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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Nusantara Medical Science Journal Jurnal Pendidikan Informatika dan Sains Jurnal Fitofarmaka Indonesia Jurnal Kreativitas PKM Jurnal Ilmu Kedokteran dan Kesehatan Pontianak Nutrition Journal (PNJ) ISM (Intisari Sains Medis) : Jurnal Kedokteran Medika Kartika : Jurnal Kedokteran dan Kesehatan Klabat Journal of Nursing Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Indonesia Sosial Sains Mestaka: Jurnal Pengabdian Kepada Masyarakat Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Innovative: Journal Of Social Science Research GEMBIRA (Pengabdian Kepada Masyarakat) Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Journal of Pharmascience
Mistika Zakiah
Departemen Farmakologi, Fakultas Kedokteran, Universitas Tanjungpura
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GAMBARAN SELF EFFICACY, SELF CARE MANAGEMENT, DAN KEPATUHAN PENGOBATAN PASIEN HIPERTENSI DI POSYANDU LANSIA Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Zakiah, Mistika; Ulfah, Ridha; Putri, Triyana Harlia
Klabat Journal of Nursing Vol. 6 No. 2 (2024): Nursing - World's Buoyant
Publisher : Fakultas Keperawatan, Universitas Klabat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37771/kjn.v6i2.1164

Abstract

Keluhan tentang masalah kesulitan tidur di waktu malam hari sering terjadi pada lansia. Kesulitan tidur dapat berpengaruh terhadap kualitas tidur lansia ditandai dengan masih banyaknya lansia yang sering mengalami terbangun dimalam hari. Guide imagery merupakan salah satu terapi non farmakologi yang sering digunakan untuk mengatasi masalah gangguan tidur dan dapat bermamfaat untuk menurunkan kecemasan, nyeri, dan memfasilitasi kualitas tidur yang baik. Penelitian ini bertujuan untuk mengetahui pengaruh Teknik relaksasi guide imagery terhadap kualitas tidur pada lansia di wilayah kerja puskesmas Jatijajar kota Depok. Metode penelitian ini mengunakan one group pretest-post test design. Teknik pengambilan sampel menggunakan Teknik Purposive sampling dengan jumlah sampel 10 lansia. Alat ukur yang digunakan adalah kuesioner PSQI. Hasil tes statistik uji paired sample t-tes didapatkan hasil kualitas tidur sebelum diberikan intervensi pada 10 lansia dengan nilai mean 8,50, dan setelah diberikan intervensi mean 4,50. Perbedaan nilai dari kedua variabel (mean difference) menunjukkan bahwa p-value <0,05. Kesimpulan dalam penelitian ini adalah ada pengaruh pemberian teknik relaksasi guide imagery terhadap kualitas tidur pada lansia. Saran bagi masyarakat agar dapat memberi dukungan pada keluarga untuk melakukan terapi relaksasi guide imageri agar dapat membantu dan memperbaiki kualitas tidur pada lansia. Complaints about difficulty sleeping at night often occur in the elderly. Difficulty sleeping can affect the sleep quality of the elderly, as indicated by the fact that many elderly people often wake up at night. Guided imagery is a non-pharmacological therapy that is often used to treat sleep disorders and can be useful for reducing anxiety, pain and facilitating good quality sleep. This study aims to determine the effect of guided imagery relaxation techniques on sleep quality in the elderly in the Jatijajar health center working area, Depok city. This research method uses a one group pretest-post test design. The sampling technique used purposive sampling technique with a sample size of 20 elderly people. The measuring instrument used is the PSQI questionnaire. The results of the statistical test of the paired sample t-test showed that the quality of sleep before the intervention was given to 20 elderly people with a mean value of 8.50, and after being given the intervention the mean was 4.50. The difference in the values ​​of the two variables (mean difference) shows that the p-value is <0.05. The conclusion of this research is that there is an influence of providing guided imagery relaxation techniques on sleep quality in the elderly. Suggestions for the community to provide support to families to carry out guided imagery relaxation therapy in order to help and improve sleep quality in the elderly.
Gambaran Pengetahuan Ibu Mengenai Infeksi Saluran Pernapasan Akut (ISPA) Pada Balita di Puskesmas Tanjung Sekayam Kecamatan Kapuas Kabupaten Sanggau Imaddudin, Muhammad Difa; Windarti, Wiwik; Zakiah, Mistika
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19694

Abstract

Latar Belakang: Infeksi Saluran Pernapasan Akut (ISPA), terutama jenis pneumonia, masih menjadi salah satu penyebab utama kematian pada anak balita di Indonesia, dengan angka kontribusi mencapai 22,30% dari keseluruhan kematian pada kelompok usia tersebut. Tingkat pengetahuan ibu berperan penting dalam upaya pencegahan serta deteksi dan penanganan dini kasus ISPA pada balita. Metode: Penelitian ini menerapkan desain deskriptif dengan pendekatan cross-sectional. Sebanyak 98 responden ibu dipilih menggunakan metode accidental sampling. Pengumpulan data dilakukan melalui kuesioner terstruktur yang dirancang untuk mengevaluasi pengetahuan ibu mengenai ISPA pada balita. Analisis data dilakukan secara univariat dengan menggunakan skala Guttman. Hasil: Dari total responden, sebanyak 32 orang (32,6%) memiliki tingkat pengetahuan yang baik, 38 orang (38,8%) memiliki pengetahuan sedang, dan 28 orang (28,6%) memiliki pengetahuan kurang terkait ISPA. Kesimpulan: Hasil penelitian menunjukkan bahwa sebagian besar ibu memiliki tingkat pengetahuan sedang mengenai ISPA pada anak balita, yang menekankan perlunya intervensi edukatif yang lebih terarah.
Peningkatan Pengetahuan Dampak Perjudian bagi Kesehatan Mental Remaja Putri, Triyana Harlia; Ulfah, Ridha; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Zakiah, Mistika; Tyas, Tri Wahyuning; Khansa, Marsyabila Puspa; Agustina, Vanisia
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 11 (2024): Volume 7 No 11 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i11.17523

Abstract

ABSTRAK Bermain menjadi salah satu karakteristik yang remaja yang dalam fase ini akan terus berkembang hingga dewasa. Permainan di masa kini tidak pula luput memanfaatkan internet, dimana internet merupakan satu kesatuan dengan kehidupan manusia karena menjadi suatu kebutuhan, tidak terkecuali remaja. Game online merupakan salah satu permainan yang mengakses internet yang berujung pada aktivitas berjudi. Judi menjadi hal yang menarik di luar permainan itu sendiri. Perjudian memiliki dampak yang menganggu kesehatan mental hingga terjadinya bunuh diri, oleh sebab itu apabila masalah perjudian tidak diinformasikan dengan tepat dan jelas, maka remaja berisiko terjebak dalam perjudian karena belum bijak dalam menentukan pilihan. Tujuan dari pelaksanaan kegiatan ini adalah meningkatkan pengetahuan remaja berkaitan dengan dampak dari perilaku perjudian pada kesehatan mental. Sasaran dalam kegiatan ini remaja SMP Negeri 5 Kota Pontianak sebanyak 30 siswa/i. Kegiatan diawali dengan membuka sesi diskusi,pre-test dan Post-Test pengetahuan diikuti dengan penyerahan buku saku serta link video edukasi. Hasil test pengetahuan siswa mengenai perjudian sebelum dan sesudah diberikan edukasi dengan rerata pre-test (5,55, SD=0,31) dan rerata post-test (7,10, SD=1,01), hasil analisis t-test didapatkan p-Value=0,004, sehingga dapat disimpulkan terdapat perbedaan tingkat pengetahuan sebelum diberikan edukasi dengan sesudah diberikan edukasi. Kata kunci: Kesehatan Jiwa, Perjudian, Remaja, Sekolah   ABSTRACT Playing is one of the characteristics of teenagers who in this phase will continue to develop into adults. Games today also do not escape the use of the internet, where the internet has become a part of human life and a necessity, including teenagers. Online games are one of the games that access the internet which ends in gambling activities. Gambling is an interesting thing outside the game itself. Gambling has an impact that interferes with mental health to suicide, therefore if the problem of gambling is not informed properly and clearly, then teenagers are at risk of being trapped in gambling because they are not wise in making choices. The purpose of implementing this activity is to increase adolescent knowledge related to the impact of gambling behavior on mental health. The target in this activity is teenagers of SMP Negeri 5 Pontianak City as many as 30 students. The activity began by opening a discussion session, pre-test and post-test knowledge followed by the submission of pocket books and educational video links. The results of the students' knowledge test regarding gambling before and after being given education with a pre-test average (5.55, SD=0.31) and a post-test average (7.10, SD=1.01), the results of the t-test analysis obtained p-Value=0.004, so it can be concluded that there is a difference in the level of knowledge before being given education and after being given education. Keywords: Adolescents, Gambling, Mental Health, School
Program Edukasi Kontrol Tekanan Darah, Cara Penggunaan Obat Anti Hipertensi yang Benar dan Self Management untuk Peserta Prolanis dengan Ceramah Interaktif di Puskesmas Kampung Dalam Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Zakiah, Mistika; Ulfah, Ridha; Putri, Triyana Harlia
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 8 (2024): Volume 7 No 8 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i8.15770

Abstract

ABSTRAK Hipertensi yang tidak terkontrol dapat menimbulkan komplikasi gagal jantung, sindrom metabolik yang memicu diabetes, penyakit jantung, stroke, demensia, dan sebagainya. Penelitian sebelumnya di wilayah kerja Puskesmas Kampung Dalam mayoritas pasien hipertensi dan mayoritas pasien tidak patuh terhadap terapi antihipertensi. Terdapat hubungan antara tingkat hipertensi dengan kepatuhan pasien. Kepatuhan Pasien berhubungan juga dengan tingkat pengetahuan pasien. Edukasi mengenai kontrol tekanan darah, cara penggunaan obat antihipertensi yang benar dan self-management pada peserta prolanis di wilayah kerja Puskesmas Kampung dalam dalam upaya meningkatkan pengetahuan masyarakat mengenai hipertensi. Ceramah interaktif yang diawali dengan pretest dan diakhiri posttest untuk mengukur pengetahuan responden. 41 orang pasien peserta prolanis mengikuti edukasi, terdapat peningkatan pengetahuan yang diukur dari peningkatan nilai posttest (70,73%) peserta yang mengikuti kegiatan edukasi. Kegiatan edukasi mengenai kontrol tekanan darah, cara penggunaan obat antihipertensi yang benar dan self-management dengan metode ceramah interaktif meningkatkan pengetahuan peserta prolanis di wilayah kerja Puskesmas Kampung Dalam. Edukasi dalam upaya meningkatkan pengetahuan masyarakat mengenai hipertensi perlu dilakukan secara rutin agar derajat kesehatan masyarakat dapat meningkat seiring waktu. Kata Kunci: Edukasi Komprehensif, Self-management, Hipertensi, Prolanis  ABSTRACT Uncontrolled hypertension can lead to complications of heart failure, metabolic syndrome that triggers diabetes, heart disease, stroke, dementia, and so on. Previous research in the work area of Puskesmas Kampung, the majority of patients with hypertension and the majority of patients were not compliant with antihypertensive therapy. There is a relationship between the level of hypertension and patient compliance. Patient compliance is also related to the level of patient knowledge. To educate participants of the Prolanis program in the Kampung Dalam Public Health Center's service area on blood pressure control, proper use of antihypertensive medication, and self-management, in an effort to increase public knowledge about hypertension. Interactive lecture that begins with a pretest and ends with a posttest to measure respondents' knowledge. 41 patients participating in prolanis participated in education, there was an increase in knowledge as measured by an increase in posttest scores (70.73%) of participants who participated in educational activities. Educational activities regarding blood pressure control, correct use of antihypertensive drugs and self-management with Interactive lecture methode increase the knowledge of prolanis participants in the Puskesmas Kampung Dalam area. Education efforts to increase public knowledge about hypertension need to be carried out regularly so that the overall health status of the community can improve over time. Keywords: Comprehensive Education, Self-Management, Hypertension,Prolanis
Dukungan Kesehatan Jiwa Bersama Teman Sebaya melalui Program Duta Kesehatan Jiwa Sekolah Putri, Triyana Harlia; Ulfah, Ridha; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Zakiah, Mistika; Luthfi, Muhammad; Rahman, Ainun Najib Febrya; Seprian, Dwin; Septiani, Haryati; Priyono, Djoko
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 11 (2024): Volume 7 No 11 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i11.17522

Abstract

ABSTRAK Masalah kesehatan jiwa yang muncul pada remaja dapat menganggu perkembangan remaja. Peran teman sebaya untuk menerima dan merangkul teman yang lainnya merupakan salah satu faktor penting seorang remaja untuk merasa diterima dilingkungan sosialnya. Dukungan teman sebaya dapat berkontribusi dalam mengidentifikasi masalah kesehatan jiwa pada kelompok remaja. Oleh sebab itu diperlukan dukungan kesehatan jiwa dan psikososial (DKJPS) yang didapatkan oleh teman sebaya melalui duta kesehatan jiwa sekolah. Tujuan dari pelaksanaan kegiatan ini adalah meningkatkan kesiapsiagaan sekolah melalui dukungan kesehatan jiwa dengan program duta kesehatan jiwa sekolah. Kegiatan diawali dengan pembagian pernyataan Pre-Test pengetahuan mengenai peran serta sebagai duta kesehatan jiwa, lalu memberikan desiminasi ilmu berupa masalah kesehatan jiwa pada remaja, duta kesehatan jiwa, serta peran dan fungsinya. Selanjutnya, membuka sesi diskusi, dan yang terakhir memberikan Post-Test pengetahuan. Pengetahuan siswa terkait dengan peran duta kesehatan jiwa dengan rerata pengetahuan sebelum (4,51 SD=2,23) dan sesudah (9,08 SD=1,51) dengan hasil analisa t-test sebesar p=0,001 yakni terdapat pengaruh desiminasi ilmu dalam meningkatkan pengetahuan serta meningkatkan peran duta sebagai dukungan teman sebaya. Duta kesehatan jiwa dapat berperan dengan maksimal agar masalah kesehatan jiwa di sekolah dapat diidentifikasi dan mendapatkan penanganan yang tepat. Kata kunci: Duta, Kesehatan Jiwa, Remaja   ABSTRACT Mental health problems that arise in adolescents can interfere with adolescent development. The role of peers to accept and embrace other friends is one of the important factors for an adolescent to feel accepted in their social environment. Peer support can contribute to identifying mental health problems in adolescent groups. Therefore, mental health and psychosocial support (DKJPS) is needed which is obtained by peers through school mental health ambassadors. The purpose of implementing this activity is to improve school readiness through mental health support with the school mental health ambassador program. The activity began with the distribution of Pre-Test statements of knowledge regarding the role of mental health ambassadors, then providing dissemination of knowledge in the form of mental health problems in adolescents, mental health ambassadors, and roles and functions. Furthermore, opening a discussion session, and finally providing Post-Test knowledge. Student knowledge related to the role of mental health ambassadors with an average knowledge before (4.51 SD = 2.23) and after (9.08 SD = 1.51) with the results of the t-test analysis of p = 0.001, namely there is an influence of dissemination of knowledge in increasing knowledge and increasing the role of ambassadors as peer support. Mental health ambassadors can play a maximum role so that mental health problems in schools can be identified and receive appropriate treatment. Keywords: Adolescents; Ambassadors; Knowledge
The Relationship of Characteristics of Hypertensive Patients to the Level of Adherence to Taking Hypertension Medication at the Pal Tiga Health Center, Pontianak Zakiah, Mistika; Saputra, Restu; Redha, Muhammad; Deni, Muhammad; Ansharullah, Ansharullah
Jurnal Indonesia Sosial Sains Vol. 5 No. 07 (2024): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v5i07.1179

Abstract

Background: One of the non-communicable diseases that is a serious health problem today is hypertension. It is often referred to as the silent killer because sufferers usually do not know they have hypertension before checking their blood pressure. Objective: To determine the relationship between patient characteristics (education, level of knowledge, and BPJS safety) and the level of adherence to hypertension medication at the Pal Tiga Pontianak Health Center. Method: This research uses a cross-sectional method. The sample in this study was 89 hypertension patients at the Pal Tiga Pontianak Health Center. The research instrument used in this study was in the form of a questionnaire filled out by the respondents. The questionnaires used were the Morisky Medication Adherence Scale (MMAS-8) and the Hypertension Knowledge-Level Scale (HK-LS). The correlation test used is a Spearman test. Result: the relationship between education, knowledge level, and BPJS participation on the level of adherence to hypertension medication of respondents, respectively p-value was obtained of 0.879; 0.189; and 0.802.  Conclusion: There is no relationship between education, knowledge level, and BPJS participation in compliance with taking hypertension medication at the Pal Tiga Pontianak Health Center. this is done by interviewing patients with an MMSA compliance questionnaire abstract that does not need to be divided into.
ANTIBACTERIAL POTENTIAL OF DAYAK ONION BULB EXTRACT (Eleutherine sp) AS A TREATMENT FOR ACNE VULGARIS: A LITERATURE REVIEW Pradhea, Tifani Antonia; Clarissa, Maria; Ridho, Muhammad; Aqsa, Sadilla; Sumarna, Dimas Aldianakhi; Assegaf, Syarifah Nurul Yanti Syahab; Zakiah, Mistika
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 4 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Acne vulgaris is a common skin disorder that can significantly affect quality of life. Although conventional antibiotic treatments are commonly used, herbal alternatives such as Eleutherine sp. (Dayak onion) bulb extract may offer therapeutic options for acne vulgaris. This study is a literature review that evaluates the antibacterial activity of Dayak onion bulb extract against bacteria that cause acne vulgaris. The search was conducted in the ScienceDirect, PubMed, Google Scholar, and Garuda databases, focusing on in vitro studies published in the last 10 years. Of the 8 articles analyzed, Dayak onion bulb extract was effective against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes. The best antibacterial activity was obtained from extracts at high concentrations with several methods. Temperature and incubation duration also affected the results. Active compounds such as flavonoids, alkaloids, triterpenoids, steroids, and tannins contributed to the antibacterial effectiveness of this extract. Dayak onion bulb extract showed strong antibacterial effectiveness, making it a potential alternative for treating acne vulgaris. This extract as an additional therapy offers a safe option as a natural acne vulgaris treatment solution. Keywords: acne vulgaris, antibacterial, Eleutherine DOI : 10.35990/mk.v8n4.p446-457
Deteksi Stunting pada Anak Prasekolah dan Pelatihan Pemantauan Pertumbuhan Anak: Upaya Mewujudkan Generasi Emas Tahun 2045 Zakiah, Mistika; Ulfah, Ridha; Asseggaf, Syarifah Nurul Yanti Rizki Syahab; Putri, Triyana Harlia
Mestaka: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2026): APRIL 2026
Publisher : Pakis Journal Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58184/mestaka.v5i2.930

Abstract

Indonesia is the country with the second highest prevalence of stunting in children under five in Southeast Asia, which in 2022 reached 31.8%. Preschool-age children are one of the groups of children at high risk of stunting. One strategy to overcome nutrition problems is to increase teachers' knowledge about the importance of health checks for students. Community service will be held at the Al-Mumtaz IT Kindergarten in Pontianak Kota District in October. The target is teachers and students. All teachers  of Al-Mumtaz IT Kindergarten  will receive training in stunting detection and education. The procedures for this community service activity are divided into several stages, namely checking the weight and height of students and analyzing the prevalence of stunting, training for teachers in detecting stunting; and providing stunting education to all teachers of Al-Mumtaz IT Kindergarten. Training activities will be carried out in the form of educational video presentations, interactive lectures and stunting early detection examination practices which begin with a pretest and end with a posttest. Then the data will be collected and articles will be made that will be published in the PKM journal, besides that a video of the implementation of the activity will also be made and published in the online media.
Pengaruh Penyakit Penyerta terhadap Toksisitas Obat Metamizole Athira Syafika; Syarifah NYRS Asseggaf; Mistika Zakiah
Journal of Pharmascience Vol. 10 No. 1 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i1.13920

Abstract

Metamizole merupakan obat yang memiliki efek analgesik, antipiretik, dan spasmolitik. Metamizole diketahui memiliki toksisitas yang dipengaruhi oleh penyakit penyerta, dosis dan interaksi obat. Hal ini yang menjadi salah satu latar belakang bagi peneliti untuk membahas lebih lanjut terkait pengaruh penyakit penyerta terhadap toksisitas metamizole. Penelitian ini bertujuan untuk mengkaji pengaruh penyakit penyerta terhadap toksisitas obat metamizole. Desain penelitian yang digunakan adalah literature review dan data yang digunakan berasal dari Google Schoolar, PubMed, dan Science Direct. Hasil dari review sepuluh jurnal menunjukkan bahwa adanya pengaruh penyakit penyerta seperti kardiovaskular, autoimun, infeksi virus, acute liver injury, kanker dan asma terhadap toksisitas obat metamizole. Pengaruh ini sering kali diperberat oleh interaksi obat seperti obat aspirin, antibiotik, antikonvulsan, dan cDMARD (methotrexate). Kesimpulan review ini adalah adanya pengaruh penyakit penyerta terhadap toksisitas obat metamizole. Penyakit penyerta tersebut antara lain adalah kardiovaskular yang dapat menyebabkan MACCE (P<0,001), autoimun yang dapat meningkatkan resiko agranulositosis dengan OR 2,28 (CI 95%: 1,294,04), infeksi virus, acute liver injury, kanker dan asma. Kata Kunci: Penyakit Penyerta, Toksisitas, Metamizole, Interaksi Obat, Efek Samping Obat Metamizole is a drug that has analgesic, antipyretic, and spasmolytic effects. Metamizole is known to have a toxicity that is influenced by comorbidities, dosage, and drug interactions. This is one of the backgrounds for researchers to discuss further regarding the effect of co-morbidities on metamizole toxicity. This study aims to examine the effect of comorbidities on the toxicity of the metamizole. The research design used was a literature review and the data used came from Google Schoolar, PubMed, and Science Direct. The results of a review of ten journals showed that there was an influence of comorbidities such as cardiovascular, autoimmune, viral infections, acute liver injury, cancer, and asthma on the toxicity of the metamizole. This effect is often exacerbated by drug interactions such as aspirin, antibiotics, anticonvulsants, and cDMARD (methotrexate). The conclusion of this study is that there is an effect of comorbidities on the toxicity of the metamizole. These comorbidities include cardiovascular disease that can cause MACCE (P < 0.001), autoimmune which can increase the risk of agranulocytosis with an OR of 2.28 (95% CI: 1.29 4.04), viral infections, acute liver injury, cancer and asthma.
Co-Authors Agustina, Vanisia Ainun Najib Febrya Rahman Alex Alex Andre Safitdra Andriani Andriani Anggita Serli Verdian Anindi, Dwi Nisa Ansharullah Ansharullah Ansharullah Ansharullah Aqsa, Sadilla Ari Widiyantoro Asseggaf, Syarifah Nurul Yanti Rizki Syahab Asseggaf, Syarifah NYRS Athira Syafika Athira Syafika Aurelion, Candra Bimo Hendrayana Carla Jean Marshellina Clarissa, Maria Danang Mustofa Delima Fajar Liana Dewinta Putri Utami Diana Natalia Edmond Daniel Beltsazar Fitri Sukmawati Hartono Putra, Galih Abisatya Haryati Septiani Hendrayana, Bimo Imaddudin, Muhammad Difa Irvandy, Muhammad Syifa Khansa, Marsyabila Puspa Len, Jenny Firda Mahyarudin, Mahyarudin Mardhia Mardhia Minami, Gabriella Stephanie Mochammad, Taufiq Muhammad Deni Muhammad Deni, Muhammad Muhammad Ibnu Kahtan Muhammad Luthfi Muhammad Redha Muhammad Redha, Muhammad Muhammad Ridho N.Y.R.S.A, Syarifah Nur, Andi Denisa Fadliah Pradhea, Tifani Antonia Priyono, Djoko Puji Astuti Putra, Galih Abisatya Hartono Putri, Triyana H. Qatrunnada, Aura Qisthi, Dianelita Asyifa Restu Saputra Ridha Ulfah Saputra, Restu Sari Andayani Sari Rahmayanti Senia Angi Giyandari Seprian, Dwin Sinaga, Jojor Putrini Sumarna, Dimas Aldianakhi Syarifah Nurul Yanti Rizki Syahab Assegaf Syarifah Nurul Yanti Syahab Asseggaf Triyana Harlia Putri Tyas, Tri Wahyuning Virhan Novianry Windarti, Wiwik