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All Journal VALENSI Nexus Kedokteran Komunitas WARTA The Indonesian Journal of Public Health Jurnal Gizi dan Kesehatan GIZI INDONESIA INDONESIAN JOURNAL OF APPLIED PHYSICS AcTion: Aceh Nutrition Journal Jurnal Gizi Klinik Indonesia Sebatik Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Aisyah : Jurnal Ilmu Kesehatan Nusantara Science and Technology Proceedings Jurnal Dharma Bhakti Ekuitas Narra J Jurnal Jaminan Kesehatan Nasional JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Smart Society Empowerment Journal Gema Lingkungan Kesehatan Plexus Medical Journal FISIO MU: Physiotherapy Evidences Media Penelitian dan Pengembangan Kesehatan
Tonang Dwi Ardyanto
Departement Of Clinical Pathology, Faculty Of Medicine, Sebelas Maret University, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Gema Lingkungan Kesehatan

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Role of Gamma-Glutamyl Transferase, High Sensitivity C Reactive Protein and Apolipoprotein B as A Marker of Disease Severity in Psoriasis Shofiyah, Laily; Ardyanto, Tonang Dwi; Prabowo, Nurhasan Agung; Aprilningsih, Hendrastutik; Myrtha, Risalina; Kuncorowati, Niken Dyah Aryani; Suwandono, Adji; Nugroho, Novianto Adi; Sari, Maria Galuh Kamenyangan; Dyanneza, Frieska
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.285

Abstract

Psoriasis can develop into systemic psoriasis, which primarily affects the liver, bile ducts, and cardiovascular system. Assessing the severity of psoriasis was crucial for determining treatment and cardiovascular disease risk. The aim of this study was to determine the role of Gamma-Glutamyl Transferase (GGT), High Sensitivity C-Reactive Protein (HS-CRP), and apolipoprotein B (APO B) in assessing the severity of psoriasis. Methods: This study was a cross-sectional, observational analytic study. A total of 33 psoriasis patients were tested for GGT, HS-CRP, APO B levels, and the Psoriasis Area and Severity Index (PASI) score. Results: The average GGT level was 70.75±56.47 u/L, the average HS-CRP level was 0.91±1.03 mg/L, the average APO B level was 110.09±26.47 mg/dL, and the average PASI score was 11.70±4.54. 12.1% of patients had mild psoriasis, 51.5% had moderate psoriasis, and 36.4% had severe psoriasis. There was a positive and strong correlation between GGT and PASI score, HS-CRP and PASI score, and APO B and PASI score. The multivariate correlation between GGT, HS-CRP, and APO B with PASI score had a value of R = 0.874, F = 31.145, p = <0.001. Conclusion: The multivariate correlation between GGT, HS-CRP, and APO B with PASI scores shows a positive and strong correlation, thus it useful for assessing the severity of psoriasis and evaluating the likelihood of cardiovascular disease.
Co-Authors Adang Muhammad Gugun, Adang Muhammad Adji Suwandono Adji Suwandono Agung Susanto Agus Kristiyanto Agus Kristiyanto Agus Sholikin Agus Sholikin Agus, Telly P. Ambar Mudigdo Amilia Yuni Damayanti Amin Subandrio, Amin Andikashwari, Sekarnira Andri Haryanto Anik Lestari Anwar, Fuad Aprilningsih, Hendrastutik Apriningsih, Apriningsih Apriningsih Apriningsih, Hendrastutik Ari Natalia Probandari Ari Probandari Artika Ramadhani Astri Tantri Indriani Astri Tantri Indriani Astri Tantri Indriani Avelia, Annisa Ayunda Oktavia Badri, Baarizah Febriana Benyamin Saut Berty Denny Hermawati Betty Suryawati Bismantara, Haryo Brian Wasita Brian Wasita Cari Cari Citra Jaya Dedy Revelino Delta Nur Septianingsih Deviro Deviro Dewi, Herlina K. Dian Ariningrum Donald Pardede Dono Indarto Dono Indarto Dyanneza, Frieska Elfi Susanti V. H. Ema Nur Fitriana Endang Suparniati Erzan Dhanalvin Eti Poncorini Pamungkasari Fajar Rakhman Wibowo Firdaus Hafidz As Shidieq Firdaus, Nais Volum Florentinus Nurtitus Frieska Dyanneza Frieska Dyanneza Frieska Dyanneza Gautama, Coana S. Gilbert Renardi Kusila Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hendrastutik Apriningsih Hermawati, Berty D. Hidayat, Syamsu Ida Nurwati Ika Mukti Virgiyanti Ika Mukti Virgiyanti Indriani, Astri Tantri Iskandar, Kasir Isnanda Putri Nur Istiqomah Istiqomah, Isnanda Putri Nur Khariri Khariri Kuncorowati, Niken Dwi Aryani Kuncorowati, Niken Dyah Aryani Kurniawati, Golda Laily Shofiyah Laily Shofiyah Lestari, Nova Dwi Maria Galuh Kamenyangan Maria Galuh Kamenyangan Sari, Maria Galuh Kamenyangan Maria Sekar Cahyaningrum Moh Fanani Mohtar Yunianto Muchtar Hanafi Muttaqien Muttaqien, Muttaqien Myrtha, Risalina Niken Dwi Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Niken Dyah Aryani Kuncorowati Nisri Ina Zahrah Novianto Adi Nugroho Nugroho, Novianto Adi Nur Hafidha Hikmayani Nurhasan Agung Prabowo Prabowo, Nurhasan A. Prabowo, Nurhasan Agung Putranto, Wachid Putri, Desy P. Qadrijati, Isna Ragil Rahma Nafila Ratih Tri Amelia Resta Farits Pradana Reviono Rini Astuti Risalina Myrtha Risalina Myrtha Rizky Amalia Puspitaningrum Rusliana, Eka Samodra, Imam Shofiyah, Laily Soeparmi Soeparmi Soetrisno Soetrisno Sri Indratni Sri Indratni Sri Mulyani Sugiarto S Tahono Tahono Tsalatshita, Risky Wan Aisyiah Baros Widana Primaningtyas Wulandari, Evi L. Yeni Farida Yulia Sari Yulita Hendrartini