Laboratorium UP3M Fakultas Kedokteran Universitas Muslim Indonesia. Hasil penelitian menunjukkan bahwa ketiga jenis minyak zaitun menunjukkan zona hambat terbatas antara 7,0 mm hingga 9,0 mm, yang semuanya dinilai “Resisten”, mengindikasikan efektivitasnya yang terbatas. Meskipun EVOO memiliki zona hambat rata-rata tertinggi (8,37 mm), tidak ada perbedaan signifikan antara ketiga jenis minyak zaitun maupun dengan Ciprofloxacin (kontrol positif) yang menunjukkan zona hambat sebesar 33 mm. Penelitian ini menyoroti pentingnya pengembangan terapi alternatif berbasis alami untuk mengatasi infeksi bakteri seperti Salmonella typhi, namun juga menekankan perlunya penelitian lebih lanjut untuk memahami potensi penuh minyak zaitun dan cara untuk meningkatkan efektivitasnya, termasuk modifikasi kimia atau pengolahan lebih lanjut.
Co-Authors Adrian Adrian Ahmad, Izhar Fitrah Alamanda Irwan, Andi Alhumaerah, Musdalifah Amrizal Muchtar Anggita, Dwi Anshary, Suci Noviyanah Arfah, Arni Isnaini Arif, Kamilah Ramadhani Arifuddin Karim, Abdul Mubdi Ardiansar Baba, Firda Bamahry, Aryanti Basri, Sri Wahyuni gayatri Briliany Rahman, Dinda Churiani, Churiani Daeng Kanang, Indah Lestari Darma, Sidrah Domu, Anugrah Julistiar Aksan Evi Sulastri Faisal Syamsu, Rachmat Faisal, M. Fathir Fauziyah, Nailatul Fazdlurrahman, Fazdlurrahman Fendy Dwimartyono G. Gunawan Gani, Azis Beru Gufron, Muh. Hadi, Santriani Harahap, Wirawan Haris, Haslianti H. Hasbi, Berry Erida Hatta, Dhian Karina Hattah, Dhian Karina Aprilani Hirda, Tiara Aviva Ikram, Dzul Imran Syafei Muhammad Nur Indarwati Abdullah, Rezky Putri Iskandar, Gina Isni D. Isnaini, Arni Jafar, Alfian Jannah, Reza Miftahul Jaya, Muhammad Alim Julyani, Sry Karim, Abdul Mubdi Ardiansar Arifuddin Kartika, Andy Visi Lantara, A. Millaty Halifah D. Maharani, Ratih Natasha Makmun, Armanto Maulidya, Dhinda Lunizar Muhammad Ilham Nurmadilla, Nesyana Pandu, Edward Purnama, Indah Dian Purnamasari, Reeny Purnamasari, Reniy Puspita, Andi Adelia Rachmat Faisal Syamsu, Rachmat Faisal Rahman, Dewi Rahman, Dinda Briliany Rifai B, Muh. Rivaldy, Naufal Safitri, Asrini Sam, Andi Dhedie Prasatia Sodiqah, Yani Sommeng, Faisal Sri Julyani Sri Vitayani Syamsu Rijal Syarifuddin Wahid Tahir, Sugiarti Usman, Muh. Muflih Wiriansya, Edward Pandu Zulfitriani Murfat