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All Journal VALENSI Indonesian Journal of Science and Technology Pharmacology and Clinical Pharmacy Research Journal of Pharmaceutical and Medicinal Sciences Jurnal Mandala Pharmacon Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Majalah Farmasetika Jurnal farmasi UIN Alauddin Makassar Borneo Journal Of Pharmascientech Current Research on Biosciences and Biotechnology Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum. Ekonomi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Wahyuni Wahyuni
Faculty Of Pharmacy Universitas Halu Oleo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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EDUKASI PEMANFAATAN TOGA SEBAGAI MINUMAN HERBAL DAN SPRAY ANTI NYAMUK PADA MASYARAKAT DESA POHARA KEC. SAMPARA KAB. KONAWE Sahidin Sahidin; Gusti Ray Sadimantara; Wahyuni Wahyuni; Fadhliyah Malik; Fahria Nadiryati Sadimantara; Rahmat Muliadi; Muhammad Israwan Azis; Jumriani Jumriani
Anoa : Jurnal Pengabdian Masyarakat Sosial, Politik, Budaya, Hukum, Ekonomi Vol 4, No 2 (2023): Oktober
Publisher : Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52423/anoa.v4i2.45920

Abstract

Indonesia has an incredibly high level of biodiversity, which makes it rich in various potentially medicinal plants. One of these is the family medicinal plant (Sari and Andjasmara, 2023). TOGA is a homegrown cultivated plant known for its herbal medicinal properties. Herbal medicine is derived from plants and processed or extracted in such a way that it becomes a powder, pill, or liquid without the use of chemicals. As it is commonly known, herbal medicines can treat diseases with minimal side effects because they are made from natural ingredients (Wulandari et al., 2017). The purpose of this community service activity is to enhance the understanding and skills of the community in utilizing plants found in the yards of the local households in the Pohara village, Sampara Subdistrict, Konawe District. These plants can be used in the production of herbal products such as herbal drinks and mosquito repellent sprays. This community service involved 31 community leaders and local residents. The method employed for community service was active participation, starting with socialization, herbal product preparation, and focused discussion sessions with community interaction. As a result of the community activities in the Pohara village, there was an improvement in skills, increased knowledge about herbal preparations, and an enhanced understanding of how to produce herbal products that are of good quality, hygienic, and safe for consumption.
Apotek Hidup: Upaya Pelestarian Penggunaan Obat Tradisional di Masyarakat melalui Pemanfaatan Tanaman Obat Keluarga Idin Sahidin; Gusti Ray Sadimantara; Muhammad Hajrul Malaka; Muhammad Azdar Setiawan; Nur Saadah Daud; Adryan Fristiohady; Yulianti Fauziah; Sernita Sernita; Musdalipah Musdalipah; Agung Wibawa Mahatva Yodha; Wahyuni Wahyuni
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 1 (2023): NADIKAMI: Januari 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

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Abstract

Penduduk Desa Lamomea Kecamatan Konda Kabupaten Konawe Selatan Provinsi Sulawesi Tenggara sebagian besar masyarakatnya berpendidikan minimal rata-rata lulusan SMA, sehingga pengetahuan tentang budidaya dan pemanfaatan tanaman obat masih sangat kurang. Salah satu upaya yang dapat dilakukan untuk membantu pelaksanaan program pemerintah terkait pemanfaatan tanaman obat. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk menyampaikan informasi tentang tanaman obat melalui sosialisasi, diskusi, dan praktik langsung budidaya tanaman obat keluarga di pekarangan rumah. Evaluasi peningkatan pengetahuan masyarakat dilakukan dengan pre-test dan post-test. Hasil dari kegiatan ini menunjukkan adanya peningkatan pengetahuan dasar tentang jenis, manfaat, dan cara membuat ramuan. Kegiatan pengabdian ini menunjukkan adanya keberhasilan dan sangat bermanfaat, karena adanya peningkatan pengetahuan dengan skor rata-rata lebih dari 60 yaitu skor rata-rata post-test 86.11 dibandingkan saat sebelum kegiatan dari nilai rata-rata pre-test 59.72. Masyarakat menunjukkan keterampilan yang memadai saat melakukan praktik langsung mulai dari penanaman, hingga pemeliharaan tanaman. Hasil budidaya tanaman obat ini, selain merupakan upaya pelestarian tanaman obat tradisional, juga mampu menghasilkan produk kosmetik yang kemudian dapat di manfaatkan sebagai produk herbal atau dijual untuk menambah nilai ekonomi.
Sosialisasi Pemanfaatan Potensi Tanaman Desa di Desa Laimeo Adryan Fristiohadi; Muhammad Hajrul Malaka; Wahyuni Wahyuni; Muhammad Israwan Aziz; La Ode Muh. Fitrawan; Astrid Indalifiany; Sahidin Sahidin; Agung Wibawa Mahatva Yodha; Rahmat Muliadi; Fadhliyah Malik
Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Vol 1 No 2 (2023): NADIKAMI: Juli 2023
Publisher : POLITEKNIK BINA HUSADA KENDARI

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Abstract

Laimeo merupakan sebuah wilayah yang ada di pesisir laut. dikarenakan hal tersebut, mayoritas mata pencaharian masyarakat setempat adalah nelayan. Sementara itu, terdapat kekayaan alam lain yang dapat dimanfaatakan potensinya dalam bidang kesehatan dan inovasi usaha lainnya. Obat-obatan tradisional Indonesia umumnya memiliki peranan yang sangat besar terutama dalam kaitannya dengan pelayanan kesehatan masyarakat. Namun demikian tampaknya pemanfaatan tanaman obat di Indonesia masih belum dilakukan secara optimal untuk kesehatan. Padahal saat ini biaya pengobatan modern cukup mahal di tambah lagi dengan krisis ekonomi yang belum sepenuhnya berakhir. Tujuan pengabdian ini untuk memberikan meningkatkan pemahaman terhadap potensi tanaman desa dalam bidang kesehatan dan beragam inovasi usaha. Metode Pengabdian dilakukan dengan memberi sosiaisasi (ceramah dan tanya jawab) pada kelompok masyarakat di desa Laimeo, Kecamatan Sawa, Kabupaten Konawe Utara. Hasil pengabdian yang dilakukan mampu meningkatkan pemahaman masyarakat desa laimeo tentang tanaman obat yang ada disekitarnya.
Anti-inflammatory Activity of Pharmaceutical Gel of Ethanolic Extract from Marine Sponge Xestospongia Sp Wa Ode Sitti Zubaydah; Wahyuni Wahyuni; Sahidin Sahidin; Tian Amalia Halik; Rina Andriani; Astrid Indalifiany; Adryan Fristiohady
Borneo Journal of Pharmacy Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.694

Abstract

The aim of this study was to determine the characteristics of the gel formula based on it’s organoleptic properties, pH, viscosity, dispersion and homogenity by stability test carried out using the cycling test method and to determine the anti-inflammatory activity of the Xestospongia Sp. in male white mice (Mus musculus) by creating an artificial edema on the mice left foot induced by 1% λ-carrageenan. The gel formula from the ethanol extract of Xestospongia Sp. sponge was physically stable in terms of its organoleptic observation, homogenity, pH and viscosity test. However, the results that were obtained after dispersion test did not fulfill the requirements. In this study, the gel formula of the ethanol extract of Xestospongia Sp. sponge was administered on the mice left foot by using the variations in extract concentration of 0.02%, 0.03%, and 0.04%, and the gel without extract as a negative control and Galtaren®gel (1% Diclofenac Sodium) as a positive control. The evaluated data were in the form of mice leg edema volume measured based on its percent of inflammation and percent of inflammatory inhibition and observed for 360 minutes. The data were analyzed by using the Kruskal-Wallis test followed by the Mann-Whitney test with a confidence level of 95%. The results of this study showed that the gel formula of ethanol extract of Xestospongia Sp. sponge has an anti-inflammatory effect on each concentration and the formula that has a large anti-inflammatory effect was obtained at extract concentration of 0.04%.
Immunomodulator Activity of Effervescent Granule of Wualae Fruit (Etlingera elatior (Jack) R.M. Smith) Based on Specific Phagocytic Activity Adryan Fristiohady; Wa Ode Siti Zubaydah; Wahyuni Wahyuni; Mirda Mirda; Saripuddin Saripuddin; Rina Andriani; La Ode Muhammad Julian Purnama; Sahidin Sahidin
Borneo Journal of Pharmacy Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i2.868

Abstract

The previous study reported that Etlingera elatior (Wualae) has activity as immunostimulant with dose at 300 mg/kg BW and 400 mg/kg BW. Formulating natural product into effervescent granule (GE) can increase practicality and interest to consume traditional medicine. This study aims to investigate the immunostimulant activity of Wualae ethanolic extract in the effervescent granule. Wualae was macerated with ethanol then formulated into effervescent granule at dose 300 mg/kgBW and 400 mg/kgBW. Formulations were evaluated. Animals were divided into 4 groups and treated with: group I (positive control); group II (negative control); group III (GE dose at 300mg/kgBW); and group IV (GE at dose 400mg/kgBW) for 7 days and at days 8, groups were infected by Staphylococcus aureus intraperitoneally. Immunostimulant activity was measured by calculating the Specific Phagocytic Activity (SPA) of macrophage. Data collected from the evaluation and measurement of the SPA then analyzed using SPSS. Results from the evaluation were considered good except the moisture content of effervescent granule. Results from SPA was found that effervescent granule at dose 300 mg/kgBW and at dose 400 mg/kgBW have 26.33% and 32.5% consecutively with significance 0.02 (p<0.05). Thus, effervescent granule has comparable phagocytosis activity with positive control.
Level of Cytokine Interleukin-6 and Interleukin 1-β on Infectious Rat Model Treated with Etlingera elatior (Jack) R.M. Smith Fruit Extract as Immunomodulator Adryan Fristiohady; Wahyuni Wahyuni; Fadhliyah Malik; Muhammad Ilyas Yusuf; Wa Ode Salma; Rini Hamsidi; Fredy Talebong; Yuliansyah Yuliansyah; La Ode Muhammad Julian Purnama; Saripuddin Saripuddin; Sahidin Sahidin
Borneo Journal of Pharmacy Vol. 3 No. 2 (2020): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v3i2.1318

Abstract

Etlingera elatior (Jack) R.M Smith or locally in Southeast Sulawesi known as Wualae fruit has activity as an immunomodulator by increasing phagocytosis activity. Prior studies have been conducted to observe the effect of E. elatior as an immunomodulator, thus further study is needed to observe the production of cytokines such as IL-1β and IL-6 which are responsible for the immune responses. Etlingera elatior fruit macerated with 96% ethanol for three days and produced a total of ±74.6 g concentrated extract. Experimental animals used were divided into four groups (n=4) and treated orally once a day for seven days as follows: group I (0.5% Na CMC); group II (Stimuno®); group III (E. elatior fruit extract dose of 300 mg/kg BW); and group IV (E. elatior fruit extract dose of 400 mg/kg BW). On the eight-day, animals were infected with Staphylococcus aureus intraperitoneally and left for an hour. Thereafter, blood was collected and assayed using ELISA Kit (Elabscience rat IL-1β and Elabscience rat IL-6). Results demonstrated that group IV increased levels of IL-1β and group III and IV increased level of IL-6 (p<0.05). Increased levels of IL-1β and IL-6 are associated with phagocytosis in the immune response. In conclusion, E. elatior fruit extract at doses of 300 and 400 mg/kg BW increases levels of IL-1β and IL-6.
Potensi Hepatoprotektor dan Antioksidan dari Rimpang Olae (Etlingera calophrys (K. Schum) A. D. Poulsen) Loly Subhiaty Idrus; Adryan Fristiohady; Arfan Arfan; Sitti Raodah Nurul Jannah; Irvan Anwar; Nurramadhani A. Sida; Wahyuni Wahyuni; Idin Sahidin; Agung Wibawa Mahatva Yodha
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.409

Abstract

Tanaman dari genus Etlingera terbukti memiliki aktivitas antioksidan. Antioksidan memiliki peran dalam melindungi sel dari stres oksidatif dan peradangan yang disebabkan oleh kerusakan hati sehingga berkontribusi terhadap efek hepatoprotektif. Tujuan penelitian ini yaitu untuk mengevaluasi aktivitas antioksidan dan hepatoprotektor dari ekstrak etanol Etlingera calophrys (EEEC) pada mencit jantan galur BALB/c usia 8-10 minggu yang diinduksi karbon tetraklorida (CCl4). Pengujian antioksidan dilakukan menggunakan metode ABTS. Pengujian hepatoprotektor menggunakan tiga variasi dosis EEEC (100, 250 dan 500 mg/kgBB) yang diberikan secara oral selama tujuh hari berturut-turut dan kemudian dilakukan evaluasi parameter biokimia darah yaitu SGOT, SGPT dan ALP. Setelah itu, hasil yang didapatkan dianalisis menggunakan oneway ANOVA. Hasil penelitian menunjukkan EEEC memiliki nilai IC50 sebesar 20,03 mg/L. EEEC juga memiliki efek hepatoprotektor pada dosis dosis 100 mg/kgBB yang ditunjukan dengan adanya penurunan kadar SGOT, SGPT, dan ALP secara signifikan (p < 0,05). Dengan demikian, dapat disimpulkan bahwa ekstrak etanol Etlingera calophrys memiliki aktivitas antioksidan sangat kuat dan berpotensi sebagai hepatoprotektor dengan mekanisme yang melibatkan aktivitas antioksidan dan kandungan flavonoid serta fenolik yang ditemukan dalam ekstrak.
PENINGKATAN IMUNITAS NON SPESIFIK (INNATE IMMUNITY) MENCIT Balb/C YANG DIBERI EKSTRAK ETANOL DAUN TUMBUHAN GALING (Cayratia trifolia L. Domin) ENHANCEMENT OF NON SPECIFIC IMMUNITY (INNATE IMMUNITY) MICE Balb/C GIVEN ETHANOL EXTRACT OF GALING PLANT (Cayratia trifolia L. Domin) Muhammad Ilyas Yusuf; . Firdayanti; . Wahyuni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v3i2.55

Abstract

Telah dilakukan penelitian tentang efek imunomodulator ekstrak etanol daun galing (Cayratia trifolia L. Domin.) terhadap daya fagositosis makrofag mencit jantan. Penelitian ini bertujuan untuk menguji efek imunomodulator ekstrak etanol daun galing terhadap peningkatan aktivitas fagositosis sel makrofag mencit jantan. Ekstrak uji dibuat dengan dua variasi dosis 400 mg/kgBB dan 500 mg/kgBB. Hasil yang didapatkan menunjukkan bahwa semua pemberian perlakuan dosis ekstrak memberikan hasil yang baik terhadap peningkatan akivitas fagositosis sel makrofag, persen aktivitas sel makrofag tertinggi ditunjukkan pada pemberian dosis ekstak 500 mg/kgBB yaitu sebesar 65, 4%, dibandingkan dengan peningkatan aktivitas sel pada dosis 400mg/kgBB dan kontrol positif dengan masing-masing memiliki persen aktivitas sel sebesar 55, 4% dan 60, 5%. Sedangkan nilai aktivitas sel terendah ditunjukkan pada kelompok kontrol negatif (NaCMC) dengan persen aktivitas sel sebesar 37, 8%. Hasil analisis data statistik (ANOVA) menunjukkan bahwa ekstrak etanol daun galing (C. trifolia L. Domin.) dapat meningkatkan imunitas non spesifik (p0,05).
Co-Authors ,, Suryani . Firdayanti A. N. T. A Mallarangeng Aan Zurniwatih P Abdulkadir Kamaluddin Adryan Fristiohadi Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Adryan Fristiohady Agung W. M. Yodha Ajeng Diantini, Ajeng Amaliah Amaliah Andini Sundowo Andryani Ningsih Annisa Fatinah Gani Arfan Arfan Asman Sadino Asman Sadino Asniar Pascayantri Asniar Pascayantri Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Asriullah Jabbar Astrid Indalifiany Bafadal, Mentarry Baru Sadarun Dayatriana Muthalib Desyandri Desyandri Dewiyanti Madu Dian Afriana Dian Munasari Dian Munasari Dian Munasari Solo Dian Munasari Solo Dwi Arini Jufri Fadhliyah Malik Fahria Nadiryati Sadimantara Fahriah Nadiryati Sadimantara Fery Indradewi Armadany Fery Indradewi Armadany Fery Indradewi Armadany Firasmi Sangadji Fitrawan, La Ode Muhammad Fredy Talebong Fristiohady Adryan Fristiohady, Adryan Gusti Ray Sadimantara Gusti Ray Sadimantara Gusti Ray Sadimantara Halik Halik Hendra Febriansyah Herdianawati Ringgu I Sahidin I Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Idin Sahidin Imran Imran Indri Wulandari Iren Meylani Irnawati Irnawati Irvan Anwar Jumriani Jumriani Junli Hong La Ode MJ Purnama La Ode Muh. Fitrawan La Ode Muhammad Fitrawan La Ode Muhammad Julian Purnama La Ode Muhammad Julian Purnama Loly Subhiaty Idrus M. Ardianti M. Hajrul Malaka Marianti A. Manggau Masrika, Nur Upik En Mesi Leorita Mesi Leorita Mirda Mirda Mirna Widasri Mohammad Ghozali Mubarak Mubarak Mubarak Mubarak Muh. Azdar Setiawan Muh. Ilyas Yusuf Muhammad H Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad Hajrul Malaka Muhammad I. Yusuf Muhammad Ilyas Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Y Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Ilyas Yusuf Muhammad Israwan Azis Muhammad Israwan Aziz Muktiarni, Muktiarni Musdalipah Musdalipah N. Nohong Nasrudin Nasrudin Nasrudin Nasrudin Nur Annisaa Nur Hikmah Nur Illiyyin Akib Nur Indri Rahayu Nur Saadah Daud Nur Syifa Rahmatika Nuralifah Nuralifah, Nuralifah Nurfenti Nurfenti Nurramadhani A. Sida Nurramadhani A. Sida Parawansah Parawansah Parawansah RAHMAT MULIADI, RAHMAT Rathapon Asasutjarit Rina Andriani Rina Andriani Rina Andryani Rina Maryanti Rini Hamsid Rini Hamsidi Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Sahidin Salsabila, Syefira Saripuddin Saripuddin Seprian Hilman Sernita Sernita Sitti Raodah Nurul Jannah Sofa Fajriah Sri Hutami Lety Grashella Sri Madani Newulasindo Tian Amalia Halik Ulan Dwi Shintia Ulfa Ulfa Wa Ode Ida Fitriah Wa Ode Nurfinti Wa Ode Salma Wa Ode Siti Zubaydah Wa Ode Sitti Zubaydah Wiwin Holidin Yodha, Agung Wibawa Mahatva Yuliansyah Yuliansyah Yulianti Fauziah Yustian Okwani