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All Journal Biotika: Jurnal Ilmiah Biologi Bionatura Farmaka Indonesian Journal of Applied Sciences Jurnal Ilmu Dasar Jurnal Natur Indonesia Jurnal Radioisotop dan Radiofarmaka Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Global Medical and Health Communication Indonesian Journal of Science and Technology MPI (Media Pharmaceutica Indonesiana) INDONESIAN JOURNAL OF PHARMACY Pharmascience IDJP (Indonesian Journal of Pharmaceutics) Indonesian Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Majalah Farmasetika Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Praeparandi : Jurnal Farmasi dan Sains Jurnal Sains dan Kesehatan
Anas Subarnas
Departemen Farmakologi Dan Farmasi Klinik, Fakultas Farmasi, Universitas Padjadjaran, Sumedang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health

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Aktivitas Antitukak Lambung Ekstrak Etanol Akar Pakis Tangkur (Polypodium feei., METT) pada Tikus Jantan Galur Wistar yang Diinduksi dengan Asetosal: Antiulcer Activity of Extract of Ethanol of Polypodium feei Roots in Male Rats Induced with Acetosal Suwandi, Deden Winda; Utami, Putri Antiyani; Subarnas, Anas
Jurnal Sains dan Kesehatan Vol. 7 No. 3 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i3.2434

Abstract

A health problem with a fairly high prevalence in humans is stomach ulcer. This disease is characterized by damage to the mucosal layer by an imbalance of proactive and aggressive factors. This study aims to determine the effect of Pakis tangkur roots as an anti-gastric ulcer. This test was carried out in vivo on male white Wistar mice. The research began by making Pakis tangkur root extract by maceration using 96% ethanol. The extract doses were 100, 200 and 400 mg/kg body weight and Sucralfate 90 mg/kg body weight was used as a positive control. Acetosal 1000 mg/kg bw is used as an ulcer inducer. The parameters observed were the number of ulcers and the severity of the ulcers. The results showed that the ethanol extract of Pakis tangkur roots at 200 mg/kg body weight and a dose of 400 mg/kg body weight had anti-gastric ulcer activity that was significantly different from the control (p<0.05). The effective dose of ethanol extract of Pakis tangkur roots is 200 mg/kg bw. Keywords:          Pakis Tangkur, Aspirin, Stomach Ulcer   Abstrak Salah satu masalah kesehatan pada manusia dengan prevalensi cukup tinggi adalah tukak lambung. Penyakit ini ditandai dengan rusaknya lapisan mukosa dinding lambung karena adanya ketidakseimbangan faktor proaktif dan agresif pada dinding lambung. Penelitian ini bertujuan untuk mengetahui efek akar pakis tangkur sebagai antitukak lambung. Pengujian ini dilakukan secara in vivo terhadap tikus putih jantan galur wistar. Pengujian diawali dengan membuat ekstrak akar pakis tangkur dengan cara maserasi menggunakan etanol 96%. Ekstrak yang digunakan adalah 100, 200 dan 400 mg/kg bb dan Sukralfat 90 mg/kg bb digunakan sebagai kontrol positif. Asetosal 1000 mg/kg bb digunakan sebagai Penginduksi tukak yang diberikan selama 7 hari. Parameter yang diamati adalah jumlah tukak dan keparahan tukak. Hasil penelitian menunjukkan bahwa ekstrak etanol akar pakis tangkur dosis 200 dan 400 mg/kg bb menunjukkan aktivitas antitukak lambung yang berbeda bermakna terhadap kontrol (p<0,05). Dosis efektif ekstrak etanol akar pakis tangkur adalah 200 mg/kg bb. Kata Kunci:         Akar Pakis Tangkur, Aspirin, Tukak Lambung  
Analgesic and anti-inflammatory activities of the extract of Polypodium feei mett roots Suwandi, Deden Winda; Renggana, Hesti; Subarnas, Anas; Rostinawati, Tina; Muchtaridi, Muchtaridi; Sadino, Asman
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.25133

Abstract

The limited scientific evidence on the analgesic and anti-inflammatory effects of Polypodium feei roots, despite their traditional use in rheumatism treatment, highlights the need for pharmacological validation. The study investigates the analgesic and anti-inflammatory properties of Polypodium feei roots, a traditional medicine used to treat rheumatism, in mice and rats with carrageenan-induced paw edema, using acetylsalicylic acid and tramadol as analgesics and diclofenac sodium as an anti-inflammatory. The writhing test results demonstrate that the extract of P. feei roots (EPFR) at dosages of 50 and 100 mg/kgBW lowered the writhing responses of rat significantly (p <0.01). The dose of 100 mg/kgBW provided more protection than acetylsalicylic acid at a level of 65 mg/kgBW. In the hot plate method, the extract increased the latency period significantly (p <0.05) as compared with the control. In the anti-inflammatory examination, the EPFR decreased edema of rat paws induced by carrageenan. The significant effect of the EPFR was shown by the dose of 100 mg/kgBW (p <0.05), but its inhibition was lower than that of a standard agent, diclofenac sodium. This study concluded that the EPFR may have peripherally and centrally analgesic activity and anti-inflammatory activity. This evidence supports the folklore claim of the efficacy of EPFR as traditional medicine for rheumatism.
Co-Authors Abdul Mutalib Abdul Mutalib Adang Hardi Gunawan Adryan Fristiohady Afiat Berbudi Agung W.M. Yodha Aji Najihudin ALIF VIRISY BERLIAN AMELIA SUCI PRAFITRI YANI Ami Tjitraresmi Andini Sundowo Ani Haerani ANI HAERANI Anis Chaerunisaa Anis Yohana Chaerunisa ANIS YOHANA CHAERUNISA Anis Yohana Chaerunisaa Anis Yohana Chaerunisaa Anton Apriyantono ASENG RAMLAN Asep Nurrahman Yulianto ASMAN SADINO, ASMAN Aulia Annisa Putri Heri Belinda, Rahma BRIGITTA TIARA PUTRI PRIYANTONO California, Salma H. Chaerunisaa, Anis Cucu Hadiansyah Dana Nasrullah Dani Sujana Dea A. A. Kurniasih DIAH SITI FATIMAH DIANTINI, AJENG - Dicky Santosa Dida Akhmad Gurnida Dika Destiani Dingse Pandiangan - ELI HALIMAH Eli Halimah, Eli Ellin Febrina Elvan Kamal Endang Sutedja Eri Amalia Euis Julaeha Fauzia Azzahra Fazrina Pratiwi Fransiska Silalahi Henni Djuhaeni Henni Djuhaeni Herri S. Sastramihardja Hesti Renggana Hideo Hayashi Hideo Hayashi Hideo Hayashi Hideo Hayashi HIRALIUS BIMA ARDIKA PUTRA I. Sahidin IIN SUPARTINAH NOER Indradi, Raden Bayu Irma Erika Herawati Iyan Sopyan Joharudin, Ade Juliani Ronike Turang Jutti Levita Karyono - Keri Lestari Khoirunnisa, Afina Khoziah Ahmad, Khoziah Kunkun J. Gurmaya Kurniasih, Dea A. A. Lika Ginanti Febriana Lutfi Sulaiman M. S. Soedjanaatmadja Magdarita Riwu Mardhiani, Yanni Dhiani Marline Abdassah Bratadiredja Martalena Ramli Maulana Yusuf Alkandahri Mega Juliana Moelyono Moektiwardoyo, Moelyono Mohammad Ghozali Muchtaridi Muchtaridi Mutiara, Intan Najihudin, Aji Nasrudin Nasrudin Nela - Simanjuntak NONI CAHYANA Noor Rain Abdullah Noor Rain Abdullah Nor Latifah Norisca Aliza Putriana NUR ALFI KUSUMAH DEWI PARAS WATI Pramesti, Ardhia Kirana Prayudi Ahmad Puja Yanti Raden Maya Febrianti Rano K. Sinuraya Ratu Ralna Ismuha Renggana, Hesti Resmi Mustarichie Riezki Amalia Risrina Nur Ekawati Rizkita Rahmi Esyanti - Ronny Lesmana Salma H. California Shinta Marpaung Sinuraya, Rano K. Siti Saidah Muthmainah Slamet Budijanto Sofa Fajriah Sri Adi Sumiwi Sri Hartini Sriwidodo Sriwidodo Supriyatna ., Supriyatna Supriyatna Supriyatna Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Supriyatna Sutardjo Surachman, Emma Suseno Amien Suwandi, Deden Winda Syafrudin Purnama Sidiq, Syafrudin Purnama Taofik Rusdiana Tati Herlina Tati Herlina Tati Herlina Tati Herlina Tina Rostinawati Triyono Triyono Triyono Triyono Unang Supratman Utami, Putri Antiyani W. Wahyuni Wenny Tilaar - Yohana Chaerunisaa, Anis Yoppi Iskandar Yulianto, Asep Nurrahman Yuni Elsa Hadisaputri