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All Journal Jurnal Pendidikan Biologi Undiksha Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Medula Indonesian Journal of Urology Bioeksperimen: Jurnal Penelitian Biologi Jurnal Penelitian Pertanian Terapan Paediatrica Indonesiana Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Jurnal Ilmu Medis Indonesia AMMA : Jurnal Pengabdian Masyarakat Bioma : Jurnal Biologi dan Pembelajaran Biologi IJIS Edu : Indonesian Journal of Integrated Science Education
Hendri Busman
Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Medula

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Review Artikel : Aktifitas Hepatoprotektor Pada Tanaman Herbal Hanifah, Farah; Busman, Hendri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1087

Abstract

The liver plays a vital role in the human body, serving as a site for the metabolism of fats, carbohydrates, and proteins, as well as detoxification of toxic compounds, bile salt formation, and vascular function. Liver damage can be caused by various factors, including drugs, infections, alcohol, autoimmune disorders, or hepatitis. Substances that induce liver damage are known as hepatotoxins, commonly including NSAIDs like paracetamol and carbon tetrachloride (CCl4). Chronic hepatitis is a significant global issue, including in Indonesia, with hepatitis B and hepatitis C viruses being the most common causes. Herbal medicine is increasingly being used for health benefits worldwide, contributing significantly to human health in preventive, curative, and rehabilitative aspects. Indonesia, rich in biodiversity, presents numerous opportunities for plants with potential hepatoprotective properties. Various herbal plants containing flavonoid compounds have been found to possess anti- inflammatory and antioxidant properties. These bioactive compounds, particularly flavonoid derivatives, act as potential antioxidant prophylactic agents, crucial in protecting against liver lesions induced by CCl4. Reactive oxygen species (ROS) are believed to be responsible for the pathogenesis of various liver diseases, and studies have shown the efficacy of herbal extracts in reducing ROS levels and lipid peroxidation in ethanol-induced liver damage. Several herbal plants exhibit hepatoprotective activities, including turmeric, bee pollen honey, cinnamon, eclipta alba, Tinospora cordifolia, Mimosa pudica, and Cassia fistula L. These plants have shown effects such as antioxidant, anti-inflammatory, and antiviral properties, contributing to the protection and regeneration of liver cells, inhibition of viral replication, and modulation of immune responses. In conclusion, numerous herbal plants exhibit hepatoprotective activities through various mechanisms, including antioxidant, anti-inflammatory, antiviral, and immunomodulatory effects. Further research and exploration of these plants' therapeutic potential could lead to the development of effective treatments for liver diseases.
Phosphatidylserine Exposure in Thalassemia Β Patients Sangging, Putu Ristyaning Ayu; Sutyarso, Sutyarso; Busman, Hendri
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1162

Abstract

Thalassemia is a genetic disorder that involves the formation of abnormal hemoglobin. Thalassemia is divided into two main categories namely alpha and beta thalassemia depending on the hemoglobin chain affected. Although some categories of thalassemia are mild and cause only mild anemia and iron deficiency problems in patients, other, more severe forms of thalassemia can result in death. Thalassemia sufferers can get treatment according to the severity of the condition. The degree of ineffective erythropoiesis is known to be associated with clinical severity in individuals with thalassemia. However, the association of ineffective erythropoiesis biomarker levels with different thalassemia genotypes is limited. Studies have explored levels of red blood cells exposed to phosphatidylserine and ineffective erythropoiesis biomarkers in patients with different genotypes. Based on the results of the review, beta thalassemia patients have the highest GDF-15 levels, followed by patients with non-deletal alpha thalassemia. Patients with non-delesional alpha thalassemia showed elevated hemoglobin levels and decreased GDF-15 levels after splenectomy. Patients with beta thalassemia and non-delesional alpha thalassemia had the highest levels of red blood cell exposure to PS and ineffective erythropoiesis biomarkers, which correlated with the clinical severity of thalassemia. Differences in erythropoiesis rates are not effective in thalassemia, which emphasizes the need for different treatment approaches in patients with different thalassemia genotypes.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter
Literature Review: Antioxidant Activity of Water Apple Leaves (Syzygium aqueum) Justisia, Adilla; Susianti; Jausal, Anisa Nuraisa; Busman, Hendri
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1321

Abstract

Antioxidant is a complex inhibit, prevent or dampen the reactions of free radicals and oxidants, as well as to prevent tissue damage. Antioxidant works by donating one of its electron to oxidant compounds thereby inhibiting the activity of these oxidant compounds. An imbalance between antioxidants and free radicals, where free radicals are more prevalent, can damage molecular organisms and cause oxidative stress that triggers damage to body cells. Oxidative damage to DNA triggers mutations that initiates cancer, cardiovascular disease, neurodegenerative disorder, autoimmune diseases, aging processes and several hereditary diseases. Currently, the use of natural antioxidants as traditional treatments is widely consumed by the community. Natural antioxidants are found in several plant sources, it is known to be more affordable and have lower side effects, making it as popular treatment choice in the community. One of the plants with a high antioxidant content is the water apple leaf (Syzygium aqueum) which rich in flavonoids, phenolics, and tannins. DPPH (2,2-diphenyl-1-picrylhydrazyl) is a common method to measure antioxidant activity, it works with the principle of hydrogen capture from antioxidants by free radicals. The parameter IC50 is used to represents the sample concentration required to capture 50% of DPPH radicals. Several studies using the DPPH method have shown that water apple leaves have strong antioxidant activity, indicated by its low IC50 value. The lower the IC50 value, the stronger the antioxidant activity.
Co-Authors Adli, Farhan Kamali Alqoriani A, Ostarica Ananta, Yoga Andriani, Silvia Angelia, Tisa Arofah, Nur Lailatul Ayu Ayssca Besty Prastiwy, Ayu Ayssca Azizah, Nailul Bayu Putra DJ Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Endang Nurcahyani Ernawiati, Eti Farisi, Salman Gina Dania Pratami, Gina Dania Ginting, Bisart Giska Tri Putri Hadibrata, Exsa Hanifah, Farah Hendri Tarigan S Indri Windarti Indriyani Indriyani Indriyani Intanri Kurniati Iswandi Darwis Jausal, Anisa Nuraisa Justisia, Adilla Karina, Salwa Al Khairun Nisa Kurniawaty, Evi Kurniawaty, Evi Kurniawaty Leni Ervina, Leni Muhammad Ilyas Muhartono Muhartono Muhartono Sudarmo Kasban Mumtazah, Dzul Fithria NA, Ahmad Mufid Nuning Nurcahyani Nursidiq, Iqbal Muhammad Rafi Puspa, Egita Windrianatama Putri, Lolyta Mutiara Rahmanisa, Soraya Rahmanisa Ramdini, Dwi Aulia Rosa, Emantis RR. Ella Evrita Hestiandari Safitri, Dewi Restika Ayu Sahroni, Mizan Sangging, Putu Ristyaning Ayu Sarasati, Filia Sembiring, Rinawati Septiani, Linda suratman Susanto, Gregorius Nugroho Susianti Susianti, Susianti Sutyarso Sutyarso Sutyarso Syakir, Muhammad Addin Syarif, Muhammad Reza Syazili Mustofa Tengku Riza Zarzani N Utami, Hanifa Fauzia Yolanda, Jennifer Ester Yulianty Yuningrum, Hesti