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All Journal Dentika Dental Journal Jurnal Sains dan Teknologi Farmasi Science and Technology Indonesia Jurnal Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea Jurnal Prima Medika Sains JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Journal of Multidisciplinary Applied Natural Science FORTE JOURNAL Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Andalas Dental Journal Formosa Journal of Sustainable Research (FJSR) Jurnal Farmasi Indonesia
Yufri Aldi
Fakultas Farmasi Universitas Andalas
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Literature Review: Effect of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Extract on NK and CD8 Cell Activity Gusriyani, Sri; Aldi, Yufri; Umar, Salman; Afriwardi, Afriwardi
JURNAL PROTEKSI KESEHATAN Vol 12 No 2 (2023): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v12i2.644

Abstract

There have been many traditional plants used for treatment, one plant that is widely used by the community for treatment is Hydrocotile sibthorpioides L. which is efficacious as an immunomodulator. In this plant, there are flavonoid compounds, namely rutin which has activity to increase the body's immune system, especially in NK and CD8 cells. NK (Natural Killer) and CD8 (Cluster of Differentiation 8) cells are components of the immune system that play an important role in immunomodulatory activity. This article review was conducted to obtain information on the effect of Hydrocotile sibthorpioides L. extract on NK and CD8 cell activity in the body. The writing method in making this research article review is comparative, which is taken from a collection of national journals and international journals. Various research results that have been obtained state that Hydrocotile sibthorpioides L. extract can affect the activity of NK and CD8 cells in improving the immune system.
Penyesuaian dosis obat pada pasien penyakit ginjal kronis serta hubungannya dengan outcome terapi Panggabean, Aminah; Fatma Sriwahyuni; Aldi, Yufri
Jurnal Prima Medika Sains Vol. 5 No. 1 (2023): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i1.3552

Abstract

Salah satu strategi pemberian obat pada pasien penyakit ginjal kronis (PGK) dapat dilakukan dengan penyesuaian dosis obat untuk memastikan outcome terapi yang optimal. Penelitian ini bertujuan mengetahui hubungan penyesuaian dosis obat dengan outcome terapi pada pasien PGK rawat inap. Penelitian ini bersifat observational dengan desain cross sectional. Teknik pengambilan sampel menggunakan teknik purposive sampling. Sebanyak 73 rekam medis pasien PGK rawat inap periode Januari-Desember 2022 di RSUD Padangsidimpuan. Penyesuaian dosis dihitung berdasarkan fungsi ginjal dengan estimasi GFR (Glomerular Filtration Rate) menggunakan formula Chronic Kidney Disease Epidemiology Collaboration (CKD-epi). Hubungan antara penyesuaian dosis dengan outcome terapi obat menggunakan analisis Chi-Square. Hasil penelitian menunjukkan terdapat 655 obat yang diresepkan, 271 ( 41,4%) obat membutuhkan penyesuaian dosis, di mana 142 (52.4%) obat diberikan dengan penyesuaian dosis dan 129 (47.6%) obat diberikan tanpa penyesuaian dosis. Dari analisis outcome terapi yang dilakukan, terdapat 72 (73,5%) obat diberikan dengan penyesuaian dosis, 56 (77,8%) obat memberikan outcome terapi membaik dan 16 (22,2%) obat memberikan outcome terapi tidak membaik. Sedangkan 26 (26,5%) obat diberi tanpa penyesuaian dosis terdapat 11 (42,3%) obat memberikan outcome terapi membaik dan 14 (53,8%) obat memberikan outcome terapi tidak membaik. Terdapat hubungan yang signifikan antara penyesuaian dosis obat dengan outcome terapi pada pasien PGK rawat inap (p=0,003).
EFEKTIVITAS PENGGUNAAN ANALGETIK DI RUMAH SAKIT Nindya Prastiwi; Hansen Nasif; Yufri Aldi
Jurnal Kesehatan - STIKes Prima Nusantara Vol 12 No 1 (2021): JURNAL KESEHATAN
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v12i1.401

Abstract

Pendahuluan : Nyeri merupakan keluhan yang paling sering diutarakan oleh pasien di rumah sakit. Nyeri yang masih dirasakan pasien setelah menerima analgesic, menandakan bahwa terdapat ketidakefektifan penggunaan analgetik pada pasien. Keefektifan penggunaan analgetik menentukan keberhasilan terapi.Tujuan : Mengetahui efektifitas penggunaan analgetik dalam penatalaksanaan nyeri pada pasien terutama dalam penggunaannya di Rumah Sakit.Metode : Literatur review. Strategi pencarian data yaitu adalah mencari langsung grey literatur melalui mesin pencarian data Google dan menggunakan database Google Scholar, Pubmed dan ScienceDirect  dengan kata kunci “Efektivitas Analgetik Rumah Sakit”. Research question dibuat dengan format PEOS dan penyaringan data menggunakan PRISMA Flowcart. Kriteria inklusi meliputi jurnal tentang efektivitas analgetic yang telah dipublikasi dalam sepuluh tahun terakhir (2010-2020), jurnal nasional dengan akreditasi sinta 1-6, dan jurnal internasional yang terindex scopus dengan ranking Q1-Q4. Kriteria eksklusi meliputi jurnal yang tidak terfokus membahas efektivitas analgetic atau intensitas nyeri, dan jurnal yang dengan metode review.Hasil : Dari 18 jurnal yang direview, Sebagian besar jurnal tersebut membahas perbandingan efektivitas antara dua atau lebih analgetik, baik  analgetik tunggal maupun kombinasi. Dari perbandingan tersebut penggunaan analgetic kombinasi dianggap efektif digunakan pengganti opioid.Kesimpulan : Efektivitas suatu analgetic dapat tercapai dengan baik bila disesuaikan dengan derajat nyeri pasien. Saat ini, penggunaan terapi multimodal  sering digunakan di rumah sakit, karena selain efektif menurunkan intensitas nyeri, kombinasi analgetik opioid dengan analgetik non narkotik mampu menekan efek samping yang ditimbukan oleh opioid, mengurangi ketergantungan penggunaan opioid pada pasien, serta mempercepat masa pemulihan, sehingga meningkatkan kepuasan pasien terhadap pelayanan kesehatan.
Effect of Anticoagulant Use on Coagulation Parameters in Covid-19 Comorbid Diabetic Patients Febria, Nurma; Wahyuni, Fatma Sri; Yufrialdi, Yufrialdi
JURNAL PROTEKSI KESEHATAN Vol 13 No 2 (2024): JPK: Jurnal Proteksi Kesehatan
Publisher : Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v13i2.853

Abstract

Coagulation disorders, one of the causes of death of severe Covid-19 patients and comorbidities that also affect coagulation is Diabetes Mellitus. In the guidelines, it is recommended to use prophylactic anticoagulants, namely Unfractionated Heparin (UFH) and Low Molecular Weight Heparin (LMWH) to overcome the problem of this coagulation disorder by paying attention to the value of coagulation parameters, namely, D-Dimer, PT, APTT and platelet values. The purpose of this study was to see the relationship between the use of prophylactic anticoagulants with a decrease / increase in the value of the coagulation parameter. The research design was retrospective pre-post test cohort study with research subjects of comorbid Covid-19 Diabetes patients treated in the ICU of RSUP Dr.M Djamil Padang. As a result, in the group of patients using UFH there was a significant decrease in D-Dimer values (p = 0.001) while the LMWH group was not significantly related (p = 0.05). For the association of anticoagulants with PT values, APTT in both groups was not significant. As for platelet values, there was a significant decrease in the UFH group. Conclusion for severe Covid-19 patients with comorbid Diabetes The use of UFH is recommended as a therapeutic option.
UJI AKTIVITAS IN VIVO DAN IN VITRO ANTI PLATELET BROMELIN TERHADAP PENYAKIT KARDIOVASKULAR Fadilla, Utami Budhi; Aldi, Yufri; Afriwardi, Afriwardi; Umar, Salman
Jurnal Farmasi Higea Vol 16, No 2 (2024)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v16i2.603

Abstract

Penyakit kardiovaskuler atau Cardiovascular Disase (CVD) adalah sekumpulan gangguan yang terjadi pada sistem jantung dan pembuluh darah. CVD dapat disebabkan oleh adanya agregasi platelet dalam saluran darah. Penggunaan anti platelet dapat meminimalkan angka kematian terhadap CVD, tetapi beberapa antiplatelet dibeberapa individu mengalami resistensi, dan bahkan menyebabkan efek samping lainnya, penggunaan fitomedika dapat menjadi alternatif dalam pengobatan CVD seperti penggunaan enzim bromelin. Enzim ini dapat digunakan untuk membantu mengurangi sensitivitas platelet terhadap ADP (Adenosine diphosphate) yang memicu agregasi platelet. Artikel ini merupakan review dari beberapa Original Research dan Review/ Open review yang diambil 10 tahun terakhir yang menjadi sumber referensi dalam artikel ini. Dari hasil telaah artikel pada sampel bromelin tersebut lebih banyak menggunakan uji in vitro dengan menggunakan metode PRP, dengan nilai aktivitas agregasi platelet bromelin berada diatas 40%. Sementara untuk pengujian in vivo pada mencit didapatkan dosis 210 µg/Kgbb sebagai dosis terbaik dan   pada tikus pada dosis 112 mg/kgbb. Sehingga dapat disimpulakan bahwa bromelin dapat menurunkan aagragasi platelet terhadap ADP yang menjadi parameter dalam CVD.
HUBUNGAN KOMORBIDITAS DAN PERILAKU TERHADAP TITER ANTIBODI DAN TERPAPAR COVID-19 PASCA VAKSIN ASTRAZENECA DOSIS LENGKAP DI UTA 45 JAKARTA Lukas, Stefanus; Diana Laila Ramatillah; Aldi, Yufri; Fatma Sri Wahyuni
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2028

Abstract

AstraZeneca vaccine has become one of the efforts to overcome the COVID-19 pandemic. This study aims to determine the relationship between the AstraZeneca vaccine and antibody titers and its association with exposure to COVID-19 infection. This study used a retrospective and prospective cohort design with convenience sampling. A total of 102 respondents who had received a complete dose of the AstraZeneca vaccine and were willing to be followed up for 18 months were involved in this study. Sociodemographic data, comorbidity history, lifestyle, and antibody titers were measured at two times: before the first dose and after the second dose of vaccinations. This study found that there was no significant relationship between comorbidities and respondent behavior (smoking and alcohol consumption) with COVID-19 antibody titers. Physical activity (exercise) showed a positive relationship with COVID-19 antibody titers. Respondents who exercised regularly had higher antibody titers than those who did not. There was a positive relationship between comorbidities, smoking, and alcohol consumption with the risk of exposure to COVID-19 infection after vaccination. This study found that physical activity (exercise) can increase COVID-19 antibody titers and provide protection against COVID-19 infection after vaccination.
Analisis Pelayanan Resep Konvensional dan Elektronik serta Pengaruhnya terhadap Kualitas Pelayanan Kefarmasian di RSUD M. Natsir Solok Indonesia Adrizal, Adrizal; Sriwahyuni, Fatma; Aldi, Yufri
JSFK (Jurnal Sains Farmasi & Klinis) Vol 6 No 3 (2019): J Sains Farm Klin 6(3), Desember 2019
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.6.3.195-199.2019

Abstract

Rumah Sakit wajib memberikan pelayanan yang berkualitas sesuai dengan Standar Pelayanan Minimal (SPM) yang telah di tetapkan. Upaya untuk meningkatkan kualitas pelayanan kefarmasian di rumah sakit dapat dilakukan dengan penerapan peresepan elektronik. Penelitian bertujuan untuk mengetahui perbedaan kualitas pelayanan kefarmasian antara peresepan konvensional dan peresepan elektronik. Desain penelitian adalah observasional analitik dengan rancangan cross sectional study. Sampel berjumlah 431 resep diambil dengan teknik random sampling. Uji statistik pada variabel waktu tunggu dan kepuasan pasien yaitu uji t–independen sedangkan variabel kesalahan pemberian obat dan kesesuaian resep dengan formularium digunakan  uji  chi_square dengan tingkat kemaknaan 0,05. Hasil penelitian menunjukan terdapat perbedaan waktu tunggu (p value:0,000), kepuasan pasien (p value:0,000) dan kesesuaian resep dengan formularium (p value:0,000) antara peresepan elektronik dengan peresepan konvensional. Namun tidak terdapat perbedaan kejadian kesalahan pemberian obat antara peresepan elektronik dengan peresepan konvensional (p value:0,063). Penelitian ini menunjukkan bahwa kualitas pelayanan kefarmasian pada peresepan elektronik lebih baik dibandingkan dengan peresepan konvensional. Pimpinan dan manajerial RSUD M.Natsir hendaknya mengimplementasikan peresepan elektronik ini pada instalasi rawat jalan dan rawat inap sehingga kualitas pelayanan kefarmasian dapat ditingkatkan.
PENGGUNAAN OBAT TRADISIONAL DAN PEMBUATAN SEDIAAN CELUP DAUN KELOR BAGI MASYARAKAT DI SAKO KECAMATAN LUBUK KILANGAN KOTA PADANG Aldi, Yufri; Umar, Salman; Azukhruf, Wanda Sabila; Alianta, Aditya Alqamal
Jurnal Hilirisasi IPTEKS Vol 7 No 4 (2024)
Publisher : LPPM (Lembaga Penelitian dan Pengabdian kepada Masyarakat) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v7i4.818

Abstract

Moringa leaf (Moringa oleifera Lam.) is a traditional medicinal plant widely recognized in Indonesia and frequently utilised by the local community. Numerous studies have demonstrated its efficacy in boosting the immune system. In light of this, enhancing community awareness regarding the health benefits of Moringa leaves is essential. The objective of this initiative was to educate the community on how to process Moringa leaves accurately and appropriately, including proper dosage frequency based on the severity of illness and duration of use. This activity took place in Batu Gadang Village, Lubuk Kilangan District, specifically on Jl. Sako. Participants included 30 PKK Cadres and Bundo Kandung from the same area. The methodology involved educational lectures followed by hands-on training. The training focused on proper harvesting techniques and the preparation of Moringa leaf powder in accordance with traditional medicinal practices. A question-and-answer session was conducted to ensure participants fully grasped the material. The results indicated a high level of engagement, evidenced by active participation in both the Q&A and practical sessions. It can be concluded that the community now has a better understanding of the medicinal uses of Moringa leaves. Participants are encouraged to continue preparing Moringa leaf infusions to promote improved immunity.
INOVASI MINUMAN SEHAT: DEMONSTRASI PEMBUATAN SIRUP SUNGKAI DI NAGARI SIPINANG, KECAMATAN PALEMBAYAN KABUPATEN AGAM Dillasamola, Dwisari; Nasif, Hansen; Alen, Yohannes; Aldi, Yufri; Syofyan, Syofyan; Sayyida, Alya
Jurnal Hilirisasi IPTEKS Vol 7 No 4 (2024)
Publisher : LPPM (Lembaga Penelitian dan Pengabdian kepada Masyarakat) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v7i4.820

Abstract

The Sungkai plant (Peronema canescens Jack.) is known for its various health benefits, particularly as a natural immunostimulant. In West Sumatra, this plant is abundant and widely used in traditional medicine. This activity aimed to provide education and a demonstration to the community on how to process Sungkai leaves into a healthy syrup, thereby increasing the use of this plant as a daily health drink. The event was conducted through a live demonstration in Kanagarian Sipinang, Palembayan District, Agam Regency. The process of making Sungkai syrup involved several stages, starting from selecting the leaves, boiling them, and mixing them with other ingredients such as sugar and/or lemon juice to enhance the flavor. The results of this activity showed high enthusiasm among participants, with a total of 40 attendees. Before the demonstration, data from questionnaires revealed that 80% of respondents had heard about Sungkai syrup. During the demonstration, most participants expressed great interest in the syrup-making process, particularly in the aspect of processing Sungkai leaves into an extract that can be used as a base for syrup. This demonstration successfully enhanced participants' knowledge and skills in utilizing Sungkai leaves as a healthy drink. With further education and support, Sungkai syrup has great potential to be developed as a flagship product that supports both public health.
Uncovering The Pharmacological Mechanism of Ficus elastica as Anti-hyperlipidemia Candidate: LC-HRMS, Network Pharmacology, In vitro and In vivo Studies Gita Susanti; Yufri Aldi; Dian Handayani; Friardi Ismed; Arif Setiawansyah
Journal of Multidisciplinary Applied Natural Science Vol. 5 No. 1 (2025): Journal of Multidisciplinary Applied Natural Science
Publisher : Pandawa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47352/jmans.2774-3047.249

Abstract

Hyperlipidemia is a major risk factor for cardiovascular diseases. While conventional treatments exist, there is a growing interest in natural remedies with fewer side effects. Ficus elastica has promising medicinal properties, yet its potential as an anti-hyperlipidemic agent remains unexplored. This study aimed to investigate the anti-hyperlipidemic effects of F. elastica using an integrated approach of LC-HRMS-based chemical bioinformatics and in vitro/in vivo experimental validation. The anti-hyperlipidemic potential of F. elastica and its mechanism of action were screened using integrative computational network pharmacology followed by in vitro HMG-CoA reductase inhibition and in vivo lipid-lowering activity in a hyperlipidemia rat model. Network pharmacology analysis identified STAT3, HSP90AA1, and TLR4 as potential core targets involved in lipid and atherosclerosis-related KEGG pathways. Molecular docking simulations revealed high-affinity interactions between F. elastica compounds and the identified targets, notably compound 41 and compound 61. In vitro assay demonstrated that ethanolic extract of F. elastica inhibited HMG-CoA reductase with an IC50 of 297.73 µg/mL. In vivo experiment using a hyperlipidemic rat model showed significant reductions in total cholesterol, triglycerides, and increased HDL levels. The reduction of triglycerides and elevation of HDL level after F. elastica ethanolic extract supplementation is similar to the effect from supplementation of simvastatin. These findings suggest that F. elastica ethanolic extract possesses notable anti-hyperlipidemic properties, likely mediated through multiple molecular targets and pathways. The study highlights the potential of F. elastica ethanolic extract as a promising candidate for anti-hyperlipidemic therapy and underscores the efficacy of integrating computational and experimental approaches in natural product research.
Co-Authors . Yanwirasti AA Sudharmawan, AA Aan Ardiansyah Aan Ardiansyah Abdillah, Rahmad Adinny Julmiza Adinny Julmiza Aditya Alqamal Alianta Adrul Fauzan Afriwardi Afriwardi Akmal Djamaan Amri Bakhtiar Andani Eka Putra Arfiandi Arfiandi Arif Setiawansyah Astari, Lita Tri Azukhruf, Wanda Sabila Ben, Elfi Sahlan Benardo Benardo Benardo Benardo Dachriyanus Deni Anggraini Densi Selpia Sopianti Densi Selpia Sopianti Dewi Gulyla Hari Dian Handayani Dian Handayani Diana Laila Ramatillah Dwisari Dillasamola Elda Mayanti Elidahanum Husni Elisma Elisma Ellyza Nasrul Elsa Badriyah Enda Markus Aginta Sembiring Erizal Erizal Erizal Zaini Fadilla, Utami Budhi Fatma Sri Wahyuni Fatma Sriwahyuni Febria, Nurma Fifi Harmely Fildzah Nurul Fajrin, Fildzah Nurul Friardi Ismed Gita Susanti Gloria, Fransisca Gusriyani, Sri Hansen Nasif Havizur Rahman Herwinda Julia Putri Hulwa Salsabila Lukas, Stefanus M Asmadi Mahyudin Mahyudin Marlina . Michael Michael Muhammad Islamoyo Muhammad Syafrudin Nikita Surya Dharma Nila Kasuma Nindya Prastiwi Nisya Ogiana Nurliyasman Panggabean, Aminah Paulina, Ida Prastiwi, Nindya Rahmad Abdillah Rahmadevi Rahmi Nofita Rama Feriska Putra Ramatillah, Diana Laila Rozi Efendi Rury Trisa Utami Rustini Rustini Salman - Salman Salman Salman Umar Salman Umar Salman Umar Sayyida, Alya Sirda Yenni Sri Oktavia Suci Sutma Suhatri Suhatri Surya Nelis Susi Susi Syofyan Syofyan Usman, Hendrizal Wahyudi, Agung Aji Widya Kardela Widya Nengsih Yahdian Rasyadi Yanelita Vipri Yanwirasti Yanwirasti Yaser Arafat Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yoneta Srangenge Zet Rizal