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Development of Pocketbooks as an Education and Compliance Module for Diabetes Mellitus Patients at the Kaliwungu Health Center, Kudus, Indonesia Fitriani, Eka; Rina Herowati; Lucia Vita Inandha Dewi
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 4 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i4.351

Abstract

Diabetes mellitus (DM) is a chronic disease that requires long-term treatment. Management of DM patients is one of them by providing education. This study aimed to determine the product trial of developing a pocketbook as an educational module using the assessment parameters of experts and DM patients who meet the eligibility criteria at Kaliwungu Health Center, Kudus. This study used qualitative and quantitative analysis. Qualitative analysis in the form of suggestions and input from experts, and quantitative analysis in the form of assessment scores. The method used in this research is research and development. Product development with Borg and Gall procedures. Product trials of pocket book development as a DM patient education module at Kaliwungu Health Center, Kudus, using expert parameters including media experts at 100%, material expert I with a value of 84%, material expert II with a value of 92.3%, material expert III with a value of 100%, expert practitioners with a value of 100% and DM patients with an average value of 80.5% in the category worth using with revision.
Network Pharmacology Approach to Acalypha indica L. and Plumbago zeylanica L. As Anti-Rheumatoid Arthritis Candidates Dini Afriliza; Rina Herowati; Ana Indrayati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.204-218

Abstract

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that can reduce quality of life. Currently, the goal of therapy is to achieve remission and prevent joint damage and disability. Acalypha indica L. and Plumbago zeylanica L. are known to be involved in rheumatoid pathogenesis. Objective: This study aimed to determine the compounds in Acalypha indica L. and Plumbago zeylanica L. that correlate with target proteins and anti-rheumatoid arthritis mechanisms. Methods: Plant compound data were collected from the KNApSAcK and IMPPAT databases, target protein data were collected using the KEGG pathway, validated using UniProt, and protein-protein interactions were analyzed using STRING. Target protein prediction using SwissTarget Prediction and SEA. Visualization of network pharmacology profiles using Cytoscape software based on the correlation between plant compounds and target proteins. Results: Acalypha indica L., which correlates with target proteins, contained quinine, gallotannin, 1,4 benzoquinone, chrysin, and kaempferol. For Plumbago zeylanica L., the compounds were vanillic acid, cinnamic acid, plumbagin, isoaffinetin, isoorientin, isovitexin, methylnaphthazarin, l-tryptophan, beta-sitosterol, stigmasterol, ficusin, suberosin, and quercetin 3-ol-rhamnoside. Conclusion: Network pharmacology visualization results showed that both Acalypha indica L. and Plumbago zeylanica L. correlated with disease target proteins in their respective rheumatoid arthritis signaling pathways.