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All Journal Dentika Dental Journal Jurnal Sains dan Teknologi Farmasi Science and Technology Indonesia JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea Jurnal Prima Medika Sains INTEGRITAS : Jurnal Pengabdian JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Journal of Multidisciplinary Applied Natural Science FORTE JOURNAL Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Andalas Dental Journal Formosa Journal of Sustainable Research (FJSR) Jurnal Farmasi Indonesia Jurnal Pengabdian Harapan Ibu (JPHI) PEDAMAS (Pengabdian Kepada Masyarakat) Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Kesehatan
Yufri Aldi
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Hubungan Sosiodemografi dengan Hasil Klinis Pasien Covid-19 di RSUD Bengkulu Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Gloria, Fransisca; Michael, Michael; Wahyudi, Agung Aji; Astari, Lita Tri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 14 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.839 KB) | DOI: 10.35617/jfionline.v14i1.59

Abstract

Coronavirus disease 2019 (Covid-19) is an infectious disease caused by SARS-CoV-2 which has a shape and behavior resembling the SARS virus. The national mortality percentage is 4.23, which is above the national average. The purpose of the study was to determine what factors were associated with the deaths of Covid-19 patients at the Bengkulu Government Hospital. With the aim of knowing the sociodemographic relationship with the clinical outcomes of Covid-19 patients in Bengkulu. Methods A retrospective cohort study was conducted in this study. This study only involved patients with confirmed Covid-19, with a total sample of 127 patients who were hospitalized during April, May, and June 2021. + oseltamivir + vitamins as treatment. The outcome of Covid-19 infection had several significant correlation factors: age (0.0001), occupation (0.0001) and comorbidities (0.0001). In conclusion, the worst clinical outcomes were mostly found in patients with diabetes and those who were over 50 years old.
Evaluasi Hasil Klinis Pada Tim Medis yang Mendapat Vaksinasi Booster di Rumah Sakit Bengkayang Kalimantan Barat Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Paulina, Ida; Gloria, Fransisca; Michael, Michael
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 14 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.685 KB) | DOI: 10.35617/jfionline.v14i2.70

Abstract

Abstract: In reducing the risk of transmission to health workers, the Government has given the 3rd Booster Covid-19 Vaccination since August 2021. This study uses the Astra Zeneca Vaccine, Moderna Vaccine and Pfizer Vaccine. The purpose of this study was to evaluate the effectiveness of the 3rd Booster vaccine and the clinical outcomes of post-vaccination health workers at West Kalimantan Hospital. Research method Observational Cross-sectional Prospective by conducting questionnaires and interviewing health workers. Samples were taken by convenience sampling and statistical analysis of chis-square. The research instrument used a questionnaire distributed in the hospital. In the study, it was found that as many as 12.60% (14 out of 118 health workers) were infected with Covid-19. The habit that influenced the effectiveness of the 3rd booster vaccination was sunbathing (p <0.05). The low severity of health workers infected with Covid-19 after the 3rd booster vaccine can be seen from the place of treatment, namely 97% independent isolation, 60% without using antivirals and 77% without using antibiotics. The type of vitamin that is most widely used is vitamin C. Hence with this booster vaccination aims to prevent and reduce the severity of patients who contract Covid-19 after vaccination.
Traditional Herb Used and Training on Preparation Moringa oleifera Lam. Herb as Dip and Capsules Yufri Aldi; Salman Umar; Aditya Alqamal Alianta; Elidahanum Husni
Warta Pengabdian Andalas Vol 31 No 1 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.1.108-115.2024

Abstract

Moringa leaves have grown abundantly in the 50 Kota Regency area. Studies have been carried out regarding moringa leaves, and research has shown that moringa leaves are effective as a medicine to increase the body's immunity. The community needs to know and understand the benefits of Moringa leaves. Based on that circumstance, the Community Service regarding how to process the Moringa leave to be dip preparation and capsule has been conducted in Jorong Padang Kandis, VII Koto Talago Sub-district, Guguk District, 50 Kota Regency, West Sumatra. The activity was carried out on 19 August 2023. The participants were the Family Welfare Movement (PKK) and Bundo Kandung groups in Jorong Padang Kandis, attended by 100 participants. The method was lectures and training on preparing Moringa herb leaf preparations and making Moringa leaf capsules, which the community can use directly. Community services topics were "The Utilisation of Traditional Medicines" and "The Efficacy and Research Results of Moringa Leaves." The training was on making Moringa leaf powder based on suitable traditional medicine-making methods, such as dips and capsules from Moringa leaf powder and extract. Community service helped the community understand that Moringa leaves can be used as a traditional medicine to protect the body from infection with microorganisms. The community also made powder packaged as a dip preparation, used like tea bags and put it into capsules.
Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Manisnya Inovasi Herbal: Pelatihan Pembuatan Permen Jelly Jahe sebagai Camilan Fungsional Lokal di Nagari Batu Kalang Utara Dillasamola, Dwisari; Yufri Aldi; Zozy Aneloi Noli; Uce Lestari; Dehan Fahresta; Abdullah Muhammad Faathir; Aditya Gufashar; Afifah Hulwah; Andhini Aurellyta Ridwan; Fashelia Azizaturrahmah; Habib Shidiq Akbar; Iva Rama Fitria; Larisa Aurellia Vilonia; Lusi Octaviana; Muhammad Fazly; Muhammad Abdul Najib; Muhammad Aidi Satryo; Muhammad Rahil Dief; Nadhira Yuri Maharani; Novita Sari; Saniya De Nafisa; Widya Faizatul Zuhri; Vika Permata Gustam; Yudistio Arnoza; Zainini Arraysa
Jurnal Pengabdian Harapan Ibu (JPHI) Vol. 7 No. 3 (2025): Jurnal Pengabdian Harapan Ibu (JPHI)
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/jphi.v7i3.1126

Abstract

The community service activity aimed to enhance public understanding and skills in utilizing ginger (Zingiber officinale) as a natural ingredient for functional food through the production of jelly candy. This initiative was motivated by the low level of public knowledge, as indicated by pre-test results showing limited understanding of the health benefits and processing techniques of ginger. The activity consisted of educational sessions, demonstrations, and hands-on practice on jelly candy production using natural ingredients, including ginger extract, sugar, jelly powder, vanilla, salt, and cinnamon. Evaluation through post-tests, interactive quizzes, and observation of practical sessions demonstrated a significant improvement in participants’ knowledge and skills. Participants showed enthusiasm and were able to independently produce ginger-based jelly candy. This program not only increased public literacy on the use of herbal ingredients but also encouraged the development of small-scale functional snack enterprises. Future implementations are expected to expand to other communities with continuous mentoring to strengthen economic and health impacts.
EDUKASI PENYULUHAN OBAT DAN PENGOBATAN GRATIS BAGI MASYARAKAT DI DESA PERKAMPUNGAN ADAT SIJUNJUNG Dwisari Dillasamola; Yoneta Srangenge; Aan Ardiansyah; Yufri Aldi; Fatma Sri Wahyuni; Elidahanum Husni; Rahmad Abdillah; Adinny Julmiza; Benardo Benardo
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 2 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i2.600

Abstract

Community health education is crucial, including education on the rational use of antibiotics, as well as halal food and medicine. Additionally, providing free medical treatment has a significant impact, encouraging the community to prioritize health and maintain it as a primary concern. This community service project was conducted in the Desa Perkampungan Adat Sijunjung. The objective of this activity is to maintain and improve the community's health status. One way to achieve this is through community service activities. The service involved educational sessions on medicines and health, as well as free medical treatment, in collaboration with the Faculty of Pharmacy and the Faculty of Medicine at Universitas Andalas. The education targeted pregnant women and the elderly, focusing on proper medication selection, rational use of antibiotics, and education on halal medicines and food. Free medical treatment involved specialist doctors and pharmacists, who also provided counseling on medications to patients. The results of the activity showed high community enthusiasm, with more than 100 prescriptions filled. The education on the rational use of medications, particularly antibiotics, is expected to increase community awareness and knowledge. This activity also highlights the importance of pharmacists in providing patient-oriented pharmaceutical services, as well as the importance of promotional and preventive efforts in maintaining public health. It can be concluded that free medical treatment is expected to encourage the community to be more health-conscious and less fearful of seeking medical care.
Comparative Anti-Inflammatory Effect of Aceclofenac-Saccharin in Mice Granuloma Model Hendrizal Usman; Yufri Aldi; Salman Umar; Rahmadevi; Erizal Zaini
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49145

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
EFEKTIVITAS PENGGUNAAN ANALGETIK DI RUMAH SAKIT Prastiwi, Nindya; Nasif, Hansen; Aldi, Yufri
Jurnal Kesehatan - STIKes Prima Nusantara Vol 12 No 1 (2021): JURNAL KESEHATAN
Publisher : LPPM Universitas Prima Nusantara Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35730/jk.v12i1.401

Abstract

Pendahuluan : Nyeri merupakan keluhan yang paling sering diutarakan oleh pasien di rumah sakit. Nyeri yang masih dirasakan pasien setelah menerima analgesic, menandakan bahwa terdapat ketidakefektifan penggunaan analgetik pada pasien. Keefektifan penggunaan analgetik menentukan keberhasilan terapi.Tujuan : Mengetahui efektifitas penggunaan analgetik dalam penatalaksanaan nyeri pada pasien terutama dalam penggunaannya di Rumah Sakit.Metode : Literatur review. Strategi pencarian data yaitu adalah mencari langsung grey literatur melalui mesin pencarian data Google dan menggunakan database Google Scholar, Pubmed dan ScienceDirect  dengan kata kunci “Efektivitas Analgetik Rumah Sakit”. Research question dibuat dengan format PEOS dan penyaringan data menggunakan PRISMA Flowcart. Kriteria inklusi meliputi jurnal tentang efektivitas analgetic yang telah dipublikasi dalam sepuluh tahun terakhir (2010-2020), jurnal nasional dengan akreditasi sinta 1-6, dan jurnal internasional yang terindex scopus dengan ranking Q1-Q4. Kriteria eksklusi meliputi jurnal yang tidak terfokus membahas efektivitas analgetic atau intensitas nyeri, dan jurnal yang dengan metode review.Hasil : Dari 18 jurnal yang direview, Sebagian besar jurnal tersebut membahas perbandingan efektivitas antara dua atau lebih analgetik, baik  analgetik tunggal maupun kombinasi. Dari perbandingan tersebut penggunaan analgetic kombinasi dianggap efektif digunakan pengganti opioid.Kesimpulan : Efektivitas suatu analgetic dapat tercapai dengan baik bila disesuaikan dengan derajat nyeri pasien. Saat ini, penggunaan terapi multimodal  sering digunakan di rumah sakit, karena selain efektif menurunkan intensitas nyeri, kombinasi analgetik opioid dengan analgetik non narkotik mampu menekan efek samping yang ditimbukan oleh opioid, mengurangi ketergantungan penggunaan opioid pada pasien, serta mempercepat masa pemulihan, sehingga meningkatkan kepuasan pasien terhadap pelayanan kesehatan.
PENGARUH PAPARAN ASAP OBAT NYAMUK BAKAR TERHADAP KADAR ESTROGEN DAN KUALITAS SPERMATOZOA PADA MENCIT (Mus musculus) Eka Desnita; Almahdy Almahdy; Yufri Aldi; Fatma Sri Wahyuni; Dachriyanus; Rama Feriska Putra
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 12 No. 1 (2026): Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v12i1.989

Abstract

Penggunaan obat nyamuk bakar berbahan aktif piretroid masih luas di lingkungan rumah tangga dan berpotensi menimbulkan dampak terhadap sistem reproduksi akibat paparan asap hasil pembakaran. Penelitian ini bertujuan untuk menganalisis pengaruh paparan asap obat nyamuk bakar terhadap kualitas spermatozoa dan kadar estrogen serum. Penelitian eksperimental dilakukan pada Mus musculus yang dibagi menjadi kelompok kontrol dan kelompok paparan. Parameter yang diamati meliputi konsentrasi spermatozoa, morfologi spermatozoa, dan kadar estrogen serum, kemudian dianalisis secara statistik untuk menentukan perbedaan antar kelompok. Hasil penelitian menunjukkan bahwa paparan asap obat nyamuk bakar secara signifikan menurunkan konsentrasi spermatozoa dan meningkatkan persentase morfologi abnormal dibandingkan kelompok kontrol (p < 0,05). Kadar estrogen serum pada kelompok paparan menunjukkan kecenderungan menurun, namun tidak berbeda signifikan secara statistik (p > 0,05). Disimpulkan bahwa paparan asap obat nyamuk bakar berbasis piretroid berpotensi menurunkan kualitas spermatozoa dan memengaruhi regulasi hormonal. Temuan ini mengindikasikan adanya risiko gangguan fungsi reproduksi akibat paparan insektisida rumah tangga secara kronis.
Enhancement of Solubility, Dissolution, and Anti-Inflammatory Activity of Aceclofenac via Multicomponent Crystal Formation with Tromethamine Hendrizal Usman; Salman Umar; Yufri Aldi; Muhammad Nasrul Siregar; Erizal Zaini
JSFK (Jurnal Sains Farmasi & Klinis) Vol 13 No 1 (2026): J Sains Farm Klin 13(1), April 2026
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.13.1.28-37.2026

Abstract

Aceclofenac (ACE) is a non-steroidal anti-inflammatory drug (NSAID) widely used for osteoarthritis and rheumatoid arthritis, yet its therapeutic performance is limited by poor aqueous solubility as a Biopharmaceutics Classification System (BCS) Class II drug. This study aimed to enhance the physicochemical and pharmacological properties of ACE by forming a multicomponent crystal (MC) with tromethamine (TRIS). The MC was produced via solvent-dropped grinding in a 1:1 molar ratio and characterized by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and Fourier-transform infrared spectroscopy (FTIR). DSC and PXRD results indicated the formation of a eutectic system with reduced crystallinity, while FTIR showed intermolecular hydrogen bonding, evidenced by the broad OH stretching band near 3000 cm⁻¹, without new covalent bond formation. Solubility increased 35.8-fold relative to pure ACE, and dissolution testing showed a markedly improved dissolution efficiency (DE₆₀) of 75.33 ± 1.57% compared with 49.10 ± 0.54% for ACE alone. In vivo anti-inflammatory assessment using a carrageenan-induced granuloma pouch model further demonstrated superior pharmacological activity of the MC, significantly reducing exudate volume (0.56 mL) and TNF-α levels (25.26 pg/mL) versus pure ACE (0.82 mL and 29.70 pg/mL). Overall, the ACE–TRIS multicomponent crystal effectively enhances solubility, dissolution, and anti-inflammatory efficacy, offering a promising approach for improving ACE’s therapeutic performance.
Co-Authors . Yanwirasti AA Sudharmawan, AA Aan Ardiansyah Aan Ardiansyah Abdillah, Rahmad Abdullah Muhammad Faathir Adinny Julmiza Adinny Julmiza Aditya Alianta Aditya Alqamal Alianta Aditya Gufashar Adrul Fauzan Afifah Hulwah Afriwardi Afriwardi Airinisa, Salsa Dwi Akmal Djamaan Almahdy Almahdy Amanda, Diva Amri Bakhtiar Andani Eka Putra Andhini Aurellyta Ridwan Arfiandi Arfiandi Arif Setiawansyah Arifna Luthfianida Astari, Lita Tri Azukhruf, Wanda Sabila Ben, Elfi Sahlan Benardo Benardo Benardo Benardo Cindy Elvionita Dachriyanus Defani, Nabillah Puteri Dehan Fahresta Deni Anggraini Densi Selpia Sopianti Densi Selpia Sopianti Dian Handayani Dian Handayani Diana Laila Ramatillah Dwisari Dillasamola Dzaki, Muhammad Eka Desnita Elda Mayanti Elidahanum Husni Elisma Elisma Ellyza Nasrul Elmi Sariani Hasibuan Elsa Badriyah Elsa Badriyah Enda Markus Aginta Sembiring Erizal Zaini Erizal Zaini Erizal Zaini Fadilla, Utami Budhi Fashelia Azizaturrahmah Fatma Sri Wahyuni Fatma Sriwahyuni Febria, Nurma Fifi Harmely Fildzah Nurul Fajrin, Fildzah Nurul Friardi Ismed Fuadiyah, Alda Gita Susanti Gloria, Fransisca Gusriyani, Sri Habib Shidiq Akbar Hansen Nasif Hari, Dewi Gulyla Haris Munandar Nasution Havizur Rahman Hendrizal Usman Hendrizal Usman Herwinda Julia Putri Hulwa Salsabila Irianti, Dira Adhani Iva Rama Fitria Larisa Aurellia Vilonia Lubis, Minda Sari Lukas, Stefanus Lusi Octaviana M Asmadi Mahyudin Mahyudin Marlina . Mega Fatimah Rosana Michael Michael Muhammad Abdul Najib Muhammad Aidi Satryo Muhammad Fazly Muhammad Islamoyo Muhammad Nasrul Siregar Muhammad Rahil Dief Muhammad Syafrudin Nabila, Alya Puti Dwi Nadhira Yuri Maharani Nikita Surya Dharma Nila Kasuma Nindya Prastiwi Nisya Ogiana Novita Sari Nurliyasman Panggabean, Aminah Paulina, Ida Prastiwi, Nindya Purnawan Pontana Putra Rafita Yuniarti Rahmadevi Rahmadevi Rahmi Nofita Rama Feriska Putra Rama Feriska Putra Ramadhan, Fadli Pratama Ramadhani, Kesha Fadhiilah Ramatillah, Diana Laila Rozi Efendi Rury Trisa Utami Rustini Rustini Salman - Salman Salman Salman Umar Salman Umar Salman Umar Salman Umar Salman Umar Saniya De Nafisa Sayyida, Alya SILVIA PERMATA SARI, SILVIA PERMATA Sirda Yenni Siska Ferilda Siti Jannah Sri Oktavia Suci Sutma Suhatri Suhatri Sulaiman Sulaiman Surya Nelis Susi Susi Syakira, Azya Hana Syofyan Syofyan Tessa Amanda Primadhini Uce Lestari Usman, Hendrizal Vika Permata Gustam Wahyudi, Agung Aji Wanda Azukhruf Wida Ningsih Widya Faizatul Zuhri Widya Kardela Widya Nengsih Yahdian Rasyadi Yanelita Vipri Yanwirasti Yanwirasti Yaser Arafat Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yoneta Srangenge Yudistio Arnoza Yuliawati Zainini Arraysa Zet Rizal Zozy Aneloi Noli Zulmai Rani