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All Journal Dentika Dental Journal Jurnal Sains dan Teknologi Farmasi Science and Technology Indonesia Jurnal Kesehatan JSFK (Jurnal Sains Farmasi & Klinis) B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Jurnal Farmasi Higea Jurnal Prima Medika Sains JPK: Jurnal Proteksi Kesehatan Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Journal of Multidisciplinary Applied Natural Science FORTE JOURNAL Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Andalas Dental Journal Formosa Journal of Sustainable Research (FJSR) Jurnal Farmasi Indonesia Jurnal Pengabdian Harapan Ibu (JPHI)
Yufri Aldi
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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POTENSI SENYAWA BROMELIN DALAM BEBERAPA PENGUJIAN TOKSISITAS FARMAKOLOGI Rama Feriska Putra; Salman Umar; Yufri Aldi; Afriwardi Afriwardi
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.865

Abstract

Bromelin merupakan enzim dengan aktivitas proteolitik khusus yang dapat diperoleh dari batang nanas (Ananas comosus), dimana telah menarik perhatian dalam berbagai aplikasi farmakologis dan medis. Studi ini menggambarkan potensi senyawa bromelin dalam beberapa uji toksisitas praklinis. Bromelin telah terbukti memiliki aktivitas antiedematous, antitrombotik, antiinflamasi, dan antikanker. Meskipun khasiatnya telah banyak diteliti, evaluasi toksisitas farmakologinya perlu diperhatikan untuk memahami batas dosis yang aman dan potensi efek samping. Dengan menggunakan desain literatur review, studi ini menyajikan temuan-temuan positif toksisitas rendah bromelin pada beberapa hewan uji, termasuk efek perlindungan terhadap sistem reproduksi pria dan potensi neuroprotektif. Meskipun hasil positif ini menunjukkan potensi terapeutik, perlu dilakukan penelitian lebih lanjut pada tingkat klinis dan preklinis untuk memvalidasi temuan ini sebelum mengaplikasikannya secara luas dalam konteks medis.
Hubungan Sosiodemografi dengan Hasil Klinis Pasien Covid-19 di RSUD Bengkulu Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Gloria, Fransisca; Michael, Michael; Wahyudi, Agung Aji; Astari, Lita Tri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 1 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.839 KB) | DOI: 10.35617/jfionline.v14i1.59

Abstract

Coronavirus disease 2019 (Covid-19) adalah penyakit menular yang disebabkan oleh SARS-CoV-2 yang memiliki bentuk dan perilaku menyerupai virus SARS. Persentase angka kematian nasional adalah 4,23, yang berada di atas angka kematian rata-rata nasional. Tujuan penelitian untuk mengetahui faktor-faktor apa saja yang berhubungan dengan kematian pasien Covid-19 di RS Pemerintah Bengkulu.Dengan tujuan Mengetahui hubungan sosiodemografi dengan luaran klinis pasien COVID-19 di Bengkulu.dengan metode Penelitian kohort retrospektif dilakukan dalam penelitian ini. Penelitian ini hanya melibatkan pasien terkonfirmasi COVID-19, dengan total sampel 127 pasien yang dirawat di rumah sakit selama April, Mei, dan Juni 2021.Dan mendapatkan hasil Semua pasien yang dirawat di Rumah Sakit Pemerintah Bengkulu antara April dan Juni 2021 menggunakan azitromisin atau levofloxacin + oseltamivir + vitamin sebagai pengobatan. Hasil dari infeksi covid-19 memiliki beberapa faktor korelasi yang signifikan: usia (0,0001), pekerjaan (0,0001) dan penyakit penyerta (0,0001). Kesimpulan Outcome klinis terburuk paling banyak ditemukan pada pasien yang menderita Diabetes dan berusia lebih dari 50 tahun.
Evaluasi Hasil Klinis Pada Tim Medis yang Mendapat Vaksinasi Booster di Rumah Sakit Bengkayang Kalimantan Barat Lukas, Stefanus; Ramatillah, Diana Laila; Aldi, Yufri; Wahyuni, Fatma Sri; Paulina, Ida; Gloria, Fransisca; Michael, Michael
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 14 No. 2 (2022): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.685 KB) | DOI: 10.35617/jfionline.v14i2.70

Abstract

Abstract: In reducing the risk of transmission to health workers, the Government has given the 3rd Booster Covid-19 Vaccination since August 2021. This study uses the Astra Zeneca Vaccine, Moderna Vaccine and Pfizer Vaccine. The purpose of this study was to evaluate the effectiveness of the 3rd Booster vaccine and the clinical outcomes of post-vaccination health workers at West Kalimantan Hospital. Research method Observational Cross-sectional Prospective by conducting questionnaires and interviewing health workers. Samples were taken by convenience sampling and statistical analysis of chis-square. The research instrument used a questionnaire distributed in the hospital. In the study, it was found that as many as 12.60% (14 out of 118 health workers) were infected with Covid-19. The habit that influenced the effectiveness of the 3rd booster vaccination was sunbathing (p <0.05). The low severity of health workers infected with Covid-19 after the 3rd booster vaccine can be seen from the place of treatment, namely 97% independent isolation, 60% without using antivirals and 77% without using antibiotics. The type of vitamin that is most widely used is vitamin C. Hence with this booster vaccination aims to prevent and reduce the severity of patients who contract Covid-19 after vaccination.
Traditional Herb Used and Training on Preparation Moringa oleifera Lam. Herb as Dip and Capsules Yufri Aldi; Salman Umar; Aditya Alqamal Alianta; Elidahanum Husni
Warta Pengabdian Andalas Vol 31 No 1 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.1.108-115.2024

Abstract

Moringa leaves have grown abundantly in the 50 Kota Regency area. Studies have been carried out regarding moringa leaves, and research has shown that moringa leaves are effective as a medicine to increase the body's immunity. The community needs to know and understand the benefits of Moringa leaves. Based on that circumstance, the Community Service regarding how to process the Moringa leave to be dip preparation and capsule has been conducted in Jorong Padang Kandis, VII Koto Talago Sub-district, Guguk District, 50 Kota Regency, West Sumatra. The activity was carried out on 19 August 2023. The participants were the Family Welfare Movement (PKK) and Bundo Kandung groups in Jorong Padang Kandis, attended by 100 participants. The method was lectures and training on preparing Moringa herb leaf preparations and making Moringa leaf capsules, which the community can use directly. Community services topics were "The Utilisation of Traditional Medicines" and "The Efficacy and Research Results of Moringa Leaves." The training was on making Moringa leaf powder based on suitable traditional medicine-making methods, such as dips and capsules from Moringa leaf powder and extract. Community service helped the community understand that Moringa leaves can be used as a traditional medicine to protect the body from infection with microorganisms. The community also made powder packaged as a dip preparation, used like tea bags and put it into capsules.
Comparative Anti-Inflammatory Effect of Aceclofenac with Saccharin and Aceclofenac in Carrageenan-Induced Granuloma Pouch Model in Mice Usman, Hendrizal; Umar, Salman; Aldi, Yufri; Rahmadevi, Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.48792

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
EDUKASI PENYULUHAN OBAT DAN PENGOBATAN GRATIS BAGI MASYARAKAT DI DESA PERKAMPUNGAN ADAT SIJUNJUNG Dillasamola, Dwisari; Srangenge, Yoneta; Ardiansyah, Aan; Aldi, Yufri; Wahyuni, Fatma Sri; Husni, Elidahanum; Abdillah, Rahmad; Julmiza, Adinny; Benardo, Benardo
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 7 No. 2 (2024)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v7i2.600

Abstract

Community health education is crucial, including education on the rational use of antibiotics, as well as halal food and medicine. Additionally, providing free medical treatment has a significant impact, encouraging the community to prioritize health and maintain it as a primary concern. This community service project was conducted in the Desa Perkampungan Adat Sijunjung. The objective of this activity is to maintain and improve the community's health status. One way to achieve this is through community service activities. The service involved educational sessions on medicines and health, as well as free medical treatment, in collaboration with the Faculty of Pharmacy and the Faculty of Medicine at Universitas Andalas. The education targeted pregnant women and the elderly, focusing on proper medication selection, rational use of antibiotics, and education on halal medicines and food. Free medical treatment involved specialist doctors and pharmacists, who also provided counseling on medications to patients. The results of the activity showed high community enthusiasm, with more than 100 prescriptions filled. The education on the rational use of medications, particularly antibiotics, is expected to increase community awareness and knowledge. This activity also highlights the importance of pharmacists in providing patient-oriented pharmaceutical services, as well as the importance of promotional and preventive efforts in maintaining public health. It can be concluded that free medical treatment is expected to encourage the community to be more health-conscious and less fearful of seeking medical care.
Comparative Anti-Inflammatory Effect of Aceclofenac-Saccharin in Mice Granuloma Model Usman, Hendrizal; Aldi, Yufri; Umar, Salman; Rahmadevi; Zaini, Erizal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49145

Abstract

Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) and suppresses prostaglandin synthesis. Its clinical utility, however, is limited by poor aqueous solubility and low bioavailability. This study evaluates the anti-inflammatory activity of a multicomponent crystal (MC) of aceclofenac with saccharin using a carrageenan-induced granuloma pouch model in mice. Male mice were divided into three groups (n = 3 per group): control, aceclofenac, and aceclofenac-saccharin multicomponent crystal, administered intraperitoneally. Inflammatory response was assessed via exudate volume and TNF-α levels. Both aceclofenac and MC significantly reduced exudate volume and TNF-α compared to the control (p < 0.05), with the MC group showing the greatest reduction. Although not statistically different from aceclofenac in TNF-α suppression, the MC demonstrated superior performance overall. The enhanced efficacy may be attributed to improved solubility and drug delivery. These outcomes support co-crystallization as a promising approach to optimize NSAID therapy.
Manisnya Inovasi Herbal: Pelatihan Pembuatan Permen Jelly Jahe sebagai Camilan Fungsional Lokal di Nagari Batu Kalang Utara Dillasamola, Dwisari; Yufri Aldi; Zozy Aneloi Noli; Uce Lestari; Dehan Fahresta; Abdullah Muhammad Faathir; Aditya Gufashar; Afifah Hulwah; Andhini Aurellyta Ridwan; Fashelia Azizaturrahmah; Habib Shidiq Akbar; Iva Rama Fitria; Larisa Aurellia Vilonia; Lusi Octaviana; Muhammad Fazly; Muhammad Abdul Najib; Muhammad Aidi Satryo; Muhammad Rahil Dief; Nadhira Yuri Maharani; Novita Sari; Saniya De Nafisa; Widya Faizatul Zuhri; Vika Permata Gustam; Yudistio Arnoza; Zainini Arraysa
Jurnal Pengabdian Harapan Ibu (JPHI) Vol. 7 No. 3 (2025): Jurnal Pengabdian Harapan Ibu (JPHI)
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/jphi.v7i3.1126

Abstract

The community service activity aimed to enhance public understanding and skills in utilizing ginger (Zingiber officinale) as a natural ingredient for functional food through the production of jelly candy. This initiative was motivated by the low level of public knowledge, as indicated by pre-test results showing limited understanding of the health benefits and processing techniques of ginger. The activity consisted of educational sessions, demonstrations, and hands-on practice on jelly candy production using natural ingredients, including ginger extract, sugar, jelly powder, vanilla, salt, and cinnamon. Evaluation through post-tests, interactive quizzes, and observation of practical sessions demonstrated a significant improvement in participants’ knowledge and skills. Participants showed enthusiasm and were able to independently produce ginger-based jelly candy. This program not only increased public literacy on the use of herbal ingredients but also encouraged the development of small-scale functional snack enterprises. Future implementations are expected to expand to other communities with continuous mentoring to strengthen economic and health impacts.
Co-Authors . Yanwirasti AA Sudharmawan, AA Aan Ardiansyah Abdullah Muhammad Faathir Adinny Julmiza Aditya Alqamal Alianta Aditya Gufashar Adrul Fauzan Afifah Hulwah Afriwardi Afriwardi Akmal Djamaan Amri Bakhtiar Andani Eka Putra Andhini Aurellyta Ridwan Ardiansyah, Aan Arfiandi Arfiandi Arif Setiawansyah Astari, Lita Tri Azukhruf, Wanda Sabila Ben, Elfi Sahlan Benardo Benardo Benardo, Benardo Dachriyanus Dehan Fahresta Deni Anggraini Densi Selpia Sopianti Densi Selpia Sopianti Dewi Gulyla Hari Dian Handayani Dian Handayani Diana Laila Ramatillah Dwisari Dillasamola Elda Mayanti Elidahanum Husni Elisma Elisma Ellyza Nasrul Elsa Badriyah Enda Markus Aginta Sembiring Erizal Erizal Erizal Zaini Fadilla, Utami Budhi Fashelia Azizaturrahmah Fatma Sri Wahyuni Fatma Sriwahyuni Febria, Nurma Fifi Harmely Fildzah Nurul Fajrin, Fildzah Nurul Friardi Ismed Gita Susanti Gloria, Fransisca Gusriyani, Sri Habib Shidiq Akbar Hansen Nasif Havizur Rahman Herwinda Julia Putri Hulwa Salsabila Iva Rama Fitria Julmiza, Adinny Larisa Aurellia Vilonia Lukas, Stefanus Lusi Octaviana M Asmadi Mahyudin Mahyudin Marlina . Michael Michael Muhammad Abdul Najib Muhammad Aidi Satryo Muhammad Fazly Muhammad Islamoyo Muhammad Rahil Dief Muhammad Syafrudin Nadhira Yuri Maharani Nikita Surya Dharma Nila Kasuma Nindya Prastiwi Nisya Ogiana Novita Sari Nurliyasman Panggabean, Aminah Paulina, Ida Prastiwi, Nindya Rahmad Abdillah Rahmad Abdillah Rahmadevi Rahmi Nofita Rama Feriska Putra Ramatillah, Diana Laila Rozi Efendi Rury Trisa Utami Rustini Rustini Salman - Salman Salman Salman Umar Salman Umar Salman Umar Saniya De Nafisa Sayyida, Alya Sirda Yenni Srangenge, Yoneta Sri Oktavia Suci Sutma Suhatri Suhatri Surya Nelis Susi Susi Syofyan Syofyan Uce Lestari Usman, Hendrizal Vika Permata Gustam Wahyudi, Agung Aji Widya Faizatul Zuhri Widya Kardela Widya Nengsih Yahdian Rasyadi Yanelita Vipri Yanwirasti Yanwirasti Yaser Arafat Yelly Oktavia Sari Yohannes Alen Yoneta Srangenge Yudistio Arnoza Zainini Arraysa Zet Rizal Zozy Aneloi Noli