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All Journal Disease Prevention and Public Health Journal Jurnal Media Gizi Indonesia (MGI) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Proceedings of the International Conference on Nursing and Health Sciences JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Prosiding University Research Colloquium Journal of Public Health Sciences Proceeding of International Conference Health, Science And Technology (ICOHETECH) Promotor: Jurnal Mahasiswa Kesehatan Masyarakat Jurnal Kesehatan Masyarakat
Eti Poncorini Pamungkasari
Universitas Sebelas Maret
Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Systematic Journal Review: Mechanical Durability Of L-PRF Organic Material At Body Temperature During The Wound Healing Phase (14 Days) Of Tympanic Membrane Perforation And Myringoplasty Surgery Antonius Christanto; Risya Cilmiaty; Made Setiamika; Ratih Dewi Yudhani; Paramasari Dirgahayu; Eti Poncorini Pamungkasari; Ida Nurwati
PROMOTOR Vol. 9 No. 1 (2026): FEBRUARI
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i1.1741

Abstract

The purpose of this study is to evaluate the viability and structural stability of L-PRF at 37°C over 14 days. It aims to determine its sustained growth factor release and potential effectiveness in regenerative clinical applications. This research employed a Systematic Journal Review (SJR) approach, surveying articles from databases such as PubMed, Scopus, and Google Scholar using specific keywords related to L-PRF. A total of 25 articles meeting the inclusion criteria were filtered for analysis. Furthermore, common experimental methods described in the literature include the preparation of L-PRF via blood centrifugation and viability testing over 14 days at 37°C, encompassing analysis of microscopic structure, mechanical properties, and biochemical and biological activities. Literature analysis indicates that L-PRF is an effective autologous biomaterial for regenerative applications, capable of continuously releasing growth factors such as PDGF, TGF-β, VEGF, and IGF for up to 14 days at body temperature. Cell viability within the fibrin matrix is maintained, positioning L-PRF as a promising active biological scaffold for accelerating tissue healing. Although challenges such as matrix degradation persist, modification strategies and optimized centrifugation protocols can enhance the effectiveness and durability of L-PRF in clinical applications.
Co-Authors Aini, Zahratul Amal Fadholah Anik Lestari Anita Febrian Permata Sari Antonius Christanto Argyo Demartoto Ari Probandari Balgis Balgis Bhisma Murti Chatarina Umbul Wahyuni Dinar Fatihah Fauzi Doni Widyandana Endang Sutisna Sulaeman Fatiah Handayani handayani Fatikhu Yatuni Asmara Fitriana Ida Nurwati Ika Tristanti Made Setiamika Martono Martono Muhammad Akhyar Mulyani, Sri Paramasari Dirgahayu R Reviono R Rusnoto Rasmaya Niruri Ratih Dewi Yudhani Ravi Masitah Retno Setyowati Revi Gama Hatta Novika Risya Cilmiaty Sapja Anantanyu, Sapja Setyo Sri Rahardjo Sri Mulyanti Suminah Suminah Syifa Maulida Rahmah Sylivia Lugereka Tri Maryani Tri Nur Kristina Vitri Widyaningsih Yulia Lanti Retno Dewi