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All Journal Jurnal Biologi Tropis Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Window of Health : Jurnal Kesehatan Jurnal Biomedika dan Kesehatan UMI Medical Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Kesehatan Tambusai INDONESIAN JOURNAL OF HEALTH Jurnal Ilmiah Kesehatan (JIKA) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh International Journal of Health and Pharmaceutical (IJHP) jpki Journal Of Medicine And Health Sciences (Medisci)
Karim, Marzelina
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Total Cholesterol and Triglyceride Levels after Giving Olive Oil and Fig Fruid Extract Against Rattus Novergicus With High-Fat Diet Sulastri, Evi; Syamsu, Rachmat Faisal; Karim, Marzelina; Royani, Ida; Karim, Abdul Mubdi Ardiansar Arifuddin
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6527

Abstract

The reserach entiled “Changes in total cholesterol levels and trigelyceride levels after administration of olive oil and fig leaf extract“ was conducted from July to September 2023. This study aims to determine changes in total cholesterol levels and triglyceride levels when given olive oil and fig friut extract to white mice on a high-fat diet. This research method use an experimental quantitative research type with a pretest-posttest control group research design then analyzed through statistical analysis test using the Microsoft Office Excel 2013 application. Based on the results of study, constant result was obtained for total cholesterol in all treatment groups, namely 86.5 mg/dL and significant results were obtained in reducing triglycerides in the olive oil treatment group and the combination of olive oil and fig fruit extract, namely in the group given olive oil of 170.5 mg. /dL (81.19%), in the group given a combination of fig fruit extract it was 43.75 mg/dL (38.55%), and the increase in the group given fig fruit extract was 38 mg/dL (29.92%). The combination of olive oil and fig fruit extract has a constant effect on total cholesterol levels and reduces triglyceride levels. Fig fruit extract has a constant effect on total cholesterol levels and increases triglyceride levels. Olive oil has a constant effect on total cholesterol levels and more significant results in reducing triglyceride levels in mice with high-fat feed in all treatment groups.
Changes HDL and LDL Levels After Using Olive Oil and Figs Extract on White Rats with A High-Fat Diet Alhumaerah, Musdalifah; Syamsu, Rachmat Faisal; Karim, Marzelina; Nurmadilla, Nesyana; Murfat, Zulfitriani
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6536

Abstract

Hypercholesterolemia often initiates the pathogenesis of atherosclerosis which can occur slowly. As free radicals increase, the need for antioxidants also increases. Reducing LDL and increasing HDL levels is the target of therapy for hyperlipidemia patients with the main goals of lifestyle changes and drug therapy. Olive oil and fig extract have therapeutic benefits as alternative treatments from MUFA content dominated by oleic acid and phenolic compounds. The polyphenol content is known to inhibit the formation of atherosclerosis and inhibit the increase in MCP-1 levels in white mice on a high-fat diet. Therefore, it is hoped that the administration of figs extract and olive oil can overcome dyslipidemia, especially changes in HDL and LDL levels in white mice. To determine changes in HDL and LDL levels. The research conducted was a true experimental research was used with a Pre-Post control group research design and test statistical analysis with Microsoft Office 2013. Showed there was an effect of fig extract (Ficus Carica L) on changes in HDL levels and the effect of olive oil (Olea europea L) on changes in LDL levels in white rats (Rattus novergicus) fed a high-fat diet. The intervention of fig extract and olive oil had a significant effect on the group given the single intervention.
Comparison of The Effectiveness of E-C Positive Pressure Ventilation Technique and Modified Chinlift Positive Pressure Ventilation Technique in Mppd at Ibnu Sina Hospital Maulidya, Dhinda Lunizar; Dwimartyono, Fendy; Maharani, Ratih Natasha; Sommeng, Faisal; Karim, Marzelina
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6634

Abstract

Mask ventilation skills are essential competencies for MPPD to master. According to SKDI, these skills include competency 4A, which is the ability to perform independently by mastering the theory, principles, indications, and steps. To date, there have been few studies evaluating the effectiveness of modified chinlift and E-C techniques regarding the tidal volume delivered (TV). Therefore, the researchers were interested in comparing the effectiveness of the E-C method and modified chinlift positive pressure ventilation technique in mask ventilation (MV) use. This study is a quantitative research with an observational analytical cross-sectional design. Researchers observed the treatments given by MPPD, totaling 22 individuals, to 6 research subjects. Data analysis for this research used Mann-Whitney and chi-square tests as Independence Tests. After applying the E-C technique, 43.8% out of 100% were successful, and 56.3% were not successful. Meanwhile, with the MCL technique, out of 100%, 40.6% were successful, and 59.4% were not successful. The E-C technique showed better results compared to the Modified Chinlift technique in MV, although statistically, the test results for the difference in success scores between the two techniques did not show any significant difference.
The Effect of Olive Oil and Tin Leaf Extract on GDP Levels in White Rats Jannah, Reza Miftahul; Syamsu, Rachmat Faisal; Karim, Marzelina; Julyani, Sry; Kartika, Andy Visi
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7293

Abstract

Diabetes Mellitus is a chronic condition characterized by fasting blood glucose levels of less than 126 mg/dl, which are above the normal range. DM is otherwise called the quiet executioner since it is frequently not understood and when it is found complexities have happened. Monounsaturated fatty acids (MUFA), which have anti-diabetic properties, can be found in olive oil, a functional food. Fig leaves contain flavonoid compounds, β-setosterol, and these polyphenols are accounted for to work as antidiabetics. The point of this study was to decide the impact of directing olive oil and fig leaf separate on fasting blood glucose levels in white rodents. This study employs a Pretest-Posttest Control Group Design and quantitative experimental research methods. The examples utilized were 24 mice. The independent t-test was used to process the results, and One Way Annova was used to carry on. According to the findings of the study, the group that received olive oil had a fasting blood glucose of 41.00 mg/dL (p0.004), the group that received fig leaf extract had a p value of 37.25 mg/dL (p0.005), and the group that received a mixture of olive oil and fig leaf extract had a p value of 39.00 mg/dL (p0.004). Olive oil and fig leaf extract both have an effect on the blood glucose levels of mice induced by Aloxan, but the combination yields more significant results. This is the study's conclusion.
Effectiveness Test of Saliara Leaf Extract (Lantana camara) on Escherichia coli Bacteria Kirby Bauer Disc Method Baba, Firda; Karim, Marzelina; Sam, Andi Dhedie Prasatia; Sodiqah, Yani; Hatta, Dhian Karina
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7294

Abstract

Death due to infection is the most common cause and is a challenge in the health sector. In 2019, 7.7 deaths were due to bacterial infections, 90 to 100 cases were urinary tract infections and Escherichia coli bacteria contributed to 90% of urinary tract infections. This research uses the Kirby Bauer Disc method to determine the effectiveness of Saliara (Lantana camara) leaves against Escherichia coli bacteria. The type of research is a Laboratory experiment using the Kirby Bauer disc method with a post-test-only control group design. Data analysis uses recording of identifying the inhibition zones formed The research showed that a sample's concentration can influence the inhibition zone's resulting diameter. Saliara leaf extract with concentrations of 100%, 150%, and 200% produced an inhibition zone of 8.55 mm; 9.59mm; 12.34 mm in the proliferation of Escherichia coli bacteria. The positive control with the antibiotic ciprofloxacin produced an inhibition zone of 19.56 mm on the growth of Escherichia coli bacteria. Control with negative distilled water does not create an inhibition zone because it does not have antibacterial activity. The conclusion is moderate inhibitory activity in Saliara (Lantana camara L.) leaf extract at concentrations of 100% and 150%. It is strong at a concentration of 200% against the growth of Escherichia coli bacteria.
Isolation and Identification of Bacteria in the Integrated Laboratory of the Faculty of Medicine, Moslem Indonesia of University Karim, Marzelina; Hattah, Dhian Karina Aprilani; Haris, Haslianti H.; Churiani, Churiani
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8219

Abstract

The integrated laboratory is one of the learning facilities at the university, especially to support the implementation of practicum. In laboratories that are full of activities, bacterial contamination often occurs which can interfere with the smooth running of research and practicum. This contamination is often caused by a lack of sterility in the work process and less than optimal indoor air quality. Therefore, it is important to know the type and number of bacteria found in the laboratory to prevent further spread of contamination. This study aims to isolate and identify bacteria in the Integrated Laboratory of the Faculty of Medicine, Universitas Muslim Indonesia. The method used in this study was descriptive research with a laboratory observational design, which was carried out by macroscopic and microscopic means to determine the type of microorganisms and the number of bacterial colonies. The results showed four types of bacteria found, namely Staphylococcus sp., Klebsiella pneumoniae, Staphylococcus epidermidis, and Bacillus sp., which were isolated from air and swab results. Airborne bacteria had the highest number of colonies at 14 CFU, while swab bacteria were found at 200 CFU. Although bacterial colonies were found in the laboratory, this number is still considered safe for the number of bacteria in the laboratory. Based on these findings, it is recommended that laboratory facilities pay more attention to aspects of cleanliness and sanitation as a whole. 
TOKSISITAS SENYAWA DMBA (7,12 DIMETHYLBENZ[A]ANTHRACENE) SEBAGAI LARUTAN KARSINOGENESIS KANKER KOLOREKTAL PADA TIKUS PUTIH (RATTUS NOVERGICUS) Rifai B, Muh.; Syamsu, Rachmat Faisal; Karim, Marzelina; Gani, Azis Beru; Hasbi, Berry Erida
Jurnal Kesehatan Tambusai Vol. 4 No. 4 (2023): DESEMBER 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i4.22209

Abstract

Kanker kolorektal (colorectal cancer/CRC) merupakan masalah kesehatan masyarakat yang ada di Indonesia dan saat ini menempati urutan keempat kanker tertinggi. Kanker merupakan penyakit yang disebabkan akibat proliferasi sel multiseluler sehingga menimbulkan perubahan sifat sel yang tidak terkendali. Kadar Malondialdehyde (MDA) merupakan salah satu marker biokimia yang digunakan untuk penelitian profil kanker. Senyawa DMBA (7,12-Dimethylbenz[a]anthracene) adalah salah satu agen Polycyclic Aromatic Hydrocarbon (PAH) yang banyak digunakan untuk mempelajari karsinogenesis. Reagen DMBA dilarutkan dengan minyak jagung dan diinduksikan 1 kali dalam seminggu secara subkutan pada tikus. Tujuan dari penelitian ini adalah untuk mengetahui toksisitas senyawa DMBA (7,12-dimethylbenz[a]anthracene) sebagai larutan karsinogenesis kanker kolorektal pada tikus putih (rattus novergicus). Penelitian yang dilakukan adalah penelitian true experimental dengan menggunakan rancangan pre dan post-test control group design untuk melihat perbedaan pada sampel sebelum dan setelah pemberian perlakuan. Hasil dari penelitian ini menunjukkan senyawa DMBA dengan dosis 20 mg/kgBB memiliki dosis letal karena pada minggu ke-3 terjadi mortalitas yang paling tinggi dari minggu sebelumnya, yaitu pada minggu ke-1 angka kematian tikus putih mencapai 4 ekor, minggu ke-2 terdapat 9 ekor tikus putih yang mati, minggu ke-3 terdapat 10 tikus ekor yang mati dan minggu ke-4 terdapat 5 ekor tikus yang mati. Selain itu senyawa DMBA juga dapat menurunkan berat badan secara signifikan, dimana hasil uji Analisa one way Anova didapatkan nilai P-value 0,000. Senyawa DMBA juga dapat meningkatkan kadar MDA darah pada tikus putih, dari hasil uji Analisa Mann whitney U test didapatkan nilai p-value 0,001. Senyawa DMBA (7,12-dimethylbenz[a]anthracene) sebagai larutan karsinogenesis kanker kolorektal memiliki efek toksisitas pada tikus putih (rattus novergicus).
Obstructive Sleep Apnea Risk, Body Fat, and BMI in Pulmonary Tuberculosis Patients Jumaide, Nurul Isnaeni; Wiriansya, Edward Pandu; Karim, Marzelina; Safitri, Asrini; Pratama, Ahmad Ardhani
Jurnal Medisci Vol 3 No 4 (2026): Vol 3 No 4 February 2026
Publisher : Ann Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62885/medisci.v3i4.1070

Abstract

Background: Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder significantly associated with body composition abnormalities. Pulmonary tuberculosis (TB) causes structural lung damage that may predispose patients to sleep disturbances, yet the relationship between OSA and body composition in TB populations remains inadequately explored. Aim: This study aimed to investigate the association between OSA severity and body composition measures including total body fat, visceral fat, subcutaneous fat, and body mass index (BMI) among pulmonary TB patients. Methods: A cross-sectional analytical observational study was conducted at RS Ibnu Sina YW-UMI Makassar from August to November 2025. Eighty-five pulmonary TB patients were selected through purposive sampling. OSA risk was assessed using the STOP-BANG questionnaire, while body composition was measured using bioelectrical impedance analysis. Chi-square tests were performed to examine associations between variables with significance set at p<0.05. Results: Significant associations were found between OSA severity and all body composition parameters: total body fat (p=0.004), visceral fat (p=0.000), subcutaneous fat (p=0.005), and BMI (p=0.000). Severe OSA showed highest prevalence of very high total body fat (46.4%), elevated visceral fat (60.7%), high subcutaneous fat (57.1%), and obesity grade 1 (35.7%). Moderate OSA occurred predominantly in underweight patients (50.0%), revealing a U-shaped BMI-OSA relationship. Conclusions: Visceral fat demonstrated the strongest association with OSA severity in pulmonary TB patients. Comprehensive body composition assessment provides superior clinical utility compared to BMI alone for OSA risk stratification. Implementation. These findings support integrating body composition monitoring into TB management protocols and provide foundation for personalized interventions addressing both infectious disease treatment and metabolic health optimization
Analisis Hubungan Faktor-Faktor Kepuasan Pasien terhadap Bed Occupancy Rate (BOR) pada Instalasi Bedah RSP Ibnu Sina Puspita, Andi Adelia; Jaya, Muhammad Alim; Karim, Marzelina; Harahap, Wirawan; Hasbi, Berry Erida
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 5 No. 1 (2026): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Februari 2
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini bertujuan untuk menganalisis hubungan antara tingkat kepuasan pasien dan Bed Occupancy Rate (BOR) pada pelayanan rawat inap Instalasi Bedah RS Ibnu Sina YW–UMI Makassar. Penelitian ini merupakan studi epidemiologi analitik korelasional dengan pendekatan potong lintang (cross-sectional) yang menggunakan data primer dan sekunder. Data primer diperoleh melalui kuesioner kepuasan pasien berbasis SERVQUAL yang mencakup lima dimensi, yaitu tangible, empathy, reliability, responsiveness, dan assurance, sedangkan datasekunder berupa laporan BOR rumah sakit Triwulan I Tahun 2025. Sampel penelitian berjumlah 89 responden yang dipilih menggunakan teknikpurposive sampling. Analisis data dilakukan secara univariat dan bivariat menggunakan uji Korelasi Spearman. Hasil penelitian menunjukkan bahwa nilai BOR Instalasi Bedah sebesar 70,85%, yang berada dalam kategori ideal sesuai standar Kementerian Kesehatan Republik Indonesia. Sebagian besar pasien menyatakan puas terhadap pelayanan yang diberikan, dengan tingkat kepuasan tertinggi pada dimensi reliability dan terendah pada dimensi responsiveness. Namun, hasil analisis bivariat menunjukkan bahwa tidak terdapat hubungan yang signifikan antara seluruh dimensi kepuasan pasien dan BOR (p > 0,05) dengan kekuatan hubungan yang sangat lemah. Penelitian ini menyimpulkan bahwa pencapaian BOR lebih dipengaruhi oleh faktor manajerial dan operasional rumah sakit dibandingkan persepsi kepuasan pasien, sehingga peningkatan mutu pelayanan dan pengelolaan BOR perlu dilakukan melalui pendekatan yang terintegrasi.
Antibacterial Extract of Red Dragon Fruit (Hylocereus polyrhizus) Peel Extract against ESBL-Producing Klebsiella pneumoniae Rivaldy, Naufal; Kartika, Andy Visi; Karim, Marzelina; Sodiqah, Yani; Anggita, Dwi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1560

Abstract

The rising prevalence of infections caused by Extended-Spectrum Beta-Lactamase (ESBL)-producing Klebsiella pneumoniae necessitates the search for alternative antibacterial agents. Red dragon fruit (Hylocereus polyrhizus) peel is a potential source of bioactive compounds. This study aimed to evaluate the in vitro antibacterial activity of red dragon fruit peel extract against ESBL-producing K. pneumoniae. The bacteria were isolated and identified via culture on MacConkey agar, Gram staining, and biochemical tests. The peel was extracted using 96% ethanol via maceration. Antibacterial activity was assessed using the disk diffusion method on Mueller-Hinton agar with extract concentrations of 20%, 40%, 60%, 80%, and 100% (v/v), with three replicates per concentration. Meropenem (10 µg) and DMSO served as positive and negative controls. The extract exhibited concentration-dependent antibacterial activity, with mean inhibition zone diameters increasing from 5,6 ± 0,3 mm at 20% to 6,1 ± 0,2 mm at 100%. The positive control produced a 30,2 ± 0,5 mm zone, while the negative control showed no inhibition. One-way ANOVA confirmed significant differences between groups (p-value < 0,05). Red dragon fruit peel extract demonstrated promising in vitro antibacterial activity against ESBL-producing K. pneumoniae, although its potency was considerably lower than meropenem.
Co-Authors Adrian Adrian Ahmad Ardhani Pratama Ahmad, Izhar Fitrah Alamanda Irwan, Andi Alhumaerah, Musdalifah Amrizal Muchtar Anggita, Dwi Anshary, Suci Noviyanah Arfah, Arni Isnaini Arifuddin Karim, Abdul Mubdi Ardiansar Baba, Firda Bamahry, Aryanti Basri, Sri Wahyuni gayatri Briliany Rahman, Dinda Churiani, Churiani Daeng Kanang, Indah Lestari Darma, Sidrah Domu, Anugrah Julistiar Aksan Evi Sulastri Faisal Syamsu, Rachmat Faisal, M. Fathir Fauziyah, Nailatul Fazdlurrahman, Fazdlurrahman Fendy Dwimartyono Gani, Azis Beru Gufron, Muh. Hadi, Santriani Harahap, Wirawan Haris, Haslianti H. Hasbi, Berry Erida Hatta, Dhian Karina Hattah, Dhian Karina Aprilani Hirda, Tiara Aviva Ida Royani Ikram, Dzul Imran Syafei Muhammad Nur Indarwati Abdullah, Rezky Putri Iskandar, Gina Isni D. Isnaini, Arni Jafar, Alfian Jannah, Reza Miftahul Jaya, Muhammad Alim Julyani, Sry Jumaide, Nurul Isnaeni Juwita Purnamasari, Juwita Karim, Abdul Mubdi Ardiansar Arifuddin Kartika, Andy Visi Lantara, A. Millaty Halifah D. Maharani, Ratih Natasha Makmun, Armanto Maulidya, Dhinda Lunizar Muhammad Ilham Nurmadilla, Nesyana Pandu, Edward Purnama, Indah Dian Purnamasari, Reeny Purnamasari, Reniy Puspita, Andi Adelia R. Bamahry, Aryanti Rachmat Faisal Syamsu, Rachmat Faisal Rahman, Dewi Rahman, Dinda Briliany Rifai B, Muh. Rivaldy, Naufal Safitri, Asrini Sam, Andi Dhedie Prasatia Sitti Fahirah Arsal, Andi Sodiqah, Yani Sommeng, Faisal Sri Julyani Sri Vitayani Syamsu Rijal Syarifuddin Wahid Tahir, Sugiarti Usman, Muh. Muflih Wahyuni Gayatri B, Sri Wiriansya, Edward Pandu Zulfitriani Murfat