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Potential Effects of Javanese Chili (Piper retrofractum Vahl.) Kombucha to Reduce Hyperglycemic and Maintain Spatial Memory: In Vitro and In Vivo Studies Suyanti, Eri Dwi; Tsani, Salma Mutiara; Hanifah, Wafiq; Nastiti, Fithratun; Maatita, Marcellino; Farmawati, Arta
Journal of Food and Culinary Vol. 8 No. 1 [Juni 2025]
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jfc.v8i1.13598

Abstract

Type 2 Diabetes Mellitus (T2DM) and Alzheimer's Disease (AD) are diseases which incidence and prevalence increase with age. Diabetic patients have 50-75% higher risk of developing AD compared to patients without diabetes. This study aimed to determine the potential effect of Javanese chili kombucha to reduce hyperglycemia and to act as a neuroprotective in diabetes patients with a risk of AD complications through in vitro and in vivo studies. The experiment carried out was fermentation of Javanese chili kombucha for 3, 6, 9, 12 and 15 days. Organoleptic tests, pH measurements, total titratable acidity (TTA), antioxidant tests and α-amylase inhibition tests were conducted to determine the best duration for kombucha fermentation. Phytochemical screening and in vivo tests using 5 groups of rats included measurements of fasting blood glucose (FBG), malondialdehyde (MDA) assay and antidementia (T-maze). The 9th day fermentation preparation was the best preparation, with organoleptic test results of brown color, sour smell with a pH of 3.43 (safe), an antioxidant IC50 value of 10.5 (very strong), an α-amylase inhibition IC50 value of 117.14 (moderate) and TTA 1.44 (normal). Phytochemical screening results show that Javanese chili kombucha contains alkaloids, flavonoids, terpenoids/steroids, saponins, and phenolics. Based on in vivo tests, Javanese chili kombucha can reduce FBG levels and can maintain the spatial memory of experimental animals with a statistically significant T-maze duration time between groups. The MDA level test showed oxidative stress results that were not significantly different between groups.
Wild Stinging Nettle (Urtica dioica) Extract Suppresses Visceral Adipose Aromatase Levels and Improves Lipid Profile in Male Obese Rats Zaenudin, Zaenudin; Tyas, Jurnalis Gempaning; Tangkari, Kabir Ardiansyah; Sutiani, Harni; Farmawati, Arta; Prasetyastuti, Prasetyastuti
Journal of Food and Culinary Vol. 8 No. 1 [Juni 2025]
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jfc.v8i1.13860

Abstract

Obesity can elevate estrogen levels through increased aromatase activity, adversely affecting male fertility. Although aromatase inhibitors are commonly used, they can disrupt lipid profiles and raise cardiovascular risks. This experimental study analyzed the effects of wild stinging nettle (Urtica dioica) extract on visceral adipose aromatase levels and serum lipid profiles in obese male rats. Twenty-five 7–8-week-old male Sprague Dawley rats were divided into five groups: normal control, obesity control, and three obesity groups receiving U. dioica extract at 125, 250, or 500 mg/kg body weight. After a 4-week intervention, blood samples were collected to measure lipid profiles, and visceral adipose tissue was harvested to assess aromatase levels. The U. dioica extract significantly reduced visceral adipose aromatase levels (p < 0.01) and improved lipid profiles in obese rats. Specifically, treated rats showed dose-dependent decreases in triglycerides, total cholesterol, and LDL-cholesterol, along with an increase in HDL-cholesterol (p < 0.05). These findings indicate that U. dioica extract can suppress adipose aromatase levels and ameliorate lipid disturbances in obesity.
Co-Authors . Sunarti . Wulandari Abdul Wahab Abdul Wahab Abrory Agus Cahya Pramana Ahmad Ghozali Ahmad Hamim Sadewa Ainun Nisa Amir, Safrullah Anggi Laksmita Dewi Aulia R, Deby Ayu Dwi Silvia Putri Bayu Sigha Iswara Bernadeta M Wara Kushartanti Bernadette Josephine Istiti Kandarina Bira Arumndari Nurrahma Bira Arumndari Nurrahma Brilliant Alendra Adianfra Deby Aulia R Deby Aulia R, Deby Deby Aulia Rahmi Deby Aulia Rahmi Desty Ervira Puspaningtyas Dianandha Septiana Rubi Dianandha Septiana Rubi Dina Septari Anindyah Dina Septari Anindyah Dono Indarto Dono Indarto DONO INDARTO Dwi Lestari Dwi Lestari Dwi Novitasari Edilburga Wulan Saptandari Emy Huriyati Emy Huriyati Enrique Aldrin Fatwa Sari Tetra Dewi Faurina Risca Fauzia Febri Indah Widhowati Gandes Retno Rahayu Ghozali, Ahmad Gita Trisna Gita Trisna Gita Trisna Gita Trisna, Gita Hadi, Novian Swasono Hanifah, Wafiq Harumi P, Made Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti Irmayanti, Irmayanti Irwan Supriyanto James Degnan Khrisnawati, Putri Kurniati Dwi Utami Kusuma, Rio Jati Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Kusumadewi Eka Damayanti Lily Arsanti Lestari Maatita, Marcellino Made Harumi P Made Harumi P, Made Made Harumi Padmaswari Made Harumi Padmaswari Maria Dara Novi Handayani, Maria Dara Novi Martalena B Purba Martalena Br Purba Martalena Br Purba, Martalena Br Mega Febia Suryajayanti Mohamad Fay Faizal Nadia Yasmine Nastiti, Fithratun Ngadikun - Ngadikun Ngadikun Nisa, Ainun Noor Rochman Hadjam Noor Rochman Hadjam Noor Rochman Hadjam, Noor Rochman Nor Istiqomah Nor Istiqomah Nor Istiqomah Novian Swasono Hadi Novidiyanto Novidiyanto Novidiyanto, Novidiyanto Nur Arfiyan Nur Arfiyan Nur Imma Fatimah Harahap Nurahma, Bira Arumndari Nyoman Odiyana P G Nyoman Odiyana P G, Nyoman Nyoman Odiyana Prayoga Griadhi Nyoman Odiyana Prayoga Griadhi Odiyana P G, Nyoman Pramudji Hastuti Pramudji Hastuti Prasetyastuti Prasetyastuti - Prasetyastuti - Prasetyastuti Prasetyastuti Prattama Santoso Utomo Prima Dhewi Ratrikaningtyas Putri Khrisnawati Putri Khrisnawati, Putri Rachmadya Nur Hidayah Ratika Marchelaona Rilani Riskiyana Risky Oktriani Safrullah Amir Sarah Safira Umarghanies Sarair Maulidya Silvi Lailatul Mahfida Siti Rahmah Projosasmito Siti Wahyuningsih Sri Wahyuni Sunarti Sunarti Sunarti Sunarti Sunarti Sunarti Sunarti Susetyowati Sutiani, Harni Suyanti, Eri Dwi Sylvia Putri Synta Haqqul Fadlilah Tangkari, Kabir Ardiansyah Tasmini Tasmini Tasmini Tasmini Toto Sudargo Toto Sudargo Tri Ratnaningsih Trisna, Gita Tsani, Salma Mutiara Tyas, Jurnalis Gempaning Umarghanies, Sarah Safira Vitria Sari Dewi Vitria Sari Dewi Wasilah Rochmah Wiryatun Lestariana Wiryatun Lestariana, Wiryatun Yafi Surya Permana Yogik Onky Silvana Wijaya Yuliana Heri Soesilo Yuliana Heri Soesilo Yuliana Heri Soesilo Yuni Afriani Yuni Afriani Yuni Afriani Yuni Afriani Yuni Afriani, Yuni Zaenudin Zaenudin Zainal Arifin Nang Agus Zunamilla Khairia