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All Journal International Journal of Public Health Science (IJPHS) MEDIA MEDIKA INDONESIANA Journal of the Medical Sciences (Berkala Ilmu Kedokteran) VISIKES Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Kesehatan Masyarakat Media Ilmu Keolahragaan Indonesia Jurnal Keolahragaan GIZI INDONESIA Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Gizi Klinik Indonesia Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Journal of Food and Culinary Journal of Community Empowerment for Health Jurnal Dunia Gizi Pena Medika : Jurnal Kesehatan Makara Journal of Health Research SWARNA Medika Respati : Jurnal Ilmiah Kesehatan Engagement: Jurnal Pengabdian Kepada Masyarakat JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Arta Farmawati
Departemen Biokimia Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan Universitas Gadjah Mada
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Potential Effects of Javanese Chili (Piper retrofractum Vahl.) Kombucha to Reduce Hyperglycemic and Maintain Spatial Memory: In Vitro and In Vivo Studies Suyanti, Eri Dwi; Tsani, Salma Mutiara; Hanifah, Wafiq; Nastiti, Fithratun; Maatita, Marcellino; Farmawati, Arta
Journal of Food and Culinary Vol. 8 No. 1 [Juni 2025]
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jfc.v8i1.13598

Abstract

Type 2 Diabetes Mellitus (T2DM) and Alzheimer's Disease (AD) are diseases which incidence and prevalence increase with age. Diabetic patients have 50-75% higher risk of developing AD compared to patients without diabetes. This study aimed to determine the potential effect of Javanese chili kombucha to reduce hyperglycemia and to act as a neuroprotective in diabetes patients with a risk of AD complications through in vitro and in vivo studies. The experiment carried out was fermentation of Javanese chili kombucha for 3, 6, 9, 12 and 15 days. Organoleptic tests, pH measurements, total titratable acidity (TTA), antioxidant tests and α-amylase inhibition tests were conducted to determine the best duration for kombucha fermentation. Phytochemical screening and in vivo tests using 5 groups of rats included measurements of fasting blood glucose (FBG), malondialdehyde (MDA) assay and antidementia (T-maze). The 9th day fermentation preparation was the best preparation, with organoleptic test results of brown color, sour smell with a pH of 3.43 (safe), an antioxidant IC50 value of 10.5 (very strong), an α-amylase inhibition IC50 value of 117.14 (moderate) and TTA 1.44 (normal). Phytochemical screening results show that Javanese chili kombucha contains alkaloids, flavonoids, terpenoids/steroids, saponins, and phenolics. Based on in vivo tests, Javanese chili kombucha can reduce FBG levels and can maintain the spatial memory of experimental animals with a statistically significant T-maze duration time between groups. The MDA level test showed oxidative stress results that were not significantly different between groups.
Wild Stinging Nettle (Urtica dioica) Extract Suppresses Visceral Adipose Aromatase Levels and Improves Lipid Profile in Male Obese Rats Zaenudin, Zaenudin; Tyas, Jurnalis Gempaning; Tangkari, Kabir Ardiansyah; Sutiani, Harni; Farmawati, Arta; Prasetyastuti, Prasetyastuti
Journal of Food and Culinary Vol. 8 No. 1 [Juni 2025]
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jfc.v8i1.13860

Abstract

Obesity can elevate estrogen levels through increased aromatase activity, adversely affecting male fertility. Although aromatase inhibitors are commonly used, they can disrupt lipid profiles and raise cardiovascular risks. This experimental study analyzed the effects of wild stinging nettle (Urtica dioica) extract on visceral adipose aromatase levels and serum lipid profiles in obese male rats. Twenty-five 7–8-week-old male Sprague Dawley rats were divided into five groups: normal control, obesity control, and three obesity groups receiving U. dioica extract at 125, 250, or 500 mg/kg body weight. After a 4-week intervention, blood samples were collected to measure lipid profiles, and visceral adipose tissue was harvested to assess aromatase levels. The U. dioica extract significantly reduced visceral adipose aromatase levels (p < 0.01) and improved lipid profiles in obese rats. Specifically, treated rats showed dose-dependent decreases in triglycerides, total cholesterol, and LDL-cholesterol, along with an increase in HDL-cholesterol (p < 0.05). These findings indicate that U. dioica extract can suppress adipose aromatase levels and ameliorate lipid disturbances in obesity.
Anti-Hyperglycemic Activity of Urtica dioica Extract in Obese Male Sprague Dawley Rats: Evaluation of HOMA-IR and HOMA-β Zaenudin, Zaenudin; Tyas, Jurnalis Gempaning; Tangkari, Kabir Ardiansyah; Sutiani, Harni; Farmawati, Arta; Prasetyastuti
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.28178

Abstract

Obesity is characterized by adipocyte accumulation that impairs glucose uptake, leading to insulin resistance, hyperglycemia, and an increased risk of diabetes mellitus. Given the limitations and adverse effects of pharmacological therapies for diabetes, alternative agents are needed. Urtica dioica contains flavonoids with anti-inflammatory and antioxidant properties that may improve glucose homeostasis. This experimental study employed a pre-test and post-test control group design using 25 male Sprague Dawley rats divided into five groups: healthy control (K1), obese control (K2), and three obese groups receiving Urtica dioica extract at doses of 125, 250, and 500 mg/kgBW (D1–D3) for four weeks. Data were analyzed using one-way ANOVA and paired t-test. Administration of Urtica dioica extract at 500 mg/kgBW (D3) significantly reduced blood glucose (79.90 ± 2.51 vs. 177.92 ± 3.30; p<0.05), increased insulin levels (16.20 ± 0.29 vs. 12.82 ± 0.28; p<0.05), decreased HOMA-IR (3.19 ± 0.07 vs. 5.63 ± 0.14; p<0.05), and enhanced HOMA-β (351.20 ± 58.77 vs. 40.21 ± 1.63; p<0.05) compared with untreated obese controls. In conclusion, four-week administration of Urtica dioica extract effectively improved insulin resistance and β-cell function in obese rats, with the most pronounced effect observed at a dose of 500 mg/kgBW.
Addressing Disparities in Clean and Healthy Living Behaviors through Targeted Health Education in a Rural Community Widodo, Irianiwati; Rinonce, Hanggoro Tri; Asysyifa, Azzahra; Syarifa, Cut Alima; Sabila, Aflifia Birruni; Nurrahma, Bira Arumndari; Farmawati, Arta; Sari, Dwi Cahyani Ratna; Nugrahaningsih, Dwi Aris Agung; Jaya, Sudi Indra; Sholikhah, Eti Nurwening; Rizal, Dicky Moch; Susilowati, Rina; Nuryastuti, Titik; Murhandarwati, E. Elsa Herdiana; Triyono, Teguh; Ratnaningsih, Tri
Engagement: Jurnal Pengabdian Kepada Masyarakat Vol. 10 No. 1 (2026): February 2026
Publisher : Asosiasi Dosen Pengembang Masyarajat (ADPEMAS) Forum Komunikasi Dosen Peneliti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29062/engagement.v10i1.2043

Abstract

Background: This study addresses the public health issue of community hygiene and wellness by focusing on the Clean and Healthy Lifestyle Behavior (CHLB) as a key parameter. The subject of the assessment is the community of Sompok Hamlet, Bantul, with the purpose of evaluating the implementation of CHLB within households to understand areas of strength and needed improvement. Purpose of the Study: The purpose is to assess the level of CHLB implementation in Sompok Hamlet. The objective is to measure household compliance across various CHLB indicators and identify specific behavioral gaps that require targeted intervention. Methods: The study employed a cross-sectional survey design conducted in 2023. Data were collected from 202 households across seven neighborhood units (RT) using a structured questionnaire to evaluate compliance with standard CHLB indicators. Results: The results showed that 68.3% of households met the criteria for independent healthy communities. High compliance was observed in indicators like access to clean water, sanitation, exclusive breastfeeding, and toddler weighing. However, significant gaps were identified in physical activity (71.3% low compliance) and indoor smoking practices (64% low compliance). Practices related to fruit/vegetable consumption, handwashing, and larva elimination showed varied results. The findings highlight the need for focused educational programs to address these specific behavioral deficiencies to promote sustainable community health.
Co-Authors . Sunarti . Wulandari Abdul Wahab Abdul Wahab Abrory Agus Cahya Pramana Aflifia Birruni Sabila Ahmad Ghozali Ahmad Hamim Sadewa Ainun Nisa Amir, Safrullah Anggi Laksmita Dewi Asysyifa, Azzahra Aulia R, Deby Ayu Dwi Silvia Putri Bayu Sigha Iswara Bernadeta M Wara Kushartanti Bernadette Josephine Istiti Kandarina Bira Arumndari Nurrahma Bira Arumndari Nurrahma Brilliant Alendra Adianfra Deby Aulia R Deby Aulia R, Deby Deby Aulia Rahmi Deby Aulia Rahmi Desty Ervira Puspaningtyas Dianandha Septiana Rubi Dianandha Septiana Rubi Dicky Moch Rizal Dicky Moch Rizal Dina Septari Anindyah Dina Septari Anindyah Dono Indarto DONO INDARTO Dono Indarto Dwi Aris Agung Nugrahaningsih Dwi Cahyani Ratna Sari Dwi Lestari Dwi Lestari Dwi Novitasari E. Elsa Herdiana Murhandarwati Edilburga Wulan Saptandari Emy Huriyati Emy Huriyati Enrique Aldrin Eti Nurwening Sholikhah Fatwa Sari Tetra Dewi Faurina Risca Fauzia Febri Indah Widhowati Gandes Retno Rahayu Ghozali, Ahmad Gita Trisna Gita Trisna Gita Trisna Gita Trisna, Gita Hadi, Novian Swasono Hanggoro Tri Rinonce Hanifah, Wafiq Harumi P, Made Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti, Irmayanti Irwan Supriyanto James Degnan Jaya, Sudi Indra Khrisnawati, Putri Kurniati Dwi Utami Kusuma, Rio Jati Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Lily Arsanti Lestari Maatita, Marcellino Made Harumi P Made Harumi P, Made Made Harumi Padmaswari Made Harumi Padmaswari Maria Dara Novi Handayani, Maria Dara Novi Martalena B Purba Martalena Br Purba Martalena Br Purba, Martalena Br Mega Febia Suryajayanti Mohamad Fay Faizal Nadia Yasmine Nastiti, Fithratun Ngadikun - Ngadikun Ngadikun Nisa, Ainun Noor Rochman Hadjam Noor Rochman Hadjam Noor Rochman Hadjam, Noor Rochman Nor Istiqomah Nor Istiqomah Nor Istiqomah Novian Swasono Hadi Novidiyanto Novidiyanto Novidiyanto, Novidiyanto Nur Arfiyan Nur Arfiyan Nur Imma Fatimah Harahap Nurahma, Bira Arumndari Nurrahma, Bira Arumndari Nyoman Odiyana P G Nyoman Odiyana P G, Nyoman Nyoman Odiyana Prayoga Griadhi Nyoman Odiyana Prayoga Griadhi Odiyana P G, Nyoman Pramudji Hastuti Pramudji Hastuti Prasetyastuti Prasetyastuti Prasetyastuti - Prasetyastuti - Prasetyastuti Prasetyastuti Prattama Santoso Utomo Prima Dhewi Ratrikaningtyas Putri Khrisnawati Putri Khrisnawati, Putri Rachmadya Nur Hidayah Ratika Marchelaona Rilani Riskiyana Rina Susilowati Risky Oktriani Safrullah Amir Sarah Safira Umarghanies Sarair Maulidya Silvi Lailatul Mahfida Siti Rahmah Projosasmito Siti Wahyuningsih Sri Wahyuni Sunarti Sunarti Sunarti Sunarti Sunarti Sunarti Sunarti Susetyowati Sutiani, Harni Suyanti, Eri Dwi Syarifa, Cut Alima Sylvia Putri Synta Haqqul Fadlilah Tangkari, Kabir Ardiansyah Tasmini Tasmini Tasmini Tasmini Teguh Triyono Titik Nuryastuti Toto Sudargo Toto Sudargo Tri Ratnaningsih Tri Ratnaningsih Trisna, Gita Tsani, Salma Mutiara Tyas, Jurnalis Gempaning Umarghanies, Sarah Safira Vitria Sari Dewi Vitria Sari Dewi Wasilah Rochmah Widodo, Irianiwati Wiryatun Lestariana Wiryatun Lestariana, Wiryatun Yafi Surya Permana Yogik Onky Silvana Wijaya Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Soesilo Yuni Afriani Yuni Afriani Yuni Afriani Yuni Afriani Yuni Afriani, Yuni Zaenudin Zaenudin Zainal Arifin Nang Agus Zunamilla Khairia