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All Journal Pharmaciana: Jurnal Kefarmasian Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Berkala Kedokteran JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Penelitian Kesehatan Suara Forikes Indonesian Journal of Chemistry SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Biosaintifika: Journal of Biology & Biology Education Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Asia Jurnal Kreativitas dan Inovasi (Jurnal Kreanova) Jurnal Masyarakat Madani Indonesia Borneo Journal of Pharmacy
Wiwied Ekasari
Fakultas Farmasi Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

 1 
Aktivitas Penghambatan Ekstrak Etanol Daun Cassia Spectabilis Terhadap Pertumbuhan Plasmodium falciparum dan Plasmodium berghei Wiwied Ekasari; Nindya Tresiana; Suciati Iryani; Tutik Sri Wahyuni; Heny Arwaty
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 3 No. 1 (2016): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (53.699 KB) | DOI: 10.20473/jfiki.v3i12016.17-21

Abstract

Background: Antimalarial screening against nine species of the genus Cassia showed that the methanol extract of leaves Cassia spectabilis have the highest activity. Since it will be used as a traditional medicine, hence it is needed further studies of antimalarial activity of these plants by choosing a safer solvent, namely ethanol. Objective: In vitro anti-malarial activity against Plasmodium falciparum was conducted using the method of Trager and Jensen. Methods: The serial solution tested were: 100, 10, 1,  0.1 and 0.01 µg/ mL, while the in vivo test was performed based on Peter's test (The days suppressive test) that using P. berghei (strain ANKA) infected mice. Results: The results showed that ethanolic extract of C. spectabilis leaves has inhibitory activity against P. falciparum with IC50 value of 12.52 µg/ mL and against P. berghei with ED50 value of 131.5 mg/kg body weight. Conclusions: A further study to see the potential of ethanol extract from C. Spectabilis leaves as anti-malaria is warranted. 
In Vitro Antimalarial Activity and Toxicity of Helianthus annuus L. Leaf Extract against Plasmodium falciparum Nuriha Marangoh; Suciati Suciati; Wiwied Ekasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 8 No. 3 (2021): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v8i32021.259-263

Abstract

Background: Malaria is one of the public health problems in Indonesia. The morbidity rate is still quite high, especially in the eastern part of Indonesia. Objective: This study aimed to determine the inhibitory activity of the leaf extracts of Helianthus annuus L. against Plasmodium falciparum strain 3D7 as well as the cytotoxicity of the extracts. Methods: The leaves of H. annuus were extracted by the maceration method with n-hexane, chloroform, and ethanol 96% to increase polarity. The antimalarial assay was performed by using Trager and Jensen method, and the cytotoxicity test was carried out by the MTT method. Results: The results of antimalarial study showed that the chloroform extract had IC50 value of 0.002 µg/mL and CC50value of 138.03 µg/mL, 96% ethanol extract had an IC50 value of 0.02 µg/mL and CC50 value of 617.81 µg/mL, and n-hexane extract had an IC50 value of 1.29 µg/mL and CC50 value of 104.89 µg/mL. The selectivity index (SI) values of the chloroform, ethanolic, and n-hexane extracts were calculated and obtained 69,015.00, 30,890.50, and 81.31, respectively. Conclusion:  To conclude, the chloroform extract of H. annuus L. leaf gave strong antimalarial activity against P. falciparum strain 3D7 without any cytotoxicity; therefore, H. annuus L. leaf can be a good candidate for the development of an antimalarial drug.
Pharmacological Effects of Glycyrrhiza glabra L. as Antihepatitis and Hepatoprotective for Children Faisal Akhmal Muslikh; Puja Adi Priatna; Wiwied Ekasari
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.126-140

Abstract

Background: The incidence of hepatitis in children has grown from the normal number of hepatitis cases since January 2022, and it will continue to rise since the etiology and pathophysiology are unknown. This case is distinct from those caused by the hepatitis A, B, C, D, and E viruses. Glycyrrhiza glabra L. is a medicinal herb that has long been used in medicine to treat respiratory, digestive, and immune system problems, but it is also known to have an inhibitory impact on the virus. Coronavirus-associated acute respiratory syndrome, hepatitis, herpes simplex virus, influenza virus. Objective: This article will look at Glycyrrhiza glabra L.'s antihepatitis and hepatoprotective properties. Methods: The Pubmed, Sage Journal, and Sciencedirect databases were searched using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards and the keywords "Glycyrrhiza glabra for hepatitis." The inclusion and exclusion criteria were followed. Results: From the search results, 17 publications were discovered that explain how Glycyrrhiza glabra L. can operate as an antihepatitis agent through anti-inflammatory, antiapoptotic, and hepatoprotective mechanisms. Conclusion: Glycyrrhiza glabra L. can be used as an anti-hepatitis and hepatoprotective in children at doses ranging from 240-480mg/kg/day.
Review: Indole Alkaloids and Antimalarial Activity in the Tabernaemontana Species Hutami, Anisa Tri; Ekasari, Wiwied; Rudyanto, Marcellino
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 11 No. 2 (2024): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v11i22024.242-252

Abstract

Background: Malaria, caused by Plasmodium parasites, is a highly prevalent and lethal illness that shows persistent ability to develop resistance. Antiplasmodial compounds that are indole-based prevent hemozoin formation, exhibiting efficacy against chloroquine-resistant Plasmodium strains. Tabernaemontana is a member of the genus comprised  to the Apocynaceae family and has long been known for its efficacy in traditional and herbal tribal medicine. Apocynaceae can be recognized by the existence of indole alkaloids, and Tabernaemontana spp. is widely identifiable for its ability to synthetize a wide variety of indole alkaloids. Objective: This literature review seeks to provide a comprehensive summary of indole alkaloid compounds from Tabernaemontana spp. and the effectiveness of Tabernaemontana spp. as antimalarials. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocols were followed to explore the PubMed, Sage Journal, ScienceDirect, and Wiley Library databases. Results: 23 publications on the antimalarial activity and indole alkaloids of several species of the genus Tabernaemontana were discovered. Conclusion: Various species of Tabernaemontana contain indole alkaloids, and extracts of the plant or parts of the plant and isolates have weak to strong antimalarial activity.
Co-Authors Abdul Rahman Achmad Fuad Hafid Achmad Toto Poernomo Afrida Yunda Nirmala AGUS HARIANTO Agus Pratiwi Andang Miatmoko Andini Putri Rahmadani Anisa Tri Hutami Anisa Tri Hutami Annisa Fatmawati Apriani Sulu Parubak Aqila Aqhnia Gerriandi Ario Imandiri, Ario Arum Widiyaningsih Aty Widyawaruyanti Ayu Indah Lestari Bertha Mangallo Budi Afriyansyah Budi Afriyansyah Dahri, Baso Devanus Lahardo Devanus Lahardo devanus lahardo Dewi Hariyani Dewi Melani Hariyadi Dihan Isro Idayati Diyah, Nuzul Wahyuning Edbert Rafael Tjandra Ega Widya Prayogo Eko Suhartono Esti Hendradi Faisal Akhmal Muslikh Fakhrina Fauzul Minnah Fatin Fadhilah Hasib Firman Wicaksana Firmansyah Ardian Ramadhani Galuh Candra Wijayanti Hadi Poerwono Hamizah Haula Handayani, Rosita Hanifa Rahma Putri Henny Helmi Heny Arwati Heny Arwaty Herra Studiawan Hilkatul Ilmi I NYOMAN WIJAYA Idha Kusumawati Iis Wahyuningsih Irawati Sholikhah Isnaeni Isnaeni Iswahjuni Iswahjuni Iswajuni, Iswajuni Jasmine Aulia Akbar Juni Ekowati Kasmawati, Henny Khalifah Yuliana Kholis Amalia Nofianti Lahardo, Devanus Lailatul Pratama Putri Lidya Tumewu Malaka, Muhammad Hajrul Marcellino Rudyanto Maria Lucia Ardhani Dwi Lestari Melanny Ika Sulistyowaty Murtihapsari Murtihapsari Nindya Tresiana Nindya Tresiana Putri Nindya Tresiana Putri Nindya Tresiana Putri Novreza Avistha Nugroho Nur Illiyyin Akib Nuriha Marangoh Paramita, Diajeng Putri Puja Adi Priatna Puji Budi Asih Purwitasari, Neny Putri Ayu Purbiastuti Retno Sari Retno Widyowati Rice Disi Oktarina Rini Hamsidi Rosalia Friska Ananda Sabarudin Sabarudin Sahu, Ram Kumar Sri Wahyuni, Tutik Suciati Suciati Suciati Suciati Suciati Suciati Suciati Suciati Sudjarwo Sudjarwo Sudjarwo Sudjarwo Sugijanto Sugijanto Sukardiman Suko Hardjono Suryadi, A. Mu’thi Andy Suryanto, Suryanto Syahrani, Achmad Tri Widiandani Tristiana Erawati Tutiek Purwanti Tutik Sri Wahyuni Viola Puspa Imelda W Wahyuni, W Wahjo Djatmiko Widyowati, Rr. Retno Yanu Andhiarto Yusuf Alif Pratama