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All Journal Jurnal Pengolahan Hasil Perikanan Indonesia Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Marinade Creative Research Journal JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Jamu Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research SANITAS: Jurnal Teknologi dan Seni Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Jurnal Kefarmasian Indonesia Journal of Natural Product for Degenerative Diseases Indonesian Journal of Jamu
Effionora Anwar
Universitas Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Other

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Preparasi dan Karakterisasi Sediaan Solid Lipid Nanoparticle (SLN) Gliklazid ANISA AMALIA; MAHDI JUFRI; EFFIONORA ANWAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Solid lipid nanoparticle (SLN) has been proposed as colloidal carriers using solid lipid as matrix material. In this study, gliclazide-loaded solid lipid nanoparticle has been prepared with high shear homogenization and freeze drying method using stearic acid as lipid material, Tween 80 and PEG 400 as surfactant, ethanol as`co-solvent and lactose as cryoprotectant. Characterization was performed on SLN dosage from before and after freeze drying, which includes the analysis of particle size, zeta potential value, morphology analysis and entrapment efficiency of gliclazide. Results indicated gliclazidecan be formulated in SLN dosage form using high shear homogenization and freeze drying method. The morphology study revealed that the prepared SLN were irregular in shape with mean particle size of 878.0 ± 246.3 nm and 745.8 ± 204.0 nm. Zeta potensial values of gliclazide-loaded SLN were found –
Uji Penetrasi In-Vitro Sediaan Gel yang Mengandung Transfersom “Rutin” Serta Uji Aktivitas Anti Artritis Reumatoid DEVI RATNASARI; EFFIONORA ANWAR; FADLINA CHANY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstrak: Rutin merupakan senyawa flavonoid yang banyak terdapat pada buah semangka dan kulit dari tanaman jenis jeruk. Rutin memiliki beberapa aktivitas farmakologi, salah satunya sebagai anti artritis reumatoid. Rutin menunjukan absorbsi yang rendah bila diberikan secara peroral karena permeasi yang rendah serta dapat mengalami degradasi di dalam saluran cerna sehingga sebagai alternatif rutin diberikan dalam bentuk transdermal. Transdermal merupakan rute pemberian obat yang mendukung transport obat dari permukaan kulit sampai ke sirkulasi sitemik. Rute pemberian ini dapat mencegah degradasi rutin dalam saluran cerna.Transfersom merupakan salah satu sistem pembawa untuk transdermal yang mampu meningkatkan efektivitas penghantaran obat. Penelitian ini bertujuan untuk melakukan uji penetrasi in-vitro dan aktivitas anti artritis reumatoid dari gel yang mengandung transfersom rutin dan gel rutin non transfersom. Uji penetrasi in-vitro menujukan penetrasi rutin dari sediaan gel transfersom sebesar 14,33% sedangkan untuk gel non transfersom sebesar 9,51%. Aktivitas anti atritis reumatoid diamati selama 28 hari dengan menghitung persen penghambatan udem pada kaki tikus. Hasil menunjukan bahwa persen penghambatan volume udem dari gel transfersom sebesar 57,82% sedangkan gel non transfersom sebesar 45,63%.
Formulasi Serum sebagai Penyembuh Luka Bakar Berbahan Baku Utama Serbuk Konsentrat Ikan Gabus (Channa striatus) SITI MARDIYANTI; EFFIONORA ANWAR; FADLINA CHANY SAPUTRI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 2 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Ikan gabus (Channa striatus) diketahui dapat menyembuhkan luka karena mengandung kadar tinggi protein, asam amino esensial dan asam lemak yang berperan dalam proses penyembuhan luka. Tujuan dari penelitian ini adalah membuat serum sebagai penyembuh luka bakar yang mengandung serbuk konsentrat ikan gabus (Channa striatus) yang telah dibuat gelasi ionik dengan kitosan dan natrium tripolifosfat sebagai zat aktif. Serbuk konsentrat ikan gabus dengan kosentrasi 7,5% (formula 1), 10% (formula 2) dan 12,5% (formula 3). Selanjutnya dibuat menjadi serum dengan menggunakan kolagen dan gelatin sebagai bahan pengental. Sediaan serum yang dihasilkan dikarakterisasi in vitro dan dievaluasi secara in vivo penyembuhan luka bakar derajat dua (deep partial thickness) pada kelinci. Suspensi dan serum yang dihasilkan dikarakterisasi secara fisik maupun kimia. Hasil pengukuran suspensi formula 1, 2 dan 3 adalah sebagai berikut: ukuran partikel berturut–turut 42,67-204,23 nm, 70,81-257,11 nm, 128,86-323,68 nm; nilai potensial zeta (+)16,9 mV, (+)18,3 mV, (+)8,4 mV; ketiga formula memiliki partikel berbentuk sferis. Dari hasil uji in vivo dan analisa histologi sediaan serum serbuk konsentrat ikan gabus-kitosan tripolifosfat dapat digunakan sebagai penyembuh luka bakar derajat dua dalam.
Formulation, Characterization and In Vitro Penetration Study of Resveratrol Solid Lipid Nanoparticles in Topical Cream FAUZIAH MAPPAMASING; EFFIONORA ANWAR; ABDUL MUN’IM
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 2 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Pada lapisan kulit terdapat komponen yang merupakan target pengrusakan akibat stres oksidatif, yaitu lemak, DNA dan protein. Stres oksidatif pada kulit ini dapat dicegah dengan penggunaan antioksidan secara topikal. Resveratrol merupakan antioksidan polifenol yang utamanya berasal dari minyak biji anggur, memiliki aktivitas antioksidan yang dapat digunakan untuk mencegah terjadinya stres oksidatif pada kulit. Tujuan penelitian ini adalah untuk memformulasi solid lipid nanoparticle (SLN) resveratrol dan mengevaluasi kemampuan SLN resveratrol sebagai nanovesikel untuk berpenetrasi melalui kulit. Pada penelitian ini, SLN dibuat dengan metode emulsifikasi pelarut. Selanjutnya dilakukan karakterisasi SLN, mencakup ukuran partikel, zeta potensial, indeks polidispersitas, efisiensi penjerapan resveratrol, morfologi SLN dan uji difusi. SLN Resveratrol dengan gliseril monostearat 0,5% menunjukkan morfologi sferis dengan rata-rata ukuran partikel 334,4±8,95 nm, rata-rata indeks polidispersitas 0,289±0,062, rata-rata efisiensi penjerapan 48,706±1,319%, dan rata-rata zeta potential –27,53±0,802 mV. Studi penetrasi in vitro pada krim SLN resveratrol 10% menghasilkan fluks 6,64± 0,19 μg/cm2/jam sementara fluks krim resveratrol 6,09±0,84 μg/cm2/jam.
Perbandingan Ekstrak Jahe Merah (Zingiber Officinale Roscoe. Var. Rubrum), Gingerol dan Shogaol sebagai Anti-Toksoplasma terhadap Parasit Toxoplasma Gondii Secara In-Vitro Siti Sa’diah; Effionora Anwar; Mahdi Jufri; Umi Cahyaningsih
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1473.786 KB) | DOI: 10.29244/jji.v4i3.160

Abstract

Metode ekstraksi dan jenis pelarut yang digunakan akan berdampak pada proses penarikan komponen aktif sehingga akan berpengaruh juga pada aktivitasnya. Jahe merah (Zingiber officinale var. Rubrum) merupakan salah satu bahan rempah yang juga berpotensi sebagai tanaman obat. Salah satu khasiat ekstrak jahe merah adalah sebagai anti toksoplasma. Pada penelitian ini telah dilakukan pembuatan ekstrak jahe merah dengan dua jenis metode yaitu maserasi dan sokhletasi masing-masing menggunakan tiga jenis pelarut (etanol 30%, etanol 70% dan etanol 96%) sehingga diperoleh enam jenis ekstrak. Kemudian masing-masing ekstrak ditentukan kadar senyawa pencirinya meliputi 6-gingerol, 8-gingerol, 10-gingerol dan 6-shogaol dengan Kromatografi Cair Kinerja Tinggi (KCKT). Selanjutnya ekstrak diuji aktivitas antitoksoplasma secara in vitro terhadap parasit Toksoplasma gondii pada fase takhizoit yang ditumbuhkan pada sel vero. Penentuan aktivitas antitoksoplasma juga dilakukan pada senyawa murni 6, 8, 10-gingerol dan 6-shogaol serta kontrol positif antibiotik spiramisin. Hasilnya menunjukkan bahwa ekstrak etanol 96% dengan metode maserasi adalah yang paling baik aktivitasnya dan 6-gingerol adalah senyawa penciri yang paling berperan sebagai anti-toksoplasma.
Uji Stabilitas Sediaan Mikroemulsi Menggunakan Hidrolisat Pati (DE 35–40) Sebagai Stabilizer Jufri, Mahdi; Anwar, Effionora; Utami, Putri Margaining
Majalah Ilmu Kefarmasian Vol. 3, No. 1
Publisher : UI Scholars Hub

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Various solubilization techniques have been developed to enhance the bioavailability of hydrophobic drugs. One of the solubilization techniques is preparation of microemulsion. Microemulsion is a potential carrier in drug delivery system because it has many advantageous characteristics. In this research, hydrophobic drug was made in a dosage form of oil in water (O/W) microemulsion using ketoprofen as a model and investigated the influence of adding starch hydrolisates with dextrose equivalent (DE) 35-40 in variety concentrations (0,0%; 1,5%; 2,0%; 2,5%) to the stability of this microemulsion system. This microemulsion consisted of isopropyl miritate as oil phase, tween 80 and lechitin as surfactants, ethanol as cosurfactant, propylene glycol as cosolvent, starch hydrolisates DE 35–40 as stabilizer, and water as external phase. The evaluation was stability test both phisically and chemically. The result showed that the stability of microemulsion system increased significantly by adding starch hydrolisates DE 35-40 at 2,5%.
Pati Pregel Pati Singkong Fosfat Sebagai Bahan Pensuspensi Sirup Kering Ampisilin Anwar, Effionora; SV, Antokalina; Harianto, Harianto
Majalah Ilmu Kefarmasian Vol. 3, No. 3
Publisher : UI Scholars Hub

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For most reason for dry suspension is the drug changes from chemical degradation or hydrolysis like ampicillin. The dry syrups that require mixing prior to administration is solving the problem. These suspension are commersial, dry mixtures that require the addition of water at the time of dispensing. Many antibiotics are formulated as dry syrups and are intented for a pediatric patient population. There are usually fewer suspending material in suspension dry syrup than in convensional suspensions. The criteria for selecting inggredients are based both on suitable reconstitution and on physical tipe of powder mixture desired. This research was carried out the possibility of using phycical and chemical modification of cassava starch as suspending material. First, pregelatinized cassava starch was made by heated the cassava starch with added amount water. Secondly, phosphorylated by adding phosphorous oxychloride for making cross-linked reaction and adding sodium monohydrogen phosphate (Na2HPO4) for making substituted reaction respectively. Both of the cassava starch phosphate derived was used in tree formulas dry syrup, as comparative suspending material was Na Alginate. Then dry syrup was evaluated accordance to Indonesian Farmacopea ed IV included sedimentation volume, redispersion, viscosity, flowing properties, pH, and ampicillin content after seven days. The result of evaluation were particle size 355-500 µm, flow rate 2,7-4,6 g/ det. Sedimention volume at temperature 27ºC during seven days for all formulas were 0,8-1,0, and redispertion 3-5 times. The viskosity of the suspensions were 58,6-357,1 cps .Flowing properties of the liquids were plastis -plastis tixotropic, pH 4,97-5,21, and ampicillin content between 93,12-99,00%.
Formulasi Tablet salut Teofilin Menggunakan Eksipien Koproses Pregelatinisasi pati Singkong- Metilselulosa sebagai bahan Penyalut Pradana, Rangga; Chaidir, Chaidir; Anwar, Effionora
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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Pregelatinized cassava star ch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient were characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis. Theophylline tablet that coated by PCS, MC, and co-processed PCSMC ratio (4:1) characterized and in vitro drug release were made in chloride medium of pH 1,2 and phosphate medium of pH 7,2. The characterization result of co-processed PCS-MC showed the improvement of functionality from PCS and synergism PCS with MC. Meanwhile, the result of in vitro drug release showed theophylline tablet that coated by MC 1%, co-processed PCS-MC (4:1) 4% and 2% could retard the drug release in both medium.
Eksplorasi dan Karakterisasi berbagai Kristal Ibuprofen Yanuar, Arry; Nursanti, Nursanti; Anwar, Effionora
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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Ibuprofen is an analgesic anti-inflammatory nonsteroidal (AINS). Generally, ibuprofen have a bad flowability because a high cohesivity. Another problem in manufacturing is the high tendency for sticking to the punches. Besides these disadvantageous properties, ibuprofen indicates bad dissolution behavior because of its hydrophobic structure. To improve the properties of ibuprofen can be used crystallization method with using variation of solvents. In this experiment observed crystallization method by cooling, evaporation, and water presence, which used methanol, ethanol, and acetone solvents. Of all the crystallization results are produced white prism-shaped crystalline. The selected method is cooling method, which is characterized using Scanning Electron Microscopy (SEM), powder X-ray diffraction, and Differential Scanning Calorimetry (DSC). These three characterizations indicate transformation of crystal form which compared with ibuprofen’s standard. The selected method also produces non cohesive powder which have the size particle is 710-1180µm, compressibility index: IBMD 14.2%, IBED 16.6%, IBAD 17.1%; angles of repose: IBMD 28.1º, IBED 29.7º, IBAD 30.1º, and have higher solubility than the common crystal’s solubility. The result indicates that crystallization method is able to improve flowrate, compressibility index, and dissolution rate properties of ibuprofen’s standard.
Eksipien Koproses Pregelatinisasi Pati Singkong Metilselulosa sebagai Bahan Penyalut Tablet Pradana, Rangga; Anwar, Effionora; Chaidir, Chaidir
Majalah Ilmu Kefarmasian Vol. 7, No. 3
Publisher : UI Scholars Hub

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Coating is one of the effective methods used in controlled release dosage form. Lots of variety in the form of a hydrophilic polymer excipient that is used to control the drug release many polymers that can be used for coating purposes, but only a few have been known to serve as a polymeric coating which functions to control the rate of drug release Pregelatinized cassava starch (PCS) is a physically modified starch. The purposes of the study were to improve functionality of PCS with making coprocess composed of PCS and methylcellulose (MC) by proportionally variation, which are 2:1, 3:1, and 4:1, as well as to applied co-processed excipient that could retard the drug release as coating material of theophylline tablet. Coprocessed excipient characterized in terms of morphology, particle size distribution, compressibility index, flow rate and angle of repose, thermal analysis, hygroscopicity, gel strength, swelling test, and moiety analysis.
Co-Authors . Chaidir . Harianto . Iskandarsyah Abdul Munim ABDUL MUN’IM Animar J Aswin Anisa Amalia Antokalina SV Antokalina SV, Antokalina Anton Bahtiar ANTON BAHTIAR Anton Bahtiar Arry Yanuar Ayun Erwina Arifianti Berna Elya Chaidir Chaidir Chaidir Chaidir DEVI RATNASARI Dian Ratih Laksmitawati DINA RAHMAWANTY Dina Rahmawanty Engkom Komariah Erny Sagita Erny Sagita Erny Sagita, Erny Esti Mumpuni, Esti FADLINA CHANY Fadlina Chany Saputri Fajar, In Rahmi Fatria FAUZIAH MAPPAMASING Firda Wery Ginanjar Pratama Harianto Harianto Hendig Winarno Henry . Henry, Henry Joshita D Joshita Djajadisastra Joshita Djajadisastra Joshita Djajadisastra, Joshita Junaedi Junaedi Junaedi Junaedi Junaedi, . Junaedi, . Komariah, Engkom KS, Yunita kurnia agustini Kurniasari, Aprilia L B S.Kardono Liza Ariantina Mahdi Jufri Mala Nurilmala Mardiyanti, Siti N. Nurjanah Nuraini Nuraini Nurjanah Nursanti Nursanti Nursanti Nursanti Putri Margaining Utami Putri Margaining Utami, Putri Margaining Raditya Iswandana RAHMAT, DENI Rahmawanty, Dina Rahmawati, Siti Irma Rangga Pradana Rangga Pradana Rangga Pradana, Rangga Rizky Clarinta Putri Rosmala Dewi Rosmala Dewi Sabrina Dahlizar Salsabiela Haz Ekaputri Silvia Surini Silvia Surini Silvia Surini Siti Mardiyanti SITI MARDIYANTI Siti Sadiah Siti Sadiah Siti Sa’diah Taufik Hidayat Umi Cahyaningsih Wanda Nisrina Aqilah Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yani, Tri Nofi Yanuarti, Rini Yesi Desmiaty, Yesi Yoga Yuniadi Yunita K S Yunita K S Yunita K S Zahara, Indah