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All Journal E-JUPEKhu Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) E-Dimas: Jurnal Pengabdian kepada Masyarakat AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal SOLMA SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) JURNAL FARMASIMED (JFM) Majalah Farmasetika Jurnal ABDINUS : Jurnal Pengabdian Nusantara JATI (Jurnal Mahasiswa Teknik Informatika) BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Penelitian Farmasi dan Herbal Jurnal Cahaya Mandalika UNES Journal of Swara Justisia Jurnal Pengabdian Masyarakat (ABDIRA) Jurnal PkM (Pengabdian kepada Masyarakat) J-KIP (Jurnal Keguruan dan Ilmu Pendidikan) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Pendidikan Indonesia (Japendi) Jurnal Pengabdian Masyarakat Bangsa Indonesian Journal of Pharmacy and Natural Product Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia JITAA : Journal Of International Taxation, Accounting And Auditing Jurnal Pengabdian Kepada Masyarakat Bangun Cipta, Rasa, & Karsa (Jurnal PKM BATASA) Jurnal Pengabdian Farmasi dan Sains Jurnal Ilmiah Kesehatan Journal of Community Development and Empowerment Kajian Ilmiah Mahasiswa Administrasi Publik (KIMAP)
Nining, Nining
Fakultas Farmasi Dan Sains Universitas Muhammadiyah Prof. DR. HAMKA
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Effect of Cosolvent and Polymer HPMC P.603/PVA-based Lamotrigine Orodispersible Film: Optimization and Physicochemical Characterization Nining, Nining; Amalia, Anisa; Benita, Clara; Andriyani, Agnes Aga; Supandi, Supandi
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.12949

Abstract

ABSTRACT. Lamotrigine (LTG), classified as BCS class II, is dissolved in cosolvent ethanol (EtOH) or ethyl acetate (EA) to enhance solubility. The objectives of this study are to identify the appropriate formulation of LTG orodispersible film (OF) based on hydroxypropyl methylcellulose Pharmacoat® 603 and polyvinyl alcohol (HPMC P.603/PVA) polymer with EtOH or EA solvency using Central Composite Design in Response Surface Methodology (CCD-RSM). An experimental approach was utilized to investigate the effect of cosolvent amount and HPMC P.603/PVA ratios on the film disintegration time (DT) and folding endurance (FE). The optimized OF-EA composition was 0.46 HPMC P.603/PVA ratio and 3.66% EA with a desirability of 0.817. In comparison, the optimal OF-EtOH composition was 0.87 HPMC P.603/PVA ratio and 6.19% EtOH with a desirability of 0.843. The characteristic data for the optimal formulas include: OF-EtOH: weight variation 92.05±4.81 mg, thickness 0.15±0.01 mm, DT 36.11±1.48 sec, and FE 310.33±5.03; and OF-EA: weight variation 93.72±1.50 mg, thickness 0.16±0.00 mm, DT 26.73±3.32 sec, and FE 470.6±37.44. Based on the OF-EtOH FE, the HPMC P.603/PVA ratio had a greater effect compared to the amount of EtOH (p<0.05). The analysis of variance (ANOVA) demonstrated that the amount of EA had a greater impact compared to the HPMC P.603/PVA ratio, with statistical significance (p<0.05). The EtOH cosolvent was preferable to EA based on the LTG solubility and OF dissolution profile. LTG OF had favorable physicochemical properties and showed promise as a rapid-dissolving formulation for therapeutic purposes. Keywords: Central composite design, cosolvency, disintegration time, folding endurance, oral film.
Penyuluhan Penggunaan Obat Rasional (POR) dalam Swamedikasi Kepada Masyarakat RW 18 Desa Cijengkol Kecamatan Setu Kabupaten Bekasi Nining, Nining; Yeni, Yeni
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 3 No 2 (2020): Volume 3 Nomor 2 Tahun 2020
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v3i2.13781

Abstract

Swamedikasi merupakan upaya pengobatan sendiri oleh masyarakat untuk mengatasi gejala penyakit, tanpa bantuan dari tenaga kesehatan. Penatalaksanaan yang irrasional dapat mengakibatkan berbagai kerugian seperti kesalahan pengobatan karena ketidaktepatan diagnosis sendiri; penggunaan obat tidak sesuai karena perolehan informasi yang salah dari media; pemborosan waktu dan biaya; dapat menimbulkan reaksi obat yang tidak diinginkan seperti sensitivitas, alergi, efek samping atau resistensi. Kegiatan ini dilakukan dengan tujuan untuk meningkatkan pemahaman dan pengetahuan masyarakat lingkungan RW 18 Desa Cijengkol Kabupaten Bekasi terutama para ibu mengenai obat yang rasional serta pemberian informasi Dagusibu (Dapatkan Gunakan Simpan dan Buang obat) di lingkungan rumah tangga. Penyuluhan diberikan dengan metode ceramah interaktif. Efektifitas penyuluhan diuji dengan rancangan quasi eksperimental pre dan post design. Peserta diberi kuisioner pre-test, selanjutnya diberi intervensi penyuluhan dan terakhir diberikan kuisioner post-test. Hasil pengamatan kegiatan menunjukkan bahwa para peserta sangat antusias mengikuti kegiatan dan hasil analisis data menunjukkan adanya pengaruh pemberian penyuluhan dalam peningkatan pengetahuan mengenai penggunaan obat rasional (POR) dalam swamedikasi berdasarkan hasil uji t-berpasangan dan uji wilcoxon.
Co-Authors Abu Rijal Algifari Agustin Yumita Andriani, Kris Andriyani, Agnes Aga anisa amalia Anisa Amalia Ari Sartinah, Ari Ari Widayanti Armadany, Fery Indradewi Aulia, Rizma Benita, Clara Budi Setiawati Chatarina Umbul Wahyuni Dania Athaya Putri Devi Puspita Sari Dinaianti, Adelia Ema Dewanti Etin Diah Permanasari Euis Erlin Fadillah Sabri Fith Khaira Nursal Fujianti Fujianti Gantini, Sri Nevi Hadi Sunaryo Hamsiati, Hamsiati Hapsari, Fadjriah hasbi, andi Ilmiyati, Nur Inding Gusmayadi Khaira Nursal, Fith Kori Yati Larasati, Kinanti Dara Laszairina, Andra Yunita MAHMUDAH, RIFA'ATUL Maspupah, Meti Mega Iswari Mone, Ansyari Naniek Setiadji Radjab Nugrahaeni, Fitria Palensia, Fadhilah Poppy Mutiara Indah Pramulani Mulya Lestari Pramulani Mulya Lestari Putri Nabila Zulvianti Putri, Dania Athaya Putri, Riska Damayanti Rahmatullah, Rizki Ridwan Zamzany, Faizal Rismawati Rismawati Ristianti Azharita Riyanto, Raditya Naufal Romansyah, Febri Romdiyah Romdiyah, Romdiyah Saleh Wikarsa Saleh Wikarsa, Saleh Sawitri, Feny Eka Seowandhi, Sundani Nurono Septia Handayani, Lidra Setiani, Fibrinika Tuta Sirewati, Sirewati Siska Elvandari Solihah, Solihah Sri Hartati Sundani Nurono Seowandhi Supandi Supandi Tahyatul Bariroh Tyarini, Indrawati Aris Widati, Endah Winda Sulistiyaningrum Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Yeni Zeinora, Zeinora