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Non-adherence to medication, malaria relapse, and asymptomatic reservoirs in malaria transmission: A narrative review Sahiddin, Muhamad; Ishak, Hasanuddin; Arsin, Andi Arsunan; Mallongi, Anwar; Arsyad, Muhammad; Hamid, Firdaus
Public Health of Indonesia Vol. 11 No. 4 (2025): October - December
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i4.1032

Abstract

Background: Malaria elimination remains a pressing global health priority, yet progress is hindered by interconnected human-driven factors that sustain residual transmission. Objectives: This review aims to integrate and analyze key factors driving residual malaria transmission, particularly non-adherence to anti-malarial medication, relapse of Plasmodium vivax and P. falciparum infections, and the persistence of asymptomatic parasite reservoirs. Methods: A narrative review was conducted by synthesizing findings from peer-reviewed studies, including observational studies, clinical trials, and program evaluations. Relevant articles were identified through PubMed, Scopus, Google Scholar, and Web of Science databases. Results: Demographic, behavioral, and health system factors were consistently associated with incomplete treatment, which in turn doubled relapse risk and extended the duration of gametocyte carriage. Biological factors, such as dormant hypnozoites and CYP2D6 polymorphisms that reduce primaquine metabolism, increased the likelihood of recurrent infections. Additionally, asymptomatic carriers disproportionately younger and mobile populations sustained transmission beyond the reach of routine surveillance. Unlike previous reviews that examined these factors separately, this review integrates them into a unified framework, emphasizing their synergistic effects on residual transmission and identifying leverage points for targeted interventions. Conclusion: Addressing residual malaria transmission requires coordinated strategies, including community-supervised or directly observed radical cure regimens, genotype-informed dosing strategies, molecular surveillance for asymptomatic infections, and culturally tailored adherence support. These interventions are essential to strengthen malaria elimination programs and advance progress toward national and global goals by 2030. Keywords: adherence medication; relapse; transmission; endemic; malaria
Larvicidal Activity of Young and Old Leaves of Ricinus communis linn (Castor) with Ethanol, Aquades, Ethyl Acetate, and N-hexane solvents against Aedes sp. Dwicahya, Bambang; Arsin, A. Arsunan; Ishak, Hasanuddin; Hamid, Firdaus; Kanan, Maria; Mallongi, Anwar; Maria, Ida Leida; Birawida, Agus Bintara; Syahrir, Muhammad
Public Health of Indonesia Vol. 12 No. 1 (2026): January - March
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v12i1.1412

Abstract

Background: Dengue fever remains a major public health problem in tropical regions, including Indonesia, where vector control relies heavily on synthetic larvicides that pose environmental and health concerns. Plant-based larvicides have emerged as promising alternatives; however, comparative evidence regarding the influence of solvent polarity and leaf developmental stage on larvicidal efficacy remains limited. Objectives: This study evaluated the larvicidal activity of young and old castor bean leaf extracts obtained using different solvents against Aedes sp. larvae. Method: A laboratory-based experimental study was conducted following WHO guidelines for mosquito larvicide testing. Young and old leaves of castor were extracted separately using n-hexane, ethyl acetate, ethanol, and distilled water through multistage maceration. Third-instar Aedes sp. larvae were exposed to graded concentrations (75–200 ppm) of each extract, with 25 larvae per treatment and three replications. Larval mortality was recorded hourly for 24 hours. Probit analysis was used to determine LC₅₀ and LC₉₀ values with 95% confidence intervals, and differences among treatments were analyzed using one-way ANOVA (p < 0.05). Results: All extracts exhibited larvicidal activity against Aedes sp., with efficacy varying according to solvent type and leaf age. Ethanol extracts of old leaves produced the highest larval mortality, while ethyl acetate extracts of young leaves showed the lowest LC₅₀ values. Phytochemical screening confirmed the presence of alkaloids, flavonoids, saponins, tannins, and steroids in most extracts. LC₅₀ values ranged from 131.403 to 410.225 ppm, whereas LC₉₀ estimates were substantially higher and exceeded the tested concentration range, indicating extrapolation beyond observed data.  Conclusion: The larvicidal effectiveness of castor leaf extracts against Aedes sp. is influenced by both solvent polarity and leaf developmental stage. Old leaves extracted with ethanol and young leaves extracted with ethyl acetate demonstrated comparatively higher larvicidal potential. These findings support the potential of castor as a botanical larvicide, although further studies incorporating standard larvicide controls, quantitative phytochemical analysis, and field validation are required before operational application.   Keywords: Aedes sp; ricinus communis linn; castor
Smart Waste Management Acceptance and Perceived Urban Environmental Health in Jabodeta Ernyasih, E.; N. Nelfiyanti; Eka Samsul Ma’arif; D. Daruki; Anwar Mallongi; Donita Lutfia Hasanah
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 9 No. 4 (2026): April 2026
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i4.10154

Abstract

Introduction: Urban waste growth in metropolitan areas intensifies sanitation challenges and environmental health risks. Smart waste management offers data-driven waste services; however, its effectiveness depends on public acceptance. Despite increasing implementation of smart waste technologies, limited empirical evidence explains how behavioral and psychosocial determinants shape citizen acceptance in developing urban contexts, particularly in relation to perceived environmental health conditions rather than objectively measured environmental outcomes. This study investigates the determinants of smart waste management acceptance and its association with perceived urban environmental health in Jabodeta, Indonesia, using an extended Technology Acceptance Model that integrates digital literacy, environmental concerns, social norms, and perceived risk Methods: A cross-sectional survey of 120 respondents was conducted and analyzed using partial least squares structural equation modeling with bootstrapping. Measurement quality met recommended thresholds, including outer loadings greater than 0.70, average variance extracted ranging from 0.52 to 0.78, strong reliability, and HTMT values below 0.90. Results: The structural model explained substantial variance in perceived ease of use (R² = 0.81) and perceived usefulness (R² = 0.69), moderate-to-strong variance in acceptance (R² = 0.62), and modest variance in perceived urban environmental health (R² = 0.18). Digital literacy positively predicted perceived ease of use (? = 0.52), while perceived risk negatively predicted perceived ease of use (? = ?0.37). Perceived ease of use strongly predicted perceived usefulness (? = 0.74). Environmental concern (? = 0.26) and social norms (? = 0.15) positively predicted perceived usefulness. Perceived usefulness (? = 0.32) and perceived ease of use (? = 0.19) positively predicted acceptance, and acceptance was positively associated with perceived urban environmental health (? = 0.43). Mediation analysis identified statistically significant indirect effects for selected pathways; however, these effects should be interpreted cautiously due to inconsistencies in directional patterns. Conclusion: The findings suggest that perceived environmental health benefits associated with smart waste management are linked to sustained public acceptance. This acceptance is supported by digital literacy, socially reinforced perceptions of usefulness, and effective risk communication combined with reliable service delivery. These results highlight the importance of behavioral and perceptual factors in shaping citizen engagement with smart environmental technologies, while acknowledging that the study reflects perceived rather than objectively measured environmental outcomes.
Co-Authors A. Arsunan Arsin A. Indahwaty Sidin A.Indahwaty Sidin Achmad Indra Awaluddin Adityawarman, Raihan Muammar Iffat Adziim, A. Muh. Faudzul Agus Bintara Birawida Aminuddin Syam Amqam, Hasnawati Andi Arsunan Arsin Andi Jamalina Andriyani Andriyani Anwar Daud Anwar Daud Ary Handayani Asih, Erny Balebu, Dwi Wahyu Bidullah, Ramli Burhanuddin Bahar D. Daruki Donita Lutfia Hasanah Dwicahya, Bambang Eka Samsul Maarif Erniyasih, Erniyasih Ernyasih, E. Ernyasih, Ernyasih Ernyasih, Ernyasih Fajar Septian Anwar Fajrini, Fini Fini Fajrini Firda Ayu Salsabilla Firmansyah, Andi Yudia Sari Gilang Anugerah Munggaran Gracia Victoria Souisa, Gracia Victoria Hamid, Firdaus Hasan Hasyim Hasanuddin Ishak Hasnawati Amqam Herawati Herawati hidayat hidayat Ida Leida Maria Ilmansyah, Salsabila Tamara Putri Irmawati, St. Lusida, Nurmalia Lutfiah Lutfiah M Alimin Maidin Mahatma Lamuru Makmur Selomo Maldi Prasetyo Maming Maria Kanan Megasari, Wa Ode Muammar Muammar Muh. Fajaruddin Natsir Muhammad Arsyad Muhammad Hatta Mukono Munaya Fauziah N. Nelfiyanti Noor Latifah Nur Juliana Nurfatmala Nurfatmala Nurmalia Lusida Putri, Vivinda Trisnowati R Silalahi, Steven Rabbaniyah, Rabbaniyah Rahman, Muhammad Abeliandri Ramadani, Asty Suci Ridwan Amiruddin ridwan haerun Ruslan La Ane, Ruslan La Sahiddin, Muhamad Sakati, Sandy Novryanto Sessu, We Ya’dilu Tenri SG, Hardiman Shabrina Vashtinia Putri Tryanda Sila, Nurlia Stang Stang Sumarni Sumarni Taufiqurrochman, Taufiqurrochman Tjowari, Elizabeth Lydia Todingan, Melisa Wesam AL Madhoun Winalda Eka Pratiwi YULIATI