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Lina Noviyanti Sutardi
Institut Pertanian Bogor
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Journal : Asian Journal of Social and Humanities

 1 
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Lingga Surya Maret Daulay; Ietje Wientarsih; Anita Esfandiari; Lina Noviyanti Sutardi; Nuzul Asmilia
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Lingga Surya Maret Daulay; Ietje Wientarsih; Anita Esfandiari; Lina Noviyanti Sutardi; Nuzul Asmilia
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Maret Daulay, Lingga Surya; Wientarsih, Ietje; Esfandiari, Anita; Sutardi, Lina Noviyanti; Asmilia, Nuzul
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Co-Authors Adi Winarto Alifin Wisnu Ananta Alpayet, Rahmat Amaq Fadholly Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Andriyanto Anggraini, Lutvi Anisa Rahma, Anisa Anisa, Rahma Anita Esfandiari April Hari Wardhana April Hari Wardhana Ardi Sandriya Aulia Andi Mustika Aulia Andri Mustika Aulia Mustika Bachmid, Salma Safitri Bambang Pontjo Priosoeryanto Bayu Febram Prasetyo Budiono, Novericko Ginger Christina Clarice Leksono Deni Afrizal Dhiya Puja Ramadhan Diah Nugrahani Pristihadi Diaz, Fariz Arrachman Dodi Darmakusuma Dodi Darmakusumah Ekowati Handharyani Elpita Tarigan Elpita Tarigan Elpita Tarigan Esti Dhamayanti Eva Harlina Fedik Abdul Rantam Fitri Ariyani Fitri, Arni Diana Guna Prajanto Gunanti . Hadri Latif Hamdika Yendri Hamdika Yendri Hamdika Yendri Putra Hamdika Yendri Putra IETJE WIENTARSIH Inayati ilmi Kamilatun Nisa Khonsa Khonsa Kusdiantoro Mohamad Kusdiantoro Muhamad Leliana Nugrahaning Widi Leliana Nugrahaning Widi Leliana Widi Leliana Widi Lingga Surya Maret Daulay Madyastuti, Rini Maret Daulay, Lingga Surya May, Ng U Mufida, Anis Arifatu Muhammad Bintang Nababan, Ratna Kristiani Nabilah, Avida Shahnaz Nina Indria Afifah Nisrina Nurmahfuzhah Nurdiansyah, Rio Dwi Haryadi Nuzul Asmilia Nuzul Asmilia Purohita, Adwisto Saktika Rachmi Ridho Raphaella widiastuti Rasyid, Baharun Ridi Arif Riki Siswandi Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Rindy Fazni Nengsih Rini, Dian Cipta Riski Rostantinata Riski Rostantinata Rizki Rostantinata Safitri, Nadiya Santosa, Alfian Shabrina Marsha Shabrina Rizki Ahadiah Silmy Kamila Widyanti Siti Rabi’ah SM Leluala Subangkit, Mawar Sus Derthi Widhyari Trioso Purnawarman Utami Idha Pangesti Waras Nurcholis Wasmen Manalu Wiwin Winarsih Yessy Anastasia Yusa Irarang Yusa Irarang Yusa Irarang