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All Journal Dentika Dental Journal Jurnal Sains dan Teknologi Farmasi Science and Technology Indonesia Jurnal Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea Jurnal Prima Medika Sains JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Journal of Multidisciplinary Applied Natural Science FORTE JOURNAL Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Andalas Dental Journal Formosa Journal of Sustainable Research (FJSR) Jurnal Farmasi Indonesia
Yufri Aldi
Fakultas Farmasi Universitas Andalas
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Preparation and Characterization of a Eutectic Mixture of Fenofibric Acid and Nicotinic Acid and Evaluatuion of In Vivo Antihyperlipidemic Activity Deni Anggraini; Hulwa Salsabila; Salman Umar; Yufri Aldi; Erizal Zaini
Science and Technology Indonesia Vol. 7 No. 4 (2022): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1086.036 KB) | DOI: 10.26554/sti.2022.7.4.514-521

Abstract

Fenofibric Acid (FA) is classified under Biopharmaceutical Classification System (BCS) class II due to its poorly soluble in water and high permeability. The present study aimed to prepare the eutectic mixture of FA with nicotinic acid (NA) and characterize its solid state properties and in vitro dissolution rate, along with its in vivo antihyperlipidemic activity. Solvent drop grinding was the method chosen to prepare the eutectic mixture of FA and NA. Solid-state properties were evaluated using thermal analysis Differential Scanning Calorimetry (DSC), crystallographic analysis Powder X-Ray Diffraction (PXRD), FT-IR spectroscopic analysis, and Scanning Electron Microscopy (SEM). To examine in vivo antihyperlipidemic activity, 16 male Swiss Webster rats were injected with 1% hyperlipidemia-inducing solution, followed by the oral administration of 9.45 mg/kg FA and NA (equivalent to 9.45 mg/kg FA), after which the decrease in cholesterol levels was measured. Two-way ANOVA was used to evaluate the data, followed by Duncan’s multiple range test (95% confidence interval). The results proved that FA formed the eutectic mixture with NA at a molar ratio of 6:4. The eutectic mixture of FA-NA had a better solubility and in vitro dissolution rate compared to intact FA, which also led to notably improved antihyperlipidemic activity.
PEMBUATAN OBAT TRADISIONAL BERBAHAN PEGAGAN EMBUN BAGI MASYARAKAT DI KENAGARIAN VII KOTO TALAGO KECAMATAN GUGUK KABUPATEN 50 KOTA Yufri Aldi; Salman Salman; Elsa Badriyah; Aditya Alqamal Alianta; Elidahanum Husni
Jurnal Hilirisasi IPTEKS Vol 5 No 4 (2022)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v5i4.621

Abstract

The purpose of this activity is so that people can process plants in a measurable and precise manner, and the frequency of use is by the severity of the disease and the length of time for drug administration. Methods of activity in the form of training and counseling. The counseling material provided on the first day was about the immune system and the benefits and results of research from Centella asiatica, which had been published in reputable international journals. The training provided was on harvesting and making Centella asiatica powder based on Good Traditional Medicine Making Methods. In the second period, there were lectures on using traditional medicine and training in making powders, and how to fill capsules using capsule boards with Centella asiatica powder. After training and counseling in the second stage, the questionnaire was filled out with the same material as the questionnaire given in the first period. This activity was carried out in Kenagarian VII Koto Talago, Guguk District, 50 Kota. Participants were PKK cadres and Bundo Kandung in Kenagarian VII Koto Talago. In the first period, it was attended by 125 participants, and in the second period, as many as 55 people. Before counseling, participants were required to fill out a questionnaire containing knowledge about the immune system and how to use traditional medicine. From the training and counseling given to the participants, it can be concluded from the questionnaire results that they have understood the body's immune system protects the body from infection by microorganisms. They have also been able to make powder and put it in capsules so that they become ready-to-use Centella asiatica capsules.
PEMBUATAN PRODUK SABUN CAIR DARI ECO-ENZYME DI KELURAHAN ANDALAS KECAMATAN PADANG TIMUR KOTA PADANG Purnawan Pontana Putra; Fatma Sri Wahyuni; Yelly Oktavia Sari; Erizal Erizal; Dachriyanus Dachriyanus; Yufri Aldi; Dedy Almasdy; Salman Salman
Jurnal Hilirisasi IPTEKS Vol 6 No 1 (2023)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v6i1.644

Abstract

Eco-Enzyme, a multifunctional liquid produced from a mixture of organic waste such as vegetables, fruits, brown sugar, coconut sugar, corn sugar, sugarcane, and water that has undergone fermentation, has various benefits for the environment and human health. Eco-Enzyme contains beneficial enzymes that accelerate biochemical reactions in the environment. The enzymes found in Eco-Enzyme can be used for various applications, such as organic liquid fertilizer for plants, an additive in detergents, floor cleaners, pesticide residue cleaners, and rust removers. Using Eco-Enzyme as a liquid soap can help reduce soil pollution. Meanwhile, using Eco-Enzyme as a cleaning agent can help reduce the use of hazardous chemicals that damage the environment. This integrated program is carried out in three stages: the first is to socialize the benefits of using Eco-Enzyme, the second is to make Eco-Enzyme, and the third is to make soap from Eco-Enzyme. The production of Eco-Enzyme begins with the collection of organic waste consisting of fruit and vegetable waste, which is then mixed with brown sugar and water and left to ferment for three months. After the Eco-Enzyme product is ready, soap-making uses ingredients such as potassium hydroxide (KOH), coconut oil, cooking oil, distilled water, orange-scented perfume, and Eco-Enzyme. Training on Eco-Enzyme and soap making is conducted in the Andalas Subdistrict, which is welcomed enthusiastically by the local community. This program is expected to serve as a reference for transforming organic waste into more practical and environmentally friendly sustainable products.
Article Review: Immunomudulatory Activity of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract Adrul Fauzan; Yufri Aldi; Salman Umar; Afriwardi Afriwardi
JURNAL PROTEKSI KESEHATAN Vol 12 No 1 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i1.636

Abstract

Various kinds of diseases can be caused by exposure to objects that are not recognized by the body. To recognize these foreign objects, a good immune system is needed. Immunomodulators are substances used to exert an effect on the immune system. The function of an immunodulator in the body can be as an immunostimulant, namely by stimulating the function of the immune system. Immunostimulating compounds can be obtained from plants. One of the plants that can be used is pegagan embun (Hydrocotyle sibthorpioides Lam.). In Hydrocotyle sibthorpioides Lam. It contains flavonoid compounds which have immunomodulatory activity. This article review was conducted to obtain information related to the immunomodulatory potential of the Hydrocotyle sibthorpioides Lam plant. The writing method for making this research article review was a comparative method, namely taken from a collection of national journals and international journals. Various research results that have been obtained prove that the extract of Hydrocotyle sibthorpioides Lam. can potentially enhance the body's immune system due to the content of flavonoid compounds which function as natural immunomodulators.
Penyuluhan dan Pelatihan Penggunaan Obat Tradisional serta Penerapan Hasil Penelitian Tumbuhan Sungkai (Peronema canescens Jack) kepada Masyarakat Dwisari Dillasamola; Yufri Aldi; Fatma Sri Wahyuni; Hansen Nasif; Yohannes Alen
Warta Pengabdian Andalas Vol 30 No 1 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.1.60-66.2023

Abstract

Indonesians, particularly those residing in rural areas with abundant plant diversity, have long relied on traditional medicine that utilizes plants. Sungkai (Peronema canescens Jack.) is one example of a widely-used traditional medicine known for its immunity-boosting properties. However, many people need more awareness of the potential benefits and risks of plants like Sungkai, so it is necessary to provide education and training to promote proper usage and ensure public safety. This community service activity aimed to equip individuals with the knowledge and skills to process plants accurately, utilize them appropriately based on the severity of the illness, and avoid any adverse side effects or toxicity. The counselling method used in this initiative involves lectures, which is effective for individuals with varying education levels, especially the general public. This program has yielded promising results, with the community displaying strong enthusiasm for the initiative. Ultimately, education and counselling services can significantly improve public understanding and use of traditional medicine.
In Vitro Anti-Inflammatory Test of Genjer Leaf Extract (Limnocharis Flava) Yufri Aldi; Nurliyasman; Herwinda Julia Putri; Rury Trisa Utami
Formosa Journal of Sustainable Research Vol. 2 No. 5 (2023): May, 2023
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/fjsr.v2i5.4196

Abstract

Tanaman genjer (Limnocharis flava L.) telah banyak dimanfaatkan untuk menjaga kesehatan pencernaan, mempercepat penyembuhan luka, menjaga kesehatan kulit, membantu menurunkan kolesterol. Senyawa fitokimia flavonoid yang terkandung dalam daun genjer diduga berkhasiat sebagai anti-inflamasi. Penelitian ini bertujuan untuk mengetahui aktivitas anti-inflamasi ekstrak daun genjer dengan menggunakan metode stabilitas membran eritrosit. Variasi konsentrasi larutan uji yang dibuat adalah 6 variasi konsentrasi yaitu 10, 50, 100, 250, 500 dan 1000 ppm. Aktivitas anti-inflamasi ekstrak kemudian dibandingkan dengan standar ibuprofen. Dari hasil uji aktivitas anti-inflamasi menggunakan metode stabilitas membran eritrosit berdasarkan perhitungan persen stabilitas menunjukkan bahwa ekstrak daun genjer pada konsentrasi 1000 ppm memiliki aktivitas tertinggi yaitu sebesar 76,70%. Dengan demikian konsentrasi ini dapat dikatakan sebagai konsentrasi tertinggi / efektif dalam memberikan perlindungan membran sel darah merah yang diinduksi larutan hipotonik. Berdasarkan hasil uji ANOVA satu arah diketahui bahwa pemberian ekstrak daun genjer berpengaruh nyata terhadap stabilitas membran eritrosit (p <0,05). Dari penelitian yang telah dilakukan dapat disimpulkan bahwa ekstrak daun genjer memiliki efek anti-inflamasi dengan menggunakan metode uji stabilitas membran eritrosit.
UJI IMUNOMODULATOR BEBERAPA SUBFRAKSI EKSTRAK ETIL ASETAT MENIRAN (Phyllanthus niruri [L]) PADA MENCIT PUTIH JANTAN DENGAN METODA CARBON CLEARANCE Yufri Aldi; Nisya Ogiana; Dian Handayani
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 1, Nomor 1, Juni 2014
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (579.16 KB) | DOI: 10.33854/JBDjbd.55

Abstract

Meniran has scientific name Phyllanthus niruri L..It uses to increase imun system of human body. Nonspecific of Imun system is first defendent to protect human body from microorganism, because it gives direct respon to antigen then it will destroy bacteria with phagocytosis process. Meniran extract is known can obstruct xanthin oksidase invitro, protect hepatocyte cell of liver from carbon tetrachloride and cytotoxity that induction with galaktosamin.To determined imunomodulator activity of some ethyl acetat extract subfraction of meniran (Phyllanthus niruri [L.]). Some ethyl acetat extract subfraction of meniran (Phyllanthus niruri [L.]) administered orally with single dose 100 mg/kg BB for eight group of subfraction and Tween 80 1% as control for 6 days. After 6 days subfractions have been conducted in white male mice with carbon clearance method. A value of Index Phagocytosis (IF) < 1 has imunosupressant activity and IF > 1 has imunostimulant activity. The increasing of phagositosis index with carbon clearance method showed the effect from each group of subfraction with control was unsignificant (P>0,05). The incerasing of leucocyte cell component especially for limfosit cell, eusinofil, and segmen neutrofil was significant for each group of subfraction (P0,05). The increasing of spleen limfosit cell showed optimal effect in subfraction number three (P
Traditional Herb Used and Training on Preparation Moringa oleifera Lam. Herb as Dip and Capsules Yufri Aldi; Salman Umar; Aditya Alqamal Alianta; Elidahanum Husni
Warta Pengabdian Andalas Vol 31 No 1 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.1.108-115.2024

Abstract

Moringa leaves have grown abundantly in the 50 Kota Regency area. Studies have been carried out regarding moringa leaves, and research has shown that moringa leaves are effective as a medicine to increase the body's immunity. The community needs to know and understand the benefits of Moringa leaves. Based on that circumstance, the Community Service regarding how to process the Moringa leave to be dip preparation and capsule has been conducted in Jorong Padang Kandis, VII Koto Talago Sub-district, Guguk District, 50 Kota Regency, West Sumatra. The activity was carried out on 19 August 2023. The participants were the Family Welfare Movement (PKK) and Bundo Kandung groups in Jorong Padang Kandis, attended by 100 participants. The method was lectures and training on preparing Moringa herb leaf preparations and making Moringa leaf capsules, which the community can use directly. Community services topics were "The Utilisation of Traditional Medicines" and "The Efficacy and Research Results of Moringa Leaves." The training was on making Moringa leaf powder based on suitable traditional medicine-making methods, such as dips and capsules from Moringa leaf powder and extract. Community service helped the community understand that Moringa leaves can be used as a traditional medicine to protect the body from infection with microorganisms. The community also made powder packaged as a dip preparation, used like tea bags and put it into capsules.
EDUKASI PENYULUHAN OBAT DAN PENGOBATAN GRATIS BAGI MASYARAKAT DI DESA PERKAMPUNGAN ADAT SIJUNJUNG Dwisari Dillasamola; Yoneta Srangenge; Aan Ardiansyah; Yufri Aldi; Fatma Sri Wahyuni; Elidahanum Husni; Rahmad Abdillah; Adinny Julmiza; Benardo Benardo
BULETIN ILMIAH NAGARI MEMBANGUN Vol 7 No 2 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i2.600

Abstract

Community health education is crucial, including education on the rational use of antibiotics, as well as halal food and medicine. Additionally, providing free medical treatment has a significant impact, encouraging the community to prioritize health and maintain it as a primary concern. This community service project was conducted in the Desa Perkampungan Adat Sijunjung. The objective of this activity is to maintain and improve the community's health status. One way to achieve this is through community service activities. The service involved educational sessions on medicines and health, as well as free medical treatment, in collaboration with the Faculty of Pharmacy and the Faculty of Medicine at Universitas Andalas. The education targeted pregnant women and the elderly, focusing on proper medication selection, rational use of antibiotics, and education on halal medicines and food. Free medical treatment involved specialist doctors and pharmacists, who also provided counseling on medications to patients. The results of the activity showed high community enthusiasm, with more than 100 prescriptions filled. The education on the rational use of medications, particularly antibiotics, is expected to increase community awareness and knowledge. This activity also highlights the importance of pharmacists in providing patient-oriented pharmaceutical services, as well as the importance of promotional and preventive efforts in maintaining public health. It can be concluded that free medical treatment is expected to encourage the community to be more health-conscious and less fearful of seeking medical care.
PERBANDINGAN GEJALA KEJADIAN IKUTAN PASCA IMUNISASI SETELAH VAKSIN COVID-19 ASTRAZENECA PERTAMA DAN KEDUA DI CENTRAL VAKSINASI UTA 45 JAKARTA Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 1 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i1.1879

Abstract

Post-Immunization Adverse Events (AEFI) are common among vaccine participants. AEFI needs to be evaluated because Covid-19 vaccination is an effort to prevent Covid-19 infection which is still relatively new and people are still afraid of post-immunization adverse events occurring. In order for community participation to increase, it is deemed necessary to carry out an AEFI evaluation for both the first dose and the second dose (complete dose). This study aims to evaluate the symptoms of AEFI 1 with AEFI 2 by measuring the number of respondents who caused local and systemic reactions after COVID-19 vaccination. The retrospektive and prospective cross sectional study were used in this study with about 113 Astrazeneca vaccine participants at the UTA'45 Jakarta vaccine center and the data met the inclusion and exclusion criteria. Data was collected through questionnaires, AEFI forms and interviews based on symptoms of local and systemic reactions. Of the 113 participants, 29 were female, while 84 were male and the reactions they caused were different, such as pain, redness, swelling at the injection site, such as fever, muscle aches throughout the body, joint pain and also weakness. Comparison of symptoms of local and systemic reaction between KIPI 1and KIPI 2. In those without symptoms, there was increase number, but in those with symptoms, the number of respondens decrease, and statistically there was sig, P value <0,05.
Co-Authors . Yanwirasti AA Sudharmawan, AA Aan Ardiansyah Aan Ardiansyah Abdillah, Rahmad Adinny Julmiza Adinny Julmiza Aditya Alqamal Alianta Adrul Fauzan Afriwardi Afriwardi Akmal Djamaan Amri Bakhtiar Andani Eka Putra Arfiandi Arfiandi Arif Setiawansyah Astari, Lita Tri Azukhruf, Wanda Sabila Ben, Elfi Sahlan Benardo Benardo Benardo Benardo Dachriyanus Deni Anggraini Densi Selpia Sopianti Densi Selpia Sopianti Dewi Gulyla Hari Dian Handayani Dian Handayani Diana Laila Ramatillah Dwisari Dillasamola Elda Mayanti Elidahanum Husni Elisma Elisma Ellyza Nasrul Elsa Badriyah Enda Markus Aginta Sembiring Erizal Erizal Erizal Zaini Fadilla, Utami Budhi Fatma Sri Wahyuni Fatma Sriwahyuni Febria, Nurma Fifi Harmely Fildzah Nurul Fajrin, Fildzah Nurul Friardi Ismed Gita Susanti Gloria, Fransisca Gusriyani, Sri Hansen Nasif Havizur Rahman Herwinda Julia Putri Hulwa Salsabila Lukas, Stefanus M Asmadi Mahyudin Mahyudin Marlina . Michael Michael Muhammad Islamoyo Muhammad Syafrudin Nikita Surya Dharma Nila Kasuma Nindya Prastiwi Nisya Ogiana Nurliyasman Panggabean, Aminah Paulina, Ida Prastiwi, Nindya Rahmad Abdillah Rahmadevi Rahmi Nofita Rama Feriska Putra Ramatillah, Diana Laila Rozi Efendi Rury Trisa Utami Rustini Rustini Salman - Salman Salman Salman Umar Salman Umar Salman Umar Sayyida, Alya Sirda Yenni Sri Oktavia Suci Sutma Suhatri Suhatri Surya Nelis Susi Susi Syofyan Syofyan Usman, Hendrizal Wahyudi, Agung Aji Widya Kardela Widya Nengsih Yahdian Rasyadi Yanelita Vipri Yanwirasti Yanwirasti Yaser Arafat Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yoneta Srangenge Zet Rizal